acetaminophen has been researched along with acetylcysteine in 1001 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 205 (20.48) | 18.7374 |
| 1990's | 149 (14.89) | 18.2507 |
| 2000's | 221 (22.08) | 29.6817 |
| 2010's | 312 (31.17) | 24.3611 |
| 2020's | 114 (11.39) | 2.80 |
| Authors | Studies |
|---|---|
| Fricke, RF; Goon, DJ; Nagasawa, HT; Roberts, JC; Zera, RT | 1 |
| Goon, DJ; Nagasawa, HT; Yuzon, DL; Zera, RT | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bharate, SS; Vishwakarma, RA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Berssenbruegge, DA; Piperno, E | 1 |
| Gerber, JG; Harbison, RD; MacDonald, JS; Nies, AS; Villeneuve, JP; Wood, AJ | 1 |
| Adriaenssens, P; Ballantyne, A; Park, J; Prescott, LF; Proudfoot, AT | 1 |
| Mann, TA; Shaw, KM; Walton, NG | 1 |
| Macy, AM | 1 |
| van Zwieten, PA | 1 |
| Gillette, JR; Hinson, JA; Nelson, SD | 1 |
| Dillman, RO; Kim, HS; Stewart, DM; Stewart, K | 1 |
| Austin, FD; Carloss, H | 1 |
| Galinsky, RE; Levy, G | 1 |
| Adam, RD; Critchley, JA; Illingworth, RN; Prescott, LF; Proudfoot, AT; Stewart, MJ | 1 |
| Crome, P; Goulding, R; Helliwell, M; Meredith, TJ; Vale, JA; Volans, GN; Widdop, B | 1 |
| Prescott, LF | 5 |
| Bargman, GJ; Newman, TJ | 1 |
| Peterson, RG; Rumack, BH | 5 |
| Prescott, LF; Proudfoot, AT; Stewart, MJ | 1 |
| Conner, CS; Scalley, RD | 1 |
| Austin, F; Carloss, H; Forrester, J; Fuson, T | 1 |
| Maurer, WG; Zeisler, J | 1 |
| Berssenbruegge, DA; Mosher, AH; Piperno, E; Smith, RB; Winkler, JD | 1 |
| Moldéus, P | 1 |
| Levy, G; Slattery, JT | 1 |
| Lyons, L; Sommaripa, AM; Studdiford, JS | 1 |
| Best, L; Krenzelok, EP; Manoguerra, AS | 1 |
| Fraser, GL | 1 |
| Marquardt, ED | 1 |
| Buckpitt, AR; Franklin, RB; Mitchell, JR; Nelson, SD; Rollins, DE | 1 |
| Davis, M; Harrison, NG; Simmons, CJ; Williams, R | 1 |
| Andrews, RS; Bond, CC; Burnett, J; Saunders, A; Watson, K | 1 |
| Davis, M; Labadarios, D; Williams, RS | 1 |
| Ema, S; Hayashi, M; Horii, S; Yamakawa, M | 1 |
| Corcoran, GB; Kamendulis, LM; Ray, SD; Shen, W | 1 |
| Brahm, J; Palma, R; Silva, G | 1 |
| Bray, GP; Harrison, PM; O'Grady, JG; Tredger, JM; Williams, R | 1 |
| Reynard, K; Riley, A; Walker, BE | 1 |
| Deshpande, JK; Gregory, DF; Tobias, JD | 1 |
| Boobis, AR; Davies, DS; Fawthrop, DJ; Nasseri-Sina, P; Wilson, J | 1 |
| Burkhart, KK; Donovan, JW | 1 |
| Block, R; Jankowski, JA; Lacoux, P; Pennington, CR | 1 |
| Chow, SY; de Morais, SM; Wells, PG | 1 |
| Batey, RG; Brotodihardjo, AE; Byth, K; Farrell, GC | 1 |
| Halkin, H; Winkler, E | 1 |
| Berthon, G; Brumas, V; Filella, M; Hacht, B | 1 |
| De Majo, W; Levy, GA; Sheiner, P | 1 |
| Brown, IR; Peterson, TC | 1 |
| Bonfiglio, MF; Hulisz, DT; Martin, BR; Traeger, SM | 1 |
| Chen, TS; Lang, CA; Richie, JP | 1 |
| Möller-Hartmann, W; Siegers, CP | 1 |
| Lewis, RK; Paloucek, FP | 1 |
| Dalhoff, K; Hansen, PB; Loft, S; Ott, P; Poulsen, HE | 1 |
| Bray, GP; Mowat, C; Muir, DF; Tredger, JM; Williams, R | 1 |
| Bray, GP; Tredger, JM; Williams, R | 1 |
| Dunphy, JA; Lewis, RP; Reilly, CS | 1 |
| Critchley, JA; Leung, NW | 1 |
| Alexander, GJ; Gimson, AE; Harrison, PM; Wendon, JA; Williams, R | 1 |
| Flanagan, RJ; Meredith, TJ | 1 |
| Augenstein, WL; Bronstein, AC; Kulig, KW; Linden, C; Rumack, BH; Smilkstein, MJ | 1 |
| Bourcier, DR; Kulkarni, AP; Mitra, A; Ravikumar, VC | 1 |
| Alexander, GJ; Forbes, A; Gove, C; Harrison, PM; Keays, R; Wendon, JA; Williams, R | 1 |
| Benson, RW; Dalhoff, K; Hinson, JA; Loft, S; Poulsen, HE; Roberts, DW | 1 |
| Alexander, GJ; Bray, GP; Harrison, PM; Keays, R; Williams, R | 1 |
| Marcuard, SP; Rolband, GC | 1 |
| Blaschke, TF; Hazle, W; Matano, R; Skinner, MH | 1 |
| Lubec, G | 1 |
| Burcham, PC; Harman, AW | 2 |
| Parker, D; Paton, D; Routledge, PA; White, JP | 1 |
| Beckett, GJ; Donovan, JW; Hussey, AJ; Prescott, LF; Proudfoot, AT | 1 |
| Ignarro, LJ; Wood, KS | 1 |
| Brahams, D | 1 |
| Harvey, JM; Jones, AF; Vale, JA | 1 |
| Eddy, AC; Kalhorn, TF; Kharasch, ED; McRorie, TI; Reynolds, R; Slattery, JT | 1 |
| Donovan, JW; Jarvie, DR; Prescott, LF; Proudfoot, AT | 1 |
| Furukawa, T; Palacin, M; Perez, C; Viña, J; Viña, JR | 1 |
| Bracht, A; Itinose, AM; Sakuno, ML | 1 |
| Dawson, AH; Henry, DA; McEwen, J | 1 |
| Burgunder, JM; Lauterburg, BH; Varriale, A | 1 |
| Bartle, WR; Derry, JE; Livingstone, DJ; Paradiso, FL | 1 |
| Archer, PG; Bronstein, AC; Kulig, K; Riggs, BS; Rumack, BH | 1 |
| Nelson, SD; Rashed, MS | 1 |
| Kulig, KW | 1 |
| Heller, MB | 1 |
| Flanagan, RJ; Mant, TG; Ruprah, M | 1 |
| Boobis, AR; Davies, DS; Tee, LG | 1 |
| Gemborys, MW; Hoefle, D; Hook, JB; Mudge, GH; Newton, JF | 1 |
| Moldéus, P; Norbeck, K; Ross, D | 1 |
| Knapp, GL; Kulig, KW; Rumack, BH; Smilkstein, MJ | 1 |
| Hayes, MA; Murray, CA; Rushmore, TH | 1 |
| Meredith, TJ; Prescott, LF; Vale, JA | 1 |
| Corcoran, GB; Wong, BK | 2 |
| Mann, KV | 1 |
| Davenport, A; Finn, R | 1 |
| Donovan, JW | 1 |
| Bruno, MK; Cohen, SD; Khairallah, EA | 1 |
| Baille, TA; Calleman, CJ; Pascoe, GA | 1 |
| Yeung, JH | 1 |
| Bailey, D; Blake, KV; Hendeles, L; Zientek, GM | 1 |
| Flesch, F; Jaeger, A; Kopferschmitt, J; Sauder, P | 1 |
| Corcoran, GB; Neese, BL; Wong, BK | 1 |
| Buckley, BM; Gray, TA; Vale, JA | 1 |
| Gabbe, SG; Landon, MB; Ludmir, J; Main, DM | 1 |
| Levy, G | 1 |
| Tenenbein, M | 2 |
| Davis, M | 1 |
| Banda, PW; Quart, BD | 3 |
| Zarro, VJ | 1 |
| Critchley, JA; Gregson, CA; Nimmo, GR; Prescott, LF; Woolhouse, NM | 1 |
| Hathcock, JN; Reicks, MM | 1 |
| Andrews, C; Jellett, L | 1 |
| Bridges, RR; Ekins, BR; Ford, DC; Jenkins, RD; Rollins, DE; Thompson, MI | 1 |
| Araya, H; Awazu, S; Hayashi, M; Horie, T | 1 |
| Hall, AH; Rumack, BH | 1 |
| Flanagan, RJ; Mant, TG | 1 |
| Read, RB; Tredger, JM; Williams, R | 1 |
| Rumack, BH | 5 |
| Collins, JJ; Robertson, RG; Van Cleave, BL | 1 |
| Harman, AW; Self, G | 1 |
| Aalen, O; Ingebrigtsen, K; Nafstad, I; Skoglund, LA | 1 |
| Smith, JP | 1 |
| DeGott, C; Descatoire, V; Geneve, J; Larrey, D; Letteron, P; Pessayre, D; Tinel, M | 1 |
| Gillen, LE; Harrison, EF; Holdiness, MR; Morgan, LR | 1 |
| Corcoran, GB; Galinsky, RE; Wong, BK | 1 |
| Burrell, DE; Kelley, AK; Rybolt, TR; Shults, JM | 1 |
| Kalhorn, TF; Nelson, SD; Slattery, JT; Wilson, JM | 1 |
| Hayashi, S; Nakai, T | 1 |
| Krenzelok, EP | 1 |
| Brzeznicka, EA; Hjelle, JJ; Klaassen, CD | 1 |
| Hazelton, GA; Hjelle, JJ; Klaassen, CD | 1 |
| Beckett, GJ; Chapman, BJ; Dyson, EH; Hayes, JD | 1 |
| Levy, M; Oren, R | 1 |
| Corcoran, GB; Hughes, H; Mitchell, JR; Racz, WJ; Smith, CV; Todd, EL | 1 |
| Corcoran, GB; Mitchell, JR; Racz, WJ; Smith, CV | 1 |
| Donovan, JW; Harrison, EF; Martin, TG; Morgan, L; Renzi, FP | 1 |
| Judson, DG | 1 |
| Lugten, PC | 1 |
| Leipold, HW; Oehme, FW; Savides, MC | 1 |
| Maldonado, AL; Mitchell, MC; Speeg, KV | 1 |
| Pakuts, A; Paul, CJ; Solomonraj, G; Whitehouse, LW; Wong, LT | 1 |
| Spielberg, SP | 1 |
| Ioannides, C; Pratt, S | 1 |
| Jørgensen, LN | 1 |
| Jollow, DJ; Keiser, H; Mitchell, JR; Potter, WZ; Thorgeirsson, SS | 1 |
| Hashimoto, M; Jollow, DJ; Mitchell, JR; Potter, WZ; Thorgeirsson, SS | 1 |
| Jagenburg, R; Nagy, A; Rödjer, S | 1 |
| Gilbertson, AA; Smith, JM | 1 |
| Vale, JA; Wheeler, DC | 1 |
| Henry, J; Volans, G | 1 |
| Miller, LF; Rumack, BH | 1 |
| Critchley, JA; Prescott, LF | 2 |
| Linden, CH; Rumack, BH | 1 |
| Beilin, LJ; Ho, SW | 1 |
| Buckley, BM; Vale, JA | 1 |
| Bateman, DN; Rawlins, MD; Woodhouse, KW | 1 |
| Proudfoot, AT | 1 |
| Birkett, DJ; Drew, R; Miners, JO | 1 |
| Mohammad, FK; St Omer, VE | 1 |
| David, RM; Shihabi, ZK | 1 |
| Nielsen, I; Pedersen, RS | 1 |
| Poulsen, HE; Ranek, L | 1 |
| Massey, TE; McElligott, TF; Racz, WJ; Walker, RM | 2 |
| Marcella, KL | 1 |
| Isom, GE; Khairy, L; Kildsig, DO | 1 |
| Delaforge, M; Hall, DE; Ioannides, C; Mulder, DE; Parke, DV; Spickett, J; Steele, CM | 1 |
| Estrela, JM; Sáez, GT; Such, L; Viña, J | 1 |
| Wells, PG | 1 |
| Stokes, IM | 1 |
| Anundi, I; Dawson, JR; Moldéus, P; Norbeck, K | 1 |
| Corcoran, GB; Lauterburg, BH; Mitchell, JR | 1 |
| Cameron, AM; Hinson, JA; Mays, JB | 1 |
| Oehme, FW; Savides, MC | 1 |
| Hopkins, S | 1 |
| Golden, DP; Mackercher, P; Mosby, EL; Smith, DJ | 1 |
| Miller, GW | 1 |
| Osterhout, SK | 1 |
| Black, M | 1 |
| Goulding, R; Meredith, TJ | 1 |
| Pflüger, KH | 1 |
| Freedman, F; Sellers, EM | 1 |
| Nasadi, M | 1 |
| Breen, KJ; Bury, RW; Desmond, PV; Forge, BH; Mashford, ML; Whelan, G | 1 |
| Dayton, H; Fretthold, D; Leickly, F; Sunshine, I; Thompson, WL; Van de Graaff, WB | 1 |
| Jackson, JE | 1 |
| Ruffalo, RL; Thompson, JF | 1 |
| Galinsky, RE; Kaysen, GA; Levy, G; Menke, DJ; Pond, SM; Roberts, SM; Tong, TG | 1 |
| Bailey, BO | 2 |
| Chinouth, RW; Czajka, PA; Peterson, RG | 1 |
| Calder, IC; Emslie, KR; Hart, SJ; Smail, MC; Tange, JD | 1 |
| Klein-Schwartz, W; Oderda, GM | 1 |
| Krenzelok, EP; North, DS; Peterson, RG | 1 |
| Paul, CJ; Solomonraj, G; Thomas, BH; Whitehouse, LW; Wong, LT | 1 |
| Massey, TE; Racz, WJ | 1 |
| Levy, G; Lin, JH | 1 |
| Balali-Mood, M; Critchley, JA; Pentland, B; Prescott, LF | 1 |
| Fischer, LJ; Green, MD | 1 |
| Nicol, RG | 1 |
| Baker, DC; Gaunt, SD; Green, RA | 1 |
| Frankl, O; Kaplinsky, N; Shnaps, Y; Tirosh, M | 1 |
| Corcoran, GB; Hughes, H; Lauterburg, BH; Mitchell, JR; Smith, CV | 1 |
| Gilligan, JE; Kemp, R; Pain, R; Phillips, PJ | 1 |
| Critchley, JA; Illingworth, RN; Prescott, LF; Proudfoot, AT | 1 |
| Levitt, T; Widdop, B | 1 |
| Davis, M; Smith, HM; Tredger, JM; Williams, R | 1 |
| Calder, I; Hart, S; Ross, B; Tange, J | 1 |
| Estrela, JM; Romero, FJ; Viña, J; Viña, JR | 1 |
| McKnight, ED; St Omer, VV | 1 |
| Emby, DJ | 1 |
| Nagasawa, HT; Zera, RT | 1 |
| Oh, TE; Shenfield, GM | 1 |
| Carloss, HW | 1 |
| Krienke, EG; von Mühlendahl, KE | 1 |
| Calder, I; Emslie, K; Hart, S; Ross, B; Smail, M; Tange, J | 1 |
| Amara, IA; Koch, GG; Peterson, RC; Rumack, BH | 1 |
| Goulding, R; Meredith, TJ; Vale, JA | 1 |
| Atwood, SJ | 1 |
| Makin, AJ; Wendon, J; Williams, R | 1 |
| Beckett, MW; Bray, GP; Hulbert, DC | 1 |
| Heathcote, J; Wanless, IR | 1 |
| Proudfoot, AT; Vale, JA | 1 |
| Ajzenberg, N; Alvin, P; Dreyfus, M; Rey, C; Tchernia, G | 1 |
| Whitcomb, DC | 1 |
| Heslet, L; Lystbaek, BB; Svendsen, LB | 2 |
| Esteban, A; Graells, ML; Mayol, MJ; Pérez-Mateo, M; Satorres, J | 1 |
| Aaron, CK; Graudins, A; Linden, CH | 1 |
| Perrone, J; Southiere, G | 1 |
| Kirsch, RE; Pillans, P; Robson, SC; Spearman, CW | 1 |
| Rose, SR | 1 |
| Tighe, TV; Walter, FG | 1 |
| Davie, A | 1 |
| Savelkoul, TJ; van Berge Henegouwen, GP | 1 |
| Chan, TY; Critchley, JA | 1 |
| Barr, SG; Harrison, JJ; Racz, WJ; Rafeiro, E | 1 |
| Smilkstein, MJ | 1 |
| Deckers, O; Hantson, P; Mahieu, P; Van Vyve, T | 1 |
| Diamond, JJ; Grande, GA; Krenzelok, EP; Safir, EF; Spiller, HA | 1 |
| De Wit, N; Gillet, R; Huyghens, L; Spapen, H; Zhang, H | 1 |
| al-Khalil, I; Douidar, SM; Habersang, RW | 1 |
| Bracht, A; Doi-Sakuno, ML; Itinose, AM | 1 |
| Jamal, AZ; Mohammed, S; Robison, LR | 1 |
| Burroughs, AK; Hansing, RL; Monto, GL; Scheuer, PJ | 1 |
| Donnelly, PJ; Racz, WJ; Walker, RM | 1 |
| Harrison, PM; Keays, R; Wendon, JA; Williams, R | 1 |
| Cheung, L; Meyer, KC; Potts, RG | 1 |
| Mutimer, D; Neuberger, J | 1 |
| Davey, L; Naidoo, D | 1 |
| Dancocks, A | 1 |
| Brent, J | 1 |
| Anantharaman, V | 1 |
| Chan, AY; Chan, TY; Critchley, JA | 1 |
| Benzick, AE; Gomez, MR; Heird, WC; Rogers, LK; Smith, CV | 1 |
| Banerjee, A; Hassig, SR; Levine, L; Linscheer, WG; Miller, C; Murthy, UK; Oates, RP; Wagner, K | 1 |
| Chamberlain, JM; Gorman, RL; Klein, BL; Klein-Schwartz, W; Oderda, GM | 1 |
| Beales, D; Ghauri, FY; McLean, AE; Nicholson, JK; Wilson, ID | 1 |
| Anker, A; Smilkstein, MJ | 1 |
| Hegarty, JE; Mulcahy, HE | 1 |
| Bray, GP | 1 |
| Jones, AF; Vale, JA | 1 |
| Esteban, A; Graells, ML; Mayole, MJ; Pérez-Mateo, M; Satorres, J | 1 |
| Grewal, KK; Racz, WJ | 1 |
| Fuller, SH; Larsen, LC | 1 |
| Lin, YS; Oehme, FW; Rumbeiha, WK | 1 |
| De Roos, FJ; Hoffman, RS | 1 |
| Feldstein, TJ; Hartfield, D; Horner, H; Kobrinsky, NL; Maksymiuk, A; Minuk, GY; White, DF | 1 |
| Cho, CH; Kaan, SK; Woo, PC | 1 |
| Dhawan, A; Sorrell, MF | 1 |
| Klaassen, CD; Liu, L | 1 |
| Bricker, JD; Dean, BS; Krenzelok, EP | 1 |
| Kind, B; Krähenbúhl, S; Meier-Abt, PJ; Wyss, PA | 1 |
| Kalafatis, N; Macrides, TA; Naylor, LM; Shihata, A; Wright, PF | 1 |
| Burkhart, KK | 1 |
| Elías, MM; Monasterolo, LA; Trumper, L | 1 |
| Perry, HE; Shannon, MW; Woolf, AD; Wright, RO | 1 |
| Chan, TY | 1 |
| Hershkovitz, E; Levitas, A; Shorer, Z; Tal, A | 1 |
| Astrup, LB; Clemmesen, JO; Dalhoff, KP; Ott, P; Poulsen, HE; Tage-Jensen, U | 1 |
| Dietrich, A; Ehrlich, W; Kröger, H; Kurpisz, M; Lange, R; Ohde, M | 1 |
| Dunlevy, TM; Wall, MP | 1 |
| Nielsen, PT; Pfeiffer, P | 1 |
| Hantson, P; Koerner, MM; Laterre, PF; Mahieu, P; Vanormelingen, P; Vekemans, MC | 1 |
| Allameh, A; Vansoun, EY; Zarghi, A | 1 |
| Washio, M | 1 |
| Chao, HT; Hung, JH; Lee, WL; Wang, PH; Yang, MJ; Yang, ML | 1 |
| Abdul-Cader, Z; Al-Ali, AK; Al-Mustafa, ZH; Qaw, FS | 1 |
| Stavem, K | 1 |
| Benitez, JG; Krenzelok, EP; Mroz, LS | 1 |
| Bearer, CF; Dart, RC; Gupta, U; Horowitz, RS; Jarvie, DR | 1 |
| Dayneka, NL; Simons, JA; Sung, L | 1 |
| Falk, JL | 1 |
| Dart, RC; Hurlbut, KM; Yip, L | 1 |
| Kearns, GL; Leeder, JS; Wasserman, GS | 2 |
| Perry, HE; Shannon, MW | 1 |
| MacConnachie, AM | 1 |
| Scharman, EJ | 1 |
| Mayer, M; Salpeter, L | 1 |
| Bridger, S; Ellis, AJ; Glucksman, E; Henderson, K; Henry, JA; Williams, R | 1 |
| Bailey, B; McGuigan, MA | 1 |
| Roberts, SM; Salminen, WF; Voellmy, R | 1 |
| Dunn, RJ | 1 |
| Jones, AL | 1 |
| Shichi, H; Zhao, C | 1 |
| Beijnen, JH; Huitema, AD; Koks, CH; Meenhorst, PL; Soesan, M | 1 |
| Tucker, JR | 1 |
| Aujla, KS; Docherty, EM; Maclean, VM; Richardson, JR | 1 |
| Cammeron, MG | 1 |
| D'Costa, DF | 1 |
| Crowe, M; Wright, B | 1 |
| Anderson, AC; Lesko, SL; Lewander, WJ; Linakis, JG; Woolf, AD; Wright, RO | 1 |
| Schmidt, WE; Wronski, R | 1 |
| Tyhach, RJ | 1 |
| Kosnik, SD; Salgia, AD | 1 |
| Davis, NM | 1 |
| Ammenti, A; Ferrante, R; Spagna, A | 1 |
| Bucci, TJ; Hinson, JA; Kusewitt, DF; Pumford, NR; Schnellmann, JG | 1 |
| Krenzelok, EP; Zed, PJ | 1 |
| Dalhoff, KP; Schmidt, LE | 1 |
| Bone-Larson, CL; Colletti, LM; Hogaboam, CM; Kunkel, SL; Lukacs, NW; Simpson, KJ; Steinhauser, ML; Strieter, RM | 1 |
| Nielsen, HB | 1 |
| Langford, JS; Sheikh, S | 1 |
| Padar, S; Smith, TJ | 1 |
| Ben Ayed, H; Descotes, J; Testud, F; Vial, T | 1 |
| Buckley, NA; Dawson, AH; O'Connell, DL; Whyte, IM | 2 |
| Agarwal, R; Shukla, GS | 1 |
| Anderson, IB; Kim, SY; Mueller, PD; Olson, KR; Woo, OF | 1 |
| AW, MM; Baker, AJ; Dhawan, A; Mieli-Vergani, G | 1 |
| Boulares, AH; Cohen, SD; Giardina, C; Inan, MS; Khairallah, EA | 1 |
| Lee, WM; Ostapowicz, G | 1 |
| Hudson, M; James, OF; Prince, MI; Thomas, SH | 1 |
| Barry, P; Casey, P; Laffoy, M; McCormick, PA; Treacy, J | 1 |
| Broughan, TA; Soloway, RD | 1 |
| Isaacson, J | 1 |
| Bates, D; Mintz, M | 1 |
| Barbet, J; d'Athis, P; Ferracci, G; Pons, G; Rey, E; Tran, A; Tréluyer, JM; Vincent, J | 1 |
| Dalhoff, K; Schmidt, LE | 1 |
| Chen, C; Hennig, GE; Manautou, JE; McCann, DJ | 1 |
| Hariram, V; Jain, S; Singh, K; Singh, S | 1 |
| Bakos, A; Hazai, E; Monostory, K; Vereczkey, L; Zacher, G | 1 |
| Law, R | 1 |
| Clifton, JC | 1 |
| Bond, GR; Sztajnkrycer, MJ | 1 |
| Carrasco, R; Caturla, J; Esteban, A; Gutiérrez, A; Mayol, MJ; Ortiz, P; Pérez-Mateo, M | 1 |
| Bucens, IK; Isbister, GK; Whyte, IM | 1 |
| Koren, G; Kozer, E | 1 |
| Bailey, B; Kapur, BM; Koren, G; Lalkin, A | 1 |
| Darville, TL; Farrar, HC; Givens, TG; Hinson, JA; James, LP; Kearns, GL; Simpson, PM; Sullivan, JE; Wasserman, GS | 1 |
| Andrus, JP; DeRosa, SC; Herzenberg, LA | 1 |
| Gómez, E; Nogué, S; Recasens, M | 1 |
| Sitar, DS; Tenenbein, M; Tenenbein, PK | 1 |
| Anton, C; Bateman, DN; Ferner, RE; Hutchings, A; Langford, NJ; Routledge, PA | 1 |
| Deng, JF; Lin, TJ; Yang, CC | 1 |
| Amirzadeh, A; McCotter, C | 1 |
| Kalantari, H; Salehi, M | 1 |
| Ahola, T; Lapatto, R | 1 |
| Hamm, J | 1 |
| Hirsh, M; Iancu, TC; Manov, I | 2 |
| Dines, A | 1 |
| Bondesen, S; Christensen, E; Ott, P; Schiødt, FV | 1 |
| Dargan, PI; Jones, AL | 3 |
| Gyamlani, GG; Parikh, CR | 1 |
| Acar, HV; Cankir, Z; Cermik, H; Cinan, U; Danaci, M; Küçükardali, Y; Nalbant, S; Ozkan, S; Top, C | 1 |
| Kearns, GL | 1 |
| Beard, RH; Farrar, HC; James, LP; Wells, E | 1 |
| Kozer, E; McGuigan, M | 2 |
| Glenthøj, J; Lorentzen, H; Olesen, T | 1 |
| Hoppu, K | 1 |
| Buckley, N; Eddleston, M | 6 |
| Höckerstedt, K; Isoniemi, H; Koivusalo, AM; Nuutinen, H; Vakkuri, A | 1 |
| Justo, P; Marrón, B; Ortiz, A; Sanz, A | 1 |
| Chua, SS; Huang, W; Moore, DD; Wei, P; Zhang, J | 1 |
| Lebray, P; Pol, S | 1 |
| Bendtsen, F; Dalhoff, K; Knudsen, TT; Schmidt, LE | 1 |
| Appelboam, AV; Dargan, PI; Knighton, J | 1 |
| Elgariani, A; Hantson, P; Janssens, P; Marion, E; Meert, P; Reynaert, M; Thys, F; Verschuren, F; Wallemacq, P; Wittebole, X | 1 |
| Buckley, NA; Dawson, AH; Seldon, M; Whyte, IM | 1 |
| Hori, Y; Iwasaki, Y; Komiyayama, Y; Kuroki, Y; Nakatani, H; Namera, A | 1 |
| McGuire, BM | 1 |
| Altintas, E; Kiykim, A; Pata, C; Sezer, K; Uyar, B; Yazar, A | 1 |
| Gillissen, A | 1 |
| MacNaughton, SM | 1 |
| Chang, C; Chapman, PB; Fleisher, M; Hwu, WJ; Krown, SE; Livingston, PO; Pinto, JT; Williams, L; Wolchok, JD | 1 |
| Berkeley, LI; Cohen, JF; Crankshaw, DL; Nagasawa, HT; Shirota, FN | 1 |
| Anton, C; Ferner, RE | 1 |
| Bellamy, L; Bryant, S; Paloucek, F; Wahl, M | 1 |
| Dart, RC; Yip, L | 1 |
| Bétrémieux, PE; Beuchée, A; de la Pintiére, A | 1 |
| Ayanoğlu-Dülger, G; Sehirli, AO; Sener, G | 1 |
| Dribben, WH; Jeffords, BK; Porto, SM | 1 |
| Ashtekar, CS; Vyas, H | 1 |
| Alsalim, W; Fadel, M | 1 |
| Johnson, BM; van Breemen, RB | 1 |
| Hinson, JA; James, LP; Lamps, LW; McCullough, SS | 1 |
| Kociancic, T; Reed, MD | 1 |
| Abdollahi, M; Jalali, N; Pajoumand, A; Shadnia, S | 1 |
| Barkan, D; Deharo, E; Ginsburg, H; Golenser, J; Krugliak, M | 1 |
| El-Bahay, C; Hanelt, S; Kahl, R; Lewerenz, V; Nastevska, C; Röhrdanz, E | 1 |
| Fukumoto, M | 3 |
| Juurlink, DN | 1 |
| Hinson, JA; James, LP; Mayeux, PR | 1 |
| Brizendine, EJ; Furbee, RB; Kao, LW; Kirk, MA; Mehta, NH; Skinner, JR | 1 |
| Guo, SH; Wu, G | 1 |
| Lifshitz, M; Melamed, R | 1 |
| Bajt, ML; Jaeschke, H; Knight, TR; Lemasters, JJ | 1 |
| Dybowska, D; Kozielewicz, D; Nowak, W; Olczak, A | 1 |
| Taylor, SE | 1 |
| Lee, SY | 1 |
| Bartlett, D | 1 |
| Bailey, B; Blais, R; Letarte, A | 1 |
| Bendtsen, F; Dalhoff, KP; Knudsen, TT; Schmidt, LE | 1 |
| Garg, U; Wasserman, GS | 1 |
| Jang, TB; Mullins, ME; Schmidt, RU | 1 |
| Müller, GJ | 1 |
| Chang, WT; Chen, WJ; Fang, CC; Tsai, CL; Weng, TI | 1 |
| Boyer, EW; Brush, DE | 1 |
| Andrade, RJ; de la Cuesta, FS; López-Torres, E; Lucena, MI; Puche, MJ; Seoane, J; Verge, C | 1 |
| Beuhler, MC; Ford, MD; Kerns, WP; Lavonas, EJ; Rouse, AM; Tomaszewski, CA; Wittler, MA | 1 |
| Chen, WJ; Fang, CC; Liu, YP; Ni, YH | 1 |
| Goldenberg, JA; Kobrinsky, NL; Ortmeier, TC; Sjolander, DE | 1 |
| Buckley, N; Chan, B; Dawson, A; Graudins, A; Kerr, F; Murray, L; Trudinger, B; Whyte, IM | 1 |
| Prescott, L | 1 |
| Marzullo, L | 1 |
| Chang, WT; Fang, CC; Tsai, CL; Walson, PD; Weng, TI | 1 |
| Caraccio, T; Feinfeld, DA; McGuigan, M; Mour, G | 1 |
| Dambach, DM; Durham, SK; Laskin, DL; Laskin, JD | 1 |
| Good, AM; Johnson, DW; Juurlink, DN; Sivilotti, ML; Yarema, MC | 1 |
| Bond, GR | 2 |
| Culley, CM; Krenzelok, EP | 1 |
| Arnáez Solís, J; Avilla Hernández, JM; Cuñarro Alonso, A; Garrido Borreguero, E | 1 |
| Daly, FF; Little, M; McCoubrie, D; Murray, L | 1 |
| Clark, LE; Herrera, JL; Wilkes, JM | 1 |
| Hendrickson, RG; Horowitz, BZ; Pizarro-Osilla, C | 1 |
| Manini, AF; Snider, C | 1 |
| Dargan, PI; Gawarammana, IB; Greene, SL; Jones, AL | 1 |
| Bangh, SA; Klein-Schwartz, W; Spiller, HA; Winter, ML | 1 |
| Ternullo, S | 1 |
| Frumin, I; Iancu, TC; Manov, I; Motanis, H | 1 |
| Burke, AS; Donahower, B; Hinson, JA; James, LP; McCullough, S | 1 |
| Davern, TJ; Fontana, RJ; Hinson, JA; James, LP; Lalani, E; Larson, AM; Lee, WM; Munoz, S; Polson, J; Shakil, AO | 1 |
| Deepa, B; Leow, M; Leow, MK; Sule, AA; Tai, DY; Tze, CC | 1 |
| Eldridge, DL; Kirk, MA; Norvell, J; Rowden, AK | 1 |
| Cantlay, G; Duncan, R; Paterson, B | 1 |
| Aakvik, R; Jacobsen, D | 1 |
| Cairon, E; Mian, P; Moling, O; Pristerá, R; Rimenti, G; Rizza, F | 1 |
| Bajt, ML; Cover, C; Jaeschke, H; Lemasters, JJ | 1 |
| Akieda, K; Inokuchi, S; Inoue, S; Morita, S; Nakagawa, Y; Otuka, H; Sekiguchi, H; Yamamoto, I | 1 |
| Kanter, MZ | 1 |
| Lovecchio, F; Pizon, AF | 1 |
| Karst, U; Lohmann, W | 1 |
| Carpenter, AB; Kiningham, KK; Sullivan, SB; Terneus, MV; Valentovic, MA | 1 |
| Liebelt, EL; White, ML | 1 |
| Maruta, S; Shimoji, H; Suenobu, T; Yoshioka, T | 1 |
| Smith, DH | 1 |
| Betten, DP; Cantrell, FL; Clark, RF; Thomas, SC; Williams, SR | 1 |
| Bateman, DN; Beer, C; Hudson, M; Pakravan, N; Simpson, K; Smith, LT; Thomas, SH | 1 |
| Ceña, V; Posadas, I; Prieto-Lloret, J; Santos, P; Vellecco, V | 1 |
| Morris, J; Nielsen, L; Shaw, M | 1 |
| Khashab, M; Kwo, PY; Tector, AJ | 1 |
| Dart, RC; Rumack, BH | 2 |
| Clouzeau-Girard, H; Combe, C; Desmoulière, A; Guyot, C; Moronvalle-Halley, V | 1 |
| Bewley, J; Bourdeaux, C | 1 |
| Draaisma, JM; Hameleers-Snijders, P; Hogeveen, M; Kramers, C; Smeitink, JA | 1 |
| Commandeur, JN; Damsten, MC; Fidder, A; Hulst, AG; Noort, D; Touw, D; Vermeulen, NP | 1 |
| Calvert, SH; Cavell, G; Glucksman, E; Gonzalez, J; Kerins, M; Selvan, VA | 1 |
| Godber, IM; Jarvis, SJ; Maguire, D | 1 |
| Atkuri, KR; Herzenberg, LA; Mantovani, JJ | 1 |
| Sawyer, TS; Spiller, HA | 1 |
| Dawson, AH; Francis, B; Whyte, IM | 1 |
| Heard, K; Jagoda, AS; Sloan, EP; Wolf, SJ | 1 |
| Larson, AM | 1 |
| Chong, VH | 1 |
| Kimball, T | 1 |
| Cattermole, GN | 1 |
| Malkowska, AM; Robinson, OD; Stephen, AF; Waring, WS | 1 |
| Brown, JM; Carpenter, AB; Terneus, MV; Valentovic, MA | 1 |
| Bird, SB; Donovan, JL; Miller, MA; Navarro, M | 1 |
| Cavalier, E; Chapelle, JP; Delanaye, P; Krzesinski, JM; Lambermont, B; Lognard, M | 1 |
| Balistreri, WF; Leonis, MA | 1 |
| Bansal, S; Cheeseman, P; Dhawan, A; Kortsalioudaki, C; Mieli-Vergani, G; Taylor, RM | 1 |
| Johnson, CE; Siden, R | 1 |
| Mazer, M; Perrone, J | 1 |
| Ali, FM; Bird, SB; Boyer, EW | 1 |
| Fang, CC; Tsai, CL; Walson, PD | 1 |
| Chan, GM; Greller, HA; Majlesi, N; Su, M | 1 |
| Doyon, S; Hayes, BD; Klein-Schwartz, W | 1 |
| Dow, MA; Pettie, JM; Robinson, OD; Stephen, AF; Waring, WS | 1 |
| Crowell, C; Deering, SH; Givens, M; Lyew, RV | 1 |
| Hoffman, RS; Howland, MA; Nelson, LS; Smith, SW | 1 |
| Danel, V; Saviuc, P | 1 |
| Heard, KJ | 1 |
| Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW | 1 |
| Bilgili, A; Eraslan, G; Onbasilar, I; Ozdemir, M; Yalçin, S | 1 |
| Cassidy, N; Drew, SA; Tracey, JA | 1 |
| Bateman, DN; Ludlam, C; Megson, I; Pakravan, N; Sharma, S; Waring, WS | 1 |
| Baud, FJ; Deye, N; Mégarbane, B | 1 |
| Farmer, BM; Hoffman, RS | 1 |
| Bateman, DN; Dear, JW; Waring, WS | 1 |
| Barceló-Martín, B; Castanyer-Puig, B; Nogué-Xarau, S | 1 |
| Goldberg, JB | 1 |
| Leiner, S | 1 |
| Buckley, N; Dawson, AH; Fernandopulle, BM; Ranganathan, SS; Senarathna, SM | 1 |
| Hayes, BD; Sarmiento, KF; Schwartz, EA | 1 |
| Doyon, S; Klein-Schwartz, W | 2 |
| Brooks, DE; Katz, KD; Kehrl, T; Sokolowski, D; Whyte, AJ | 1 |
| Dribben, WH; Halcomb, SE; McCammon, CA; Mullins, ME | 1 |
| Benhalim, S; Waring, WS | 1 |
| Motha, R; Sesin, P; Zolnierz, M | 1 |
| Busuttil, RW; Chun, LJ; Hiatt, JR; Tong, MJ | 1 |
| Chang, CY; Martin, P; Tan, HH | 1 |
| Galanopoulou, P; Giannioti, K; Liapi, C; Mikros, E; Papalois, A; Theocharis, S; Zira, A | 1 |
| Bateman, DN; Sandilands, EA | 1 |
| Bockewitz, E; Burda, AM; Kubic, A; Wahl, M | 1 |
| Ariyananda, PL; Fernando, WK | 1 |
| Krishnan, GP; Majlesi, N; Nelson, L; Olsen, A; Olsen, D | 1 |
| Capparelli, E; Davern, TJ; Hinson, JA; James, LP; Lee, WM; Letzig, L; Roberts, DW; Simpson, PM | 1 |
| Easter, JS; Ganetsky, M; Kimlin, EJ | 1 |
| Athuraliya, TN; Jones, AL | 1 |
| Davern, TJ; Fontana, RJ; Hynan, LS; Larson, AM; Lee, WM; McCashland, T; Murray, NG; Reisch, JS; Robuck, PR; Rossaro, L; Stravitz, RT | 1 |
| Jian, W; Yao, M; Zhang, D; Zhu, M | 1 |
| Bailey, B; Berlin, RJ; Brant, RF; Chalut, D; Dart, RC; Johnson, DW; Lee, JS; Nettel-Aguirre, A; Plint, AC; Purssell, RA; Rumack, BH; Rutledge, T; Seviour, CA; Sivilotti, ML; Spyker, DA; Stiell, IG; Thompson, M; Tyberg, J; Yarema, MC | 1 |
| Chan, GM; Greller, HA; Gupta, AK; Su, MK | 1 |
| Millea, PJ | 1 |
| Chan, B; Graudins, A; Naidoo, D; Pham, HN; Salonikas, C | 1 |
| Lopez, DP | 1 |
| Czauderna, P; Fuchs, J; Knap, N; Losin, M; Neuwelt, AJ; Neuwelt, EA; Pagel, MA; Warmann, S; Wozniak, M; Wu, YJ | 1 |
| Anoush, M; Eghbal, MA; Fathiazad, F; Hamzeiy, H; Kouzehkonani, NS | 1 |
| Güvenç, B; Murt, M; Rana Alpay, N; Satar, S; Sebe, A | 1 |
| Jaeschke, H; Saito, C; Zwingmann, C | 1 |
| Betten, DP; Burner, EE; Clark, RF; Thomas, SC; Tomaszewski, C | 1 |
| Marchetti, A; Rossiter, R | 1 |
| Dehpour, AR; Javidnia, K; Kheradpezhouh, E; Miri, R; Monabati, A; Noorafshan, A; Panjehshahin, MR | 1 |
| Connors, NJ; Ghaffari, G; Hernandez, SH; Hoffman, RS; Howland, MA | 1 |
| Chan, GM; Greller, HA; Gupta, AK; Lee, DC; Su, MK | 1 |
| Saberi, M; Zaree Mahmodabady, A | 1 |
| Nematollahi, D; Shayani-Jam, H | 1 |
| Al-Jabi, SW; Awang, R; Sweileh, WM; Syed Sulaiman, SA; Zyoud, SH | 1 |
| Nevin, DG; Shung, J | 1 |
| Dargan, P; Dawson, A; Dissanayake, D; Shihana, F | 1 |
| Krenzelok, EP; Martello, JL; Pummer, TL | 1 |
| Riordan, SM; Williams, R | 1 |
| Coulson, J; Thompson, JP | 1 |
| Bateman, DN; Dear, J | 1 |
| Margaretten, M; Olson, KR; Wiegand, TJ | 1 |
| Mehrpour, O; Sanaei-Zadeh, H; Shadnia, S | 1 |
| Buckley, NA; Eddleston, M; Li, Y | 1 |
| Clemmesen, JO; Ott, P; Schmidt, LE | 1 |
| Christensen, HR; Dalhoff, K; Rolff, HC | 1 |
| Al-Jabi, SW; Awang, R; Khan, HR; Sawalha, AF; Sulaiman, SA; Sweileh, WM; Zyoud, SH | 1 |
| Bémeur, C; Butterworth, RF; Desjardins, P; Vaquero, J | 1 |
| Avizeh, R; Najafzadeh, H; Razijalali, M; Shirali, S | 1 |
| de Silva, V; Rathnayake, A | 1 |
| Taéron, C | 1 |
| Cantrell, FL; Clark, R; Tomaszewski, C | 1 |
| Aguilera, E; Al-Helial, M; Arnold, T; Bebarta, VS; Bogdan, G; Buchanan, J; Clark, RF; Dart, R; Delgado, J; Froberg, B; Haur, W; Heard, K; Hoppe, J; Kao, L; Kokko, J; Lares, C; Lavonas, E; McDonagh, J; Mendoza, C; Mlynarchek, S; O'Malley, G; Odujebe, O; Qi, M; Rhyee, S; Stanford, C; Tan, HH; Tran, NN; Varney, S; Zosel, A | 1 |
| Brok, J; Gluud, C | 1 |
| Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH | 3 |
| Kamijo, Y | 1 |
| Hirose, Y | 1 |
| Ford, RM; Sakaria, SS; Subramanian, RM | 1 |
| Dehpour, AR; Golestan Jahromi, M; Nabavizadeh, F; Nahrevanian, H; Vahedian, J; Zare-Mehrjardi, A | 1 |
| Carter, M; Lim, LY; Loh, JW; Saunders, M; Schneider, J | 1 |
| Acharya, M; Lau-Cam, CA | 2 |
| García, C; García-Trevijano, ER; Penella, E; Sandoval, J; Torres, L; Viña, JR; Zaragozá, R | 1 |
| Hoffman, RS; Jang, DH; Punja, M | 1 |
| Babu, IR; Goessling, W; Lord, AM; North, TE; Tannenbaum, SR; Vedder, LM; Wishnok, JS; Zon, LI | 1 |
| Offerman, SR | 1 |
| Bechtel, LK; Charlton, NP; Holstege, CP; Lawrence, DT | 1 |
| Green, TJ; Johnson, D; Juurlink, D; Langmann, C; Sivilotti, ML; Yarema, M | 1 |
| Abdelwahab, SA; Elbitar, HI; Ibrahim, SA; Morsy, MA; Zedan, MZ | 1 |
| Ceschi, A; Hofer, KE; Kupferschmidt, H; Rauber-Lüthy, C | 1 |
| Erbaş, M; Erkan, ME; Gezer, S; Güneş, H; Kandiş, H; Kara, IH; Yildirim, HA; Yildirim, U | 1 |
| Beringer, RM; Parry, S; Stoddart, PA; Thompson, JP | 1 |
| Abdel-Rahman, SM; Brown, A; Hinson, JA; James, LP; Letzig, L; McCullough, SS; Milesi-Hallé, A | 1 |
| Ballali-Mood, M; Mehrpour, O | 1 |
| Bodmer, M; Monte, AA | 1 |
| Arya, S; Contractor, H; Gauge, V; Nabi, S; Naqvi, N; Titu, H | 1 |
| Lee, WM | 1 |
| Carvalho-Silva, M; Daufenbach, JF; Ferreira, GK; Gonçalves, CL; Jeremias, GC; Jeremias, IC; Panatto, JP; Ramos, AC; Rezin, GT; Rochi, N; Scaini, G; Streck, EL | 1 |
| Chandrasekaran, VR; Chien, SP; Hsu, DZ; Liu, MY | 1 |
| Coleman, P; Leikin, JB; Whiteley, PM; Zell-Kanter, M | 1 |
| Bisschops, LA; Bisschops, WA; Kramers, C; van Rossum, LK; Vroegop, MP | 1 |
| Aleksa, K; Bajcetic, M; Baw, B; Chen, N; Cutler, M; Freeman, D; Hanly, LN; Koren, G; Malkin, B; Palassery, R; Regueira, O; Rieder, MJ; Turner, C; Vasylyeva, TL | 1 |
| James, LP; Khandelwal, N; Larson, AM; Lee, WM; Sanders, C | 1 |
| Deasy, C; Oakley, E; Robinson, J | 1 |
| Marsh, A; Myall, K; Sidney, J | 1 |
| Masubuchi, Y; Nakayama, J; Sadakata, Y | 1 |
| Bagdure, D; Heard, K; Monte, A; Wang, GS | 1 |
| Butterworth, RF | 1 |
| Jang, DH; Pizon, AF; Wang, HE | 1 |
| Bateman, DN; Dear, JW; Ferner, RE | 1 |
| Burda, AT; Ipema, HJ; Wahl, MS | 1 |
| Halcomb, SE; Johnson, MT; McCammon, CA; Mullins, ME | 1 |
| Dougherty, PP; Klein-Schwartz, W | 1 |
| Heard, K; Schaeffer, TH | 1 |
| Chiou, LL; Dong, CY; Huang, GT; Lee, HS; Li, FC; Lin, CJ; Lo, SY; Lo, W; Sun, TL; Wang, SS | 1 |
| Anusornsuwan, T; Chomchai, C; Chomchai, S | 1 |
| Coulter, CV; Duffull, SB; Isbister, GK; Shen, F | 1 |
| Beitollahi, H; Hosseinzadeh, R; Raoof, JB | 1 |
| Blackford, MG; Felter, T; Gothard, MD; Reed, MD | 1 |
| Bockus, A; Boggess, N; Ding, WX; Jaeschke, H; Ni, HM | 1 |
| Mullins, ME; Vitkovitsky, IV | 1 |
| Armenian, P; Blanc, PD; Gerona, RR; Mookherjee, S; Wu, AH | 1 |
| Borrelli, MJ; Brown, AT; Chaudhuri, S; Jambhekar, K; James, LP; McCullough, S; Ou, X; Pandey, T | 1 |
| Cash, WJ; Iqbal, M; McCormick, PA; Sarwar, S | 1 |
| Anscombe, M; Berling, I; Isbister, GK | 1 |
| Mullins, ME; Schwarz, E | 1 |
| Bersten, AD; Bihari, S; Verghese, S | 1 |
| García, C; Martínez, M; Nicolás, M; Porta, R; Sánchez, L | 1 |
| Bateman, DN; Rumack, BH | 1 |
| Green, J; Heard, K | 1 |
| Buckley, N; Fernandopulle, R; Senarathna, SM; Sri Ranganathan, S | 1 |
| Hewawasam, RP; Jayatilaka, KA; Pathirana, C | 1 |
| Dargan, PI; Keep, J; McQuade, DJ; Wood, DM | 1 |
| Hosoya, J; Iseki, K; Shiraishi, T; Suzuki, T; Takahashi, N; Tominaga, A; Toyoguchi, T | 1 |
| Andersen, ME; Clewell, HJ; Harrill, AH; Howell, BA; Siler, SQ; Watkins, PB; Woodhead, JL; Yang, Y | 1 |
| Waring, WS | 2 |
| Betto, MR; Campos, MM; Driemeier, D; Lazarotto, LF; Leite, CE; Watanabe, TT | 1 |
| Becker, HE; de Haan, L; Schellens, JH; van Leeuwen, WA; van Westrhenen, R | 1 |
| Choate, J; Emre, SH; Luczycki, SM; Maitta, RW; Wu, Y | 1 |
| Boyajian, M; Cheerharan, M; Iorio, ML; Kaufman, SS; Reece-Stremtan, S | 1 |
| Garrard, AR; Hodgman, MJ | 1 |
| Bryczkowski, C; Geib, AJ | 1 |
| Brent, J; Finkelstein, Y; Gorodetsky, R; Schwartz, T; Wax, PM; Wiegand, TJ | 1 |
| Baltaci, D; Colakoglu, S; Kandis, H; Kara, IH; Karakus, A; Kaya, H; Memisogullari, R; Saritas, A; Yildirim, U | 1 |
| Rollstin, AD; Seifert, SA | 1 |
| Osterhoudt, K; Selbst, SM | 1 |
| Mycyk, MB; Wahl, MS; Williamson, K | 1 |
| Cao, F; Liu, Y; Ma, H; Qiu, Y; Xu, J; Zhang, J | 1 |
| Greene, S; McD Taylor, D; McIntyre, S | 2 |
| Cao, F; Hou, Y; Liu, Y; Ma, H; Qiu, Y; Xu, J; Xu, L; Zhang, J | 1 |
| Abdelmegeed, MA; Banerjee, A; Hardwick, JP; Jang, S; Song, BJ | 1 |
| Caro, J; Gosselin, S; Hoffman, RS; Juurlink, DN; Whyte, I; Yarema, M | 1 |
| Dargan, PI; Hitchings, AW; Wood, DM | 1 |
| Al-Hourani, K; Bateman, DN; Dear, JW; Dow, M; Mansi, R; Pettie, J | 1 |
| Bateman, DN; Coyle, J; Dear, JW; Eddleston, M; Gray, A; Lewis, S; Sandilands, EA; Thanacoody, HK; Thomas, SH; Webb, DJ | 1 |
| Agilli, M; Alp, BF; Aydin, FN; Aydin, I; Cayci, T; Macit, E; Ozcan, A; Ozkan, E; Oztosun, M; Taslipinar, MY; Toygar, M; Ucar, F | 1 |
| Alipour, M; Buonocore, C; Omri, A; Pucaj, K; Suntres, ZE; Szabo, M | 1 |
| Agilli, M; Alp, BF; Altayli, E; Aydin, FN; Aydin, I; Cayci, T; Cermik, H; Ozkan, E; Taslipinar, MY; Toygar, M; Ucar, F | 1 |
| Amathieu, R; Chemit, M; Compagnon, P; Costentin, C; Dhonneur, G; Levesque, E; Merle, JC | 1 |
| Schmidt, LE | 1 |
| Mullins, ME; Schwarz, ES | 1 |
| Downey, KJ; Gavin, T; Geohagen, BC; Liu, Q; LoPachin, RM; Zhang, L | 1 |
| Beauchamp, GA; Hart, KW; Lindsell, CJ; Lyons, MS; Otten, EJ; Smith, CL; Ward, MJ; Wright, SW | 1 |
| Kam, RY | 1 |
| Jiang, S; Ni, SZ; Xia, J; Zhao, Y; Zhou, XL; Zhu, YQ | 1 |
| Coulson, JM; Thompson, JP | 1 |
| Clancy, C; James, L; Mazer-Amirshahi, M; Reid, N; van den Anker, J | 1 |
| Lackey, G; McCulloh, RJ; Vyas, D | 1 |
| Dargan, PI; Spencer, T; Wood, DM; Yamamoto, T | 1 |
| Hewett, DG; Shields, J; Waring, WS | 1 |
| Agilli, M; Altayli, E; Aydin, FN; Aydin, I; Cayci, T; Eyi, YE; Kaldirim, U; Macit, E; Taslipinar, MY; Toygar, M; Tuncer, SK; Ucar, F; Yigit, N | 1 |
| Bass, S; Zook, N | 1 |
| Amani, V; Donson, AM; Foreman, NK; Neuwelt, AJ; Neuwelt, EA; Nguyen, T; Rapkin, LB; Venkatamaran, S; Vibhakar, R; Wu, YJ | 1 |
| Cooper, JG; Teo, AI | 1 |
| Curry, SC; Jaeschke, H; Li, F; Ma, X; McGill, MR; Sharpe, MR; Williams, CD | 1 |
| Marti, C; Ramlawi, M; Sarasin, F | 1 |
| Freeman, R | 1 |
| Bunchorntavakul, C; Reddy, KR | 2 |
| Benger, J; Bramley, K; Carroll, R; Griffin, L; Gunnell, D; Potokar, J; Williams, S | 1 |
| Liss, DB; Mullins, ME; Paden, MS; Schwarz, ES | 1 |
| Garland, JS; Hanly, LN; Juurlink, DN; Lenga, I; Poley, R; Sivilotti, ML; Thompson, M | 1 |
| Sanaei-Zadeh, H | 1 |
| Duffull, SB; Isbister, GK | 2 |
| Berman, AJ; Gilberti, B; Rahman, S | 1 |
| Liu, X; Wang, Q; Xu, R; Yang, J; Zang, M; Zhang, J | 1 |
| Antoine, DJ; Park, K; Pirmohamed, M | 1 |
| Bateman, DN; Butcher, I; Cooper, JG; Coyle, J; Dear, JW; Eddleston, M; Gray, A; Lewis, SC; Rodriguez, A; Sandilands, EA; Thanacoody, HK; Thomas, SH; Veiraiah, A; Vliegenthart, AD; Webb, DJ | 1 |
| Carbajo-Pescador, S; Carvalho, NR; da Rosa, EF; da Silva, MH; Dalla Corte, CL; González-Gallego, J; Mauriz, JL; Soares, FA; Tassi, CC | 1 |
| Antoine, DJ; Dear, JW | 2 |
| Abe, N; Aritomi, K; Irie, T; Irikura, M; Ishitsuka, Y; Kai, H; Shimizu, D; Shuto, T; Tomishima, Y | 1 |
| Beger, RD; Bhattacharyya, S; Gill, P; James, LP; Kearns, GL; Letzig, LG; Marshall, JD; Pence, L; Reed, MD; Simpson, PM; Sullivan, JE; Van Den Anker, JN; Yan, K | 1 |
| Burda, G; Gole, J; Hermon, M; Mostafa, G; Trittenwein, G; Vargha, R | 1 |
| Bateman, DN; Carroll, R; Coyle, J; Cranfield, KR; Dargan, PI; Dear, JW; Dow, M; Eddleston, M; Elamin, ME; Gray, A; Hook, C; Peart, L; Pettie, J; Sandilands, EA; Thomas, SH; Veiraiah, A; Webb, D; Wood, DM; Yamamoto, T | 1 |
| Gosselin, S; Villeneuve, E; Whyte, I | 1 |
| Graudins, A; Greene, SL; Kerr, F; Wong, A | 1 |
| Bronstein, AC; Bucher-Bartelson, B; Dart, RC; Green, JL; Heard, K; Heard, S; Rumack, BH | 1 |
| Hoffman, R; Kessler, B | 1 |
| Bateman, DN; Dear, JW; Eddleston, M; Thanacoody, HK; Thomas, SH | 1 |
| Chomchai, C; Chomchai, S; Lawattanatrakul, N | 1 |
| Chomchai, C; Chomchai, S | 2 |
| Dorko, K; Forster, J; Jaeschke, H; Kumer, SC; McGill, MR; Schmitt, TM; Xie, Y | 1 |
| de Vries, I; Koppen, A; Meulenbelt, J; van Riel, A | 2 |
| Graudins, A | 1 |
| Atamanalp, SS; Bakan, E; Demiryilmaz, I; Kisaoglu, A; Ozogul, B; Suleyman, H; Turan, MI; Yilmaz, I | 1 |
| Andersen, J; Askbo, N; Hedeland, RL; Iskandar, A; Jørgensen, MH | 1 |
| Ambros, VR; Curry, SC; Jaeschke, H; Kanchagar, C; Lee, RC; McGill, MR; Veksler-Lublinsky, I; Ward, J | 1 |
| Rastegar, A; Vichot, AA | 1 |
| Eisenbach, C; Hoyler, B; Mogler, C; Sandig, C; Steinebrunner, N; Stremmel, W; Vittas, S | 1 |
| Avellini, C; De Vita, S; Maset, M; Quartuccio, L; Soardo, G | 1 |
| Ercal, N; Fan, W; Khayyat, A; Tobwala, S | 1 |
| Dargan, PI; Greene, SL; Leang, Y; Taylor, DM; Wood, DM | 1 |
| Buckley, NA; Medlicott, NJ; Owens, KH; Reith, DM; Whyte, IM; Zacharias, M | 1 |
| Zhang, C | 1 |
| Barnes, DM; Evans, M; Paterson, E | 1 |
| Brito, MV; Costa, FD; Costa, LA; Teixeira, RK; Vasconcelos, DM; Yamaki, VN; Yasojima, EY | 1 |
| Bi, H; Chen, P; Fan, X; Gonzalez, FJ; Huang, M; Jiang, Y; Qu, A; Tan, H; Wang, Y; Zeng, H | 1 |
| Cao, F; Hou, Y; Li, S; Liu, Y; Qiu, Y; Wu, Z; Xu, J; Yang, H; Yang, S; Yao, W | 1 |
| Furmaga, J; Kleinschmidt, K; Wax, P | 1 |
| Jones, DL; McGovern, AJ; Mullins, ME; Vitkovitsky, IV | 1 |
| de Wolff, JF; Jiad, E; Palipane, N | 1 |
| Hu, J; Quan, Q; Ren, X; Sun, Z; Zhang, Q | 1 |
| Arai, T; Kitamura, D; Koyama, R; Mizuta, R; Yuasa, M | 1 |
| Janssen, J; Singh-Saluja, S | 1 |
| Corwin, D; Srinivasan, V; Verceles, AC | 1 |
| Bateman, DN | 3 |
| Anaradian, PC; Karowski, K; Kirschner, RI; Martin, TG; Schrader, RM; Seifert, SA | 1 |
| Ly, BT; O'Connell, CW; Schneir, A; Villano, JH | 1 |
| Jaeschke, H | 1 |
| Dargan, PI; Greene, SL; Sivilotti, ML; Wong, A; Wood, DM | 1 |
| Andrus, JP; Herzenberg, LA; Owumi, SE | 1 |
| Curtis, RM; Sivilotti, ML | 1 |
| Gerkin, RD; Levine, M; O'Connor, AD; Padilla-Jones, A | 1 |
| Buckley, NA; Chiew, AL; Duffull, SB; Isbister, GK | 1 |
| Al-Jabi, SW; Awang, R; Sweileh, WM; Waring, WS; Zyoud, SH | 1 |
| Dağlı, B; Demirci, B; Gökçimen, A; Kahyaoğlu, F; Ömürlü, İK; Uysal, HB; Yılmaz, M | 1 |
| Durgun, HM; Dursun, R; Guloglu, C; Gunduz, E; İçer, M; Turkcu, G; Üstündağ, M; Yuksel, H; Zengin, Y | 1 |
| Antoine, DJ; Dear, JW; Park, BK | 1 |
| Hernandez, SH; Hoffman, RS; Howland, M; Schiano, TD | 1 |
| Faine, BA; Genzen, JR; Hunsaker, JJ; Krasowski, MD; Nelson, LS | 1 |
| Chien, CC; Chiu, YT; Lin, TH; Liu, CC; Liu, RH; Su, HL; Tsai, MS; Wang, SH | 1 |
| Dawson, AH; Galappatthy, P | 1 |
| Gerkin, R; Levine, M; O'Connor, AD; Padilla-Jones, A | 1 |
| Jacobitz, KL; Kirschner, RI; Rozier, CM; Smith, LM | 1 |
| Fernandez, D; Nelson, LS | 1 |
| Graudins, A; Wong, A | 3 |
| Ercal, N; Hart, M; Khayyat, A; Tobwala, S | 1 |
| Bateman, DN; Dear, JW; Thomas, SH | 2 |
| Berling, I; Downes, MA; Isbister, GK; Mcnamara, K; Page, CB; Whyte, IM | 1 |
| Coen, M; Foster, J; Holmes, E; Kavanagh, TJ; Kyriakides, M; Maitre, L; Mohar, I; Nelson, SD; Stamper, BD; Wilson, ID | 1 |
| Cogger, V; de Cabo, R; Hilmer, SN; Huizer-Pajkos, A; Jones, B; Kane, AE; Le Couteur, DG; Mach, J; McKenzie, C; Mitchell, SJ | 1 |
| Donnelly, MC; Hayes, PC; Simpson, KJ | 1 |
| Bailey, B; Dart, RC; Heard, K; Johnson, DW; Lucyk, SN; Nettel-Aguirre, A; Rumack, BH; Sivilotti, ML; Spyker, DA; Victorino, C; Yarema, MC | 1 |
| Ghanem, CI; Manautou, JE; Mottino, AD; Pérez, MJ | 1 |
| Atmaca, HT; Bayir, Y; Canayakin, D; Halici, Z; Keles, MS; Kilic Baygutalp, N; Kocak Ozgeris, FB; Sezen Karaoglan, E | 1 |
| Al-Hourani, K; Bateman, DN; Beckwith, HK; Cairney, DG; Dear, JW; Eddleston, M | 1 |
| Ghannoum, M; Gosselin, S; Grunbaum, AM; Kazim, S; Villeneuve, E | 1 |
| Buckley, NA; Dawson, AH; Isbister, GK | 2 |
| Personne, M | 2 |
| Archer, JR; Bailey, GP; Dargan, PI; Elamin, ME; Najafi, J; Thomas, SH; Waring, WS; Wood, DM | 1 |
| Aljenedil, S; Alyahya, B; Gosselin, S; Holody, E; Larocuque, A; Tamur, S | 1 |
| Rice, TW; Stollings, JL; Wheeler, AP | 1 |
| Egashira, T; Fukusaki, M; Goto, S; Terao, Y; Tuji, T; Urabe, S | 1 |
| Archer, JR; Bailey, GP; Dargan, PI; Flanagan, RJ; Rab, E; Wood, DM | 1 |
| Dunning, JR; Osterhoudt, KC; Trella, JD | 1 |
| Bogaerts, E; Colle, I; Devisscher, L; Geerts, A; Hoorens, A; Paridaens, A; Raevens, S; van Grunsven, LA; Van Vlierberghe, H; Vandewynckel, YP; Verhelst, X | 1 |
| Sklar, GE; Tan, CJ | 1 |
| Antoine, DJ; Bateman, DN; Clarke, JI; Cooper, JG; Dargan, PI; Dear, JW; Eddleston, M; Gray, A; Homer, NZ; Kimmitt, RA; Lewis, SC; Seymour, JH; Vliegenthart, A; Webb, DJ; Wood, DM | 1 |
| Green, JP; Johnson, DW; Nettel-Aguirre, A; Rumack, BH; Sivilotti, ML; Spyker, DA; Victorino, C; Yarema, MC | 1 |
| Brogren, J; Höjer, J; Salmonson, H; Sjöberg, G; Tellerup, M | 1 |
| Archer, JRH; Dargan, PI; Davies, CL; Dines, AM; Greene, SL; Marks, DJB; Wood, DM | 1 |
| Heppell, SPE; Isbister, GK | 1 |
| Evans, J; Petchey, WG; Sampaziotis, F; Serjeant, L | 1 |
| Darweesh, SK; El-Tahawy, MA; Ibrahim, MF | 1 |
| Ejiri, Y; Kotake, Y; Ohta, S; Ohtsuki, Y; Sanoh, S; Santoh, M | 1 |
| Gerkin, RD; O'Connor, AD; Spyres, MB | 1 |
| Nettel-Aguirre, A; Rumack, BH; Sivilotti, MLA; Yarema, MC | 1 |
| Graudins, A; Sivilotti, MLA; Wong, A | 1 |
| Antelava, N; Ghonghadze, M; Liluashvili, K; Okujava, M; Pachkoria, K | 1 |
| Liss, D; Mullins, ME; Schwarz, ES | 1 |
| Allegaert, K; Flint, RB; Knibbe, CAJ; Roofthooft, DW; Simons, SHP; Tibboel, D; van den Anker, JN; van Dijk, M; van Lingen, RA; van Rongen, A | 1 |
| Graudins, A; Landersdorfer, C; Wong, A | 1 |
| Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; Kirby, KA; Page, CB | 1 |
| Goldberger, D; Vearrier, D | 1 |
| Deng, LL; He, X; Li, J; Li, YJ; Liao, SG; Liao, XM; Liu, T; Wang, M; Wang, YL; Xu, GB; Zhong, RF; Zhou, M | 1 |
| Antoine, DJ; Brillant, N; Burton, NC; Elmasry, M; Fenwick, S; Goldring, CE; Kipar, A; Kitteringham, NR; Park, BK; Poptani, H; Rodriguez, JM; Sharkey, JW | 1 |
| Graudins, A; Gunja, N; McNulty, R; Sivilotti, MLA; Wong, A | 1 |
| Graudins, A; Gunja, N; McNulty, R; Wong, A | 1 |
| Mullins, ME; O'Grady, L; Schwarz, ES | 1 |
| Gambhir, HS; Pruthi, S; Shah, S | 1 |
| Allen, L; Antoine, DJ; Clarke, JI; Cooper, J; Dargan, PI; Dear, JW; Francis, B; Jorgensen, AL; Park, BK; Pirmohamed, M; Shen, J; Thomas, SHL; Wood, D; Wraight, J | 1 |
| Harmouche, E; Howland, MA; K Su, M | 1 |
| Dervay, K; Fixl, AN; Woods, RM | 1 |
| Chandru, P; Gunja, N; Lim, JME; McNulty, R | 1 |
| Serratrice, J; Spahr, L; Verdon, I | 1 |
| Bailey, B; Chopra, P; Gosselin, S; Johnson, D; Nettel-Aguirre, A; Purssell, R; Rumack, B; Sivilotti, MLA; Spyker, D; Thompson, M; Victorino, C; Yarema, M | 1 |
| Howard, L; Reynard, C | 1 |
| Brok, J; Buckley, NA; Chiew, AL; Gluud, C | 1 |
| Cheung, B; Gantier, M; Graudins, A; Nejad, C; Wong, A | 1 |
| Ko, JL; Lai, YY; Liou, GG; Tsai, MS; Tsou, HK; Wang, SH; Wang, YH | 1 |
| Harmouche, E; Hoffman, RS; Howland, MA | 1 |
| Arianto, L; Bisgaard, AS; Dan-Nielsen, S; Heedeland, RL; Jans, SR; Jørgensen, MH | 1 |
| Ferreras, D; Lopez-Lopez, V; Martinez, M; Parrilla-Paricio, P; Pons Miñano, JA; Ramirez-Romero, P; Robles-Campos, R; Ros, J; Sanchez-Bueno, F; Sanmartin, J | 1 |
| Nguyen, V | 1 |
| Lucyk, S | 1 |
| Dennis, K; Ding, WX; Li, J; Li, T; Matye, D; Wang, Y; Zhang, Y | 1 |
| Khan, R; Koppe, S | 1 |
| Hu, H; Huo, Y; Yan, M; Yin, S | 1 |
| Dalhoff, K; Dart, RC; Kaelin, B; Macias-Perez, IM; Pavliv, L; Petersen, TS; Rasmussen, DN; Schmidt, LE | 1 |
| Achour, S; Benlamkaddem, S; Boukatta, B; Elbouazzaoui, A; Houari, N; Iken, I; Kanjaa, N; Sbai, H | 1 |
| Blomgren, A; Grundemar, L; Högestätt, ED; Nilsson, JLÅ; Nilsson, UJ | 1 |
| Graudins, A; Greene, S; Gunja, N; Koutsogiannis, Z; McNulty, R; Sivilotti, M; Taylor, D; Wong, A | 1 |
| Foex, BA; Woodhead, K | 1 |
| Chan, BY; Lee, HH; Leung, DC; Ling, WH; Mak, CM; Ng, CW; Tsang, HM | 1 |
| Arce, DY; Boyer, EW; Farber, MK; Gray, KJ; Reale, SC | 1 |
| Chao, X; Ding, WX; Du, K; Jaeschke, AH; Jaeschke, H; Ramachandran, A; Weemhoff, JL; Woolbright, BL | 1 |
| Archer, J; Dargan, PI; Hope, L; Layne, K; Rab, E; Wood, DM | 1 |
| Choy, KW; Dear, JW; Doery, J; Graudins, A; Homer, N; Wong, A | 1 |
| Coudert, C; Dualé, C; Macian, N; Papet, I; Pereira, B; Pickering, G | 1 |
| Almacioglu, M; Demirkasimoglu, M; Eyison, RK; Ivelik, K; Kenar, L; Kunak, ZI; Ortatatli, M; Sezigen, S | 1 |
| Bayat, Z; Kadioglu, E; Ozatik, FY; Ozatik, O; Teksen, Y | 1 |
| Dear, J | 1 |
| Dart, RC; Hoyte, C | 1 |
| Green, JP; Johnson, DW; Mutsaers, A; Rumack, BH; Sivilotti, MLA; Spyker, DA; Tucker, D; Yarema, MC | 1 |
| Hendrickson, RG | 1 |
| Choy, KW; Doery, J; Gantier, M; Graudins, A; Nejad, C; Wong, A | 1 |
| Moore, R; Nicholas, WA | 1 |
| Ali, M; Misurati, M; Pooni, J; Rodgers, R | 1 |
| Ho, SM; Jiang, W; Khanal, T; Kim, K; Leung, YK; Timchenko, N | 1 |
| Altinbas, A; Ayhan, S; Canakci, E; Kokturk, S; Noyan, T; Tas, N | 1 |
| Bateman, DN; Dear, JW | 2 |
| Ignarro, LJ; Jynge, P; Karlsson, JOG; Lundström, I | 1 |
| Fratita, M; Owens, R; O’Dwyer, M; Spring, A | 1 |
| Black, P; Dear, JW; Gallagher, B; Grahamslaw, J; Henriksen, D; Lee, RJ; Morrison, EE; O'Brien, R; Oatey, K; Oosthuyzen, W; Weir, CJ | 1 |
| Elmgren, A; Helander, A; Nordmark Grass, J | 1 |
| Kubo, T; Lee, SH; Oe, T; Ozawa, M | 1 |
| Algren, DA; Beuhler, MC; Holstege, CP; Mullins, ME; Sivilotti, MLA; Thompson, M; Yarema, MC | 1 |
| Awad, NI; Bridgeman, PJ; Cocchio, C; Geib, AJ; Roy, A | 1 |
| Karlsson, JOG | 1 |
| Dear, JW | 2 |
| Jackson, A; Little, M | 1 |
| Chen, Q; Chen, YH; Li, J; Li, Z; Lin, L; Shen, E; Wan, X; Xia, M; Yan, D; Zhan, W; Zhang, G; Zhang, Q | 1 |
| Höjer, J; Lindeman, E; Nordmark Grass, J; Personne, M | 1 |
| Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; James, LP; McArdle, K; Pickering, JW | 1 |
| Beuhler, MC; Shah, KR | 2 |
| Hays, WB; Patel, KH; Woolum, JA | 1 |
| Buckley, NA; Chiew, AL; Isoardi, KZ; Pomerleau, A; Reith, D; Soderstrom, J; Wong, A | 1 |
| Colle, I; Debacker, PJ; Devisscher, L; Geerts, A; Lefere, S; Raevens, S; Van Campenhout, S; Van Vlierberghe, H; Verhelst, X | 1 |
| Dart, R; Graudins, A; Heard, K; Sivilotti, MLA; Wong, A | 1 |
| Ishitsuka, Y; Kadowaki, D; Kondo, Y | 1 |
| Ahn, JH; Cho, GC; Cho, YS | 1 |
| Canseco, K; Goodnough, R | 1 |
| Boley, SP; Crow, EM; Levine, M; Spyres, MB; Stellpflug, SJ | 1 |
| Audley, KM; Rosini, JM | 1 |
| Azandaryani, MT; Firozian, F; Karami, S; Nili-Ahmadabadi, A; Ranjbar, A | 1 |
| Elgamasy, S; Ghozy, S; Islam, SMS; Kamel, MG; Khalil, A; Morra, ME | 1 |
| Beuhler, MC; Dulaney, A; Fox, C; Geib, AJ; Kerns Ii, W; Kopec, K; Murphy, C; Shah, KR | 1 |
| Hayden, JC; Kelly, L; McNicholas, F | 1 |
| James, J; Myers, M; Ponnusamy, A; Stauss, M | 1 |
| Aamir, M; Fatima, S; Naz, S | 1 |
| Chiew, A; Isbister, GK | 1 |
| Freeman, WE; Mullins, ME; Yeager, LH | 1 |
| Cao, DJ; Epperson, LC; Weiss, ST | 1 |
| Allie, S; Chughlay, MF; Cohen, K; Gunter, H; Hickman, N; Maartens, G; Moosa, MS; Setshedi, M; Sonderup, M; Spearman, CW; Stead, DF; Stewart, A; Wasserman, S | 1 |
| Blind, F; Hall, B; Wilson, K | 1 |
| Akakpo, JY; Jaeschke, H; Ramachandran, A | 1 |
| Akgun, E; Boyacioglu, M; Kum, S | 1 |
| Eshrati, R; Ghafourian Hesami, M; Gudarzi, S; Jafari, M; Nazari, A; Samizadeh, E | 1 |
| Ilan, Y; Lichtenstein, Y; Shabat, Y | 1 |
| Chabert, A; Gitton, A; Oudart, JB; Schneider, N; Simon, A | 1 |
| Dalhoff, KP; Daoud, A; Petersen, TS | 1 |
| Baumgartner, K; Devgun, J; Filip, A; Liss, D; Mullins, M; Schwarz, E | 1 |
| Antonucci, R; Capobianco, G; Cuzzolin, L; Locci, C | 1 |
| Ezhilarasan, D; Raghunandhakumar, S | 1 |
| Dastjerdi, M; Farrokhfall, K; Mehrpour, O; Nakhaee, S; Roumi, H | 1 |
| Loubani, O; McDougall, G; Murphy, NG | 1 |
| Enver Ozan, İ; Erdem Güzel, E; Gül, M; Kavak Balgetir, M; Kaya Tektemur, N; Ozan Kocamüftüoğlu, G; Özcan Yıldırım, S; Tektemur, A; Yalçın, T | 1 |
| Cumpston, KL; Downs, JW; Kershner, EK; Rose, SR; Troendle, MM; Wills, BK | 1 |
| Bateman, DN; Choi, H; Dear, JW; Drum, CL; Ibrahim, B; Khoo, BBJ; Leroy Sivappiragasam, P; Ng, ML | 1 |
| Bathaie, SZ; Hashemi, SA; Kyani, A | 1 |
| Abd-Eldayem, AM; Ahmed, E; Ahmed, EA | 1 |
| Akpunonu, P; Bailey, AM; Baum, RA; Geraghty, L; Howell, MM; Mohan, S; Su, MK; Weant, KA; Webb, AN; Woolum, JA | 1 |
| Buckley, NA; Chiew, AL | 1 |
| Choi, SW; Kang, HK; Kang, KS; Kim, DH; Kim, MS; Kim, NG; Kook, MG; Lee, JY; Ogay, V; Sarsenova, M; Sung, EA | 1 |
| Chiang, WK; Howland, MA; Mahonski, SG; Melchert, K; Trebach, J | 1 |
| Thimme, R; Vogelbacher, LC | 1 |
| Kewcharoen, J; Narimasu, T; Nishimura, Y | 1 |
| Deye, N; Diallo, A; Gourlain, H; Goury, A; Malissin, I; Mégarbane, B; Nuzzo, A; Péron, N; Salem, S; Vicaut, E; Voicu, S | 1 |
| Burnham, K; Knight, S; Smith, H; Yang, T | 1 |
| Graudins, A; O'Callaghan, C; Wong, A | 1 |
| Akakpo, JY; Curry, SC; Jaeschke, H; Jaeschke, MW; Ramachandran, A; Rumack, BH | 1 |
| Dissanayake, DMDIB; Gunaratne, WMSN; Kularatne, SAM; Kumarasiri, PVR; Kumarihamy, KWMPP | 1 |
| Albertson, TE; Chenoweth, JA; Lai, L; Lewis, JC; Lim, M; Mendoza, E | 1 |
| Link, SL; Osmon, S; Rampon, G; Rumack, BH; Scalzo, AJ | 2 |
| Graudins, A; Syafira, N; Wong, A; Yarema, M | 1 |
| Bøgevig, S; Chrstensen, MB; Dalhoff, KP; Daoud, A; Gade, C; Mathiesen, PR; Petersen, TS | 1 |
| Hodgson, SE; Wong, A | 1 |
| Lebin, JA; Mudan, A | 1 |
| Dayasiri, K; Rao, S | 1 |
| Hoffman, RS; Mahonski, S; Mohan, S | 1 |
| Bateman, DN; Dear, JW; Eddleston, M; Vale, JA | 1 |
| Thanacoody, HKR | 1 |
| Akakpo, JY; Curry, SC; Jaeschke, H; Ramachandran, A; Rumack, BH | 1 |
| Berland, NG; Calello, DP; Leonard, J | 1 |
| Baum, RA; Su, MK; Weant, KA | 1 |
| Aytuğ, H; Çoban, FK; Demirel, HH; İnce, S; İslam, İ | 1 |
| Ağın, H; Atakul, G; Çağlar, A; Çolak, M; Karaarslan, U; Soydan, E; Topal, S | 1 |
| Chomchai, C; Chomchai, S; Mekavuthikul, P; Phuditshinnapatra, J | 1 |
| Akakpo, JY; Begher-Tibbe, B; Brackhagen, L; Brecklinghaus, T; Canbay, A; Copple, IM; Curry, SC; Friebel, A; Ghallab, A; Goldring, C; González, D; Hassan, R; Hengstler, JG; Hobloss, Z; Hoehme, S; Hofmann, U; Jaeschke, H; Kappenberg, F; Longerich, T; Luedde, T; Marchan, R; Murad, W; Myllys, M; Olyaee, M; Overbeck, N; Rahnenführer, J; Reinders, J; Schreiter, T; Seddek, AL; Sezgin, S; Sowa, JP; Trauner, M; Urban, S; Vucur, M; Zühlke, S | 1 |
| Hussein, RM; Kandeil, MA; Khallaf, RA; Mohammed, NA | 1 |
| Duan, L; Jaeschke, H; Ramachandran, A; Sanchez-Guerrero, G | 1 |
| Andrys, R; Cesla, P; Kubat, M; Malinak, D; Mikysek, T; Musilek, K; Rousar, T; Rousarova, E; Vanova, J | 1 |
| Dart, RC; Kaiser, SK | 1 |
| Berg, SE; Filip, AB; Mullins, ME; Schwarz, ES | 1 |
| Camarena-Michel, A; Hoyte, C; Leonard, J; Pennington, S; Sudanagunta, S; Wang, GS | 1 |
| Codinach-Martín, M; Gispert-Ametller, MÀ; Nogué-Xarau, S; Ortega-Pérez, J; Puiguriguer-Ferrando, J; Rodríguez-Mariblanca, A; Salgado-García, E | 1 |
| Abbas, AA; Ahmed, AE; Hamdy, A | 1 |
| Chen, Y; Ge, W; Song, W; Yan, R | 1 |
| Wong, A | 1 |
| Abdel Kader, H; Humphries, C; Kidd, R; Roberts, G; Smith, J; Taheem, A | 1 |
| Aithal, GP; Alvarez-Alvarez, I; Andrade, RJ; Arikan, C; Atallah, E; Lucena, MI; Medina-Caliz, I; Niu, H | 1 |
| Abhyankar, S; Adelusi, O; Apte, U; Dawn, B; Duan, L; Jaeschke, H; Nguyen, NT; Ramachandran, A; Robarts, DR; Soder, RP; Umbaugh, DS; Woolbright, B | 1 |
| Cai, X; Chen, Z; Deng, J; Du, Z; Hua, S; Khan, NU; Liu, Z; Zhang, D; Zhou, M | 1 |
| Ding, KN; Guo, YN; He, YM; Liang, SS; Lu, MH; Shen, XL; Tang, LP | 1 |
| Chen, M; Du, J; Wu, B; Xiao, Y; Zhang, F; Zhang, L; Zhang, X | 1 |
| Desgranges, A; Hu, K; Monney Chaubert, C | 1 |
| Motohashi, K; Thanacoody, RH | 1 |
| Almási, A; Kovács, S; Kulcsár, G; Mészáros, P; Páskuj, M | 1 |
| Cumaoğlu, B; Günay, N; Oğuz Cumaoğlu, M; Tekin, Y | 1 |
| Balinski, A; Bower, R; Lee, M; McCarron, J | 1 |
| Janković, SM | 1 |
| Filip, AB; Mullins, ME | 1 |
| Anderson, M; Gray, L; Kelgeri, C; Rajaraman, N | 1 |
| Carr, D; Cohen, K; Costello, E; Dorfman, JR; Goldring, C; Gunter, H; Maartens, G; Moosa, MS; Patel, C; Pirmohamed, M; Russomanno, G | 1 |
| Huang, L; Luo, G; Zhang, Z | 1 |
| Haar, I; Strehle, EM | 1 |
| Albert, K; Hasara, S; Wilson, K | 1 |
| Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; Isoardi, KZ; Page, C; Ress, K; Stathakis, P | 1 |
| Akradi, L; Mokhtari, Z; Raeeszadeh, M | 1 |
| Capossela, L; Chiaretti, A; Curatola, A; Ferretti, S; Gatto, A; Graglia, B; Pansini, V | 1 |
| Gupta, A; Gupta, M; Gupta, S; Jesrani, G; Sood, D | 1 |
| Ezhilarasan, D; Gayatri Devi, R | 1 |
| Aki, T; Funakoshi, T; Tanaka, H; Uemura, K; Unuma, K | 1 |
| Banner, W; Beuhler, MC; Burns, MM; Cantrell, LF; Cole, JB; Dart, RC; Funk, AR; Heard, KJ; Hendrickson, RG; Lucyk, SN; Matoushek, T; Mazer-Amirshahi, M; Mullins, ME; Nelson, LS; Ruha, AM; Rumack, BH; Simone, K; Sivilotti, MLA; Stolbach, AI; Stork, CM; Su, MK; Varney, SM | 1 |
| Arantes, KC; Botelho, AFM; da Silva, M; da Silva, RHS; de Amorim, J; de Melo E Silva, D; de Moura, M; de Paula, L; Martins, DB; Melo, MM; Miguel, MP | 1 |
| Abdul Rouf, PV; Abushanab, D; Ahmed, N; Azad, A; Devi, D; Elbdairy, M; Elgassim, M; Elkassem, W; Elmoheen, A; Elqasass, H; Gasim, M; Hail, MA; Hanssens, Y; Mohammed, HR; Mohammed, S; Salem, W; Thomas, B; Vincent, M | 1 |
| Bendavid, C; Collet, N; Gicquel, T; Le Divenah, F; Lefèvre, CR; Pawlowski, M; Pelletier, R; Robert, E; Ropert, M | 1 |
127 review(s) available for acetaminophen and acetylcysteine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Assessment and treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Overdose; Gastric Lavage; Humans; Ipecac | 1991 |
Use of N-acetylcysteine in clinical toxicology.
Topics: Acetaminophen; Acetylcysteine; Animals; Contraindications; Humans; Poisoning; Toxicology | 1991 |
[Paracetamol hepatotoxicity].
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Infant | 1990 |
Pediatric toxicology: current controversies and recent advances.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Child Abuse; Child, Preschool; Digitoxin; Digoxin; Emetics; Female; Gastric Lavage; Humans; Hydrocarbons; Immunoglobulin Fab Fragments; Infant; Male; Naloxone; Narcotics; Poisoning | 1986 |
Protective agents for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimetidine; Cysteamine; Glucuronates; Glutathione; Humans; Inactivation, Metabolic; Lipid Peroxides; Liver; Methionine; Necrosis; Propylthiouracil | 1986 |
[Therapy of toxic hepatitis].
Topics: Acetaminophen; Acetylcysteine; Adrenal Cortex Hormones; Age Factors; Aged; Animals; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Male; Middle Aged; Prognosis; Sex Factors | 1985 |
The treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; Biotransformation; Chemical and Drug Induced Liver Injury; Cysteamine; Glutathione; Humans; Liver; Methionine; Necrosis; Sulfhydryl Compounds | 1983 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Chemical and Drug Induced Liver Injury; Child; Ethanol; Humans; Infusions, Parenteral | 1983 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Cysteine; Dose-Response Relationship, Drug; Glutathione; History, 20th Century; Humans; Kinetics; Liver Diseases; Prognosis; Prothrombin Time; Time Factors | 1984 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Glutathione; Hepatic Encephalopathy; Humans; Liver; Liver Function Tests; Methionine | 1980 |
Paracetamol.
Topics: Acetaminophen; Acetylcysteine; Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Cysteamine; Dextropropoxyphene; Humans; Infant; Kidney Diseases; Methionine | 1980 |
Treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Glutathione; Humans; Liver | 1981 |
Hepatotoxicity: newer aspects of pathogenesis and treatment.
Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Contraceptives, Oral; Female; Humans; Isoniazid; Liver Diseases; Liver Diseases, Alcoholic; Liver Neoplasms; Male; Nonprescription Drugs; Propylthiouracil; Rifampin | 1995 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Dose-Response Relationship, Drug; Drug Overdose; Humans; Liver; Methionine | 1995 |
[Paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Charcoal; Denmark; Intestinal Absorption; Kidney; Liver; Poisoning; Risk Factors | 1995 |
[Acetylcysteine in paracetamol overdose; intravenous but also oral therapy is helpful even in late application].
Topics: Acetaminophen; Acetylcysteine; Humans; Poisoning; Time Factors | 1994 |
[Acetylcysteine: a promising antioxidant for cardiorespiratory disorders].
Topics: Acetaminophen; Acetylcysteine; Acquired Immunodeficiency Syndrome; Antioxidants; Chemical and Drug Induced Liver Injury; Humans; Myocardial Reperfusion Injury; Nitrates; Reactive Oxygen Species; Respiratory Distress Syndrome | 1994 |
Paracetamol hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatic Encephalopathy; Humans; Intubation; Liver Diseases; Prognosis; Stomach | 1993 |
Paracetamol poisoning and the kidney.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Kidney | 1993 |
Management of acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Poisoning | 1996 |
[Clinical-toxicological case (1). Dosage of N-acetylcysteine in acute paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Antidotes; Drug Administration Schedule; Female; Humans; Poisoning | 1996 |
Hemolysis after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Hemolysis; Humans; Injections, Intravenous; Male; Poisoning; Suicide | 1996 |
[Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of the Liver].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Denmark; Humans; Infusions, Intravenous; Poisoning | 1996 |
[Acetaminophen poisoning].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Bromisovalum; Drug Combinations; Humans; Liver; Plasma Exchange; Renal Dialysis | 1997 |
Deaths from low dose paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Fatal Outcome; Female; Humans; Male; Risk Factors | 1998 |
Management of anaphylactoid reactions to intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Anti-Allergic Agents; Diphenhydramine; Free Radical Scavengers; Histamine H1 Antagonists; Humans; Infusions, Intravenous; Practice Guidelines as Topic; Prospective Studies; Retrospective Studies | 1998 |
Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: a critical review.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Female; Free Radical Scavengers; Humans; Male; Poisoning | 1998 |
When acetaminophen use becomes toxic. Treating acute accidental and intentional overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Humans; Liver Failure; Poisoning; Risk Factors | 1999 |
Treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anti-Ulcer Agents; Antidotes; Charcoal; Child; Cimetidine; Drug Overdose; Female; Humans; Pregnancy; Time Factors | 1999 |
Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Charcoal; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Therapy, Combination; Female; Free Radical Scavengers; Humans; Infant; Injections, Intravenous; Liver Diseases; Male; Middle Aged; Poisoning; Transaminases | 1999 |
Acetaminophen intoxication during treatment: what you don't know can hurt you.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Overdose; Humans; Iatrogenic Disease; Infant; Infant, Newborn; Risk Factors | 2000 |
Acute hepatic failure: a Western perspective.
Topics: Acetaminophen; Acetylcysteine; Antiviral Agents; Drug-Related Side Effects and Adverse Reactions; Health Care Costs; Hepatitis, Viral, Human; Humans; Liver Failure, Acute; Liver Transplantation; Prevalence; Prostaglandins | 2000 |
Phytonadione therapy in a multiple-drug overdose involving warfarin.
Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anticoagulants; Antidotes; Antifibrinolytic Agents; Azabicyclo Compounds; Charcoal; Drug Interactions; Drug Overdose; Female; Gastric Lavage; Humans; Hypnotics and Sedatives; International Normalized Ratio; Piperazines; Vitamin K; Vitamin K 1; Warfarin | 2000 |
[About paracetamol again].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Cimetidine; Drug Overdose; Humans; Liver; Liver Failure, Acute | 2001 |
Chronic acetaminophen overdosing in children: risk assessment and management.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child; Drug Overdose; Expectorants; Humans; Liver; Risk Factors | 2001 |
Paracetamol overdose in a preterm neonate.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Charcoal; Colorimetry; Free Radical Scavengers; Half-Life; Humans; Infant, Newborn; Infant, Premature; Male; Medication Errors; Treatment Outcome | 2001 |
Management of paracetamol overdose: current controversies.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Interactions; Drug Overdose; Female; Humans; Liver Diseases; Pregnancy; Risk Factors | 2001 |
[N-Acetylcysteine: new possibilities to use an old substance].
Topics: Acetaminophen; Acetylcysteine; Antioxidants; Free Radical Scavengers; Glutathione; Humans; Liver Failure; Oxidative Stress; Randomized Controlled Trials as Topic; Shock, Septic | 1999 |
Acute acetaminophen overdose in adolescents and adults.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Age Factors; Antidotes; Critical Care; Drug Overdose; Free Radical Scavengers; Humans; Liver Failure; Medical History Taking; Metabolic Clearance Rate; Nursing Assessment; Physical Examination; Time Factors; United States | 2000 |
Acetaminophen poisoning: an update for the intensivist.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Critical Care; Humans; Liver Transplantation; Prognosis | 2002 |
[Treatment of paracetamol intoxication. Correctly given antidote treatment will prevent liver damage].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Poisoning; Time Factors; Treatment Outcome | 2002 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Humans; Methionine; Poisoning; Randomized Controlled Trials as Topic; Suicide Prevention; Survival Rate; Treatment Outcome | 2002 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Humans; Methionine | 2002 |
[Practical analysis of toxic substances useful for clinical toxicology--4--Acetaminophen].
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Colorimetry; Female; Humans; Liver Diseases; Predictive Value of Tests; Severity of Illness Index; Suicide, Attempted; Ultraviolet Rays | 2002 |
The critically ill liver patient: fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Brain Edema; Critical Illness; Diagnosis, Differential; Female; Free Radical Scavengers; Hepatic Encephalopathy; Humans; Liver Function Tests; Liver Transplantation; Middle Aged; Prognosis | 2003 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Antidotes; Chemistry, Pharmaceutical; Drug Overdose; Drug Packaging; Humans; Poisoning; Risk Factors; Time Factors; United Kingdom | 2003 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Oral methionine compared with intravenous n-acetyl cysteine for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Evidence-Based Medicine; Humans; Methionine | 2003 |
Acetaminophen intoxication and length of treatment: how long is long enough?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Time Factors | 2003 |
[Acetaminophen poisoning].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Charcoal; Drug Overdose; Glutathione; Humans; Liver; Prognosis; Time Factors | 2003 |
Acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Cytokines; Humans; Kupffer Cells; Liver Diseases; Mitochondria, Liver; Oxidative Stress; Tyrosine | 2003 |
[Clinical application of N-acetylcysteine in liver disease].
Topics: Acetaminophen; Acetylcysteine; Humans; Liver Diseases | 2004 |
Acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Monitoring; Drug Overdose; Emergency Nursing; Emergency Treatment; Gastric Lavage; Humans; Suicide, Attempted; United States | 2004 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Humans | 2003 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Gastric Lavage; Humans | 2004 |
An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Dose-Response Relationship, Drug; Exanthema; Humans; Infusions, Intravenous; Liver Diseases; Practice Guidelines as Topic; Pruritus | 2005 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Humans; Methionine | 2004 |
A clinical and pharmacoeconomic justification for intravenous acetylcysteine: a US perspective.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Contrast Media; Humans; Injections, Intravenous; Kidney Diseases | 2005 |
Acetaminophen overdose in pregnancy.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Fetus; Humans; Liver; Pregnancy; Pregnancy Complications | 2005 |
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; Liver; Liver Diseases; Liver Neoplasms; Verapamil | 2006 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Humans; Poisoning | 2006 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Humans; Methionine | 2005 |
[Alcohol abuse case of severe liver dysfunction induced by acetaminophen poisoning which was diagnosed as non-hepatic toxicity on admission].
Topics: Acetaminophen; Acetylcysteine; Administration, Rectal; Adult; Alcoholism; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver Diseases; Plasma Exchange; Severity of Illness Index; Suicide, Attempted; Therapeutics | 2006 |
Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Child; Drug Overdose; Female; Humans; Injections, Intravenous; Pregnancy | 2006 |
Update on antidotes for pediatric poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Antidotes; Antivenins; Child; Child, Preschool; Cholinergic Antagonists; Cholinesterase Inhibitors; Crotalid Venoms; Emergencies; Ethylene Glycol; Female; Fomepizole; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fragments; Infant; Infusions, Intravenous; Injections, Intramuscular; Male; Methanol; Poisoning; Practice Guidelines as Topic; Pyrazoles; Snake Bites; Syringes | 2006 |
Epidemiology of acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug-Related Side Effects and Adverse Reactions; Free Radical Scavengers; Hepatitis, Autoimmune; Hepatitis, Viral, Human; Humans; Liver Failure, Acute; Liver Transplantation; Metabolic Diseases; Neoplasms; Prognosis; Vascular Diseases | 2007 |
N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Controlled Clinical Trials as Topic; Cysteine; Cystic Fibrosis; Free Radical Scavengers; Glutathione; HIV Infections; Humans; Prodrugs; Quality of Life | 2007 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver | 2007 |
Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Female; Humans; Kidney; Liver; Middle Aged | 2008 |
Acetylcysteine for acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Humans; Liver; Male; Poisoning; Practice Guidelines as Topic | 2008 |
[Acetylcysteine].
Topics: Acetaminophen; Acetylcysteine; Antidotes; Dosage Forms; Humans | 2008 |
Acetaminophen hepatotoxicity and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Failure, Acute; Liver Transplantation; Male; United Kingdom; United States | 2009 |
Adverse reactions associated with acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Blood Coagulation; Chemical and Drug Induced Liver Injury; Humans; Infusions, Intravenous; International Normalized Ratio; Liver Diseases; Risk Factors | 2009 |
N-acetylcysteine: multiple clinical applications.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Expectorants; Female; Free Radical Scavengers; Hearing Loss; Humans; Influenza, Human; Neoplasms; Polycystic Ovary Syndrome; Respiratory Tract Diseases | 2009 |
Emergency: acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Disease Progression; Drug Labeling; Emergencies; Emergency Treatment; Female; Humans; Liver Diseases; Nonprescription Drugs; Patient Education as Topic; Risk Factors; Substance Abuse Detection; Suicide, Attempted; Time Factors | 2009 |
[Intravenous or oral N acetylcysteine therapy in paracetamol poisoned patients. Should treatment guidelines be reviewed?].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Drug Administration Schedule; Drug Overdose; Humans; Infusions, Intravenous; Poisoning; Practice Guidelines as Topic | 2010 |
Critical care management of patients before liver transplantation.
Topics: Acetaminophen; Acetylcysteine; Brain Edema; Drug Overdose; End Stage Liver Disease; Hepatopulmonary Syndrome; Homeostasis; Humans; Liver Failure, Acute; Liver Transplantation; Postoperative Period; Preoperative Care; Treatment Outcome | 2010 |
Intravenous acetylcysteine for the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Free Radical Scavengers; Humans; Injections, Intravenous; Time Factors; Treatment Outcome | 2011 |
[Intentional paracetamol intoxication in children].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Humans | 2011 |
Acute poisoning following ingestion of medicines: initial management. How to treat life-threatening complications and to evaluate the risk of delayed effects and psychological distress.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Charcoal; Depression; Gastric Lavage; Humans; Poisoning; Risk | 2010 |
Hepatic encephalopathy: a central neuroinflammatory disorder?
Topics: Acetaminophen; Acetylcysteine; Animals; Brain Edema; Hepatic Encephalopathy; Humans; Hypothermia, Induced; Liver Failure, Acute; Minocycline | 2011 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Ambulatory Care; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Transplantation; Nomograms; Physical Examination | 2011 |
Assessment of the clinical use of intravenous and oral N-acetylcysteine in the treatment of acute acetaminophen poisoning in children: a retrospective review.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Child; Clinical Trials as Topic; Databases, Factual; Drug Utilization Review; Humans; Injections, Intravenous; Medical Records; Poisoning; Retrospective Studies; Time Factors | 2011 |
Lack of toxicity after paracetamol overdose in a extremely preterm neonate.
Topics: Abdominal Pain; Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Free Radical Scavengers; Half-Life; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Infusions, Intravenous; Medication Errors; Metabolic Clearance Rate; Sepsis; Treatment Outcome | 2012 |
Acetaminophen and acetylcysteine dose and duration: past, present and future.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans; Multicenter Studies as Topic; United States; United States Food and Drug Administration | 2012 |
Acetylcysteine therapy for acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Emergency Treatment; Humans; Molecular Structure; Structure-Activity Relationship; Treatment Outcome | 2012 |
Criteria for acetylcysteine treatment and clinical outcomes after paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Humans; Risk Factors | 2012 |
Emergency ABO-incompatible liver transplant secondary to fulminant hepatic failure: outcome, role of TPE and review of the literature.
Topics: ABO Blood-Group System; Acetaminophen; Acetylcysteine; Adult; Antibodies, Monoclonal, Murine-Derived; Antidepressive Agents; Biliary Tract Surgical Procedures; Blood Group Incompatibility; Cholestasis; Combined Modality Therapy; Depressive Disorder; Emergencies; Female; Graft Rejection; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Liver Failure, Acute; Liver Function Tests; Plasma Exchange; Postoperative Complications; Rituximab; Stents; Suicide, Attempted | 2012 |
A review of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Interactions; Drug Overdose; Ethanol; Humans; Liver Failure, Acute; Liver Transplantation; Nomograms; Time Factors | 2012 |
Combined butalbital/acetaminophen/caffeine overdose: case files of the Robert Wood Johnson Medical School Toxicology Service.
Topics: Acetaminophen; Acetylcysteine; Adult; Barbiturates; Caffeine; Drug Combinations; Drug Overdose; Female; Hemoperfusion; Humans; Renal Dialysis; Treatment Outcome; Vasopressins; Xanthines | 2012 |
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Cholestasis; Combined Modality Therapy; Diagnosis, Differential; Disease Management; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Illicit Drugs; Liver Failure, Acute; Liver Function Tests; Liver Transplantation; Mushroom Poisoning; Neurologic Examination; Occupational Diseases; Respiratory Insufficiency; Sepsis; Shock; Time Factors; Valproic Acid | 2013 |
[N-acetylcysteine].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Antipyretics; Free Radical Scavengers; Humans; Time Factors | 2013 |
Intravenous acetylcysteine for indications other than acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Animals; Antidotes; Drug Overdose; Hepatitis, Alcoholic; Humans; Liver Failure, Acute | 2013 |
Acetaminophen-related hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antipyretics; Chemical and Drug Induced Liver Injury; Humans; Liver Failure, Acute; Risk Factors | 2013 |
What is the clinical significance of 5-oxoproline (pyroglutamic acid) in high anion gap metabolic acidosis following paracetamol (acetaminophen) exposure?
Topics: Acetaminophen; Acetylcysteine; Acidosis; Amino Acid Metabolism, Inborn Errors; Analgesics, Non-Narcotic; Antipyretics; Disease Susceptibility; Free Radical Scavengers; Glutathione Synthase; Humans; Pyrrolidonecarboxylic Acid; Severity of Illness Index | 2013 |
Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Overdose; Humans | 2014 |
Recommendations for the paracetamol treatment nomogram and side effects of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Free Radical Scavengers; Hospitals, Group Practice; Humans; Netherlands; Nomograms; Poisoning; Risk Assessment | 2014 |
Efficacy and safety of acetylcysteine in "non-acetaminophen" acute liver failure: A meta-analysis of prospective clinical trials.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Clinical Trials as Topic; Free Radical Scavengers; Humans; Infusions, Intravenous; Liver Failure, Acute; Prospective Studies; Treatment Outcome | 2015 |
How much did you take? Reviewing acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Drug Dosage Calculations; Drug Overdose; Female; Humans; Liver; Male; Middle Aged; Practice Guidelines as Topic | 2015 |
Paracetamol poisoning: beyond the nomogram.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Biomarkers; Drug Overdose; Humans; Nomograms; Risk Assessment | 2015 |
Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Biomarkers; Cell Death; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Free Radical Scavengers; Hepatocytes; Humans; Liver; Liver Failure, Acute; Mice | 2015 |
Evidence for the changing regimens of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Drug Administration Schedule; Drug Overdose; Humans | 2016 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Gastric Lavage; Humans; Liver Transplantation; Methionine; Poisoning; Renal Dialysis; Treatment Outcome | 2015 |
The changing face of liver transplantation for acute liver failure: Assessment of current status and implications for future practice.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Contraindications; Free Radical Scavengers; Humans; Liver Failure, Acute; Liver Transplantation; Prognosis; Quality of Life; Rare Diseases; Survival Rate; Treatment Outcome; Waiting Lists | 2016 |
Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Brain; Chemical and Drug Induced Liver Injury; Humans; Liver | 2016 |
Risk prediction of hepatotoxicity in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antioxidants; Biomarkers; Blood Coagulation; Chemical and Drug Induced Liver Injury; Decision Support Techniques; Humans; Liver; Liver Function Tests; Nomograms; Predictive Value of Tests; Prognosis; Prothrombin Time; Risk Assessment; Risk Factors; Severity of Illness Index | 2017 |
Interventions for paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Cysteamine; Dimercaprol; Drug Overdose; Gastric Lavage; Humans; Intestinal Absorption; Liver Failure, Acute; Liver Transplantation; Methionine; Randomized Controlled Trials as Topic | 2018 |
Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and Acute Liver Failure.
Topics: Acetaminophen; Acetylcysteine; Biomarkers; Humans; Liver Failure, Acute; Liver Transplantation | 2018 |
Modern Management of Acute Liver Failure.
Topics: Acetaminophen; Acetylcysteine; Biomarkers; Blood Coagulation Disorders; Brain Diseases; Free Radical Scavengers; Humans; Intracranial Hypertension; Liver Failure, Acute; Liver Transplantation; Monitoring, Physiologic; Mushroom Poisoning; Renal Replacement Therapy | 2018 |
Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions.
Topics: Acetaminophen; Acetylcysteine; Autophagy; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Humans; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Oxidative Stress; Reactive Oxygen Species | 2018 |
BET 1: In paracetamol overdose, is oral N-acetylcysteine as effective as intravenous N-acetylcysteine?
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Administration, Oral; Adolescent; Drug Overdose; Humans; Male | 2018 |
What is the most appropriate dose of
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose; Humans | 2019 |
Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Australia; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; New Zealand; Practice Guidelines as Topic | 2020 |
Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?
Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Female; Glutathione; Humans; Male; Mitochondria, Liver; Oxidative Stress; Pregnancy | 2020 |
A clinician's guide to self-poisoning with paracetamol in youth: The what, when and why?
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Child; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2020 |
Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Animals; Antidotes; Cimetidine; Drug Overdose; Edetic Acid; Fomepizole; Humans; Mitochondria; Pyridoxal Phosphate | 2020 |
Novel strategies for the treatment of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Edetic Acid; Fomepizole; Hepatocytes; Humans; Liver Failure, Acute; Pyridoxal Phosphate | 2020 |
Paracetamol overdose in the newborn and infant: a life-threatening event.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infant; Infant, Newborn; Pregnancy; Prenatal Exposure Delayed Effects | 2021 |
Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2021 |
A review of alternative intravenous acetylcysteine regimens for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2021 |
Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0-6 years.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Child; Child, Preschool; Denmark; Humans; Infant; Infant, Newborn; Retrospective Studies | 2022 |
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Hepatocytes; Humans; Mice | 2022 |
The Roles of Antidotes in Emergency Situations.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Fomepizole; Humans; Methylene Blue | 2022 |
Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Adult; Carnitine; Chemical and Drug Induced Liver Injury; Child; Drug-Related Side Effects and Adverse Reactions; Glutathione; Glycyrrhizic Acid; Humans; Infant, Newborn; Liver; Liver Failure, Acute; Retrospective Studies; S-Adenosylmethionine; Ursodeoxycholic Acid | 2022 |
Toxicology in the emergency department: what's new?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Australia; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Emergency Service, Hospital; Humans | 2022 |
The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Oxidative Stress | 2023 |
Role of N-acetylcysteine in liver injury due to dengue fever.
Topics: Acetaminophen; Acetylcysteine; Dengue; Humans; Liver Failure, Acute | 2023 |
36 trial(s) available for acetaminophen and acetylcysteine
| Article | Year |
|---|---|
Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Biological Transport; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hemodynamics; Hepatic Encephalopathy; Hepatitis C; Hepatitis, Alcoholic; Humans; Male; Middle Aged; Oxygen; Oxygen Consumption | 1991 |
Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Child; Drug Overdose; Female; Humans; Injections, Intravenous; Liver; Male; Prospective Studies; Risk Factors; Time Factors | 1991 |
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Liver Diseases; London; Male; Middle Aged; Prospective Studies; Prothrombin Time; Survival Rate | 1991 |
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Humans; Liver; Mortality; Multicenter Studies as Topic; Time Factors; Transaminases | 1988 |
Letter: Cysteamine for paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Blood Specimen Collection; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Clinical Trials as Topic; Cysteamine; Dimercaprol; Humans; Penicillamine; Poisoning; Time Factors | 1974 |
Clinical safety of high oral doses of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Diarrhea; Drug Administration Schedule; Electrocardiography; Electrolytes; Humans; Liver; Liver Diseases; Rats; Vomiting | 1983 |
Adverse reactions to intravenous N-acetylcysteine in Chinese patients with paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Asian People; Chlorpheniramine; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Male | 1994 |
Effects of PEG-electrolyte (Colyte) lavage on serum acetaminophen concentrations. A model for treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Aged; Blood Glucose; Charcoal; Drug Overdose; Electrolytes; Gastric Lavage; Humans; Intestinal Absorption; Male; Polyethylene Glycols | 1993 |
Use of activated charcoal in a simulated poisoning with acetaminophen: a new loading dose for N-acetylcysteine?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adsorption; Adult; Biological Availability; Charcoal; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Diseases; Headache; Humans; Intestinal Absorption; Poisoning; Sleep Stages; Time Factors | 1993 |
Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Antineoplastic Agents; Carcinoma, Small Cell; Drug Combinations; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Time Factors | 1996 |
Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drugs, Investigational; Female; Free Radical Scavengers; Humans; Injections, Intravenous; Male; Statistics, Nonparametric | 1998 |
Effect of metoclopramide dose on preventing emesis after oral administration of N-acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Antiemetics; Child; Child, Preschool; Drug Overdose; Female; Humans; Male; Metoclopramide; Middle Aged; Prospective Studies; Regression Analysis | 1999 |
Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antineoplastic Agents, Alkylating; Carmustine; Cohort Studies; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Glutathione; Glutathione Reductase; Humans; Leukocytes, Mononuclear; Liver Neoplasms; Lymphatic Metastasis; Male; Maximum Tolerated Dose; Melanoma; Neoplasm Metastasis; Skin Neoplasms; Time Factors | 2003 |
A 20-hour treatment for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Adolescent; Adult; Drug Administration Schedule; Female; Humans; Liver Diseases; Male; Middle Aged; Poisoning | 2003 |
In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh).
Topics: Acetaminophen; Acetylcysteine; Adult; Biotransformation; Catechols; Cimicifuga; Dietary Supplements; Dose-Response Relationship, Drug; Female; Glutathione; Humans; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Middle Aged; NADP; Plant Extracts; Quinones | 2003 |
The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Anaphylaxis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; International Normalized Ratio; Liver Diseases; Male; Nausea | 2005 |
Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Interactions; Drug Overdose; Female; Humans; Male; Prospective Studies | 2008 |
Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Liver Failure, Acute; Liver Transplantation; Male; Middle Aged; Survival Rate; Young Adult | 2009 |
Evaluation of prophylactic and therapeutic effects of silymarin and N-acetylcysteine in acetaminophen-induced hepatotoxicity in cats.
Topics: Acetaminophen; Acetylcysteine; Animals; Bilirubin; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Liver; Male; Methemoglobinemia; Protective Agents; Silymarin | 2010 |
N-acetylcysteine as a novel prophylactic treatment for ifosfamide-induced nephrotoxicity in children: translational pharmacokinetics.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adolescent; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents, Alkylating; Area Under Curve; Child; Drug Overdose; Female; Humans; Ifosfamide; Male; Protective Agents; Rats; Rats, Wistar | 2012 |
Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP).
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Double-Blind Method; Humans; Ondansetron; Scotland; Vomiting | 2013 |
Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Antiemetics; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Liver Failure, Acute; Male; Middle Aged; Nausea; Ondansetron; Poisoning; Treatment Outcome; United Kingdom; Vomiting | 2014 |
A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Antidotes; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose; Female; Humans; Male; Prospective Studies; Time Factors; Transaminases; Treatment Outcome; Young Adult | 2014 |
Population pharmacokinetic-pharmacodynamic modelling to describe the effects of paracetamol and N-acetylcysteine on the international normalized ratio.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Cohort Studies; Cross-Over Studies; Double-Blind Method; Female; Humans; International Normalized Ratio; Male; Middle Aged; Models, Biological; Prospective Studies; Retrospective Studies; Young Adult | 2015 |
An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects.
Topics: Acetaminophen; Acetylcysteine; Adult; Area Under Curve; Dietary Supplements; Estradiol; gamma-Glutamyltransferase; Humans; Inactivation, Metabolic; Liver; Male; Pilot Projects; Plant Extracts; Raphanus; Treatment Outcome; Up-Regulation | 2014 |
Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Area Under Curve; Biotransformation; Cysteine; Female; Gestational Age; Glucuronides; Glutathione; Humans; Infant, Extremely Premature; Infant, Newborn; Infusions, Intravenous; Male; Netherlands; Sulfates | 2017 |
The NACSTOP Trial: A Multicenter, Cluster-Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Creatinine; Feasibility Studies; Female; Free Radical Scavengers; Humans; Male; Young Adult | 2019 |
Paracetamol metabolite concentrations following low risk overdose treated with an abbreviated 12-h versus 20-h acetylcysteine infusion.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Biotransformation; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Poisoning; Treatment Outcome; Victoria; Young Adult | 2019 |
N-acetylcysteine prevents glutathione decrease and does not interfere with paracetamol antinociceptive effect at therapeutic dosage: a randomized double-blind controlled trial in healthy subjects.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Cross-Over Studies; Double-Blind Method; Drug Interactions; Expectorants; Glutathione; Humans; Male; Pain; Pain Measurement; Young Adult | 2019 |
Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N-acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: study protocol for a randomi
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Clinical Trials Data Monitoring Committees; Clinical Trials, Phase I as Topic; Data Interpretation, Statistical; Drug Overdose; Drug Therapy, Combination; Edetic Acid; Female; Humans; Male; Outcome Assessment, Health Care; Pyridoxal Phosphate; Randomized Controlled Trials as Topic; Research Design | 2019 |
MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; MicroRNAs; Young Adult | 2019 |
Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial).
Topics: Acetaminophen; Acetylcysteine; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Overdose; Edetic Acid; Female; Humans; Male; Protective Agents; Pyridoxal Phosphate; Time Factors; Young Adult | 2019 |
Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5).
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Australia; Benzoquinones; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Imines; Liver; Male; Middle Aged; Prospective Studies; Treatment Outcome; Young Adult | 2020 |
A Randomized Controlled Trial of Intravenous N-Acetylcysteine in the Management of Anti-tuberculosis Drug-Induced Liver Injury.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Chemical and Drug Induced Liver Injury; Double-Blind Method; Female; Humans | 2021 |
A metabolomic analysis of thiol response for standard and modified N-acetyl cysteine treatment regimens in patients with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Monitoring; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Metabolomics; Middle Aged; Oxidation-Reduction; ROC Curve; Sulfhydryl Compounds | 2021 |
Analysis of serum microRNA-122 in a randomized controlled trial of N-acetylcysteine for treatment of antituberculosis drug-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Alanine Transaminase; Antibiotics, Antitubercular; Chemical and Drug Induced Liver Injury; Female; Humans; Male; MicroRNAs; Placebos | 2023 |
838 other study(ies) available for acetaminophen and acetylcysteine
| Article | Year |
|---|---|
Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids.
Topics: Acetaminophen; Animals; Buthionine Sulfoximine; Cysteine; Drug Therapy; Glutathione; Liver; Methionine Sulfoximine; Mice; Prodrugs; Rats; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1987 |
Prodrugs of L-cysteine as liver-protective agents. 2(RS)-Methylthiazolidine-4(R)-carboxylic acid, a latent cysteine.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cysteine; Magnetic Resonance Spectroscopy; Mice; Thiazoles | 1982 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics | 2015 |
Reversal of experimental paracetamol toxicosis with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Antidotes; Female; Mice; Mice, Inbred Strains; Time Factors | 1976 |
Effect of N-acetylcysteine on hepatic covalent binding of paracetamol (acetaminophen)
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Inactivation, Metabolic; Liver; Male; Mice; Protein Binding | 1977 |
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Drug Evaluation; Female; Follow-Up Studies; Humans; Infusions, Parenteral; Male; Methionine; Middle Aged | 1977 |
Anaphylactoid reaction to N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Drug Hypersensitivity; Female; Humans | 1979 |
Preventing hepatotoxicity in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Chemical and Drug Induced Liver Injury; Diuretics; Glutathione; Hemoperfusion; Humans; Peritoneal Dialysis; Poisoning; Renal Dialysis | 1979 |
[Therapy of paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Methionine | 1979 |
Metabolism of [p-18O]-phenacetin: the mechanism of activation of phenacetin to reactive metabolites in hamsters.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cricetinae; Glutathione; Hydroxylation; In Vitro Techniques; Isotope Labeling; Male; Mesocricetus; Oxygen Isotopes; Phenacetin; Sulfates | 1979 |
Acetaminophen overdose: a growing health care hazard.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Gastric Lavage; Humans; Liver Diseases; Middle Aged; Time Factors | 1979 |
Management of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Humans; Liver; Necrosis | 1979 |
Effect of N-acetylcysteine on the pharmacokinetics of acetaminophen in rats.
Topics: Acetaminophen; Acetylcysteine; Animals; Drug Interactions; Glucuronates; Kinetics; Male; Rats; Time Factors | 1979 |
Acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Liver; Methionine | 1979 |
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Infusions, Parenteral; Kidney Diseases; Liver Diseases; Male; Methionine; Middle Aged; Risk; Time Factors | 1979 |
Intravenous N-acetylcysteine: the treatment of choice in paracetamol poisoning?
Topics: Acetaminophen; Acetylcysteine; Humans; Methionine | 1979 |
Paracetamol poisoning. Prevention of liver damage.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Necrosis | 1979 |
Acetaminophen hepatotoxicity and malnutrition.
Topics: Acetaminophen; Acetylcysteine; Adult; Anorexia Nervosa; Humans; Liver; Male; Nutrition Disorders; Suicide, Attempted | 1979 |
Treating acute acetaminophen poisoning with acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Female; Humans; Liver; Middle Aged; Suicide, Attempted | 1977 |
Paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Cysteamine; Humans | 1978 |
Cysteamine or N-acetylcysteine for paracetamol poisoning?
Topics: Acetaminophen; Acetylcysteine; Cysteamine; Humans; Time Factors | 1978 |
Toxicity of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Cysteamine; Humans; Methionine | 1978 |
The chief scientist reports ... prevention of hepatic necrosis following paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Liver Diseases; Male; Methionine; Middle Aged; Scotland | 1978 |
Acetaminophen poisoning: a case report of the use of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Codeine; Female; Humans; Liver Function Tests; Meperidine; Promethazine | 1978 |
Acute acetaminophen intoxication.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Liver; Male; Methionine; Suicide, Attempted | 1978 |
Intravenous acetylcysteine as treatment for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Half-Life; Humans; Infusions, Parenteral; Male | 1978 |
Pathophysiology of acetaminophen overdosage toxicity: implications for management.
Topics: Acetaminophen; Acetylcysteine; Animals; Dogs; Dose-Response Relationship, Drug; Edema; Female; Mice; Transaminases | 1978 |
Acetaminophen overdose: incidence, diagnosis, and management in 416 patients.
Topics: Acetaminophen; Acetylcysteine; Child; Child, Preschool; Female; Humans; Infant; Male; United States | 1978 |
Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse.
Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; Glucuronates; Glutathione; In Vitro Techniques; Liver; Male; Mice; Phenobarbital; Rats; Sulfates; Time Factors | 1978 |
Acetaminophen kinetics in acutely poisoned patients.
Topics: Acetaminophen; Acetylcysteine; Adult; Computers; Cysteine; Glucuronates; Humans; Kinetics; Models, Biological; Oxidation-Reduction; Sulfates | 1979 |
Treatment of acetaminophen overdosage with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Humans; Male | 1977 |
N-acetylcysteine for acetaminophen overdosage (cont.)
Topics: Acetaminophen; Acetylcysteine; Humans | 1977 |
Acetaminophen toxity.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Necrosis; Sulfhydryl Compounds | 1977 |
IND status for N-acetylcysteine in acetaminophen overdosage.
Topics: Acetaminophen; Acetylcysteine; Humans | 1977 |
Case report on acetaminophen intoxication.
Topics: Acetaminophen; Acetylcysteine; Adult; Humans; Male | 1977 |
Treatment of acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Humans; Methionine | 1977 |
Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography.
Topics: Acetaminophen; Acetylcysteine; Cell-Free System; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Microsomes, Liver | 1977 |
Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteine; Female; Glucuronates; Humans; Liver Diseases; Male; Suicide; Sulfates | 1976 |
Isolation and identification of paracetamol metabolites.
Topics: Acetaminophen; Acetylcysteine; Cysteine; Glucuronates; Humans; Sulfates | 1976 |
Metabolism of paracetamol after therapeutic and hepatotoxic doses in man.
Topics: Acetaminophen; Acetylcysteine; Cysteine; Glucuronates; Humans; Liver; Sulfates | 1976 |
[Two cases of severe liver injuries induced by acetaminophen].
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Female; Glucagon; Humans; Insulin; Liver; Male; Plasma Exchange; Suicide, Attempted | 1992 |
Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: effects of Ca(2+)-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death.
Topics: Acetaminophen; Acetylcysteine; Adenosine Diphosphate; Animals; Aurintricarboxylic Acid; Benzamides; Calcium; Cell Death; Cell Nucleus; Cells, Cultured; DNA; DNA Damage; DNA Repair; Egtazic Acid; Endonucleases; Enzyme Activation; Glutathione; Liver; Male; Mice | 1992 |
[Paracetamol overdose: a new form of suicide in Chile and the value of N-acetylcysteine administration].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Chile; Drug Overdose; Female; Humans; Middle Aged; Suicide, Attempted | 1992 |
Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Anticonvulsants; Drug Interactions; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Longitudinal Studies; Male; Middle Aged; Prognosis; Risk Factors | 1992 |
Respiratory arrest after N-acetylcysteine for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Drug Overdose; Female; Heart Arrest; Humans | 1992 |
Ondansetron to prevent emesis following N-acetylcysteine for acetaminophen intoxication.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Female; Humans; Infusions, Intravenous; Ipecac; Ondansetron; Poisoning; Recurrence; Vomiting | 1992 |
Cytoprotection by iloprost against paracetamol-induced toxicity in hamster isolated hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cell Survival; Cricetinae; Glutathione; Iloprost; Imines; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Mesocricetus; Prostaglandin Antagonists; Prostaglandins | 1992 |
N-acetylcysteine in treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Cimetidine; Drug Overdose; Drug Therapy, Combination; Humans | 1992 |
Does hypothermia protect against the development of hepatitis in paracetamol overdose?
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Hypothermia; Intermittent Positive-Pressure Ventilation; Liver Function Tests; Time Factors | 1992 |
Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Biotransformation; Glucosyltransferases; Heterozygote; Jaundice; Male; Metabolism, Inborn Errors; Phenotype; Rats; Rats, Inbred Strains | 1992 |
Hepatotoxicity from paracetamol self-poisoning in western Sydney: a continuing challenge.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infusions, Intravenous; Liver Function Tests; Male; New South Wales; Patient Admission; Prognosis; Retrospective Studies | 1992 |
Paracetamol overdose in Israel--1992.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Glutathione; Humans; Inactivation, Metabolic; Israel | 1992 |
Can N-acetyl-L-cysteine affect zinc metabolism when used as a paracetamol antidote?
Topics: Acetaminophen; Acetylcysteine; Antidotes; Computer Simulation; Digestive System Physiological Phenomena; Hydrogen-Ion Concentration; Potentiometry; Zinc | 1992 |
Acetylcysteine and fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Biological Transport; Chemical and Drug Induced Liver Injury; Hemodynamics; Humans; Liver Circulation; Liver Diseases; Oxygen | 1992 |
Cysteamine in combination with N-acetylcysteine prevents acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Cysteamine; Cytochrome P-450 Enzyme System; Drug Interactions; Liver; Male; Mice | 1992 |
Anaphylactoid reaction to intravenous acetylcysteine associated with electrocardiographic abnormalities.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Drug Overdose; Electrocardiography; Female; Humans; Infusions, Intravenous | 1992 |
Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney.
Topics: Acetaminophen; Acetylcysteine; Aging; Animals; Body Weight; Cysteine; Cystine; Dose-Response Relationship, Drug; Glutathione; Kidney; Male; Mice; Mice, Inbred C57BL; Organ Size | 1992 |
Nephrotoxicity of paracetamol in the rat--mechanistic and therapeutic aspects.
Topics: Acetaminophen; Acetylcysteine; Acetylglucosaminidase; Animals; Antidotes; Ditiocarb; gamma-Glutamyltransferase; Kidney Diseases; L-Iditol 2-Dehydrogenase; Male; Rats; Rats, Inbred Strains | 1991 |
Acute ethanol administration reduces the antidote effect of N-acetylcysteine after acetaminophen overdose in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Drug Administration Schedule; Drug Interactions; Ethanol; Male; Mice; Poisoning | 1991 |
The effect of chronic alcohol intake on prognosis and outcome in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alcoholism; Aspartate Aminotransferases; Brain Edema; Chemical and Drug Induced Liver Injury; Creatinine; Dialysis; Ethanol; Female; Humans; Hydrogen-Ion Concentration; Liver Diseases; Male; Platelet Count; Positive-Pressure Respiration; Prognosis; Thrombin Time | 1991 |
S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mortality; S-Adenosylmethionine | 1992 |
Paracetamol metabolism after general anaesthesia.
Topics: Acetaminophen; Acetylcysteine; Adult; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Female; Humans; Male; Middle Aged; Postoperative Period; Sulfates; Time Factors | 1991 |
Increased oxidative metabolism of paracetamol in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Acetylcysteine; Adult; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Cysteine; Cytochrome P-450 Enzyme System; Hepatitis B; Humans; Liver Neoplasms; Middle Aged; Oxidation-Reduction; Reference Values | 1991 |
Effect of ascorbic acid esters on hepatic glutathione levels in mice treated with a hepatotoxic dose of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Isocitrate Dehydrogenase; Liver; Male; Mice; Sulfobromophthalein | 1991 |
Mechanism of paracetamol toxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Humans; Immunoassay; Liver | 1990 |
Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Aspartate Aminotransferases; Drug Evaluation; Female; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Liver; Male; Necrosis; Prognosis; Prothrombin Time; Retrospective Studies; Time Factors | 1990 |
Acetylcysteine in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Hepatic Encephalopathy; Humans; Prognosis; Time Factors | 1990 |
Cimetidine in the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Cimetidine; Drug Overdose; Drug Therapy, Combination; Female; Humans | 1991 |
Acetaminophen metabolism in recovering alcoholics.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Aged; Alcoholism; Female; Humans; Longitudinal Studies; Male; Middle Aged | 1990 |
Mitochondrial dysfunction in paracetamol hepatotoxicity: in vitro studies in isolated mouse hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Membrane; Cell Survival; Cells, Cultured; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Mice; Mitochondria, Liver; Oxygen Consumption | 1990 |
Safety of late acetylcysteine treatment in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Drug Overdose; Female; Humans; Male; Middle Aged; Time Factors | 1990 |
Intravenous N-acetylcysteine, hepatotoxicity and plasma glutathione S-transferase in patients with paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Alanine Transaminase; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Glutathione Transferase; Humans; Infusions, Intravenous; Male; Middle Aged | 1990 |
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine | 1987 |
Paracetamol-induced stimulation of glycogenolysis in isolated mouse hepatocytes is not directly associated with cell death.
Topics: Acetaminophen; Acetylcysteine; Animals; Cell Survival; In Vitro Techniques; Liver; Liver Glycogen; Male; Mice; Phosphorylase a; Polychlorinated Biphenyls; Time Factors | 1989 |
Paracetamol overdose: timing the antidote.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Drug Administration Schedule; Female; Forensic Medicine; Heroin Dependence; Humans; Suicide | 1989 |
Hypophosphataemia and phosphaturia in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Evaluation Studies as Topic; Female; Glucose; Hepatic Encephalopathy; Humans; Male; Phosphates; Potassium; Severity of Illness Index | 1989 |
Lack of effect of cimetidine on acetaminophen disposition in humans.
Topics: Acetaminophen; Acetylcysteine; Adult; Cimetidine; Female; Glutathione; Humans; Least-Squares Analysis; Liver; Male | 1989 |
The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Injections, Intravenous; Liver Function Tests; Male | 1989 |
Effect of oral glutathione on hepatic glutathione levels in rats and mice.
Topics: Acetaminophen; Acetylcysteine; Adenosine Triphosphate; Animals; Cysteine; Fasting; Glutathione; Liver; Maleates; Methionine; Mice; Rats; Rats, Inbred Strains | 1989 |
Metabolic effects of acetaminophen. Studies in the isolated perfused rat liver.
Topics: Acetaminophen; Acetylcysteine; Animals; Energy Metabolism; Fructose; In Vitro Techniques; Liver; Liver Glycogen; Male; Mitochondria, Liver; Oxygen Consumption; Perfusion; Pyruvates; Rats; Rats, Inbred Strains | 1989 |
N-acetylcysteine in the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Humans | 1989 |
Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Male; Middle Aged; Product Surveillance, Postmarketing; Retrospective Studies; Time Factors | 1989 |
Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration.
Topics: Acetaminophen; Acetylcysteine; Adult; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Half-Life; Humans; Male; Sulfhydryl Compounds | 1989 |
Delayed acetaminophen toxicity despite acetylcysteine use.
Topics: Acetaminophen; Acetylcysteine; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Humans | 1989 |
Acute acetaminophen overdose during pregnancy.
Topics: Abortion, Spontaneous; Acetaminophen; Acetylcysteine; Acute Disease; Adult; Female; Fetal Death; Humans; Pregnancy; Pregnancy Complications; Prospective Studies | 1989 |
Use of thermospray liquid chromatography-mass spectrometry for characterization of reactive metabolites of 3'-hydroxyacetanilide, a non-hepatotoxic regioisomer of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cysteine; Isomerism; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice | 1989 |
Adverse reactions to N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Humans | 1989 |
Overdoses.
Topics: Acetaminophen; Acetylcysteine; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cathartics; Charcoal; Humans; Hypnotics and Sedatives; Ipecac; Naloxone; Narcotics; Parasympatholytics; Poisoning; Salicylates | 1985 |
Acute carbon tetrachloride poisoning in 19 patients: implications for diagnosis and treatment.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Aged; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Child; Child, Preschool; Chromatography, Gas; Female; Humans; Male; Middle Aged | 1985 |
N-acetylcysteine for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Glutathione; Humans; In Vitro Techniques; Liver; Methionine | 1986 |
Metabolism and excretion of a glutathione conjugate of acetaminophen in the isolated perfused rat kidney.
Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; gamma-Glutamyltransferase; Glutathione; In Vitro Techniques; Kidney; Male; Metabolic Clearance Rate; Perfusion; Rats; Rats, Inbred F344 | 1986 |
The generation and subsequent fate of glutathionyl radicals in biological systems.
Topics: Acetaminophen; Acetylcysteine; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Cysteine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Glutathione Disulfide; Horseradish Peroxidase; Nitrogen; Oxygen; Phenetidine; Spin Labels | 1985 |
Influences of glutathione status on different cytocidal responses of monolayer rat hepatocytes exposed to aflatoxin B1 or acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Aflatoxin B1; Aflatoxins; Animals; Carmustine; Cells, Cultured; Drug Interactions; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Inbred F344 | 1986 |
Why do patients still die from paracetamol poisoning?
Topics: Acetaminophen; Acetylcysteine; Adult; Child, Preschool; Gastric Lavage; Humans; Methionine | 1986 |
Effects of esterase inhibitors and buthionine sulfoximine on the prevention of acetaminophen hepatotoxicity by N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Esterases; Isoflurophate; Lysine; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Nitrophenols; Organophosphorus Compounds; Phenylmethylsulfonyl Fluoride | 1987 |
Treatment of acetaminophen overdose when oral acetylcysteine therapy is not tolerated.
Topics: Acetaminophen; Acetylcysteine; Child, Preschool; Female; Humans | 1988 |
Paracetamol (acetaminophen) poisoning resulting in acute renal failure without hepatic coma.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Female; Hepatic Encephalopathy; Humans; Kidney Tubular Necrosis, Acute; Male | 1988 |
Dosage of acetylcysteine in acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Dose-Response Relationship, Drug; Humans; Time Factors | 1988 |
Hepatotoxic and hepatoprotective potential of histamine (H2)-receptor antagonists.
Topics: Acetaminophen; Acetylcysteine; Animals; Cimetidine; Humans; Liver | 1988 |
Antidotal effectiveness of N-acetylcysteine in reversing acetaminophen-induced hepatotoxicity. Enhancement of the proteolysis of arylated proteins.
Topics: Acetaminophen; Acetylcysteine; Animals; Aspartate Aminotransferases; Glutathione; Liver; Male; Mice; Mice, Inbred C57BL | 1988 |
Identification of S-(2,5-dihydroxyphenyl)-cysteine and S-(2,5-dihydroxyphenyl)-N-acetyl-cysteine as urinary metabolites of acetaminophen in the mouse. Evidence for p-benzoquinone as a reactive intermediate in acetaminophen metabolism.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chromatography, High Pressure Liquid; Cysteine; Hydroquinones; Male; Mice; Mice, Inbred BALB C; Quinones | 1988 |
Effect of sulphydryl drugs on paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antimetabolites; Blood Proteins; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cysteine; Glutathione; Liver; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Sulfhydryl Compounds | 1988 |
Death of a child associated with multiple overdoses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Organ Size; Renal Dialysis | 1988 |
[Acute paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Prognosis | 1987 |
Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Calcium; Chemical and Drug Induced Liver Injury; Liver; Male; Mice; Organ Size; Proteins; Spectrophotometry, Atomic; Time Factors | 1987 |
Hyperlactataemia and metabolic acidosis following paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Lactates; Lactic Acid; Liver; Male; Middle Aged; Prospective Studies; Suicide, Attempted; Time Factors | 1987 |
Maternal acetaminophen overdose at 15 weeks of gestation.
Topics: Acetaminophen; Acetylcysteine; Adult; Female; Fetus; Humans; Liver; Necrosis; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Time Factors; Ventilators, Mechanical | 1986 |
Sulfate conjugation in drug metabolism: role of inorganic sulfate.
Topics: Acetaminophen; Acetylcysteine; Animals; Arylsulfotransferase; Biotransformation; Chemical and Drug Induced Liver Injury; Computers; Humans; Kidney Failure, Chronic; Kinetics; Rats; Salicylamides; Sulfates; Sulfurtransferases | 1986 |
The use of N-acetylcysteine long after an acetaminophen overdose in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Lethal Dose 50; Male; Mice; Time Factors | 1987 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Biotransformation; Chemical and Drug Induced Liver Injury; Humans; Kinetics; Risk; Time Factors | 1987 |
Inter-subject and ethnic differences in paracetamol metabolism.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Black People; Cysteine; Ethanol; Female; Ghana; Glucuronates; Humans; Kenya; Male; Scotland; Sex Characteristics; Smoking; Sulfates; White People | 1986 |
Effects of methionine deficiency and ethanol ingestion on acetaminophen metabolism in mice.
Topics: Acetaminophen; Acetylcysteine; Aniline Hydroxylase; Animals; Body Weight; Diet; Ethanol; Glutathione; Male; Methionine; Mice; Microsomes, Liver; Protein Biosynthesis; Sulfates | 1987 |
Paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Chemical and Drug Induced Liver Injury; Female; Gastric Lavage; Humans | 1987 |
The effect of activated charcoal on N-acetylcysteine absorption in normal subjects.
Topics: Absorption; Acetaminophen; Acetylcysteine; Adult; Charcoal; Drug Evaluation; Female; Humans; Male; Random Allocation | 1987 |
Alteration in rat liver microsomal membranes induced by acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cytochrome P-450 Enzyme System; Fluorescence Polarization; Male; Membranes; Microsomes, Liver; NADP; Rats; Rats, Inbred Strains | 1987 |
Management of acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Intubation, Gastrointestinal; Liver; Male; Risk; Time Factors | 1986 |
Coma and metabolic acidosis early in severe acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Adolescent; Aged; Blood Gas Analysis; Chemical and Drug Induced Liver Injury; Coma; Female; Half-Life; Humans; Male; Middle Aged | 1986 |
Analysis of factors responsible for continuing mortality after paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Alcoholism; Antidotes; Dextropropoxyphene; Disseminated Intravascular Coagulation; Drug Combinations; Hepatic Encephalopathy; Humans; Liver Function Tests; Male; Methionine; Retrospective Studies | 1986 |
Acetaminophen overdose in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Child; Child, Preschool; Glutathione; Humans; Inactivation, Metabolic; Intestinal Absorption; Liver; Medical History Taking; NADPH-Ferrihemoprotein Reductase; Oxidoreductases | 1986 |
Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Circular Dichroism; Glutathione; Isomerism; Liver; Male; Mice; Models, Biological; Time Factors | 1986 |
Acetaminophen overdose in the second trimester of pregnancy.
Topics: Acetaminophen; Acetylcysteine; Adult; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications | 1986 |
Comparison of the protective effects of N-acetylcysteine, 2-mercaptopropionylglycine and dithiothreitol against acetaminophen toxicity in mouse hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Amino Acids, Sulfur; Animals; Cells, Cultured; Dithiothreitol; Glutathione; Liver; Male; Mice; Tiopronin | 1986 |
Efficacy of paracetamol-esterified methionine versus cysteine or methionine on paracetamol-induced hepatic GSH depletion and plasma ALAT level in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Drug Compounding; Glutathione; Liver; Male; Methionine; Mice; Time Factors | 1986 |
Drug overdose: changing concepts for modern drugs.
Topics: Acetaminophen; Acetylcysteine; Adult; Anthracenes; Bicarbonates; Ethylene Glycols; Female; Humans; Liver; Male; Maprotiline; Middle Aged; Suicide, Attempted; Time Factors | 1986 |
Pre- or post-treatment with methoxsalen prevents the hepatotoxicity of acetaminophen in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Drug Synergism; Glutathione; Liver; Male; Methoxsalen; Mice; Microsomes, Liver; Oxygenases; Rats; Rats, Inbred Strains; Time Factors | 1986 |
High-performance liquid chromatographic determination of N-acetylcysteine in human serum following acetaminophen overdosage.
Topics: Acetaminophen; Acetylcysteine; Chromatography, High Pressure Liquid; Dinitrofluorobenzene; Humans; Indicators and Reagents | 1986 |
Dissociation of increased sulfation from sulfate replenishment and hepatoprotection in acetaminophen-poisoned mice by N-acetylcysteine stereoisomers.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Mice, Inbred ICR; Stereoisomerism; Sulfates | 1986 |
In vitro coadsorption of acetaminophen and N-acetylcysteine onto activated carbon powder.
Topics: Acetaminophen; Acetylcysteine; Adsorption; Charcoal; Chemical Phenomena; Chemistry, Physical; Hydrogen-Ion Concentration; Particle Size; Powders | 1986 |
Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans.
Topics: Acetaminophen; Acetylcysteine; Adult; Chromatography, High Pressure Liquid; Female; Glutathione; Humans; Kinetics; Male | 1987 |
Use of activated charcoal.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans | 1986 |
Comparison of the effects of sodium sulfate and N-acetylcysteine on the hepatotoxicity of acetaminophen in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Dose-Response Relationship, Drug; Glutathione; Half-Life; Liver; Male; Mice; Mice, Inbred Strains; Phosphoadenosine Phosphosulfate; Sulfates | 1986 |
Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cysteine; Glucuronates; Glucuronic Acid; Glutathione; Kinetics; Liver; Liver Glycogen; Male; Mice; Phosphoadenosine Phosphosulfate; Protein Binding; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1986 |
Plasma glutathione S-transferase measurements after paracetamol overdose: evidence for early hepatocellular damage.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Glutathione Transferase; Humans; Liver Diseases | 1985 |
Paracetamol overdosage in Jerusalem.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Male; Medication Errors; Suicide, Attempted | 1985 |
Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Bile; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Glutathione; Inactivation, Metabolic; Male; Mass Spectrometry; Metabolic Clearance Rate; Mice; Mice, Inbred ICR | 1985 |
Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Necrosis; Rats; Rats, Inbred F344; Time Factors | 1985 |
Concomitant use of activated charcoal and N-acetylcysteine.
Topics: Absorption; Acetaminophen; Acetylcysteine; Administration, Oral; Adsorption; Adult; Charcoal; Drug Evaluation; Drug Interactions; Half-Life; Humans; Male | 1985 |
Paracetamol poisoning in cats.
Topics: Acetaminophen; Acetylcysteine; Animals; Cat Diseases; Cats | 1985 |
Paracetamol poisoning in cats.
Topics: Acetaminophen; Acetylcysteine; Animals; Cat Diseases; Cats | 1985 |
Effects of various antidotal treatments on acetaminophen toxicosis and biotransformation in cats.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Antidotes; Biotransformation; Cat Diseases; Cats; Chromatography, High Pressure Liquid; Glutathione; Half-Life; Injections, Intravenous; Methemoglobin; Sulfates | 1985 |
Additive protection of cimetidine and N-acetylcysteine treatment against acetaminophen-induced hepatic necrosis in the rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cimetidine; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Imines; Liver; Male; Necrosis; Rats; Rats, Inbred F344 | 1985 |
Postabsorption antidotal effects of N-acetylcysteine on acetaminophen-induced hepatotoxicity in the mouse.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Body Weight; Chemical and Drug Induced Liver Injury; Glutathione; Indocyanine Green; Liver; Liver Function Tests; Male; Mice; Time Factors | 1985 |
Acetaminophen toxicity in lymphocytes heterozygous for glutathione synthetase deficiency.
Topics: Acetaminophen; Acetylcysteine; Animals; Child; Glutathione Synthase; Heterozygote; Humans; In Vitro Techniques; Lymphocytes; Male; Mice; Peptide Synthases | 1985 |
Mechanism of the protective action of n-acetylcysteine and methionine against paracetamol toxicity in the hamster.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Glutathione; Liver; Male; Mesocricetus; Methionine; Organ Size | 1985 |
[Survival after self-poisoning with 80 grams of paracetamol].
Topics: Acetaminophen; Acetylcysteine; Female; Humans; Methionine; Middle Aged; Prognosis | 1985 |
Acetaminophen: acute overdose toxicity in children.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Ethanol; Humans; Time Factors | 1985 |
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.
Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Paper; Cysteamine; Cytochrome P-450 Enzyme System; Desipramine; Dimercaprol; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutathione; Humans; Indicators and Reagents; Liver; Male; Mass Spectrometry; Methyltransferases; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Sulfhydryl Compounds; Time Factors; Tritium | 1974 |
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Depression, Chemical; Glutathione; Liver; Mass Spectrometry; Methylcholanthrene; Mice; Necrosis; Phenobarbital; Piperonyl Butoxide; Rats; Species Specificity; Stimulation, Chemical; Tritium | 1974 |
Separation of p-acetamidophenol metabolites by gel filtration on Sephadex G 10.
Topics: Acetaminophen; Acetylcysteine; Biotransformation; Chromatography; Chromatography, Gel; Dextrans; Gluconates; Methods; Paper; Sulfates | 1968 |
Management of distalgesic poisoning.
Topics: Acetaminophen; Acetylcysteine; Cysteamine; Dextropropoxyphene; Drug Combinations; Humans; Liver | 1981 |
Anaphylactoid reaction to acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Hypersensitivity; Female; Humans; Middle Aged | 1982 |
New approaches in managing drug overdosage and poisoning.
Topics: Acetaminophen; Acetylcysteine; Adrenergic beta-Antagonists; Adult; Analgesics, Opioid; Child; Cholinesterase Inhibitors; Glucagon; Humans; Immunotherapy; Intestinal Absorption; Methionine; Naloxone; Physostigmine; Poisoning; Poisons; Self Administration | 1983 |
ABC of poisoning. Analgesics: II--Paracetamol.
Topics: Acetaminophen; Acetylcysteine; Analgesics; Diagnosis; Humans; Ipecac; Methionine; Therapeutic Irrigation; Time Factors | 1984 |
Clinical features and management of analgesic poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics; Analgesics, Opioid; Humans; Ibuprofen; Mefenamic Acid; Phenylbutazone; Salicylates | 1984 |
Asthma associated with N-acetylcysteine infusion and paracetamol poisoning: report of two cases.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Asthma; Female; Humans | 1983 |
Asthma associated with N-acetylcysteine infusion and paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Asthma; Humans | 1983 |
Asthma associated with N-acetylcysteine infusion and paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Asthma; Humans | 1984 |
Adverse reactions to N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Edetic Acid; Female; Humans; Male; Skin Tests; Time Factors; Urticaria | 1984 |
Clinical features and management of Distalgesic overdose.
Topics: Acetaminophen; Acetylcysteine; Dextropropoxyphene; Drug Combinations; Drug Interactions; Humans; Naloxone | 1984 |
Mechanism of action of paracetamol protective agents in mice in vivo.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Buthionine Sulfoximine; Cysteamine; Cysteine; Glutathione; Liver; Male; Methionine; Methionine Sulfoximine; Mice; Mice, Inbred C3H | 1984 |
Effect of antidotal N-acetylcysteine on the pharmacokinetics of acetaminophen in dogs.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Colorimetry; Dogs; Drug Administration Schedule; Female; Kinetics | 1984 |
Colorimetric assay for acetaminophen in serum.
Topics: Acetaminophen; Acetylcysteine; Autoanalysis; Colorimetry; Humans; Indicators and Reagents; Kinetics; Naphthalenesulfonates; Sodium Nitrite | 1984 |
[Paracetamol poisoning. Specific treatment with methionine or N-acetylcysteine?].
Topics: Acetaminophen; Acetylcysteine; Antidotes; Humans; Methionine | 1984 |
[Paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Risk; Suicide, Attempted | 1984 |
Hypersensitivity-like reactions to N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Drug Hypersensitivity; Female; Humans; Injections, Intravenous; Male | 1984 |
Ultrastructural effects of acetaminophen in isolated mouse hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Animals; Cell Survival; Cytoplasm; Liver; Male; Mice; Microscopy, Electron; Microvilli; Tiopronin | 1983 |
Acetaminophen poisoning in cats and man.
Topics: Acetaminophen; Acetylcysteine; Animals; Cat Diseases; Cats; Humans | 1983 |
Reversal of acetaminophen intoxication with an N-acetylcysteine-liposome preparation.
Topics: Acetaminophen; Acetylcysteine; Animals; Lethal Dose 50; Liposomes; Liver; Male; Mice; Necrosis | 1983 |
A comparison of the protective effects of N-acetyl-cysteine and S-carboxymethylcysteine against paracetamol-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Carbocysteine; Chemical and Drug Induced Liver Injury; Cricetinae; Cysteine; Humans; In Vitro Techniques; Kidney; Male; Mesocricetus; Microsomes, Liver; Protein Binding | 1983 |
The effect of cysteine and N-acetyl cysteine on rat liver glutathione (GSH).
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Cysteine; Glutathione; Injections, Intraperitoneal; Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1983 |
Physiological and environmental determinants of phenytoin teratogenicity: relation to glutathione homeostasis, and potentiation by acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cleft Palate; Drug Synergism; Female; Fetal Resorption; Glutathione; Homeostasis; Mice; Phenytoin; Pregnancy; Teratogens; Time Factors | 1983 |
The effect of alcohol on the toxicity of acetaminophen in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Ethanol; Male; Mice; Microsomes, Liver | 1984 |
Paracetamol overdose in the second trimester of pregnancy. Case report.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Female; Fetal Blood; Humans; Infant, Newborn; Male; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second | 1984 |
Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child, Preschool; Ethanol; Humans; Infant; Liver Function Tests; Poison Control Centers; Prospective Studies | 1984 |
The effectiveness of N-acetylcysteine in isolated hepatocytes, against the toxicity of paracetamol, acrolein, and paraquat.
Topics: Acetaminophen; Acetone; Acetylcysteine; Acrolein; Aldehydes; Amino Acids; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Male; Maleates; Paraquat; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo.
Topics: Acetaminophen; Acetylcysteine; Animals; Bile; Chemical and Drug Induced Liver Injury; Glucuronates; Glutathione; Male; Rats; Rats, Inbred Strains; Sulfates | 1983 |
Acetaminophen-induced hepatic glycogen depletion and hyperglycemia in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Hyperglycemia; Liver Glycogen; Male; Mice | 1983 |
Acetaminophen and its toxicity.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Cats; Chemical and Drug Induced Liver Injury; Cricetinae; Dogs; Ethanol; Glutathione; Guinea Pigs; Humans; Kinetics; Liver; Mice; Rats | 1983 |
Paracetamol.
Topics: Acetaminophen; Acetylcysteine; Humans; Methionine; Poisoning | 1980 |
Acetominophen toxicity. Report of two cases.
Topics: Acetaminophen; Acetylcysteine; Adult; Female; Humans; Male; Suicide, Attempted | 1981 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Female; Gastric Lavage; Humans | 1981 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Humans | 1981 |
[Toxicology and therapy of paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Cysteamine; Drug Interactions; Ethanol; Gastric Lavage; Glutathione; Half-Life; Methionine; Phenobarbital; Poisoning | 1980 |
Treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Humans; Infusions, Parenteral | 1982 |
Paracetamol self-poisoning: diagnosis, management, and outcome.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Australia; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Female; Hospitalization; Humans; Injections, Intravenous; Liver Diseases; Liver Function Tests; Methionine; Middle Aged; Suicide, Attempted; Time Factors | 1982 |
Adsorbent and cathartic inhibition of enteral drug absorption.
Topics: Acetaminophen; Acetylcysteine; Adsorption; Animals; Cathartics; Charcoal; Chemistry, Pharmaceutical; Dogs; Female; Intestinal Absorption; Male; Methionine; Mice; Resins, Plant; Time Factors | 1982 |
Cimetidine protects against acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Animals; Cimetidine; Female; Guanidines; Humans; Liver; Male; Mice; Mice, Inbred Strains | 1982 |
Cimetidine and acetylcysteine as antidote for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Therapy, Combination; Guanidines; Humans; Liver Diseases; Time Factors | 1982 |
The effect of mild alcohol consumption on the metabolism of acetaminophen in man.
Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Ethanol; Humans; Liver; Time Factors | 1982 |
Massive intoxication with acetaminophen and propoxyphene: unexpected survival and unusual pharmacokinetics of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adult; Animals; Cimetidine; Dextropropoxyphene; Female; Humans; Kinetics; Lethal Dose 50; Male; Mice; Renal Dialysis; Time Factors | 1982 |
Acetaminophen poisoning and its treatment.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans | 1982 |
N-acetylcysteine adsorption by activated charcoal.
Topics: Acetaminophen; Acetylcysteine; Adsorption; Charcoal; In Vitro Techniques | 1980 |
Paracetamol and the isolated perfused kidney: metabolism and functional effects.
Topics: Acetaminophen; Acetylcysteine; Animals; Drug Stability; Kidney; Kinetics; Male; Oxidation-Reduction; Perfusion; Protein Binding; Rats | 1981 |
Adsorption of oral antidotes for acetaminophen poisoning (methionine and n-acetylcysteine) by activated charcoal.
Topics: Acetaminophen; Acetylcysteine; Adsorption; Antidotes; Charcoal; Chemical Phenomena; Chemistry; Methionine | 1981 |
Effect of activated charcoal administration on acetylcysteine serum levels in humans.
Topics: Acetaminophen; Acetylcysteine; Adsorption; Charcoal; Humans; Intestinal Absorption; Kinetics; Male | 1981 |
Acetaminophen-induced hypothermia, hepatic congestion, and modification by N-acetylcysteine in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Body Temperature; Chemical and Drug Induced Liver Injury; Hemoglobins; Male; Mice; Time Factors | 1981 |
N-acetylcysteine-induced inhibition of gastric emptying: a mechanism affording protection to mice from the hepatotoxicity of concomitantly administered acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Drug Interactions; Gastric Emptying; Intestinal Absorption; Liver; Male; Mice; Sulfhydryl Compounds | 1981 |
Effects of N-acetylcysteine on metabolism, covalent binding, and toxicity of acetaminophen in isolated mouse hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cell Membrane; Cells, Cultured; Drug Interactions; Liver; Male; Mice; Protein Binding | 1981 |
Sulfate depletion after acetaminophen administration and replenishment by infusion of sodium sulfate or N-acetylcysteine in rats.
Topics: Acetaminophen; Acetylcysteine; Animals; Male; Rats; Rats, Inbred Strains; Sodium; Sulfates; Time Factors | 1981 |
Effects of microsomal enzyme induction on paracetamol metabolism in man.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Anticonvulsants; Antipyrine; Cysteine; Enzyme Induction; Female; Half-Life; Humans; Liver; Male; Microsomes, Liver; Middle Aged | 1981 |
Age- and sex-related differences in acetaminophen metabolism in the rat.
Topics: Acetaminophen; Acetylcysteine; Aging; Animals; Female; Glucuronates; Liver; Male; Rats; Sex Factors; Sulfates | 1981 |
Treatment of paracetamol poisoning in a cat.
Topics: Acetaminophen; Acetylcysteine; Animals; Cat Diseases; Cats; Poisoning | 1981 |
Clinicopathologic evaluation N-acetylcysteine therapy in acetaminophen toxicosis in the cat.
Topics: Acetaminophen; Acetylcysteine; Animals; Cat Diseases; Cats; Glutathione; Heinz Bodies; Hematocrit; Methemoglobin | 1981 |
[Acute hepatocellular damage due to paracetamol].
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Tests | 1981 |
Alkylation and peroxidation injury from chemically reactive metabolites.
Topics: Acetaminophen; Acetylcysteine; Alkylation; Animals; Antioxidants; Biotransformation; Drug-Related Side Effects and Adverse Reactions; Glutathione; Glutathione Disulfide; Humans; Lipid Peroxides; Liver; Microsomes, Liver; Peroxides; Pharmaceutical Preparations; Vitamin E | 1981 |
Paracetamol concentrations, hepatotoxicity, and antidotes.
Topics: Acetaminophen; Acetylcysteine; Humans; Methionine; Risk; Time Factors | 1980 |
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Injections, Intravenous; Liver Diseases | 1980 |
Plasma concentrations of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Humans; Time Factors | 1980 |
Effects of sulphur-containing compounds on paracetamol activation and covalent binding in a mouse hepatic microsomal system.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cysteamine; In Vitro Techniques; Male; Methionine; Mice; Microsomes, Liver; Mixed Function Oxygenases; Sulfur; Tiopronin | 1980 |
Acetaminophen hepatotoxicity and overdose.
Topics: Acetaminophen; Acetylcysteine; Humans; Liver | 1980 |
Renal metabolism of paracetamol: studies in the isolated perfused rat kidney.
Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Kidney Tubules; Rats; Time Factors | 1980 |
Effect of acetaminophen (paracetamol) and its antagonists on glutathione (GSH) content in rat liver.
Topics: Acetaminophen; Acetylcysteine; Animals; Glutathione; In Vitro Techniques; Liver; Methionine; Rats; Time Factors | 1980 |
Acetylcysteine for treatment of acetaminophen toxicosis in the cat.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Cat Diseases; Cats; Female; Male | 1980 |
Treatment of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Injections, Intravenous | 1980 |
N-Acetyl-DL-penicillamine and acetaminophen toxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Male; Mice; Necrosis; Penicillamine | 1980 |
Intravenous N-acetylcysteine for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Middle Aged | 1980 |
Acetylcysteine (Parvolex) for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Humans | 1980 |
Aspirin vs acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Aspirin; Humans | 1980 |
[Paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Kidney Tubular Necrosis, Acute; Liver; Methionine; Transaminases | 1980 |
Paracetamol metabolism by the isolated perfused rat kidney.
Topics: Acetaminophen; Acetylcysteine; Animals; Kidney; Kidney Tubules; Perfusion; Pharmaceutical Preparations; Rats; Regional Blood Flow | 1980 |
Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alcoholism; Aspartate Aminotransferases; Drug Evaluation; Gastric Lavage; Humans; Liver | 1981 |
Treatment of severe acetaminophen poisoning with intravenous acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Cysteamine; Humans; Injections, Intravenous; Liver; Methionine | 1981 |
Age as a variable in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Age Factors; Child; Child, Preschool; Female; Half-Life; Humans; Infant; Male | 1981 |
Treatment of acetaminophen poisoning. The use of oral methionine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Humans; Liver; Methionine; Time Factors | 1981 |
The laboratory in the diagnosis and management of acetaminophen and salicylate intoxications.
Topics: Acetaminophen; Acetylcysteine; Acid-Base Imbalance; Aspirin; Child, Preschool; Female; Hepatic Encephalopathy; Humans; Infant; Liver; Male; Poisoning; Salicylates; Time Factors | 1980 |
A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993).
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Brain Edema; Chi-Square Distribution; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Liver; Liver Failure; Liver Transplantation; Male; Middle Aged; Prognosis; Retrospective Studies; Risk Factors; Survival Rate | 1995 |
The management of paracetamol overdose by junior doctors.
Topics: Acetaminophen; Acetylcysteine; Documentation; Drug Overdose; Health Knowledge, Attitudes, Practice; Humans; Medical Audit; Medical Staff, Hospital; Surveys and Questionnaires; Time Factors | 1995 |
[Acute liver failure caused by paracetamol: should treatment with N-acetylcysteine be prolonged?].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Liver Failure, Acute | 1995 |
Acetaminophen poisoning and liver function.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Female; Humans; Liver | 1994 |
[Paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Denmark; Female; Humans; Kidney; Liver; Male; Poisoning | 1995 |
Protective effect of diltiazem against acetaminophen hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Calcium; Cell Survival; Chemical and Drug Induced Liver Injury; Diltiazem; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Liver; Mice | 1995 |
Overdose of extended-release acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Delayed-Action Preparations; Drug Overdose; Female; Half-Life; Humans | 1995 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Drug Overdose; Humans | 1995 |
Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Benzoquinones; Chemical and Drug Induced Liver Injury; Clinical Protocols; Drug Overdose; Humans; Imines | 1993 |
Subtleties of managing acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Child, Preschool; Drug Overdose; Humans; Infant; Ipecac; Poisoning; Time Factors | 1994 |
Delayed toxic acetaminophen level after initial four hour nontoxic level.
Topics: Acetaminophen; Acetylcysteine; Adult; Dextropropoxyphene; Drug Overdose; Female; Humans; Naproxen; Time Factors | 1994 |
Acetaminophen poisoning and liver function.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans | 1994 |
Effects of N-acetylcysteine and dithiothreitol on glutathione and protein thiol replenishment during acetaminophen-induced toxicity in isolated mouse hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Dithiothreitol; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Methionine Sulfoximine; Mice; Sulfhydryl Compounds | 1994 |
A new loading dose for N-acetylcysteine? The answer is no.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Drug Interactions; Drug Therapy, Combination; Humans; Poisoning | 1994 |
Severe acetaminophen poisoning with favorable outcome after medical treatment: report of 2 cases.
Topics: Acetaminophen; Acetylcysteine; Adult; Charcoal; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Female; Gastric Lavage; Humans; Liver Function Tests; Male; Poisoning; Suicide, Attempted | 1993 |
A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Charcoal; Child; Child, Preschool; Drug Overdose; Female; Humans; Logistic Models; Male; Middle Aged; Prospective Studies; Treatment Outcome | 1994 |
Severe hepatotoxicity, acute renal failure, and pancytopenia in a young child after repeated acetaminophen overdosing.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Overdose; Female; Humans; Pancytopenia; Peritoneal Dialysis | 1994 |
N-acetylcysteine stimulates hepatic glycogen deposition in the rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Drug Combinations; Eating; Food Deprivation; Injections, Intraperitoneal; Liver; Liver Glycogen; Male; Rats; Rats, Wistar | 1994 |
Serum sickness-like illness associated with N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Humans; Male; Serum Sickness | 1994 |
Attenuation of acetaminophen hepatitis by prostaglandin E2. A histopathological study.
Topics: 16,16-Dimethylprostaglandin E2; Acetaminophen; Acetylcysteine; Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Liver; Male; Rats; Rats, Sprague-Dawley | 1994 |
Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Liver Diseases; Male; Mice; Mice, Inbred Strains; Mitochondria, Liver; Oxygen Consumption | 1994 |
Cerebral blood flow and metabolism in fulminant liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Blood Flow Velocity; Brain; Brain Edema; Drug Overdose; Epoprostenol; Female; Glucose; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Lactates; Male; Mannitol; Middle Aged; Oxygen; Regional Blood Flow; Respiration, Artificial | 1994 |
Acetaminophen treatment nomogram.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Reference Values | 1994 |
Acute liver failure: improving outcome despite a paucity of treatment options.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Hepatic Encephalopathy; Humans; Liver Transplantation; Prognosis | 1993 |
Urinary screen for acetaminophen (paracetamol) in the presence of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; False Negative Reactions; Female; Humans; Middle Aged | 1993 |
Paracetamol cardiotoxicity.
Topics: Acetaminophen; Acetylcysteine; Humans; Poisoning | 1993 |
Are activated charcoal-N-acetylcysteine interactions of clinical significance?
Topics: Absorption; Acetaminophen; Acetylcysteine; Charcoal; Drug Interactions; Drug Therapy, Combination; Humans; Poisoning | 1993 |
Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Drug Overdose; Gastric Lavage; Humans; Liver | 1993 |
Paracetamol poisoning and hepatotoxicity in Chinese--the Prince of Wales Hospital (Hong Kong) experience.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; China; Drug Combinations; Drug Overdose; Female; Hong Kong; Humans; Liver; Male; Middle Aged; Nausea; Time Factors; Vomiting | 1993 |
Attenuation of acetaminophen hepatotoxicity in mice as evidence for the bioavailability of the cysteine in D-glucose-L-cysteine in vivo.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Animals; Biological Availability; Cysteine; Drug Interactions; Glucose; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred ICR | 1994 |
Induction of 5-oxoprolinuria in the rat following chronic feeding with N-acetyl 4-aminophenol (paracetamol).
Topics: Acetaminophen; Acetylcysteine; Animals; Glucuronates; Magnetic Resonance Spectroscopy; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Sulfates | 1993 |
Underdosing the antidote for acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Drug Labeling; Humans | 1993 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans; Liver Failure, Acute | 1993 |
Liver damage and plasma concentrations of paracetamol and its metabolites after paracetamol overdosage in mice.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Cysteine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Liver; Male; Mice | 1993 |
Intracellular calcium disruption as a secondary event in acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Calcium; Cell Membrane; Chelating Agents; Chemical and Drug Induced Liver Injury; Dithiothreitol; Fura-2; In Vitro Techniques; Male; Mice; Sulfhydryl Compounds | 1993 |
Comparison of N-acetylcysteine and methylene blue, alone or in combination, for treatment of acetaminophen toxicosis in cats.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cat Diseases; Cats; Drug Therapy, Combination; Female; Humans; Liver Failure; Male; Methylene Blue; Poisoning; Sex Characteristics | 1995 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Drug Administration Schedule; Humans; Liver Failure; Poisoning | 1996 |
Evidence for potential application of zinc as an antidote to acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Drug Therapy, Combination; Glutathione; Liver; Malondialdehyde; Mice; Mice, Inbred ICR; Sulfates; Zinc Compounds; Zinc Sulfate | 1995 |
Acetaminophen overdose: need to consider intravenous preparation of N-acetylcysteine in the United States.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Child; Drug Overdose; Humans; Infusions, Intravenous; United States | 1996 |
Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats.
Topics: Acetaminophen; Acetylcysteine; Animals; Arylsulfotransferase; Binding Sites; Biological Availability; Biotransformation; Cathartics; Chromatography, High Pressure Liquid; Expectorants; Free Radical Scavengers; Liver; Male; Mice; Phosphoadenosine Phosphosulfate; Rats; Rats, Sprague-Dawley; Species Specificity; Sulfates | 1996 |
Outpatient N-acetylcysteine treatment for acetaminophen poisoning: an ethical dilemma or a new financial mandate?
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Ambulatory Care; Analgesics, Non-Narcotic; Female; Follow-Up Studies; Free Radical Scavengers; Humans; Length of Stay; Liver; Male; Patient Compliance; Poison Control Centers; Poisoning; Retrospective Studies; Self Administration | 1996 |
Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestanols; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Mice; Necrosis | 1996 |
The acetaminophen nomogram: will it withstand the test of the extended relief formulation?
Topics: Acetaminophen; Acetylcysteine; Delayed-Action Preparations; Drug Overdose; Humans; Reference Values | 1996 |
Nephrotoxicity of acetaminophen in male Wistar rats: role of hepatically derived metabolites.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Common Bile Duct; gamma-Glutamyltransferase; Glutathione; Kidney; Male; Rats; Rats, Wistar | 1996 |
The epidemiology of acetaminophen (paracetamol) poisoning in Hong Kong.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Cohort Studies; Female; Free Radical Scavengers; Hepatic Encephalopathy; Humans; Longitudinal Studies; Male; Poisoning | 1996 |
Status epilepticus following intravenous N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anticonvulsants; Blindness; Child, Preschool; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Phenobarbital; Status Epilepticus | 1996 |
Protection from acetaminophen-induced liver damage by the synergistic action of low doses of the poly(ADP-ribose) polymerase-inhibitor nicotinamide and the antioxidant N-acetylcysteine or the amino acid L-methionine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Synergism; Male; Methionine; Mice; Mice, Inbred Strains; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors | 1997 |
Pediatric subacute acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Free Radical Scavengers; Humans; Male | 1997 |
Adverse reactions to N-acetylcysteine in Inuit to paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Greenland; Humans; Infusions, Intravenous; Inuit; Poisoning | 1996 |
Heart donation after fatal acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Coma; Female; Heart Transplantation; Humans; Jaundice; Male; Middle Aged; Tissue Donors; Tomography, Emission-Computed | 1997 |
Role of glutathione conjugation in protection of weanling rat liver against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Aging; Analgesics, Non-Narcotic; Animals; Glutathione; Inactivation, Metabolic; Liver; Male; Rats | 1997 |
Acetaminophen poisoning in late pregnancy. A case report.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Blood Gas Analysis; Fatal Outcome; Female; Fetal Death; Fetal Distress; Free Radical Scavengers; Humans; Pregnancy; Pregnancy Complications; Suicide | 1997 |
Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Cimetidine; Free Radical Scavengers; Glutathione; Histamine H2 Antagonists; Liver; Liver Diseases; Male; Mice; Microsomes, Liver; Necrosis; Survival Rate | 1997 |
[Anaphylactic reaction to N-acetylcysteine after poisoning with paracetamol].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Overdose; Expectorants; Humans; Infusions, Intravenous; Male | 1997 |
Angioedema with oral N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Angioedema; Antidotes; Humans; Male; Poisoning | 1997 |
Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Biological Transport; Chromatography, High Pressure Liquid; Drug Overdose; Fatal Outcome; Female; Fetal Blood; Free Radical Scavengers; Humans; Maternal-Fetal Exchange; Placenta; Poisoning; Pregnancy | 1997 |
Dilution of intravenous N-acetylcysteine as a cause of hyponatremia.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Child, Preschool; Epilepsy, Tonic-Clonic; Female; Free Radical Scavengers; Glucose; Humans; Hyponatremia; Infusions, Intravenous; Sodium; Sorption Detoxification | 1997 |
Oral N-acetylcysteine given intravenously for acetaminophen overdose: we shouldn't have to, but we must.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Liver Failure; Poisoning | 1998 |
Intravenous administration of oral N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Case-Control Studies; Child; Child, Preschool; Drug Evaluation; Drug Overdose; Drugs, Investigational; Female; Free Radical Scavengers; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Male; Middle Aged; Retrospective Studies; Safety; Survival Rate; Treatment Outcome; United States; United States Food and Drug Administration | 1998 |
Acetaminophen overdose with therapeutic intent.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Free Radical Scavengers; Humans | 1998 |
Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Emergency Nursing; Free Radical Scavengers; Humans; Methionine | 1998 |
Use of ondansetron and other antiemetics in the management of toxic acetaminophen ingestions.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Antiemetics; Female; Humans; Male; Ondansetron; Poison Control Centers; Retrospective Studies; Vomiting | 1998 |
More on interference of N-acetylcysteine in measurement of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; False Negative Reactions; Female; Humans; Suicide, Attempted | 1998 |
Effect of N-acetylcysteine on heat shock protein induction by acetaminophen in mouse liver.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Liver; Male; Mice; Molecular Chaperones; Neoplasm Proteins; Protein Binding | 1998 |
Massive sulfasalazine and paracetamol ingestion causing acidosis, hyperglycemia, coagulopathy, and methemoglobinemia.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Acute Disease; Adult; Anti-Inflammatory Agents; Blood Coagulation Disorders; Blood Platelets; Drug Combinations; Drug Overdose; Humans; Hyperglycemia; Infusions, Intravenous; Male; Methemoglobinemia; Methylene Blue; Partial Thromboplastin Time; Sodium Bicarbonate; Suicide, Attempted; Sulfasalazine | 1998 |
Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Allyl Compounds; Animals; Antimutagenic Agents; Benzoquinones; Cataract; Ciliary Body; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Disulfides; Drug Therapy, Combination; Garlic; Glutathione; Imines; Lens, Crystalline; Liver; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Plants, Medicinal | 1998 |
A dose-dependent delayed hypersensitivity reaction to acetaminophen after repeated acetaminophen intoxications.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Drug Hypersensitivity; Expectorants; Female; Humans | 1998 |
Late-presenting acute acetaminophen toxicity and the role of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Child; Clinical Protocols; Drug Overdose; Humans; Liver Diseases; Risk Factors; Time Factors | 1998 |
Deaths from low dose paracetamol poisoning. Nomogram does not show absolute concentration for treatment.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Hospitalization; Humans; Organizational Policy; Risk Factors; Scotland | 1998 |
Deaths from low dose paracetamol poisoning. Lower threshold has probably not overburdened hospital services in Gloucester.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Death, Sudden; Humans | 1998 |
Deaths from low dose paracetamol poisoning. More evidence needed to change recommendations.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Humans; Practice Guidelines as Topic | 1998 |
Deaths from low dose paracetamol poisoning. Use of oral methionine for overdose below threshold for acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Humans; Methionine | 1998 |
[ACC in liver failure].
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Humans | 1999 |
More on interference of N-acetylcysteine in measurement of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Humans; Reagent Kits, Diagnostic | 1999 |
Be prepared for acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Humans; Pharmaceutical Services | 1977 |
Renal impairment without hepatic damage after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adolescent; Charcoal; Drug Overdose; Female; Humans; Kidney; Liver; Treatment Outcome | 1999 |
Deferoxamine delays the development of the hepatotoxicity of acetaminophen in mice.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chelating Agents; Deferoxamine; Dose-Response Relationship, Drug; Kupffer Cells; Liver; Male; Mice | 1999 |
[Side-effects of N-acetylcysteine treatment in patients with paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Female; Humans; Male; Retrospective Studies | 1999 |
Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines.
Topics: Acetaminophen; Acetylcysteine; Animals; Aspartate Aminotransferases; Cell Division; Cells, Cultured; Chemokine CXCL2; Chemokine CXCL5; Chemokines, CXC; Chemotactic Factors; Female; Hepatocyte Growth Factor; Interleukin-8; Liver; Liver Regeneration; Mice; Monokines; Receptors, Chemokine; Receptors, Interleukin; Receptors, Interleukin-8B | 1999 |
[N-acetylcysteine].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Expectorants; Humans | 1999 |
An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antiemetics; Female; Humans; Metoclopramide; Poisoning; Sulfhemoglobinemia | 1999 |
Transformation of an acetaminophen toxicity nomogram to an artificial neural network.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Computer Simulation; Gastrointestinal Transit; Liver Diseases; Neural Networks, Computer | 1999 |
[No N-acetylcysteine in the absence of verified paracetamol intoxication].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Humans; Poisoning | 1999 |
Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen (paracetamol) overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Charcoal; Drug Overdose; Drug Therapy, Combination; Female; Gastric Lavage; Humans; Male; Middle Aged | 1999 |
Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Brain; Curcuma; Glutathione; Ketones; Liver; Male; Maleates; Plant Extracts; Rats; Rats, Inbred Strains; Vitamin E | 1999 |
Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Age Distribution; Aged; Analgesics, Non-Narcotic; Child; Drug Overdose; Emergency Service, Hospital; Female; Free Radical Scavengers; Hospitals, Urban; Humans; Liver; Male; Middle Aged; Retrospective Studies; Sex Distribution; Time Factors | 2000 |
Neonatal paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Female; Free Radical Scavengers; Humans; Infant, Newborn; International Normalized Ratio; Maternal-Fetal Exchange; Pregnancy; Prenatal Exposure Delayed Effects | 1999 |
Acetaminophen inhibits NF-kappaB activation by interfering with the oxidant signal in murine Hepa 1-6 cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Blotting, Western; Carcinoma, Hepatocellular; DNA Probes; DNA-Binding Proteins; Fluoresceins; Hydrogen Peroxide; I-kappa B Proteins; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidation-Reduction; Pyrrolidines; Signal Transduction; Thiocarbamates; Tumor Cells, Cultured | 2000 |
Reduction in incidence of severe paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Humans; Incidence; Legislation, Drug; Liver Diseases; Male; Poisoning; Severity of Illness Index; United Kingdom | 2000 |
Delays in administration of acetylcysteine in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Drug Overdose; Humans; Ireland; Liver Failure; Middle Aged; Professional Practice; Retrospective Studies; Time Factors | 2000 |
Acetaminophen hepatoxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Child; Child, Preschool; Drug Overdose; Female; Humans; Liver; Male; Middle Aged; Poisoning; Pregnancy; Pregnancy in Adolescence; Substance-Related Disorders; Suicide; Suicide, Attempted | 2000 |
Index of suspicion. Case 3. Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Poisoning | 1999 |
N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Expectorants; Heart Diseases; Humans; Neoplasms; Respiratory Tract Diseases | 2000 |
Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dioxolanes; Drug Combinations; Drug Overdose; Liver; Male; Rats; Rats, Sprague-Dawley; Time Factors | 2001 |
Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Denmark; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Poisoning; Prognosis; Risk Factors | 2001 |
Effects of clofibrate and indocyanine green on the hepatobiliary disposition of acetaminophen and its metabolites in male CD-1 mice.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anions; Anticholesteremic Agents; Bile Ducts; Chromatography, High Pressure Liquid; Clofibrate; Coloring Agents; Drug Interactions; Glucuronides; Indocyanine Green; Liver; Male; Mice; Time Factors | 2000 |
Paracetamol (acetaminophen) poisoning: report of two cases.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Drug Overdose; Female; Gastric Lavage; Humans; India; Infusions, Intravenous; Poisoning | 2000 |
Severity of overdose after restriction of paracetamol availability. Why hasn't strategy for minimising paracetamol poisoning been enacted?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Humans; Methionine; Poisoning | 2001 |
I'll have my N-acetylcysteine with an orange twist.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Carbonated Beverages; Communication; Emergency Treatment; Female; Free Radical Scavengers; Humans; Physician-Patient Relations; Suicide, Attempted; Vomiting | 2001 |
Effect of different doses of S-adenosyl-L-methionine on paracetamol hepatotoxicity in a mouse model.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Female; Free Radical Scavengers; Liver; Liver Failure; Mice; S-Adenosylmethionine | 2000 |
Is chronic poisoning with acetaminophen in children a frequent occurrence in Toronto?
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Child, Preschool; Chronic Disease; Free Radical Scavengers; Humans; Ontario; Retrospective Studies; Treatment Outcome; Urban Population | 2001 |
Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Overdose; Female; Humans; Infant; Interleukin-8; Liver Function Tests; Male; Prothrombin Time | 2001 |
Effects of legislation restricting pack sizes of paracetamol on self poisoning. Paracetamol should be packaged with its antidote.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Therapy, Combination; Humans | 2001 |
[Anaphylactoid reaction in relation to the use of N-acetylcysteine the prevention of paracetamol hepatotoxicity].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Suicide, Attempted | 2001 |
Interaction between N-acetylcysteine and activated charcoal: implications for the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Binding Sites; Charcoal; Drug Interactions; Free Radical Scavengers; Humans | 2001 |
Random and systematic medication errors in routine clinical practice: a multicentre study of infusions, using acetylcysteine as an example.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Infusions, Intravenous; Medication Errors; Poisoning | 2001 |
Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Coma; Diagnosis, Differential; Drug Overdose; Fatal Outcome; Female; Free Radical Scavengers; Humans; Hyperglycemia; Liver Failure; Pancreatitis; Pancytopenia; Renal Insufficiency; Rhabdomyolysis; Shock; Suicide, Attempted | 2001 |
The intravenous use of oral acetylcysteine (mucomyst) for the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Drug Overdose; Expectorants; Female; Humans; Infusions, Intravenous | 2002 |
The protective effect of garlic oil on hepatotoxicity induced by acetaminophen in mice and comparison with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Garlic; Liver; Male; Mice; Mice, Inbred Strains | 2001 |
Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Apoptosis; Carcinoma, Hepatocellular; Cell Nucleus; Cell Survival; Cytoplasm; Dose-Response Relationship, Drug; Drug Antagonism; Flow Cytometry; Free Radical Scavengers; Glutathione; Hepatocytes; Humans; Liver Neoplasms; Oxidative Stress; Reactive Oxygen Species; Tumor Cells, Cultured | 2002 |
Antidotes.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Free Radical Scavengers; Humans; Naloxone; Narcotic Antagonists; Narcotics | 2001 |
The value of plasma acetaminophen half-life in antidote-treated acetaminophen overdosage.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Antidotes; Drug Overdose; Female; Half-Life; Hepatic Encephalopathy; Humans; Liver Failure, Acute; Male; Middle Aged; Prospective Studies; Statistics, Nonparametric | 2002 |
Acetaminophen toxicity: suicidal vs. accidental.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Female; Hospitalization; Hospitals, Urban; Humans; Male; Middle Aged; New York; Retrospective Studies; Suicide, Attempted | 2002 |
Acetaminophen hepatotoxicity: the first 35 years.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Anticonvulsants; Aspartate Aminotransferases; Barbiturates; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Therapy, Combination; Enzyme Induction; Ethanol; Humans; Liver; Liver Diseases; Nutritional Physiological Phenomena; Phenytoin | 2002 |
Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats.
Topics: Acetaminophen; Acetylcysteine; Alcohol Dehydrogenase; Analgesics, Non-Narcotic; Animals; Antidotes; Drug Therapy, Combination; Fomepizole; Liver; Male; Necrosis; Pyrazoles; Rats; Rats, Wistar; Transaminases | 2002 |
Acetaminophen poisoning in children: treat early and long enough.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Decision Making; Drug Overdose; Free Radical Scavengers; Humans; Infant; Liver Diseases; Liver Function Tests; Time Factors | 2002 |
Predictors of outcome after acetaminophen poisoning in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Arkansas; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Decision Making; Drug Overdose; Female; Free Radical Scavengers; Humans; Infant; Liver Diseases; Liver Function Tests; Male; Predictive Value of Tests; Prothrombin Time; Retrospective Studies; Sensitivity and Specificity | 2002 |
Treatment strategies for early presenting acetaminophen overdose: a survey of medical directors of poison centers in North America and Europe.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Data Collection; Drug Overdose; Europe; Humans; North America; Physician Executives; Poison Control Centers; Poisoning; Surveys and Questionnaires | 2002 |
Approaches toward repeated supratherapeutic doses of paracetamol in children: a survey of medical directors of poison centres in North America and Europe.
Topics: Acetaminophen; Acetylcysteine; Child; Drug Overdose; Europe; Free Radical Scavengers; Health Care Surveys; Humans; North America; Physician Executives; Poison Control Centers; Surveys and Questionnaires | 2002 |
Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism?: a case against.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Drug Interactions; Free Radical Scavengers; Humans; Liver | 2002 |
N-acetylcysteine overdosage after insignificant acetaminophen intake.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Drug Overdose; Expectorants; Female; Humans | 2002 |
[Without liver transplantation paracetamol intoxication is often be lethal, in spite of N-acetylcysteine therapy].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans; Liver Failure, Acute; Liver Transplantation; Prognosis; Treatment Outcome | 2002 |
[Paracetamol nephropathy].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Apoptosis; Cells, Cultured; Humans; Kidney Tubules | 2002 |
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Androstanols; Animals; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Imines; Isoenzymes; Liver; Mice; Mice, Knockout; Mice, Transgenic; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Time Factors; Transcription Factors | 2002 |
N-acetylcysteine for paracetamol poisoning: effect on prothrombin.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Humans; Liver Failure; Prothrombin Time | 2002 |
Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Overdose; Female; Humans; Infusions, Intravenous; Liver Failure; Male; Middle Aged; Prothrombin Time; Retrospective Studies | 2002 |
Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Asthma; Fatal Outcome; Female; Humans; Hypoxia, Brain | 2002 |
Effervescent paracetamol poisoning: a case report.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Ethanol; Half-Life; Humans; Male; Suicide, Attempted | 2002 |
Effect of paracetamol poisoning on international normalised ratio.
Topics: Acetaminophen; Acetylcysteine; Factor IX; Factor VII Deficiency; Humans; International Normalized Ratio; Liver Function Tests; Poisoning; Prothrombin Time; Time Factors; Vitamin K | 2003 |
Successful treatment of acute hepatic injury caused by paracetamol intoxication in a late-referral patient by N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Humans; Infusions, Intravenous; Liver; Liver Function Tests; Male; Middle Aged; Severity of Illness Index; Suicide, Attempted; Treatment Outcome | 2003 |
[Is systemic administration of N-acetylcysteine effective?].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; Drug Overdose; Expectorants; Humans; Injections, Intravenous; Pulmonary Disease, Chronic Obstructive | 2003 |
Acetaminophen toxicosis in a Dalmatian.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Ascorbic Acid; Dog Diseases; Dogs; Emergency Treatment; Female; Fluid Therapy; Free Radical Scavengers; Liver; Methemoglobinemia; Sodium Bicarbonate; Treatment Outcome | 2003 |
Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Free Radical Scavengers; Glutathione; Mice; Prodrugs | 2003 |
Medication errors detected in infusions.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug-Related Side Effects and Adverse Reactions; Free Radical Scavengers; Humans; Infusions, Intravenous; Medication Errors | 2003 |
Acute acetaminophen poisoning in children: kids aren't just little adults.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Age Factors; Analgesics, Non-Narcotic; Charcoal; Child; Emergency Treatment; Female; Humans; Infant; Liver; Metabolic Clearance Rate; Time Factors; Treatment Outcome | 2003 |
Intravenous propacetamol overdose in a term newborn.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Female; Free Radical Scavengers; Humans; Infant, Newborn; Injections, Intravenous; Medication Errors | 2003 |
Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: a comparative study.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Blood Urea Nitrogen; Creatinine; Kidney; Liver; Melatonin; Mice; Vitamin E | 2003 |
Stability and microbiology of inhalant N-acetylcysteine used as an intravenous solution for the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Chromatography, High Pressure Liquid; Drug Stability; Injections, Intravenous | 2003 |
Warning note on a blood gas report leading to diagnosis of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Blood Glucose; Dextropropoxyphene; Drug Combinations; Drug Overdose; Glasgow Coma Scale; Humans; Intensive Care Units, Pediatric; Lactates; Male; Poisoning; Seizures | 2003 |
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chemokines; Drug Interactions; Immunoenzyme Techniques; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Necrosis; Nitric Oxide; Reactive Nitrogen Species; Up-Regulation | 2003 |
Successful treatment of acetaminophen overdose associated with hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Liver; Liver Failure, Acute | 2003 |
Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.
Topics: Acetaminophen; Acetylcysteine; Aminoquinolines; Animals; Antimalarials; Chloroquine; Disulfiram; Drug Synergism; Glutathione; Indomethacin; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum | 2003 |
Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity.
Topics: Acetaminophen; Acetylcysteine; alpha-Tocopherol; Analgesics, Non-Narcotic; Animals; Antioxidants; Blotting, Northern; Cell Death; Chemical and Drug Induced Liver Injury; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Formazans; Hepatocytes; Lipid Peroxides; Liver Diseases; Male; Neutral Red; Rats; Rats, Wistar; RNA; Silybin; Silymarin; Tetrazolium Salts | 2003 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Humans; Liver; Liver Diseases | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Cardiovascular Diseases; Child; Child, Preschool; Drug Eruptions; Drug Hypersensitivity; Drug Interactions; Drug Overdose; Female; Free Radical Scavengers; Histamine H1 Antagonists; Humans; Indiana; Infant; Infusions, Intravenous; Male; Middle Aged; Respiratory Tract Diseases; Retrospective Studies; Survival Analysis | 2003 |
Acetaminophen toxic level and N-acetylcysteine therapy: two patient reports.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Drug Overdose; Female; Free Radical Scavengers; Humans; Time Factors | 2004 |
Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Cell Separation; Cell Survival; Cells, Cultured; Fluoresceins; Free Radical Scavengers; Glutathione; Hepatocytes; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred C3H; Oxidative Stress; Reactive Oxygen Species; Tetrazolium Salts; Trypan Blue | 2004 |
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis.
Topics: Acetaminophen; Acetylcysteine; Antioxidants; Apoptosis; Calcium; Cations, Divalent; Cell Line, Tumor; Cell Nucleus; Flow Cytometry; Glutathione; Hepatoblastoma; Humans; Liver Neoplasms; Microscopy, Electron; Necrosis; Oxidation-Reduction; Oxidative Stress; Phosphatidylserines | 2004 |
Acute hepatic failure in the course of alcohol-paracetamol syndrome--case report.
Topics: Acetaminophen; Acetylcysteine; Ethanol; Humans; Liver Failure, Acute; Male; Middle Aged; Poisoning | 2003 |
Acetaminophen intoxication and length of treatment: how long is long enough?--A comment.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Confidence Intervals; Drug Administration Schedule; Free Radical Scavengers; Humans | 2004 |
Can liver toxicity occur at repeated borderline supratherapeutic doses of paracetamol?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Infant; Liver; Male; Respiratory Tract Infections | 2004 |
Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child, Preschool; Drug Overdose; Fatal Outcome; Female; Humans; Infusions, Intravenous; Intracranial Hypertension; Medication Errors; Poisoning; Status Epilepticus | 2004 |
[Effect of N-acetylcysteine on prothrombin index in patients with uncomplicated paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Overdose; Female; Humans; Liver Failure; Male; Middle Aged; Prothrombin Time; Retrospective Studies | 2004 |
Intravenous administration of N-acetylcysteine: interference with coagulopathy testing.
Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Injections, Intravenous; International Normalized Ratio; Liver Diseases; Male; Prothrombin Time | 2004 |
What is the rate of adverse events with intravenous versus oral N-acetylcysteine in pediatric patients?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Child; Child, Preschool; Humans; Infant; Injections, Intravenous; Retrospective Studies | 2004 |
Paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Child; Drug Overdose; Humans; Massive Hepatic Necrosis; Sorption Detoxification | 2004 |
Acute acetaminophen intoxication in Taiwan: outcomes and risk factors.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Humans; Male; Retrospective Studies; Risk Factors; Taiwan | 2004 |
Intravenous N-acetylcysteine for children.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child; Clinical Protocols; Humans; Injections, Intravenous | 2004 |
The administration of N-acetylcysteine causes a decrease in prothrombin time in patients with paracetamol overdose but without evidence of liver impairment.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Blood Coagulation; Drug Overdose; False Positive Reactions; Female; Humans; Liver; Male; Prognosis; Prothrombin Time; Retrospective Studies | 2005 |
Intravenous administration of N-acetylcysteine: oral and parenteral formulations are both acceptable.
Topics: Acetaminophen; Acetylcysteine; Dosage Forms; Humans; Injections, Intravenous | 2005 |
Fulminant hepatic failure due to chronic acetaminophen intoxication in an infant.
Topics: Acetaminophen; Acetylcysteine; Chronic Disease; Emergency Medicine; Female; Humans; Infant; Liver Failure, Acute; Poisoning; Treatment Outcome | 2005 |
Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue.
Topics: Acetaminophen; Acetylcysteine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Beckwith-Wiedemann Syndrome; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Hepatoblastoma; Humans; Infant; Liver Neoplasms | 2005 |
Oral or intravenous N-acetylcysteine for acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemical and Drug Induced Liver Injury; Humans; Infusions, Intravenous; Liver Diseases; Time Factors | 2005 |
A patient-tailored N-acetylcysteine protocol for acute acetaminophen intoxication.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Retrospective Studies | 2005 |
Acute renal dysfunction in acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Age Distribution; Aged; Drug Overdose; Emergency Treatment; Female; Follow-Up Studies; Humans; Incidence; Kidney Function Tests; Male; Middle Aged; New York City; Risk Assessment; Severity of Illness Index; Sex Distribution; Treatment Outcome | 2005 |
Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Chemokines; Gene Expression; Glutathione; Humans; Inflammation Mediators; Injections, Intraperitoneal; Interleukin-1; Interleukin-10; Interleukin-4; Liver; Macrophage Inflammatory Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Necrosis; NF-kappa B p50 Subunit; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Time Factors; Transcription Factors; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2006 |
A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Overdose; Emergency Medicine; Female; Humans; Liver Diseases; Logistic Models; Male; Models, Theoretical; Outcome and Process Assessment, Health Care; Retrospective Studies; Risk Assessment; Risk Factors; Transaminases | 2005 |
A new acetaminophen nomogram with a different purpose.
Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Interactions; Drug Overdose; Emergency Medicine; Humans; Liver Diseases; Nomograms; Outcome and Process Assessment, Health Care; Risk Assessment | 2005 |
[Atypical presentation of acute paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Child, Preschool; Female; Humans | 2005 |
A potentially fatal prescribing error in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug Prescriptions; Female; Humans; International Normalized Ratio; Medication Errors | 2005 |
Not so fast!
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Dose-Response Relationship, Drug; Drug Administration Schedule; Emergency Medicine; Humans; Infusions, Intravenous; Retrospective Studies | 2006 |
Intravenous loading infusion rates of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Administration Schedule; Drug Evaluation; Emergency Medicine; Humans; Infusions, Intravenous | 2006 |
Australian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Emergency Medicine; Humans; Infusions, Intravenous | 2006 |
Efficacy of activated charcoal administered more than four hours after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Charcoal; Child; Drug Overdose; Female; Humans; Liver Function Tests; Male; Middle Aged; Poison Control Centers; Prospective Studies; Treatment Outcome; United States | 2006 |
Acetadote (intravenous acetylcysteine): adverse effects more significant than with oral acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Drug Interactions; Drug Overdose; Emergency Treatment; Humans; Infusions, Intravenous; Nausea; Patient Selection; Practice Guidelines as Topic; Safety Management; United States; United States Food and Drug Administration; Vomiting | 2006 |
Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress.
Topics: Acetaminophen; Acetylcysteine; Aerobiosis; Animals; Cell Nucleus; Hepatocytes; Hypoxia-Inducible Factor 1; Liver; Male; Mice; Oxidative Stress; Oxygen | 2006 |
Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Blood Proteins; Chromatography, High Pressure Liquid; Female; Humans; Liver Failure, Acute; Male; Middle Aged; Poisoning | 2006 |
Potentially fatal paracetamol overdose and successful treatment with 3 days of intravenous N-acetylcysteine regime--a case report.
Topics: Acetaminophen; Acetylcysteine; Adult; Amylases; Antidotes; Codeine; Drug Overdose; Female; Humans; Liver Function Tests; Narcotics; Suicide, Attempted; Tablets; Time Factors | 2006 |
New recommendation for N-acetylcystiene dosing may reduce incidence of adverse effects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Body Weight; Drug Overdose; Humans; Practice Guidelines as Topic | 2006 |
[Paracetamol poisoning--occurrence and treatment].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Liver; Male; Middle Aged; Patient Admission; Retrospective Studies; Time Factors | 2006 |
Severe hepatotoxicity after therapeutic doses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Hepatitis B; Hepatitis C; HIV Seropositivity; Humans; Italy; Male; Middle Aged; Risk Factors; Substance Abuse, Intravenous | 2006 |
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury.
Topics: Acetaminophen; Acetylcysteine; Active Transport, Cell Nucleus; Animals; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; Benzimidazoles; Carbocyanines; Carrier Proteins; Cell Nucleus; Cell Survival; Cells, Cultured; Cytochromes c; DNA Fragmentation; Endodeoxyribonucleases; Hepatocytes; Immunohistochemistry; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Mitochondria; Mitochondrial Proteins | 2006 |
Adverse reaction from use of intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infusions, Intravenous; Liver Transplantation | 2006 |
Simulation of the detoxification of paracetamol using on-line electrochemistry/liquid chromatography/mass spectrometry.
Topics: Acetaminophen; Acetylcysteine; Chromatography, Liquid; Electrochemistry; Glutathione; Mass Spectrometry; Molecular Structure; Online Systems | 2006 |
Comparison of S-Adenosyl-L-methionine and N-acetylcysteine protective effects on acetaminophen hepatic toxicity.
Topics: Acetaminophen; Acetylcysteine; Aldehydes; Animals; Antidotes; Blotting, Western; Glutathione; Liver; Male; Mice; Mice, Inbred C57BL; Organ Size; Protein Carbonylation; S-Adenosylmethionine | 2007 |
[Post-marketing surveillance of acetylcysteine oral solution 17.6% "SENJU" for the antidote to acetaminophen overdose--use--results surveillance].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Antidotes; Charcoal; Child; Child, Preschool; Drug Overdose; Female; Gastric Lavage; Humans; Infant; Male; Middle Aged; Pregnancy; Product Surveillance, Postmarketing; Solutions; Treatment Outcome | 2006 |
Managing acute acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Female; Humans; Nomograms | 2007 |
A prospective evaluation of shortened course oral N-acetylcysteine for the treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; California; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Confidence Intervals; Drug Overdose; Female; Humans; Infant; Liver Function Tests; Male; Middle Aged; Prospective Studies; Risk Assessment; Surveys and Questionnaires; Treatment Outcome | 2007 |
Liver unit admission following paracetamol overdose with concentrations below current UK treatment thresholds.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Emergency Service, Hospital; Female; Hospitalization; Humans; Liver Failure; Male; Retrospective Studies; United Kingdom | 2007 |
Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line.
Topics: Acetaminophen; Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochromes c; Dinoprostone; Disulfiram; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Free Radical Scavengers; Glutathione; Humans; Metalloporphyrins; Neuroblastoma; Prostaglandin-Endoperoxide Synthases; Staurosporine; Time Factors | 2007 |
What is your diagnosis? Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Blood Chemical Analysis; Blood Gas Analysis; Diagnosis, Differential; Dog Diseases; Dogs; Male; Poisoning; Urinalysis | 2007 |
Patient-tailored acetylcysteine administration.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Function Tests | 2007 |
Specific activation of the different fibrogenic cells in rat cultured liver slices mimicking in vivo situations.
Topics: Acetaminophen; Acetylcysteine; Animal Use Alternatives; Animals; Antioxidants; Bile Ducts, Intrahepatic; Cell Survival; Disease Models, Animal; Drug Antagonism; Epidermal Growth Factor; Estradiol; Fibroblasts; Hepatocytes; Kupffer Cells; Liver; Liver Cirrhosis; Male; Necrosis; Organ Culture Techniques; Portal System; Rats; Rats, Wistar; Thioacetamide | 2007 |
Death from paracetamol overdose despite appropriate treatment with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Fatal Outcome; Free Radical Scavengers; Humans; Male; Middle Aged; Multiple Organ Failure | 2007 |
[Risk of acute hepatic insufficiency in children due to chronic accidental overdose of paracetamol (acetaminophen)].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child, Preschool; Drug Overdose; Female; Free Radical Scavengers; Humans; Liver; Liver Failure, Acute; Prognosis; Transaminases | 2007 |
Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chromatography, Liquid; Cysteine; Humans; Imines; Microsomes, Liver; Models, Biological; Molecular Structure; Oligopeptides; Protein Binding; Rats; Reproducibility of Results; Serum Albumin; Tandem Mass Spectrometry | 2007 |
Weight-based N-acetylcysteine dosing chart to minimise the risk of calculation errors in prescribing and preparing N-acetylcysteine infusions for adults presenting with paracetamol overdose in the emergency department.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Clinical Competence; Drug Administration Schedule; Drug Overdose; Emergencies; Expectorants; Humans; Infusions, Parenteral; Medical Staff, Hospital; Medication Errors; Nursing Staff, Hospital | 2007 |
Hypokalaemia following paracetamol overdose in two teenage girls.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Hypokalemia; Liver; Suicide, Attempted | 2007 |
Impact of activated charcoal after acute acetaminophen overdoses treated with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Registries; Retrospective Studies | 2007 |
Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Child; Child, Preschool; Database Management Systems; Drug Overdose; Humans; Infant; Infusions, Intravenous; Retrospective Studies | 2007 |
Clinical policy: critical issues in the management of patients presenting to the emergency department with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Emergency Service, Hospital; Humans; Poisoning | 2007 |
Acetaminophen overdose and N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Brunei; Drug Overdose; Humans | 2007 |
Clinical excellence exemplar.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Free Radical Scavengers; Humans; Patient Care Management; Physician-Nurse Relations; Poison Control Centers | 2007 |
Oral N-acetylcysteine for acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Emergency Service, Hospital; Health Care Surveys; Humans; Wales | 2007 |
Acute acetaminophen overdose is associated with dose-dependent hypokalaemia: a prospective study of 331 patients.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Hypokalemia; Male; Middle Aged; Nomograms; Predictive Value of Tests; Prospective Studies; Risk Factors; ROC Curve; Statistics, Nonparametric | 2008 |
Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aldehydes; Analysis of Variance; Animals; Blotting, Western; Drug Overdose; Glutathione; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred C57BL; Microscopy, Polarization; Organ Size; Protein Carbonylation; S-Adenosylmethionine; Time Factors | 2008 |
Antiemetic use in acetaminophen poisoning: how does the route of N-acetylcysteine administration affect utilization?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Antidotes; Antiemetics; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Male; Metoclopramide; Ondansetron; Poisoning; Retrospective Studies; Treatment Outcome | 2007 |
Acetylcysteine and enzymatic creatinine: beware of laboratory artefact!
Topics: Acetaminophen; Acetylcysteine; Antidotes; Antioxidants; Blood Chemical Analysis; Creatinine; Humans; In Vitro Techniques; Reproducibility of Results | 2008 |
Is there a "NAC" to treating acute liver failure in children?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child; Free Radical Scavengers; Humans; Injections, Intravenous; Liver Failure, Acute | 2008 |
Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Female; Follow-Up Studies; Free Radical Scavengers; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Liver Failure, Acute; Male; Retrospective Studies; Survival Rate; Treatment Outcome; United Kingdom | 2008 |
Stability of a flavored formulation of acetylcysteine for oral administration.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Chromatography, High Pressure Liquid; Drug Overdose; Drug Stability; Drug Storage; Expectorants; Humans; Pharmaceutical Solutions; Refrigeration; Sweetening Agents; Temperature; Time Factors | 2008 |
Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Liver; Models, Statistical; Registries; Risk | 2008 |
Key features of the patient-tailored N-acetylcysteine protocol.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; California; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Overdose; Female; Humans; Infant; Liver Function Tests; Male; Middle Aged; Risk Assessment; Surveys and Questionnaires; Treatment Outcome | 2008 |
Comment on "Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Ethanol; Free Radical Scavengers; Humans; International Normalized Ratio | 2008 |
Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Child; Child, Preschool; Databases, Factual; Drug Overdose; Female; Hospitals; Humans; Infusions, Intravenous; Male; Medication Errors; Middle Aged; Personnel Staffing and Scheduling; Poison Control Centers; Retrospective Studies; Time Factors; Treatment Outcome; United States | 2008 |
Caring for the mother, concentrating on the fetus: intravenous N-acetylcysteine in pregnancy.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Female; Free Radical Scavengers; Humans; Pregnancy; Pregnancy Outcome | 2008 |
Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Aged; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Half-Life; Humans; Male; Time Factors | 2008 |
[Acute acetaminophen overdose].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2008 |
A nutrient mixture prevents acetaminophen hepatic and renal toxicity in ICR mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Ascorbic Acid; Aspartate Aminotransferases; Blood Urea Nitrogen; Creatinine; Kidney; Liver; Lysine; Male; Mice; Mice, Inbred ICR; Organ Size; Proline; Tea | 2008 |
Synergistic action of sodium selenite and N-acetylcysteine in acetaminophen-induced liver damage.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Combinations; Drug Synergism; Free Radical Scavengers; L-Lactate Dehydrogenase; Male; Mice; Sodium Selenite | 2008 |
Cardiac arrest following therapeutic administration of N-acetylcysteine for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Drug Overdose; Heart Arrest; Humans; Male; Suicide, Attempted; Time Factors | 2008 |
Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Blood Coagulation Factors; Drug Overdose; Female; Histamine Release; Humans; Inflammation Mediators; Logistic Models; Male; Odds Ratio; Pedigree; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Sex Factors; Time Factors | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Humans; Liver; Poisoning; Prothrombin Time | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Humans; Poisoning; Treatment Refusal | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Humans; Liver; Poisoning; Risk Assessment | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Half-Life; Humans; Liver; Poisoning | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Epinephrine; Free Radical Scavengers; Humans | 2008 |
Acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Humans; Liver; Liver Diseases; Poisoning | 2008 |
Management of acute paracetamol poisoning in a tertiary care hospital.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Analgesics, Non-Narcotic; Antidotes; Charcoal; Emetics; Evidence-Based Medicine; Female; Hospitals, Public; Humans; Male; Methionine; Poisoning; Sodium Bicarbonate; Sri Lanka; Time Factors; Treatment Outcome; Young Adult | 2008 |
Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Charcoal; Diphenhydramine; Drug Combinations; Drug Overdose; Fatal Outcome; Female; Free Radical Scavengers; Histamine H1 Antagonists; Humans; Liver Failure; Middle Aged; Suicide, Attempted | 2009 |
Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Observation; Retrospective Studies | 2009 |
Safety and effectiveness of acetadote for acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Antidotes; Female; Humans; Infusions, Intravenous; Length of Stay; Male; Middle Aged; Retrospective Studies; Transaminases; Young Adult | 2010 |
Comment: Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Humans; Infusions, Intravenous; Medication Errors | 2008 |
Serum acetaminophen concentrations after acute overdose are not altered by opioid co-ingestion.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Interactions; Drug Overdose; Female; Humans; Male; Poisoning; Prospective Studies; Time Factors; Young Adult | 2008 |
Comment: frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans; Infusions, Intravenous; Medication Errors; Time Factors | 2009 |
Acetaminophen hepatotoxicity: current management.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Cimetidine; Comorbidity; Disease Progression; Drug and Narcotic Control; Free Radical Scavengers; Humans; Liver Failure; Liver Transplantation; Prognosis; Renal Dialysis; Severity of Illness Index; Treatment Outcome | 2009 |
Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Cimetidine; Disease Models, Animal; Liver; Magnetic Resonance Spectroscopy; Male; Rabbits; Silybin; Silymarin | 2009 |
Hepatotoxicity in an infant following supratherapeutic dosing of acetaminophen for twenty-four hours.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Infant; Liver; Male; Poison Control Centers | 2009 |
Paracetamol poisoning below toxic level causing liver damage in a fasting adult.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fasting; Female; Free Radical Scavengers; Humans; Liver; Liver Diseases; Risk Factors; Young Adult | 2009 |
Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquinones; Biomarkers; Biotransformation; Databases as Topic; Drug Overdose; Female; Half-Life; Humans; Imines; Liver Failure, Acute; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Models, Statistical; Nonlinear Dynamics; Young Adult | 2009 |
A 46-year-old woman with altered mental status and garbled speech.
Topics: Acetaminophen; Acetylcysteine; Diagnosis, Differential; Diphenhydramine; Electrocardiography; Female; Humans; Mental Disorders; Middle Aged; Poisoning; Speech Disorders; Spinal Puncture; Tomography, X-Ray Computed | 2009 |
Prolonged N-acetylcysteine therapy in late acetaminophen poisoning associated with acute liver failure--a need to be more cautious?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Drug Administration Schedule; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Liver Failure, Acute; Mice | 2009 |
Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chromatography, High Pressure Liquid; Clozapine; Diclofenac; Glutathione; Humans; Microsomes, Liver; Rats; Tandem Mass Spectrometry | 2009 |
Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Antidotes; Canada; Chemical and Drug Induced Liver Injury; Child; Cohort Studies; Critical Pathways; Drug Administration Schedule; Drug Overdose; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Male; Retrospective Studies; Risk; United States; Young Adult | 2009 |
NAC: still the way to go.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Drug-Related Side Effects and Adverse Reactions; Humans; Liver Failure; Mice | 2009 |
Is the oral acetylcysteine protocol the best treatment for late-presenting acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Time Factors | 2009 |
Early presentation following overdose of modified-release paracetamol (Panadol Osteo) with biphasic and prolonged paracetamol absorption.
Topics: Acetaminophen; Acetylcysteine; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Delayed-Action Preparations; Drug Overdose; Female; Free Radical Scavengers; Humans; Infusions, Intravenous | 2009 |
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cisplatin; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Drug Synergism; Free Radical Scavengers; Glutathione; Hepatoblastoma; Hepatocytes; Humans; Liver Neoplasms; Mice; Rats; Time Factors | 2009 |
The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Collagenases; Garlic; Glutathione; Hepatocytes; Liver; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2009 |
Severe acetaminophen poisoning treated with a fractionated plasma separation and absorption system: A case report.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Female; Humans; Liver Function Tests; Plasmapheresis; Poisoning; Treatment Outcome | 2009 |
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Energy Metabolism; Glutathione; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Peroxynitrous Acid; Reactive Oxygen Species; Up-Regulation | 2010 |
A retrospective evaluation of shortened-duration oral N-acetylcysteine for the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; California; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Poison Control Centers; Poisoning; Practice Guidelines as Topic; Retrospective Studies; Treatment Outcome; Young Adult | 2009 |
Managing acute acetaminophen poisoning with oral versus intravenous N-acetylcysteine: a provider-perspective cost analysis.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Costs and Cost Analysis; Drug Overdose; Humans; Injections, Intravenous; Length of Stay; Models, Economic; Time Factors; United States | 2009 |
Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Biomarkers; Catalase; Curcumin; Drug Synergism; Glutathione Peroxidase; Kidney; Kidney Diseases; Liver; Liver Diseases; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Serologic Tests | 2010 |
Regarding "comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning" by Yarema et al.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Drug Administration Schedule; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous | 2009 |
IV versus oral N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous | 2009 |
The protective effects of N-Acetl-cysteine, oxo-thiazolidine-carboxylate, acetaminophen and their combinations against sulfur mustard cytotoxicity on human skin fibroblast cell line (HF2FF).
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Catalase; Cell Line; Cell Survival; Chemical Warfare Agents; Cytoprotection; Drug Interactions; Fibroblasts; Free Radical Scavengers; Glutathione; Humans; Mustard Gas; Pyrrolidonecarboxylic Acid; Skin; Thiazolidines | 2009 |
Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Electrochemistry; Glutathione; Oxidation-Reduction | 2010 |
Incidence of adverse drug reactions induced by N-acetylcysteine in patients with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcotic; Antidotes; Chi-Square Distribution; Drug Overdose; Female; Humans; Infusions, Intravenous; Malaysia; Male; Retrospective Studies; Time Factors; Young Adult | 2010 |
Intravenous paracetamol overdose in a preterm infant during anesthesia.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Free Radical Scavengers; Hernia, Inguinal; Humans; Infant; Infant, Newborn; Infant, Premature; Infusions, Intravenous; International Normalized Ratio; Male; Medical Errors | 2010 |
A modified low-cost colorimetric method for paracetamol (acetaminophen) measurement in plasma.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Calibration; Chromatography, High Pressure Liquid; Cohort Studies; Colorimetry; Humans; Indicators and Reagents; Prospective Studies; Reproducibility of Results; Sri Lanka | 2010 |
Cost minimization analysis comparing enteral N-acetylcysteine to intravenous acetylcysteine in the management of acute acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Cohort Studies; Cost-Benefit Analysis; Costs and Cost Analysis; Drug Overdose; Female; Humans; Infusions, Intravenous; Length of Stay; Liver Function Tests; Male; Middle Aged; Retrospective Studies | 2010 |
Liver: Management of non-acetaminophen-induced ALF.
Topics: Acetaminophen; Acetylcysteine; Free Radical Scavengers; Humans; Liver Failure, Acute; Liver Transplantation; Randomized Controlled Trials as Topic | 2010 |
Paracetamol (acetaminophen) attenuates in vitro mast cell and peripheral blood mononucleocyte cell histamine release induced by N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Histamine Release; Humans; Leukocytes, Mononuclear; Male; Mast Cells; Trypan Blue | 2010 |
Medicine, poison, and mystic potion: a personal perspective on paracetamol Louis Roche lecture, Stockholm, 2009.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Risk Factors | 2010 |
Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venovenous hemodiafiltration.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Antidotes; Coma; Combined Modality Therapy; Drug Overdose; Female; Hemodiafiltration; Humans; Hypotension; Young Adult | 2010 |
Late extensive intravenous administration of N-acetylcysteine can reverse hepatic failure in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Delayed Diagnosis; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Intensive Care Units; Liver Failure, Acute; Male; Treatment Outcome | 2011 |
IV versus oral acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Data Interpretation, Statistical; Humans; Infusions, Intravenous; Regression Analysis | 2010 |
[Treatment of paracetamol poisoning to revision].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Poisoning; Practice Guidelines as Topic | 2010 |
Relationship between serum acetaminophen concentration and N-acetylcysteine-induced adverse drug reactions.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Male; Middle Aged; Retrospective Studies; Young Adult | 2010 |
N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Azoxymethane; Brain Edema; Carcinogens; Cytokines; Disease Models, Animal; Hepatic Encephalopathy; Inflammation; Inflammation Mediators; Liver Failure, Acute; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2010 |
Cost of the paracetamol overdose epidemic.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Methionine; Sri Lanka; Suicide | 2010 |
[N-Acetylcysteine].
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Bronchi; Child; Child, Preschool; Expectorants; Humans; Infusions, Intravenous; Tracheotomy | 2010 |
Intravenous and enteral N-acetylcysteine can be both cost effective.
Topics: Acetaminophen; Acetylcysteine; Cost-Benefit Analysis; Humans; Infusions, Intravenous; Infusions, Parenteral; Poisoning | 2010 |
A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Administration Routes; Drug Overdose; Humans; Infusions, Intravenous; Injections, Intravenous; Nausea; Safety; Treatment Outcome; Vomiting | 2010 |
[Comment of the paracetamol debate--next step].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Humans; Infusions, Intravenous; Poisoning | 2010 |
N-acetylcysteine-induced headache in hospitalized patients with acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Cohort Studies; Drug Overdose; Female; Headache; Hospitalization; Humans; Infusions, Intravenous; Male; Retrospective Studies; Risk Factors; Young Adult | 2011 |
[Are nomograms available for the treatment of acetaminophen poisoning?].
Topics: Acetaminophen; Acetylcysteine; Biomarkers; Chemical and Drug Induced Liver Injury; Humans; Liver Function Tests; Nomograms | 2010 |
[Are nomograms available for the treatment of acetaminophen poisoning? Pros: usefullness of nomogram-based decision-making in the treatment of acute acetaminophen overdose in Japan: single center experience with 61 consecutive patients in Niigata City Gen
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hospitals, General; Humans; Japan; Liver Function Tests; Male; Nomograms; Young Adult | 2010 |
An analysis of the length of hospital stay after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Costs and Cost Analysis; Drug Overdose; Female; Humans; Injections, Intravenous; Length of Stay; Male; Time Factors; Young Adult | 2011 |
Effects of delay in infusion of N-acetylcysteine on appearance of adverse drug reactions after acetaminophen overdose: a retrospective study.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Antidotes; Drug Overdose; Female; Humans; Male; Retrospective Studies; Risk Factors; Time Factors; Young Adult | 2010 |
Protective effect of ghrelin on acetaminophen-induced liver injury in rat.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Ghrelin; Liver; Male; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2010 |
Spinning disc processing technology: potential for large-scale manufacture of chitosan nanoparticles.
Topics: Acetaminophen; Acetylcysteine; Chitosan; Microscopy, Electron, Transmission; Nanoparticles; Particle Size | 2010 |
Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Glutathione Transferase; Humans; Liver; Liver Diseases; Male; Malondialdehyde; Rats; Rats, Sprague-Dawley; Taurine | 2010 |
Molecular mechanisms of Id2 down-regulation in rat liver after acetaminophen overdose. Protection by N-acetyl-L-cysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Cytoprotection; Down-Regulation; Drug Overdose; Gene Expression Regulation; Genes, myc; Glutathione; Inhibitor of Differentiation Protein 2; Liver; Male; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Signal Transduction | 2010 |
Response to "A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose".
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Drug Overdose; Humans; Injections, Intravenous | 2010 |
PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Animals, Genetically Modified; Chemical and Drug Induced Liver Injury; Dinoprostone; Genes, Reporter; Glutathione; Liver; Liver Failure, Acute; Proteome; Signal Transduction; Zebrafish | 2010 |
The clinical management of acetaminophen poisoning in a community hospital system: factors associated with hospital length of stay.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Antidotes; California; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Overdose; Female; Hospitals, Community; Humans; Infusions, Intravenous; Length of Stay; Male; Medical Records; Poison Control Centers; Practice Patterns, Physicians'; Retrospective Studies | 2011 |
5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acid-Base Equilibrium; Acidosis; Acute Disease; Adult; Analgesics, Non-Narcotic; Female; Free Radical Scavengers; Humans; Pyrrolidonecarboxylic Acid | 2010 |
Multiplying the serum aminotransferase by the acetaminophen concentration to predict toxicity following overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aspartate Aminotransferases; Cohort Studies; Drug Overdose; Humans; Retrospective Studies | 2010 |
Curative effects of hydrogen sulfide against acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antidotes; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Glutathione; Hepatocytes; Hydrogen Sulfide; Male; Malondialdehyde; Mice; Nitric Oxide; Tumor Necrosis Factor-alpha | 2010 |
Paracetamol orodispersible tablets: a risk for severe poisoning in children?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Child, Preschool; Databases, Factual; Free Radical Scavengers; Humans; Infant; Retrospective Studies; Risk Factors; Tablets | 2011 |
Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Data Interpretation, Statistical; Female; Kidney; Kidney Function Tests; Radionuclide Imaging; Rats; Rats, Wistar; Thioglycolates; Thiophenes | 2011 |
Intravenous paracetamol overdose: two case reports and a change to national treatment guidelines.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infant; Injections, Intravenous; Male; Practice Guidelines as Topic; United Kingdom | 2011 |
Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Coloring Agents; Disease Models, Animal; Indocyanine Green; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred Strains; Time Factors | 2011 |
Why not formulate an acetaminophen tablet containing N-acetylcysteine to prevent poisoning?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Combinations; Drug Overdose; Humans; Nonprescription Drugs; Poisoning; Tablets | 2011 |
"Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with iv nac and continuous venovenous hemodiafiltration" by Wiegand et al., Clin Toxicol (Phila) 48:156-159.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Coma; Drug Overdose; Half-Life; Hemodiafiltration; Humans | 2010 |
ST segment elevation secondary to paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Antidotes; Coronary Angiography; Drug Overdose; Electrocardiography; Female; Heart Diseases; Humans | 2011 |
Commentary.
Topics: Acetaminophen; Acetylcysteine; Bilirubin; Diagnosis, Differential; False Positive Reactions; Female; Humans; Liver Failure, Acute | 2011 |
Inhibition of mitochondrial respiratory chain in the brain of rats after hepatic failure induced by acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Brain; Deferoxamine; Down-Regulation; Drug Evaluation, Preclinical; Electron Transport; Liver Failure; Male; Mitochondria; Rats; Rats, Wistar; Taurine | 2011 |
Anti-hepatotoxic effects of 3,4-methylenedioxyphenol and N-acetylcysteine in acutely acetaminophen-overdosed mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants; Aspartate Aminotransferases; Benzodioxoles; Chemical and Drug Induced Liver Injury; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred C3H; Phenols | 2011 |
A gargantuan acetaminophen level in an acidemic patient treated solely with intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Infusions, Intravenous; Middle Aged; Suicide, Attempted | 2013 |
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Free Radical Scavengers; Humans; Liver Failure, Acute; Male; Middle Aged; Prognosis; Retrospective Studies; Severity of Illness Index; Survival Rate; Transaminases | 2011 |
Using 0.45% saline solution and a modified dosing regimen for infusing N-acetylcysteine in children with paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Child; Combined Modality Therapy; Drug Administration Schedule; Emergency Treatment; Female; Glucose; Home Infusion Therapy; Humans; Infusions, Intravenous; Infusions, Parenteral; Male; Medical Records; Patient Admission; Poisoning; Retreatment; Retrospective Studies; Sodium; Sodium Chloride | 2011 |
Mind the gap! An unusual metabolic acidosis.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Anti-Bacterial Agents; Antioxidants; Female; Floxacillin; Humans; Middle Aged; Pyrrolidonecarboxylic Acid; Sepsis; Sodium Bicarbonate | 2011 |
Protective effects of exogenous glutathione and related thiol compounds against drug-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Female; Furosemide; Glutathione; Interleukin-6; Liver; Male; Mice; Mice, Inbred Strains | 2011 |
Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Child; Cholinergic Antagonists; Diphenhydramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose; Female; Free Radical Scavengers; Half-Life; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Intensive Care Units, Pediatric; International Normalized Ratio; Liver Failure; Liver Function Tests; Metabolic Clearance Rate; Suicide, Attempted | 2011 |
The in vitro effect of N-acetylcysteine on prothrombin time in plasma samples from healthy subjects.
Topics: Acetaminophen; Acetylcysteine; Adult; Blood Coagulation; Dose-Response Relationship, Drug; Female; Humans; Male; Prothrombin Time | 2011 |
Self-treatment of acetaminophen overdose with dietary-supplement acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Dietary Supplements; Drug Overdose; Humans; Internet; Male; Self Medication | 2011 |
Evaluation of a simplified N-acetylcysteine dosing regimen for the treatment of acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Administration Schedule; Drug Approval; Female; Humans; Male; Medication Errors; Middle Aged; Off-Label Use; Retrospective Studies; United States; United States Food and Drug Administration; Young Adult | 2011 |
Unexpected late rise in plasma acetaminophen concentrations with change in risk stratification in acute acetaminophen overdoses.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Combinations; Drug Interactions; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Nomograms; Poisoning; Retrospective Studies; Risk Assessment; Time Factors; Young Adult | 2012 |
Massive acetylcysteine overdose associated with cerebral edema and seizures.
Topics: Acetaminophen; Acetylcysteine; Adult; Brain Edema; Drug Overdose; Female; Humans; Medication Errors; Seizures | 2011 |
Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Bile Canaliculi; Cell Membrane; Liver; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Microscopy, Fluorescence, Multiphoton; Necrosis | 2011 |
Acetaminophen psi parameter: a useful tool to quantify hepatotoxicity risk in acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Logistic Models; Male; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Thailand; Young Adult | 2011 |
A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Antioxidants; Area Under Curve; Computer Simulation; Drug Administration Schedule; Drug Overdose; Humans; Infusions, Intravenous; Models, Biological | 2011 |
Fabrication of a nanostructure-based electrochemical sensor for simultaneous determination of N-acetylcysteine and acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Calibration; Carbon; Catalysis; Chemistry Techniques, Analytical; Electrochemistry; Electrodes; Fluorenes; Humans; Limit of Detection; Nanostructures; Oxidation-Reduction; Time Factors; Water | 2011 |
Activation of autophagy protects against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Adenine; Analgesics, Non-Narcotic; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Green Fluorescent Proteins; Hepatocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Primary Cell Culture; TOR Serine-Threonine Kinases | 2012 |
Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Female; Hemolysis; Hemolytic-Uremic Syndrome; Humans; Medication Errors; Poisoning; Treatment Outcome; Young Adult | 2011 |
5-oxoprolinemia causing elevated anion gap metabolic acidosis in the setting of acetaminophen use.
Topics: Acetaminophen; Acetylcysteine; Acid-Base Equilibrium; Acidosis; Adult; Amino Acid Metabolism, Inborn Errors; Analgesics, Non-Narcotic; Female; Free Radical Scavengers; Glutathione Synthase; Humans | 2012 |
Correlation of MRI findings to histology of acetaminophen toxicity in the mouse.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Expectorants; Liver Failure, Acute; Magnetic Resonance Imaging; Male; Mice; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic; Treatment Outcome | 2012 |
Paracetamol overdose: the liver unit perspective.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Early Diagnosis; Humans; Liver Failure, Acute; Liver Transplantation; Time Factors | 2012 |
Intravenous paracetamol toxicity in a malnourished child.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child Nutrition Disorders; Child, Preschool; Delayed Diagnosis; Humans; Infusions, Intravenous; Male; Medication Errors | 2012 |
No need to change treatment of early presenting patients with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Antioxidants; Humans | 2012 |
Delayed and prolonged elevated serum paracetamol level after an overdose - possible causes and implications.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Humans; Liver Function Tests; Male; Nomograms; Time Factors | 2011 |
Intravenous acetaminophen in the United States: iatrogenic dosing errors.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Drug Dosage Calculations; Drug Overdose; Free Radical Scavengers; Humans; Iatrogenic Disease; Infant; Infusions, Intravenous; Medication Errors; Nomograms; Poison Control Centers; United States | 2012 |
A cost effectiveness analysis of the preferred antidotes for acute paracetamol poisoning patients in Sri Lanka.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Chemical and Drug Induced Liver Injury; Cost-Benefit Analysis; Decision Trees; Humans; Methionine; Sri Lanka; Time Factors | 2012 |
Effect of Asparagus falcatus on acetaminophen toxicity in mice: a comparison of antioxidative effect with N-acetyl cysteine.
Topics: Acetaminophen; Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Asparagus Plant; Chemical and Drug Induced Liver Injury; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts | 2008 |
Paracetamol toxicity: What would be the implications of a change in UK treatment guidelines?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Costs; Drug Overdose; Emergency Service, Hospital; Free Radical Scavengers; Health Care Costs; Hospitals, Urban; Humans; London; Practice Guidelines as Topic; Retrospective Studies; Risk; Risk Assessment; United Kingdom | 2012 |
[Study of the serum concentrations of acetaminophen overdose].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Liver Failure, Acute; Male; Middle Aged; Prescription Drug Misuse; Young Adult | 2012 |
An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Benzoquinones; Chemical and Drug Induced Liver Injury; Cohort Studies; Computer Simulation; Hepatocytes; Humans; Imines; Infusions, Intravenous; Liver; Prescription Drug Misuse; Risk Factors | 2012 |
Effects of treatment with enalapril on hepatotoxicity induced by acetaminophen in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Enalapril; Female; Glutathione; Male; Mice; Mice, Inbred C57BL | 2012 |
[The subclinical course of a paracetamol intoxication: pitfall for patient and clinician].
Topics: Acetaminophen; Acetylcysteine; Humans; Liver; Male; Poisoning; Time Factors; Young Adult | 2012 |
Paracetamol (acetaminophen) overdose and acetylcysteine administration: should the United Kingdom adopt a single '150-line'?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Practice Guidelines as Topic; Risk Assessment; Risk Factors; United Kingdom | 2012 |
Acute liver failure following cleft palate repair: a case of therapeutic acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cleft Palate; Humans; Infusions, Intravenous; Liver Failure, Acute | 2013 |
The Toxicology Investigators Consortium Case Registry--the 2011 experience.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Antidepressive Agents; Child; Child, Preschool; Databases, Factual; Drug Overdose; Emergency Service, Hospital; Female; Humans; Male; Middle Aged; Oxycodone; Prospective Studies; Psychotropic Drugs; Registries; Substance-Related Disorders; Young Adult | 2012 |
N-Acetyl cysteine and erdosteine treatment in acetaminophen-induced liver damage.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Antipyretics; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; International Normalized Ratio; Oxidants; Prothrombin Time; Rats; Rats, Wistar; Thioglycolates; Thiophenes | 2014 |
Acetaminophen/diphenhydramine overdose in profound hypothermia.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cholinergic Antagonists; Diphenhydramine; Drug Combinations; Drug Overdose; Female; Humans; Hypothermia; Infusions, Intravenous; Nonprescription Drugs; Rewarming; Treatment Outcome | 2013 |
Pediatric emergency medicine: legal briefs.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Appendicitis; Asthma; Child; Child, Preschool; Cystic Fibrosis; Diagnostic Errors; Drug Labeling; Drug Overdose; Emergencies; False Negative Reactions; Fatal Outcome; Female; Heart Rate, Fetal; Humans; Ibuprofen; Lymphoma, Non-Hodgkin; Male; Malpractice; Marfan Syndrome; Mediastinal Neoplasms; Medication Errors; Nuchal Cord; Patient Safety; Persistent Vegetative State; Pleurisy; Pregnancy; Respiratory Sounds; Social Media; Stevens-Johnson Syndrome; Suicide; Tomography, X-Ray Computed; Transportation of Patients; Unnecessary Procedures; Young Adult | 2012 |
Direct comparison of 20-hour IV, 36-hour oral, and 72-hour oral acetylcysteine for treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antidotes; Child; Drug Administration Schedule; Drug Overdose; Female; Humans; Injections, Intravenous; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult | 2013 |
Effect of N-acetylcysteine on pharmacokinetics of acetaminophen in piglets.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Female; Male; Swine | 2013 |
Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Australia; Body Weight; Drug Dosage Calculations; Emergency Service, Hospital; Female; Free Radical Scavengers; Humans; Male; Medication Errors; Poisoning; Retrospective Studies; Young Adult | 2013 |
Comparative evaluation of the effects of taurine and thiotaurine on alterations of the cellular redox status and activities of antioxidant and glutathione-related enzymes by acetaminophen in the rat.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; Glutathione Reductase; Glutathione Transferase; L-Lactate Dehydrogenase; Liver; Male; Malondialdehyde; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Taurine | 2013 |
The combination effects of acetaminophen and N-acetylcysteine on cytokines production and NF-κB activation of lipopolysaccharide-challenged piglet mononuclear phagocytes in vitro and in vivo.
Topics: Acetaminophen; Acetylcysteine; Animals; Cytokines; Drug Synergism; Female; Inflammation Mediators; Interleukin-10; Lipopolysaccharides; Male; Monocytes; Sus scrofa; Transcription Factor RelA | 2013 |
Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury.
Topics: Acetaminophen; Acetanilides; Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Mice; Mitochondria, Liver; Nitrates; Oxidative Stress; Proteins; Superoxide Dismutase | 2013 |
Treating acetaminophen overdose: thresholds, costs and uncertainties.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Cost-Benefit Analysis; Drug Overdose; Health Care Costs; Humans; Practice Guidelines as Topic | 2013 |
Dissemination and uptake of a new treatment pathway for paracetamol poisoning in the UK: a survey of healthcare professionals.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Delivery of Health Care; Government Regulation; Health Care Surveys; Health Knowledge, Attitudes, Practice; Health Personnel; Health Plan Implementation; Humans; Information Dissemination; Injections, Intravenous; Pilot Projects; Practice Guidelines as Topic; Surveys and Questionnaires; United Kingdom | 2013 |
The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Drug Overdose; Female; Hospitalization; Humans; Male; Middle Aged; Predictive Value of Tests; Prognosis; Young Adult | 2013 |
The effects of N-acetylcysteine and ozone therapy on oxidative stress and inflammation in acetaminophen-induced nephrotoxicity model.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Analgesics, Non-Narcotic; Animals; Drug Evaluation, Preclinical; Free Radical Scavengers; Kidney; Male; Nephritis; Oxidative Stress; Ozone; Random Allocation; Rats; Rats, Sprague-Dawley | 2013 |
Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Body Weight; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Liposomes; Liver; Male; Peroxidase; Rats; Rats, Sprague-Dawley | 2013 |
The relationship between N-acetylcysteine, hyperbaric oxygen, and inflammation in a rat model of acetaminophen-induced nephrotoxicity.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Creatinine; Free Radical Scavengers; Hyperbaric Oxygenation; Inflammation; Interleukin-6; Male; Neopterin; Oxygen; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Urea | 2013 |
Identification of patients at risk of anaphylactoid reactions to N-acetylcysteine in the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Hypersensitivity; Ethnicity; Female; Humans; Logistic Models; Male; Recurrence; Risk Factors; Young Adult | 2013 |
Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning: Reply.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Body Weight; Drug Dosage Calculations; Female; Free Radical Scavengers; Humans; Male; Medication Errors | 2013 |
Response to Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning: Reply.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Body Weight; Drug Dosage Calculations; Female; Free Radical Scavengers; Humans; Male; Medication Errors | 2013 |
Protective properties of 2-acetylcyclopentanone in a mouse model of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Hepatocytes; Injections, Intraperitoneal; Ketones; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Quantum Theory | 2013 |
Performance of a multi-disciplinary emergency department observation protocol for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Ambulatory Care; Cohort Studies; Drug Overdose; Emergency Service, Hospital; Emergency Services, Psychiatric; Female; Free Radical Scavengers; Hospitals, University; Humans; Infusions, Intravenous; Interdisciplinary Communication; Length of Stay; Male; Middle Aged; Retrospective Studies; Severity of Illness Index; Young Adult | 2013 |
How safe is acetaminophen?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Safety | 2013 |
Roles of lipoxin A4 in preventing paracetamol-induced acute hepatic injury in a rabbit model.
Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Chemical and Drug Induced Liver Injury; Hepatocytes; Inflammation; Interleukin-10; Lipoxins; Liver; Male; Rabbits; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2013 |
Anaphylactoid reactions to N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Hypersensitivity; Female; Humans; Male | 2013 |
Elevated acetaminophen concentration measured after nasal insufflation of Percocet®.
Topics: Acetaminophen; Acetylcysteine; Administration, Intranasal; Adult; Drug Combinations; Drug Overdose; Female; Free Radical Scavengers; Humans; Insufflation; Nose; Opioid-Related Disorders; Oxycodone | 2013 |
Acute overdose: suicide attempt.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Diphenhydramine; Drug Overdose; Education, Pharmacy; Electrocardiography; Female; Humans; Seizures; Suicide, Attempted | 2013 |
Incidence and management of N-acetylcysteine-related anaphylactoid reactions during the management of acute paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Drug Overdose; Female; Humans; Incidence; Male; Retrospective Studies | 2014 |
Missed paracetamol (acetaminophen) overdose due to confusion regarding drug names.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Delayed Diagnosis; Drug Overdose; Drug Packaging; Humans; Internet; Male; Terminology as Topic; Time Factors; Young Adult | 2013 |
Hyperbaric oxygen treatment and N-acetylcysteine ameliorate acetaminophen-induced liver injury in a rat model.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hyperbaric Oxygenation; Interleukin-6; Liver; Male; Neopterin; Protective Agents; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2013 |
Preclinical high-dose acetaminophen with N-acetylcysteine rescue enhances the efficacy of cisplatin chemotherapy in atypical teratoid rhabdoid tumors.
Topics: Acetaminophen; Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Cisplatin; Drug Evaluation, Preclinical; Glutathione; Humans; Membrane Potential, Mitochondrial; Rhabdoid Tumor | 2014 |
The epidemiology and management of adult poisonings admitted to the short-stay ward of a large Scottish emergency department.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antidotes; Central Nervous System Depressants; Charcoal; Drug Overdose; Emergency Service, Hospital; Ethanol; Female; Follow-Up Studies; Free Radical Scavengers; Hospitalization; Humans; Length of Stay; Male; Mental Disorders; Middle Aged; Naloxone; Narcotic Antagonists; Patient Admission; Patient Discharge; Public Health; Retrospective Studies; Scotland; Self-Injurious Behavior | 2013 |
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mitochondria | 2014 |
[Paracetamol overdose].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Nonprescription Drugs | 2013 |
MHRA recommendations on the use of intravenous acetylcysteine in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Child; Child, Preschool; Drug Overdose; Humans; Middle Aged; Practice Guidelines as Topic; Young Adult | 2014 |
Epidemiology, management and outcome of paracetamol poisoning in an inner city emergency department.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Disease Management; Drug Overdose; Emergency Service, Hospital; England; Female; Hospitals, Urban; Humans; Male; Outcome Assessment, Health Care; Prospective Studies; Wales | 2015 |
Antidote removal during haemodialysis for massive acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Coma; Drug Monitoring; Drug Overdose; Female; Free Radical Scavengers; Half-Life; Humans; Liver Failure; Male; Metabolic Clearance Rate; Middle Aged; Renal Dialysis; Young Adult | 2013 |
Reliability of the reported ingested dose for predicting the requirement of N-acetylcysteine in paracetamol overdose patients.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Male | 2013 |
Understanding probability and exposure in paracetamol overdose risk assessment.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Male | 2013 |
When is research clinical advice? Interpreting an exploratory study of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Male | 2013 |
Letter in response to Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Female; Humans; Male | 2013 |
Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Glycyrrhizic Acid; Hepatobiliary Elimination; Injections, Intraperitoneal; Liver; Male; Rats, Sprague-Dawley; Silybin; Silymarin; Spironolactone; Time Factors | 2014 |
Treatment of paracetamol overdose: room for improvement?
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Antiemetics; Female; Humans; Male; Ondansetron; Vomiting | 2014 |
New therapeutic approach: diphenyl diselenide reduces mitochondrial dysfunction in acetaminophen-induced acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Benzene Derivatives; Chemical and Drug Induced Liver Injury; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria; Organoselenium Compounds; Oxidative Stress; Protein Carbonylation; Reactive Oxygen Species | 2013 |
Evaluation of three-dimensional cultured HepG2 cells in a nano culture plate system: an in vitro human model of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Anthracenes; Cells, Cultured; Cyclosporine; Cytochrome P-450 CYP2E1; Drug Evaluation, Preclinical; Glutathione; Hep G2 Cells; Humans; Liver; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Nanotechnology; Toxicity Tests | 2014 |
Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Age Factors; Alanine Transaminase; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Chromatography, High Pressure Liquid; Discriminant Analysis; Female; Humans; Least-Squares Analysis; Male; Mass Spectrometry; Metabolomics; Sex Factors | 2014 |
Treatment with N-acetylcystein and total plasma exchange for extracorporeal liver support in children with paracetamol intoxication.
Topics: Acetaminophen; Acetylcysteine; Ammonia; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Hypothermia, Induced; Infant; Intensive Care Units, Pediatric; Liver Failure, Acute; Liver Function Tests; Plasma; Plasma Exchange; Respiratory Tract Infections | 2014 |
Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Child; Child, Preschool; Female; Health Care Costs; Hospitalization; Humans; Infant; Male; Middle Aged; Practice Guidelines as Topic; Prospective Studies; Risk Assessment; United Kingdom; Young Adult | 2014 |
Four-hour acetaminophen concentration estimation after ingested dose based on pharmacokinetic models.
Topics: Acetaminophen; Acetylcysteine; Adult; Age Factors; Antidotes; Child; Drug Overdose; Humans; Models, Biological; Referral and Consultation; Time Factors; Tissue Distribution; United Kingdom | 2014 |
Paracetamol toxicity: what would be the implications of a change in Australian treatment guidelines?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Costs and Cost Analysis; Drug Overdose; Emergency Service, Hospital; Free Radical Scavengers; Health Care Costs; Hospitalization; Humans; Practice Guidelines as Topic; Retrospective Studies; Victoria | 2014 |
Treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Antiemetics; Female; Humans; Male; Ondansetron; Vomiting | 2014 |
Treatment of paracetamol overdose--authors' reply.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Antiemetics; Female; Humans; Male; Ondansetron; Vomiting | 2014 |
Acetaminophen Psi Nomogram: a sensitive and specific clinical tool to predict hepatotoxicity secondary to acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Nomograms; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Sensitivity and Specificity; Thailand | 2014 |
Predicting acute acetaminophen hepatotoxicity with acetaminophen-aminotransferase multiplication product and the Psi parameter.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Likelihood Functions; Male; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Thailand; Time Factors; Young Adult | 2014 |
Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Cell Death; Enzyme Activation; Female; Glutathione; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Mitochondria, Liver; Mitochondrial Diseases; Necrosis; Primary Cell Culture; Proteins; Subcellular Fractions; Young Adult | 2014 |
Overdose with modified-release paracetamol (Panadol Osteo®) presenting to a metropolitan emergency medicine network: a case series.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Child; Clinical Audit; Delivery of Health Care; Drug Overdose; Emergency Medical Services; Female; Guideline Adherence; Humans; Male; Middle Aged; Practice Guidelines as Topic; Retrospective Studies; Time Factors; Young Adult | 2014 |
Damage induced by paracetamol compared with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Rats; Rats, Wistar; Thiamine Pyrophosphate | 2014 |
Early predictors of severe acetaminophen-induced hepatotoxicity in a paediatric population referred to a tertiary paediatric department.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Chemical and Drug Induced Liver Injury; Child; Dose-Response Relationship, Drug; Female; Hospital Departments; Humans; Male; Pediatrics; Referral and Consultation; Retrospective Studies; Severity of Illness Index; Suicide, Attempted; Tertiary Care Centers; Time Factors | 2014 |
Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Hepatitis; Humans; Ischemia; MicroRNAs; Poisoning; Real-Time Polymerase Chain Reaction | 2014 |
Use of anion gap in the evaluation of a patient with metabolic acidosis.
Topics: Acetaminophen; Acetylcysteine; Acid-Base Equilibrium; Acidosis; Aged, 80 and over; Bicarbonates; Confusion; Drug Substitution; Female; Free Radical Scavengers; Humans; Pyrrolidonecarboxylic Acid; Serum Albumin; Treatment Outcome | 2014 |
Pharmacologic cholinesterase inhibition improves survival in acetaminophen-induced acute liver failure in the mouse.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Disease Models, Animal; Free Radical Scavengers; Interleukin-1beta; Lactate Dehydrogenases; Liver; Liver Failure, Acute; Mice; Mice, Inbred BALB C; Neostigmine; Tumor Necrosis Factor-alpha | 2014 |
Acetaminophen-induced liver injury in a woman with febrile flare of systemic lupus erythematosus.
Topics: Acetaminophen; Acetylcysteine; Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; Fever; Glucocorticoids; Humans; Liver; Lupus Erythematosus, Systemic; Prednisone; Treatment Outcome | 2014 |
Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Overdose; Free Radical Scavengers; Humans; Lipid Peroxidation; Liver Neoplasms; Mitochondria, Liver; Oxidative Stress; Reactive Oxygen Species | 2015 |
Reported ingested dose of paracetamol as a predictor of risk following paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Male; Risk; Self Report; Young Adult | 2014 |
When to treat paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Free Radical Scavengers; Humans; Nomograms | 2014 |
Attenuation of copaiba oil in hepatic damage in rats.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Corn Oil; Disease Models, Animal; Fabaceae; gamma-Glutamyltransferase; Male; Plant Oils; Random Allocation; Rats, Wistar; Treatment Outcome | 2014 |
Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Glutathione; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Plant Extracts; Schisandra; Signal Transduction; Tablets | 2015 |
Reply: To PMID 24930458.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Free Radical Scavengers; Humans; Nomograms | 2014 |
The anti-inflammatory effects of acetaminophen and N-acetylcysteine through suppression of the NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes.
Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents; Carrier Proteins; Caspase 1; Cells, Cultured; Drug Combinations; Drug Synergism; Gene Expression Regulation; Inflammasomes; Interleukin-18; Interleukin-1beta; Leukocytes, Mononuclear; Lipopolysaccharides; Mononuclear Phagocyte System; Swine | 2015 |
N-Acetylcysteine (NAC)-Induced Hyponatremia Caused by an Electronic Medical Record (EMR) Order Error.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Biomarkers; Electronic Health Records; Epilepsy, Tonic-Clonic; Female; Humans; Hyponatremia; Infant; Infusions, Intravenous; Medical Order Entry Systems; Medication Errors; Poisoning; Risk Factors; Sodium; Time Factors | 2015 |
Can AST/ALT ratio indicate recovery after acute paracetamol poisoning?
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Humans; Predictive Value of Tests; Recovery of Function; Retrospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome | 2015 |
Paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Practice Guidelines as Topic; Time Factors | 2015 |
Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acrolein; Animals; Blotting, Western; Cell Culture Techniques; Chemical and Drug Induced Liver Injury; Drug Overdose; Liver; Mesna; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
An accidental overdose of N-acetylcysteine during treatment for acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Body Weight; Drug Dosage Calculations; Drug Overdose; Female; Humans; Infusions, Intravenous; Medication Errors; Suicide, Attempted; Young Adult | 2015 |
Acetaminophen concentrations prior to 4 hours of ingestion: impact on diagnostic decision-making and treatment.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Child; Decision Making; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Retrospective Studies; Toxicity Tests, Acute; Young Adult | 2015 |
Case Files from the University of California San Diego Health System Fellowship Coma and Severe Acidosis: Remember to Consider Acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Antidotes; Biomarkers; Coma; Drug Overdose; Humans; Infusions, Intravenous; Male; Poisoning; Predictive Value of Tests; Risk Factors; Severity of Illness Index; Treatment Outcome | 2015 |
External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Databases, Factual; Decision Support Techniques; Drug Overdose; Female; Hospitals, Teaching; Humans; Likelihood Functions; Male; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; United Kingdom | 2015 |
Changing the Management of Paracetamol Poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Antiemetics; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Protocols; Free Radical Scavengers; HMGB1 Protein; Humans; MicroRNAs; Ondansetron; Vomiting | 2015 |
Co-administration of N-Acetylcysteine and Acetaminophen Efficiently Blocks Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Combinations; Gene Expression Regulation, Enzymologic; Male; Mice; Transaminases | 2015 |
A descriptive analysis of aspartate and alanine aminotransferase rise and fall following acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Decision Support Techniques; Drug Overdose; Female; Humans; Kaplan-Meier Estimate; Liver Transplantation; Male; Middle Aged; Models, Biological; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Young Adult | 2015 |
Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Area Under Curve; Aspartate Aminotransferases; Biomarkers; Blood Coagulation; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Drug Overdose; Female; Humans; Male; Predictive Value of Tests; Prothrombin Time; Reproducibility of Results; Retrospective Studies; Risk Assessment; Risk Factors; ROC Curve; Young Adult | 2016 |
Global research productivity of N-acetylcysteine use in paracetamol overdose: A bibliometric analysis (1976-2012).
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Bibliometrics; Biomedical Research; Drug Overdose; Humans; Publishing | 2015 |
Biochemical and Histological Effects of Thiamine Pyrophosphate against Acetaminophen-Induced Hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Glutathione; Liver; Liver Function Tests; Malondialdehyde; Nitric Oxide; Oxidative Stress; Peroxidase; Rats, Wistar; Thiamine Pyrophosphate | 2016 |
Is montelukast as effective as N-acetylcysteine in hepatic injury due to acetaminophen intoxication in rats?
Topics: Acetaminophen; Acetates; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclopropanes; Cytochrome P-450 CYP1A2 Inducers; Disease Models, Animal; Free Radical Scavengers; Male; Quinolines; Rats; Rats, Wistar; Sulfides | 2016 |
The pharmacokinetics and extracorporeal removal of N-acetylcysteine during renal replacement therapies.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Half-Life; Hemofiltration; Humans; Infusions, Intravenous; Prospective Studies; Renal Dialysis; Tissue Distribution | 2015 |
N-acetylcysteine interference of Trinder-based assays.
Topics: Acetaminophen; Acetylcysteine; Ferric Compounds; Humans; Poisoning; Retrospective Studies | 2016 |
Galangin Prevents Acute Hepatorenal Toxicity in Novel Propacetamol-Induced Acetaminophen-Overdosed Mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Alpinia; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Disease Models, Animal; Flavonoids; Glutathione; Helichrysum; Liver; Male; Mice, Inbred BALB C; Oxidative Stress; Phytotherapy; Plant Extracts; Protective Agents; Silymarin | 2015 |
Paracetamol overdose: relevance of recent evidence for managing patients in Sri Lanka.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Disease Management; Drug Overdose; Free Radical Scavengers; Humans; Sri Lanka | 2015 |
Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Prothrombin Time | 2016 |
Nomogram line crossing after acetaminophen combination product overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Antidotes; Chemical and Drug Induced Liver Injury; Child; Decision Support Techniques; Drug Combinations; Drug Overdose; Female; Histamine Antagonists; Humans; Male; Middle Aged; Nomograms; Poison Control Centers; Predictive Value of Tests; Prospective Studies; Risk Assessment; Risk Factors; Treatment Outcome; Young Adult | 2016 |
In Response to: "Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Prothrombin Time | 2016 |
Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Anaphylaxis; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Retrospective Studies; Young Adult | 2016 |
N-acetylcysteine amide, a promising antidote for acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Antioxidants; Chemical and Drug Induced Liver Injury; Glutamate Dehydrogenase; Glutathione; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Oxidative Stress; Survival Analysis | 2016 |
New regimens for intravenous acetylcysteine, where are we now?
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antiemetics; Drug Overdose; Endpoint Determination; Humans; Randomized Controlled Trials as Topic | 2016 |
A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Hospitalization; Humans; Liver; Male; Middle Aged; Prospective Studies; Young Adult | 2016 |
Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Biomarkers; Biotransformation; Chemical and Drug Induced Liver Injury; Energy Metabolism; Eosinophilia; Glutathione; Isomerism; Liver; Magnetic Resonance Imaging; Male; Metabolomics; Mice, Inbred C57BL; Necrosis; Oxidative Stress; Specific Pathogen-Free Organisms; Tissue Distribution | 2016 |
N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice.
Topics: Acetaminophen; Acetylcysteine; Age Factors; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Free Radical Scavengers; Male; Mice; Mice, Inbred C57BL; Random Allocation | 2016 |
How to treat paracetamol overdose and when to do it.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2016 |
Outcomes of Patients With Premature Discontinuation of the 21-h Intravenous N-Acetylcysteine Protocol After Acute Acetaminophen Overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Female; Humans; Male; Retrospective Studies; Treatment Outcome | 2016 |
Paracetamol-induced nephrotoxicity and oxidative stress in rats: the protective role of Nigella sativa.
Topics: Acetaminophen; Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Creatinine; Cytoprotection; Disease Models, Animal; Ethanol; Female; Glutathione; Kidney; Kidney Diseases; Malondialdehyde; Nigella sativa; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Wistar; Seeds; Solvents; Superoxide Dismutase; Urea | 2016 |
ACMT Position Statement: Duration of Intravenous Acetylcysteine Therapy Following Acetaminophen Overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antioxidants; Clinical Decision-Making; Drug Administration Schedule; Drug Overdose; Humans; Infusions, Intravenous; Toxicology; Treatment Outcome | 2017 |
Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Alanine Transaminase; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Hospitalization; Humans; Male; Nomograms; Retrospective Studies; Risk Factors; United Kingdom | 2016 |
Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adolescent; Coma; Drug Overdose; Emergency Service, Hospital; Ethanol; Female; Half-Life; Humans; Ibuprofen; Lactic Acid; Liver; Renal Dialysis | 2016 |
Treatments for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Drug Overdose; Female; Humans; Methionine; Time Factors; Young Adult | 2016 |
N-acetylcysteine regimens for paracetamol overdose: Time for a change?
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Drug Administration Schedule; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Incidence | 2016 |
[Paracetamol 665 mg has caused several cases of difficult-to-treat poisoning – New treatment recommendations to prevent liver damage].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Humans; Practice Guidelines as Topic | 2016 |
Guidance on acetylcysteine for paracetamol ingestion needs review.
Topics: Acetaminophen; Acetylcysteine; Analgesics; Antidotes; Drug Overdose; Health Services Needs and Demand; Humans; Practice Guidelines as Topic; United Kingdom | 2016 |
Authors' reply to Thomas and colleagues.
Topics: Acetaminophen; Acetylcysteine; Analgesics; Antidotes; Dissent and Disputes; Drug Overdose; Humans; Practice Guidelines as Topic | 2016 |
Delays during the administration of acetylcysteine for the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Antidotes; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Medication Errors; Retrospective Studies; Time Factors; Young Adult | 2016 |
Double-peaked Acetaminophen Concentration Secondary to Intestinal Trauma.
Topics: Acetaminophen; Acetylcysteine; Adult; Ethanol; Female; Humans; Intestines; Period Circadian Proteins; Wounds, Stab; Xenopus Proteins | 2016 |
Incidence and characterization of acute kidney injury after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Biomarkers; Creatinine; Drug Overdose; Female; Humans; Incidence; Intensive Care Units; Liver Diseases; Male; Middle Aged; Retrospective Studies | 2016 |
[A Case of Acetaminophen Poisoning Associated with Tramcet Overdose].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Drug Overdose; Female; Humans; Tramadol; Treatment Outcome | 2016 |
An assessment of the variation in the concentration of acetylcysteine in infusions for the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chromatography, High Pressure Liquid; Drug Overdose; Hospitals, Teaching; Humans; Infusions, Intravenous; Prospective Studies; United Kingdom | 2017 |
A Novel Oral Formulation of N-Acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemistry, Pharmaceutical; Humans | 2016 |
Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Endoplasmic Reticulum Stress; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Taurochenodeoxycholic Acid; Unfolded Protein Response | 2017 |
Characterisation and outcomes of adult patients with paracetamol overdose presenting to a tertiary hospital in Singapore.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Anaphylaxis; Drug Overdose; Female; Humans; Liver; Liver Failure, Acute; Liver Transplantation; Male; Middle Aged; Retrospective Studies; Singapore; Suicide, Attempted; Tertiary Care Centers; Treatment Outcome; Young Adult | 2017 |
Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antiemetics; Area Under Curve; Biomarkers; Chemical and Drug Induced Liver Injury; Cohort Studies; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Overdose; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Ondansetron; Reproducibility of Results; ROC Curve; Toxicokinetics; Young Adult | 2017 |
Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine?
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Female; Humans; Male; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity; Time Factors; Young Adult | 2017 |
[Overdose of modified-release paracetamol calls for changed treatment routines. New guidelines from the Swedish Poisons Information Centre].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Delayed-Action Preparations; Drug Overdose; Humans; Male; Poison Control Centers; Practice Guidelines as Topic; Sweden | 2016 |
Outcomes from massive paracetamol overdose: a retrospective observational study.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Biomarkers; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Creatinine; Drug Overdose; Female; Humans; Male; Prevalence; Retrospective Studies; Treatment Outcome; Young Adult | 2017 |
Lack of respiratory depression in paracetamol-codeine combination overdoses.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Child; Codeine; Critical Care; Drug Combinations; Drug Overdose; Female; Glasgow Coma Scale; Humans; Length of Stay; Male; Middle Aged; Naloxone; Narcotic Antagonists; Respiration, Artificial; Respiratory Insufficiency; Retrospective Studies; Suicide, Attempted; Treatment Outcome; Young Adult | 2017 |
Haemodialysis in acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Fluid Therapy; Free Radical Scavengers; Humans; Renal Dialysis; Young Adult | 2017 |
Effect of N-Acetylcysteine on Mortality and Liver Transplantation Rate in Non-Acetaminophen-Induced Acute Liver Failure: A Multicenter Study.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Cohort Studies; Female; Hospitalization; Humans; Length of Stay; Liver Failure, Acute; Liver Transplantation; Male; Middle Aged; Mortality; Prospective Studies; Young Adult | 2017 |
Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Gene Expression Regulation; Glutathione; Hepatocytes; Imines; Male; Primary Cell Culture; Protein Stability; Proteolysis; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2017 |
Limitations of the evidence supporting use of undetectable acetaminophen levels obtained <4 hours post-ingestion to rule out toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2017 |
Reply to: Limitations of the evidence supporting use of undetectable acetaminophen levels obtained <4 hours post-ingestion to rule out toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2017 |
Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Male; Middle Aged; Retrospective Studies; Sensitivity and Specificity; Young Adult | 2017 |
[EFFECT OF ACETYLCYSTEINE, CORVITIN AND THEIR COMBINATION ON THE FUNCTIONAL STATE OF LIVER IN RATS WITH PARACETAMOL INDUCED TOXIC HEPATITIS].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Flavonoids; Liver; Male; Protective Agents; Rats, Wistar | 2017 |
When two is not better than one.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2017 |
Acetylcysteine (Cetylev) for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Compounding; Drug Overdose; Humans; Tablets; Treatment Outcome | 2017 |
Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Computer Simulation; Drug Overdose; Humans; Infusions, Intravenous; Models, Biological | 2017 |
Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2).
Topics: Acetaminophen; Acetylcysteine; Adult; Australia; Charcoal; Chemical and Drug Induced Liver Injury; Databases, Factual; Dose-Response Relationship, Drug; Drug Overdose; Early Medical Intervention; Female; Humans; Male; Poison Control Centers; Prospective Studies; Retrospective Studies; Treatment Outcome | 2017 |
Evaluation of a Food and Drug Administration Mandate to Limit Acetaminophen in Prescription Combination Products.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug and Narcotic Control; Drug Approval; Drug Combinations; Drug Compounding; Drug Overdose; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Poison Control Centers; Policy Making; Pregnancy; Prescription Drugs; Program Evaluation; Protective Factors; Risk Factors; Time Factors; United States; United States Food and Drug Administration; Young Adult | 2017 |
Discovery and structure-activity relationship of auriculatone: A potent hepatoprotective agent against acetaminophen-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Binding Sites; Cell Line; Cell Survival; Cytochrome P-450 CYP3A; Glutathione; Humans; Liver; Molecular Docking Simulation; Oleanolic Acid; Protective Agents; Protein Structure, Tertiary; Structure-Activity Relationship | 2017 |
Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bilirubin; Biomarkers; Cell Survival; Chemical and Drug Induced Liver Injury; Glutathione; HMGB1 Protein; Liver; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Photoacoustic Techniques | 2017 |
Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Diseases; Male; Middle Aged; Retrospective Studies; Risk Factors; Young Adult | 2018 |
Analysis of an 8-hour acetylcysteine infusion protocol for repeated supratherapeutic ingestion (RSTI) of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Middle Aged; Prospective Studies; Retrospective Studies | 2018 |
A comment on 'An assessment of the variation in the concentrations of acetylcysteine in infusions for the treatment of paracetamol overdose'.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans | 2017 |
Laundry Blues: a case of methemoglobinemia with laundry detergent and Tylenol ingestion.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Bipolar Disorder; Brain Diseases; Detergents; Female; Ferrocyanides; Free Radical Scavengers; Humans; Indoles; Methemoglobinemia; Methylene Blue; Respiration, Artificial; Respiratory Insufficiency; Suicide, Attempted; Treatment Outcome; Young Adult | 2017 |
A 10-fold bolus dose of N-acetylcysteine with fatal consequences.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Drug Dosage Calculations; Fatal Outcome; Female; Humans; Infusions, Intravenous; Medication Errors | 2018 |
Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Glutamate Dehydrogenase; HMGB1 Protein; Humans; Keratin-18; Male; MicroRNAs; Middle Aged; Prospective Studies; Risk Assessment; Young Adult | 2018 |
Being overweight or obese as a risk factor for acute liver injury secondary to acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Body Mass Index; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Obesity; Retrospective Studies; Risk Assessment; Risk Factors; Thailand; Young Adult | 2018 |
In response to: "Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning".
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2018 |
Intravenous
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Education, Nursing, Continuing; Humans; United States | 2017 |
Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Male; Middle Aged | 2018 |
[N-acetylcysteine : effective treatment in severe alcoholic hepatitis ?]
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antiviral Agents; Drug Overdose; Hepatitis, Alcoholic; Humans; Liver Failure, Acute | 2018 |
Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Canada; Cohort Studies; Drug Overdose; Female; Histamine Antagonists; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Sex Factors; Treatment Outcome; Young Adult | 2018 |
Bet 1: A slower rate of initial N-acetylcysteine infusion in the treatment of acute paracetamol overdose to reduce adverse reactions.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2018 |
Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Cystic Fibrosis; Drug Overdose; Female; Humans; MicroRNAs; Retrospective Studies; Risk Factors; Treatment Outcome; Young Adult | 2018 |
Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice.
Topics: Acetaminophen; Acetylcysteine; Acute Lung Injury; Animals; Apoptosis; Cytochrome P-450 CYP2E1; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Glucuronosyltransferase; Inflammation; Kaempferols; Male; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oxidative Stress; Superoxide Dismutase | 2018 |
In response to: fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2018 |
Retrospective study of paracetamol poisoning in children aged zero to six years found no cases of liver injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Child, Preschool; Denmark; Female; Humans; Incidence; Infant; Male; Retrospective Studies | 2018 |
Molecular Adsorbent Recirculating System Treatment Can Reduce Blood Levels of N-Acetylcysteine in Patients With Acetaminophen Overdose: Case Reports.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Free Radical Scavengers; Humans; Male; Sorption Detoxification | 2018 |
Calculated decisions: King's College Criteria for Acetaminophen Toxicity
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Biomarkers; Decision Making; Humans; Liver Failure, Acute; Liver Transplantation; Prognosis; Sensitivity and Specificity; Time Factors | 2018 |
Calculated decisions: Acetaminophen Overdose and N-Acetylcysteine (NAC) Dosing
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Decision Making; Drug Overdose; Humans; Time Factors | 2018 |
Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anticholesteremic Agents; Bile Acids and Salts; Cholestyramine Resin; Cysteine; Free Radical Scavengers; Glutathione; Hepatocytes; Homeostasis; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2018 |
Fewer adverse effects associated with a modified two-bag intravenous acetylcysteine protocol compared to traditional three-bag regimen in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Child; Child, Preschool; Denmark; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Infant; Male; Middle Aged; Practice Guidelines as Topic; Young Adult | 2018 |
Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Drug Overdose; Female; Humans; Suicide, Attempted; Tablets; Treatment Outcome; Young Adult | 2018 |
N,N'-Bis(2-mercaptoethyl)isophthalamide Binds Electrophilic Paracetamol Metabolites and Prevents Paracetamol-Induced Liver Toxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; Benzene Derivatives; Benzoquinones; Chelating Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Imines; Mice; Sulfhydryl Compounds | 2018 |
Performance evaluation of five commercial assays for detection of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Bilirubin; Hemolysis; Humans; Immunoenzyme Techniques; Linear Models; Reproducibility of Results; Sensitivity and Specificity | 2019 |
Toxic Ingestion of Acetaminophen and Acetylsalicylic Acid in a Parturient at 33 Weeks Gestation: A Case Report.
Topics: Acetaminophen; Acetylcysteine; Adult; Aspirin; Cesarean Section; Charcoal; Drug Overdose; Female; Fetal Heart; Humans; Point-of-Care Systems; Pregnancy; Pregnancy Trimester, Third; Suicide, Attempted; Thrombelastography | 2019 |
Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspase 3; Chemical and Drug Induced Liver Injury; Hepatocytes; Male; Mice, Inbred C57BL; Necrosis; Organophosphorus Compounds; Piperidines; Receptor-Interacting Protein Serine-Threonine Kinases | 2019 |
An evaluation of the role of mixing techniques in the observed variation in acetylcysteine infusion concentrations.
Topics: Acetaminophen; Acetylcysteine; Dose-Response Relationship, Drug; Drug Compounding; Drug Dosage Calculations; Drug Overdose; Humans; Infusion Pumps; Infusions, Intravenous | 2019 |
Victims of chemical terrorism, a family of four who were exposed to sulfur mustard.
Topics: Acetaminophen; Acetylcysteine; Administration, Cutaneous; Administration, Inhalation; Adult; Albuterol; Asian People; Chemical Terrorism; Child, Preschool; Cyclopentolate; Female; Gentamicins; Humans; Infant, Newborn; Lidocaine; Male; Methylprednisolone; Mustard Gas; Silver Sulfadiazine; Skin; Syria; Terrorism; Turkey | 2019 |
Effects of hydrogen sulfide on acetaminophen-induced acute renal toxicity in rats.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Acute-Phase Proteins; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Adhesion Molecules; Free Radical Scavengers; Hydrogen Sulfide; Kidney Tubules; Lipocalin-2; Lipocalins; Male; Oxidative Stress; Proto-Oncogene Proteins; Rats; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2019 |
Transition to two-bag intravenous acetylcysteine for acetaminophen overdose: a poison center's experience.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Clinical Protocols; Drug Overdose; Drug Packaging; Humans; Infusions, Intravenous | 2019 |
Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Canada; Chemical and Drug Induced Liver Injury; Clinical Decision-Making; Databases, Factual; Decision Support Techniques; Drug Overdose; Female; Hospitalization; Humans; Male; Nomograms; Patient Selection; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Time-to-Treatment; Young Adult | 2019 |
Using the 150 rule to prevent hepatotoxicity from acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Diagnosis, Differential; Disease Progression; Drug Overdose; Female; Humans; Liver Failure, Acute | 2019 |
Haemodiafiltration as an effective treatment option for massive paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Aged, 80 and over; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Hemodiafiltration; Humans; Suicide, Attempted; Treatment Outcome | 2019 |
NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Epigenesis, Genetic; Hep G2 Cells; Humans; Liver Failure, Acute; Mice; Mice, Knockout; Orphan Nuclear Receptors; RNA, Long Noncoding; Signal Transduction; Tumor Suppressor Protein p53 | 2019 |
Acute acetaminophene-induced hepatotoxicity and nephrotoxicity; therapeutic effect of dexmedetomidine.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dexmedetomidine; Glutathione; Liver; Oxidative Stress; Rats | 2019 |
Comment on "What is the most appropriate dose of N acetylcysteine after massive acetaminophen overdose?" by Hendrickson et al.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2020 |
Letter in response to: "Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: stud
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Edetic Acid; Humans; Pyridoxal Phosphate; Research Design | 2019 |
An Under-Recognised Cause of Iatrogenic, Severe Metabolic Acidosis
Topics: Acetaminophen; Acetylcysteine; Acidosis; Aged, 80 and over; Anti-Bacterial Agents; Antipyretics; Arthroplasty, Replacement, Hip; Blood Gas Analysis; Drug Interactions; Floxacillin; Hip Prosthesis; Humans; Iatrogenic Disease; Male; Prosthesis-Related Infections; Pyrrolidonecarboxylic Acid; Renal Insufficiency, Chronic; Renal Replacement Therapy; Severity of Illness Index; Sodium Bicarbonate; Staphylococcal Infections; Surgical Wound Infection | 2019 |
[Improved and harmonised laboratory analysis of paracetamol provides safer assessment of poisoning cases].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Clinical Laboratory Services; Drug Overdose; Humans; Poisoning; Practice Guidelines as Topic; Sweden; Time Factors | 2019 |
LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cysteine; Edema; Exanthema; Glutathione; Humans; Imines; Male; Protein Binding; Serum Albumin; Skin Diseases; Tandem Mass Spectrometry | 2019 |
Comment on "Transition to two-bag intravenous acetylcysteine for acetaminophen overdose".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Poisons | 2020 |
Protocol deviations in intravenous acetylcysteine therapy for acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Clinical Protocols; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult | 2020 |
Gastrointestinal AEs seen in the POP trial due to SOD mimetic activity of calmangafodipir?
Topics: Acetaminophen; Acetylcysteine; Edetic Acid; Humans; Pyridoxal Phosphate; Superoxide Dismutase | 2019 |
Gastrointestinal AEs seen in the POP trial due to SOD mimetic activity of calmangafodipir? - Authors' reply.
Topics: Acetaminophen; Acetylcysteine; Edetic Acid; Humans; Pyridoxal Phosphate; Superoxide Dismutase | 2019 |
Electronic intravenous N-acetyl cysteine ordering tool: A retrospective review.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Electronics; Humans; Retrospective Studies | 2020 |
Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL.
Topics: Acetaminophen; Acetylcysteine; Animals; Apoptosis; Cell Line; Chemical and Drug Induced Liver Injury; Cytokines; Hepatocytes; Humans; Inflammation; Leukocytes; Liver; Liver Failure; Male; Mice; Mice, Inbred C57BL; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand | 2020 |
[Simplified N-acetylcystein treatment after paracetamol overdose - new recommendations from Swedish Poisons Information Centre].
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Drug Overdose; Humans; Poison Control Centers; Poisoning; Practice Guidelines as Topic | 2019 |
Fomepizole as an Adjunctive Treatment in Severe Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Humans; Male; Treatment Outcome | 2020 |
Use of fomepizole, n-acetylcysteine, and hemodialysis for massive acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Fomepizole; Free Radical Scavengers; Humans; Male; Middle Aged; Renal Dialysis | 2020 |
Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Free Radical Scavengers; Glycine; Inflammation; Male; Mice; Mice, Inbred C57BL; Serine Proteinase Inhibitors; Sulfonamides | 2020 |
Adducts Post Acetaminophen Overdose Treated with a 12-Hour vs 20-Hour Acetylcysteine Infusion.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Controlled Clinical Trials as Topic; Drug Overdose; Female; Humans; Infusions, Parenteral; Liver Function Tests; Male; Protein Binding; Time Factors; Treatment Outcome; Young Adult | 2020 |
Elevated procalcitonin levels in patients with acetaminophen intoxication: two case reports: A CARE-compliant article.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aspartate Aminotransferases; C-Reactive Protein; Drug Overdose; Emergency Service, Hospital; Female; Humans; Male; Middle Aged; Procalcitonin; Treatment Outcome; Young Adult | 2020 |
Truncated IV acetylcysteine treatment duration has potential to safely preserve resources during the COVID-19 pandemic.
Topics: Acetaminophen; Acetylcysteine; COVID-19; Duration of Therapy; Humans; Pandemics; SARS-CoV-2 | 2021 |
Delayed peaks of acetaminophen in overdose patients with concomitant abdominal trauma.
Topics: Abdominal Injuries; Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Fatal Outcome; Female; Humans; Suicide, Attempted; Treatment Outcome; Wounds, Nonpenetrating; Wounds, Stab | 2021 |
Increased Intravenous N-Acetylcysteine Dosing Following Massive Acetaminophen Ingestion: A Case Report.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Drug Administration Schedule; Female; Humans; Liver Function Tests; Suicide, Attempted; Young Adult | 2020 |
Improvement of therapeutic potential N-acetylcysteine in acetaminophen hepatotoxicity by encapsulation in PEGylated nano-niosomes.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Delivery Systems; Liposomes; Male; Nanoparticles; Particle Size; Polyethylene Glycols; Rats; Rats, Wistar; Surface-Active Agents | 2020 |
First case of focal epilepsy associated with SARS-coronavirus-2.
Topics: Acetaminophen; Acetylcysteine; Aged; Ambroxol; Anticonvulsants; Cough; COVID-19; COVID-19 Drug Treatment; Dipyrone; Epilepsies, Partial; Female; Fever; Humans; Nasopharynx; Radiography, Abdominal; SARS-CoV-2; Treatment Outcome | 2020 |
Fomepizole as an adjunctive treatment in severe acetaminophen ingestions: a case series.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug Therapy, Combination; Female; Fomepizole; Humans; Middle Aged; Treatment Outcome | 2021 |
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Colitis, Ischemic; Colorimetry; Dimensional Measurement Accuracy; False Positive Reactions; Free Radical Scavengers; Humans; Hyperbilirubinemia; Liver Failure; Liver Function Tests; Male; Middle Aged; Reproducibility of Results | 2020 |
Late Diagnosis of Paracetamol Poisoning is Always Lethal in Young Adult.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Delayed Diagnosis; Humans; Male; Young Adult | 2020 |
The changing face of paracetamol toxicity and new regimens for an old antidote acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans | 2021 |
A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Hypersensitivity; Drug Overdose; Female; Histamine Antagonists; Humans; Infusions, Intravenous; Severity of Illness Index; Time Factors; Treatment Outcome | 2021 |
Clinical Progress Note: Goal-Directed N-acetylcysteine Treatment of Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Goals; Humans; Motivation | 2021 |
The potential protective role of folic acid against acetaminophen-induced hepatotoxicity and nephrotoxicity in rats.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Folic Acid; Free Radical Scavengers; Oxidative Stress; Rats, Sprague-Dawley | 2021 |
Comparison of ameliorative effects of Taraxacum syriacum and N-acetylcysteine against acetaminophen-induced oxidative stress in rat liver and kidney.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Ethanol; Free Radical Scavengers; Glutathione; Humans; Kidney; Lipid Peroxidation; Liver; Male; Malondialdehyde; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase; Taraxacum | 2021 |
Short-Term Cohousing of Sick with Healthy or Treated Mice Alleviates the Inflammatory Response and Liver Damage.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Concanavalin A; Coprophagia; Dexamethasone; Ecosystem; Gastrointestinal Microbiome; Hepatitis, Autoimmune; Housing, Animal; Male; Mice; Mice, Inbred C57BL; Treatment Outcome | 2021 |
A Mysteriously Low Creatinine Concentration.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Creatinine; Drug Overdose; Female; Humans | 2020 |
Comment on "The changing face of paracetamol toxicity and new regimens for an old antidote acetylcysteine".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans | 2021 |
N-acetylcysteine for acetaminophen toxicity: The one-bag regimen.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Humans | 2021 |
Boldine treatment protects acetaminophen-induced liver inflammation and acute hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Animals; Aporphines; Chemical and Drug Induced Liver Injury; Cytokines; Gene Expression Regulation; Liver; Male; Mice; Necrosis | 2021 |
N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Drug Synergism; Drug Therapy, Combination; Hot Temperature; Male; Pain; Rats, Sprague-Dawley | 2021 |
N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental transfer - a case report.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Brain Diseases; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy; Risk Factors; Treatment Outcome | 2021 |
The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Liver; Mice | 2021 |
Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Poison Control Centers; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Young Adult | 2021 |
The
Topics: Acetaminophen; Acetylcysteine; Benzoquinones; COVID-19 Drug Treatment; Humans; Hydrogen; Imines; Vitamin K; Vitamin K Epoxide Reductases | 2022 |
Can granulocyte colony stimulating factor (G-CSF) ameliorate acetaminophen-induced hepatotoxicity?
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Gene Expression Regulation; Granulocyte Colony-Stimulating Factor; L-Lactate Dehydrogenase; Malondialdehyde; Nitric Oxide; Rats; Rats, Wistar | 2021 |
Evaluation of Dosing Strategies of N-acetylcysteine for Acetaminophen Toxicity in Patients Greater than 100 Kilograms: Should the Dosage Cap Be Used?
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Obesity; Retrospective Studies | 2021 |
Establishing a 3D In Vitro Hepatic Model Mimicking Physiologically Relevant to In Vivo State.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Biomimetics; Bioprinting; Cell Proliferation; Free Radical Scavengers; Hep G2 Cells; Humans; Hydrogels; In Vitro Techniques; Liver; Models, Biological; Printing, Three-Dimensional; Tissue Engineering; Tissue Scaffolds; Toxicity Tests | 2021 |
Intravenous Acetaminophen Overdose in an Infant With Toxicokinetic Data.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Infant; Male; Retrospective Studies; Toxicokinetics | 2023 |
[Unusual cause of a PCT-elevation].
Topics: Abdominal Pain; Acetaminophen; Acetylcysteine; Adult; Diagnosis, Differential; Female; Humans; Nausea; Poisoning; Procalcitonin; Suicide, Attempted | 2021 |
Extremely Elevated Procalcitonin in a Case of Acetaminophen Overdose and Acute Liver Injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Male; Middle Aged; Procalcitonin | 2022 |
Plasma procalcitonin may be an early predictor of liver injury in acetaminophen poisoning: A prospective cohort study.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Multivariate Analysis; Nomograms; Paris; Predictive Value of Tests; Procalcitonin; Prospective Studies; ROC Curve; Young Adult | 2021 |
A two-bag acetylcysteine regimen is associated with shorter delays and interruptions in the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Australia; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies | 2022 |
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cell Proliferation; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Hepatocytes; Humans; Male; Mice; Mice, Inbred C57BL; Time Factors | 2021 |
Use of intravenous N-acetylcysteine in acute severe hepatitis due to severe dengue infection: a case series.
Topics: Acetaminophen; Acetylcysteine; Adult; Animals; Hepatitis; Humans; Infant, Newborn; Male; Retrospective Studies; Severe Dengue | 2021 |
Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Eating; Humans; Retrospective Studies | 2022 |
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Humans | 2022 |
Comparing development of liver injury using the two versus three bag acetylcysteine regimen despite early treatment in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Retrospective Studies; Victoria | 2022 |
Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Eating; Humans | 2022 |
Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Fomepizole; Humans | 2022 |
Fifteen-minute update: International normalised ratio as the treatment end point in children with acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Child; Humans; International Normalized Ratio; Liver Diseases; Vitamin K | 2023 |
Authors' reply to Comment on Single bag high dose intravenous N-acetylcysteine associated with decreased hepatotoxicity compared to triple bag intravenous N-acetylcysteine in high-risk acetaminophen ingestions.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Eating; Humans | 2022 |
Reply to Comments on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Fomepizole; Humans | 2022 |
Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Fomepizole; Humans | 2022 |
Comment on Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Fomepizole; Humans | 2022 |
Large paracetamol overdose - Higher dose NAC is NOT required.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies | 2023 |
Large paracetamol overdose-Higher dose acetylcysteine is required.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2023 |
Should the Dosage Cap Be Used in Patients Greater than 100 kg Receiving N-acetylcysteine for Acetaminophen Toxicity?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug-Related Side Effects and Adverse Reactions; Humans | 2022 |
The Cents of the Dosage Cap in Patients Greater than 100 Kilograms Receiving N-Acetylcysteine for Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug-Related Side Effects and Adverse Reactions; Humans | 2022 |
Acetaminophen-Induced Nephrotoxicity: Suppression of Apoptosis and Endoplasmic Reticulum Stress Using Boric Acid.
Topics: Acetaminophen; Acetylcysteine; Animals; Apoptosis; Boron; Endoplasmic Reticulum Stress; Kidney Diseases; Rats | 2023 |
The association between N-acetylcysteine treatment and hepatic healing in patients with non-acetaminophen-induced liver injury in pediatric intensive care: A single-center retrospective study.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Critical Care; Female; Humans; Liver Failure, Acute; Male; Retrospective Studies; Transaminases; Treatment Outcome | 2022 |
Sensitivity of dose-estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack-Matthew Nomogram.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Middle Aged; Nomograms; Retrospective Studies; Sensitivity and Specificity; Young Adult | 2022 |
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; Liver; Mice; Mice, Inbred C57BL | 2022 |
Evaluation of the hepatoprotective effect of curcumin-loaded solid lipid nanoparticles against paracetamol overdose toxicity
Topics: Acetaminophen; Acetylcysteine; Animals; Curcumin; Liposomes; Nanoparticles; Nitric Oxide Synthase Type II; Rats; Rats, Wistar | 2022 |
Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Liver; Male; Mice; Mice, Inbred C57BL; Receptor, Adenosine A2B | 2022 |
Optimization of gradient reversed phase high performance liquid chromatography analysis of acetaminophen oxidation metabolites using linear and non-linear retention model.
Topics: Acetaminophen; Acetylcysteine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Reverse-Phase; Humans | 2022 |
Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015-2020.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Databases, Factual; Fomepizole; Humans | 2022 |
Comparison of Two-Bag Versus Three-Bag N-Acetylcysteine Regimens for Pediatric Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Child; Cohort Studies; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies | 2023 |
N-acetylcysteine as an antidote for paracetamol poisoning: a multicenter study.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Emergency Service, Hospital; Female; Humans; Male; Retrospective Studies | 2022 |
Compromised blood-bile barrier after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Bile; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver | 2022 |
Metabolic Competency of Larval Zebrafish in Drug-Induced Liver Injury: A Case Study of Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glutathione; Imines; Larva; Liver; Mammals; Sulfates; Zebrafish | 2022 |
Comment: Comparison of 2-Bag Versus 3-Bag
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Humans | 2023 |
SNAPTIMED study: does the Scottish and Newcastle Antiemetic Protocol achieve timely intervention and management from the emergency department to discharge for paracetamol poisoning?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antiemetics; Drug Overdose; Emergency Service, Hospital; Humans; Patient Discharge; Retrospective Studies; Scotland | 2023 |
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts.
Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Disease Models, Animal; Fibroblasts; Hepatocytes; Humans; Liver; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Wharton Jelly | 2022 |
Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury.
Topics: Acetaminophen; Acetylcysteine; Autophagy; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Ferroptosis; Heme Oxygenase-1; Hereditary Sensory and Motor Neuropathy; Humans; Liver; NF-E2-Related Factor 2; Oxidative Stress; Silicon Dioxide; Xanthophylls | 2022 |
Yinhuang oral liquid protects acetaminophen-induced acute liver injury by regulating the activation of autophagy and Nrf2 signaling.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Kelch-Like ECH-Associated Protein 1; Liver; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; RNA, Messenger; Signal Transduction; Superoxide Dismutase; TOR Serine-Threonine Kinases | 2022 |
The nuclear receptor REV-ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Liver; Luciferases; Mice; Receptors, Cytoplasmic and Nuclear | 2022 |
[A case of pyroglutamic metabolic acidosis after cotreatment by flucloxacillin and paracetamol].
Topics: Acetaminophen; Acetylcysteine; Acidosis; Aged; Floxacillin; Humans; Male; Methicillin | 2022 |
Investigation of Intestinal Absorption and Excretion of Paracetamol in Streptozotocin-Induced Hyperglycemia.
Topics: Acetaminophen; Acetylcysteine; Animals; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Glucuronides; Glutathione; Hyperglycemia; Intestinal Absorption; Prostaglandin-Endoperoxide Synthases; Rats; Streptozocin; Sulfates | 2022 |
Therapeutic effect of 6-shogaol on acetaminophen-induced hepatotoxicity in mice: an experimental study.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Liver Diseases; Mice; Nitrates; Nitrites | 2022 |
Intravenous acetaminophen associated with acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Brain Diseases; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Failure, Acute | 2022 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COVID-19; Drug Overdose; Fomepizole; Humans | 2023 |
Fomepizole should be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Fomepizole; Humans | 2023 |
Paracetamol overdose in children: management following an initial N-acetylcysteine regimen.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Child; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies | 2023 |
Acute kidney injury after treatment of paracetamol overdose using new N-acetylcysteine guideline.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Analgesics, Non-Narcotic; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2023 |
Implementation of a pharmacist toxicology service on treatment of paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmacists; Retrospective Studies | 2023 |
Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM-7).
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Retrospective Studies | 2023 |
Comparative Effect of the Active Substance of Thyme with N-Acetyl Cysteine on Hematological Parameters and Histopathological Changes of Bone Marrow and Liver in Rat Models of Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Bone Marrow; Chemical and Drug Induced Liver Injury; Liver; Rats; Rats, Wistar; Thymus Plant | 2023 |
Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; COVID-19; Digestive System Diseases; Drug Overdose; Female; Humans | 2023 |
Concurrent administration of farnesol protects acetaminophen-induced acute hepatic necrosis in mice.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Farnesol; Glutathione; Liver; Mice; Necrosis; NF-kappa B; Transaminases | 2023 |
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells.
Topics: Acetaminophen; Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Glutathione; Homeostasis; Humans; Liver; Liver Neoplasms; Oxidation-Reduction | 2023 |
Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement.
Topics: Acetaminophen; Acetylcysteine; Ambulatory Care; Canada; Child; Drug-Related Side Effects and Adverse Reactions; Evidence-Based Medicine; Humans; Poisons | 2023 |
Effects of coenzyme Q10 and N-acetylcysteine on experimental poisoning by paracetamol in Wistar rats.
Topics: Acetaminophen; Acetylcysteine; Adult; Animals; Humans; Rats; Rats, Wistar; Saline Solution | 2023 |
Patterns and outcomes of paracetamol poisoning management in Hamad Medical Corporation, Qatar: A retrospective cohort study.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Qatar; Retrospective Studies; Young Adult | 2023 |
Developing new antidotes for poisons with existing effective treatments: a case study of fomepizole in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Fomepizole; Humans; Mice; Poisons | 2023 |
Avoiding falsely low creatinine concentrations measured in patients treated with N-acetylcysteine for acetaminophen intoxication using enzymo-amperometric method - An in vitro and in vivo study.
Topics: Acetaminophen; Acetylcysteine; Creatinine; Humans; Peroxidase; Peroxidases; Retrospective Studies | 2023 |