acetaminophen has been researched along with acetaminophen sulfate ester in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (16.42) | 18.7374 |
| 1990's | 19 (28.36) | 18.2507 |
| 2000's | 20 (29.85) | 29.6817 |
| 2010's | 15 (22.39) | 24.3611 |
| 2020's | 2 (2.99) | 2.80 |
| Authors | Studies |
|---|---|
| Prescott, LF | 1 |
| Bach, GG; Barker, F; Cherry, WF; Goresky, CA; Pang, KS; Schwab, AJ | 1 |
| Edwards, G; Mansor, SM; Roberts, PJ; Ward, SA | 1 |
| Lunte, CE; Puckett, DL; Scott, DO; Sorenson, LR; Steele, KL | 1 |
| Klaassen, CD; Madhu, C | 1 |
| Goon, D; Klaassen, CD | 1 |
| Brouwer, KL; Jones, JA | 1 |
| Bhargava, VO; Hirate, J; Horikoshi, I; Zhu, CY | 1 |
| Nakamura, J; Podder, SK; Sasaki, H; Shibasaki, J | 1 |
| Comeau, AM; Ecobichon, DJ; Hidvegi, S; Varma, DR | 1 |
| Gee, D; Pannall, P; Ramakrishna, BS; Roberts-Thomson, IC; Roediger, WE; Weiss, A | 1 |
| Critchley, JA; Prescott, LF; Speirs, GC; Temple, RM; Winney, RJ | 1 |
| Baba, S; Nakamura, J; Nakamura, T; Sasaki, H; Shibasaki, J | 1 |
| Corcoran, GB; Galinsky, RE; Shum, L; Wong, BK | 1 |
| Flanagan, RJ; Prescott, LF; Roberts, I; Strang, J | 1 |
| Corcoran, GB; Galinsky, RE | 1 |
| Bales, JR; Nicholson, JK; Sadler, PJ; Timbrell, JA | 1 |
| Jung, D; Zafar, NU | 1 |
| Critchley, JA; Lau, GS | 1 |
| Acharya, SK; Davies, MH; Elias, E; Mills, CO; Ngong, JM; Waring, RH; Weaver, JB; Yucesoy, M | 1 |
| Birt, DD; Grandjean, AC; Gwilt, PR; Lear, CL; Nagel, DL; Ruddon, RW; Tempero, MA | 1 |
| Martin, U; Prescott, LF; Temple, RM; Winney, RJ | 1 |
| Birkett, DJ; Miners, JO | 1 |
| Franklin, MR; Galinsky, RE; Raftogianis, RB | 1 |
| Ali, BH; Bashir, AK; Cheng, Z; el Hadrami, G; McKellar, QA | 1 |
| Awazu, S; Hayashi, M; Iida, S; Mizuma, T; Sakuma-Sawada, N | 1 |
| Caddick, S; Farrant, RD; Lindon, JC; Nicholls, AW; Nicholson, JK; Wilson, ID | 1 |
| Kim, ND; Kwak, MK; Lee, MG; Lee, WI | 1 |
| Anand, KJ; Deinum, JT; Kuizenga, AJ; Okken, A; Quak, JM; Tibboel, D; van Dam, JG; van Lingen, RA | 1 |
| Alberti, A; Elia, M; Pirrone, P; Romano, C; Waring, RH | 1 |
| Brouwer, KL; Jansen, PL; Turner, KC; Ward, ES; Xiong, H | 1 |
| Aster, R; Bougie, D | 1 |
| Itoh, H; Nagano, T; Takeyama, M | 2 |
| Kulkarni, SG; Pegram, AA; Smith, PC | 1 |
| Anderson, BJ; Holford, NH; Jansman, FG; Pluim, MA; Tibboel, D; van den Anker, JN; van der Marel, CD; van Lingen, RA | 1 |
| Evans, AM; Lucas, AN; Milne, RW; Nation, RL; Reynolds, GD | 1 |
| Cherrington, NJ; Klaassen, CD; Maher, JM; Slitt, AL | 1 |
| Evans, AM; Jensen, LS; Milne, RW; Valentine, J | 1 |
| Chung, JH; Jung, DW; Kim, SJ; Kim, YC; Lee, JY; Moon, CK; Park, HA | 1 |
| Bridges, AS; Brouwer, KL; Hoffmaster, KA; Humphreys, JE; Kalvass, JC; Polli, JW; Tian, X; Webster, LO; Zamek-Gliszczynski, MJ; Zhao, R | 1 |
| Allegaert, K; de Hoon, J; Devlieger, H; Tibboel, D; Vanhole, C; Verbesselt, R | 1 |
| Apak, R; Cekiç, SD; Filik, H; Kiliç, E; Sener, I | 1 |
| Chantharaksri, U; Fucharoen, P; Fucharoen, S; Howard, TA; Morales, NP; Sanvarinda, Y; Sirankapracha, P; Tankanitlert, J; Temsakulphong, A; Ware, RE | 1 |
| Chantharaksri, U; Fucharoen, P; Fucharoen, S; Howard, TA; Morales, NP; Tankanitlert, J; Ware, RE | 1 |
| Boos, J; Hempel, G; Koling, S; Lanvers, C; Würthwein, G | 1 |
| Dawson, PA; Hewavitharana, AK; Lee, S; Markovich, D; Shaw, PN | 1 |
| Hickling, J; Kumara De Silva, R; Medlicott, NJ; Reith, D; Yang, L; Zacharias, M | 1 |
| Aleksunes, LM; Csanaky, IL; Klaassen, CD; Reisman, SA | 1 |
| Kim, SJ; Kim, SY; Kim, YC; Kwon, DY; Lee, MY | 1 |
| Aantaa, R; Kuusniemi, K; Liukas, A; Neuvonen, PJ; Niemi, M; Olkkola, KT; Virolainen, P | 1 |
| McLachlan, AJ; Rittau, AM | 1 |
| Doherty, JP; Kulmatycki, K; Li, W; Smith, HT; Tse, FL | 1 |
| Allegaert, K; de Hoon, J; Knibbe, CA; Kulo, A; Lewi, L; Peeters, MY; Smits, A; van de Velde, M; Verbesselt, R | 1 |
| Adnet, F; Bossard, AE; Bouchemal, N; Fleyfel, M; Galinski, M; Hamza, L; Le Moyec, L; Racine, SX | 1 |
| Bois, FY; Bricks, T; Cotton, J; Leclerc, E; Maciel, L; Merlier, F; Paullier, P; Prot, JM | 1 |
| Barnes, DM; Evans, M; Paterson, E | 1 |
| Kadowaki, D; Otagiri, M; Seo, H; Taguchi, K; Tokuno, M; Yamasaki, K | 1 |
| A-Kader, HH; Bataille, AM; Campion, SN; Canet, MJ; Cherrington, NJ; Erickson, RP; Ferreira, DW; Hardwick, RN; Manautou, JE; Merrell, MD; Xanthakos, SA | 1 |
| Court, MH; Epstein, CR; Giesing, D; Greenblatt, DJ; Harmatz, JS; Kadota, T; Kurosaki, C; Nakagawa, Y; Nakamura, T; Zhao, Y | 1 |
| Allegaert, K; Danhof, M; de Hoon, J; Knibbe, CA; Krekels, EH; Tibboel, D; van Ham, S | 1 |
| Achterbergh, R; Lammers, LA; Mathôt, RA; Pistorius, MC; Romijn, JA | 1 |
| Ghallab, A; Hassan, R; Hengstler, JG; Kuepfer, L; Sezgin, S; Spiteller, M; Zühlke, S | 1 |
| Amant, F; Annaert, P; Conings, S; Paulus, J; Qi, B; Tseke, F; Van Calsteren, K; Van den Broeck, A | 1 |
| Adams, E; Augustijns, P; Ramana, P; Van Schepdael, A | 1 |
| AlMasoud, N; Alomar, TS; Goodacre, R; Lima, C; Xu, Y | 1 |
| Islam, A; Kahyo, T; Mamun, MA; Nabi, MM; Oyama, S; Rahman, MM; Sakamoto, T; Sato, T; Setou, M; Takahashi, Y | 1 |
1 review(s) available for acetaminophen and acetaminophen sulfate ester
| Article | Year |
|---|---|
Kinetics and metabolism of paracetamol and phenacetin.
Topics: Acetaminophen; Administration, Oral; Adult; Animals; Biotransformation; Humans; Intestinal Absorption; Kinetics; Metabolic Clearance Rate; Phenacetin; Tissue Distribution | 1980 |
10 trial(s) available for acetaminophen and acetaminophen sulfate ester
| Article | Year |
|---|---|
The adverse influence of pregnancy upon sulphation: a clue to the pathogenesis of intrahepatic cholestasis of pregnancy?
Topics: Acetaminophen; Adult; Arylsulfotransferase; Blood Platelets; Cholestasis; Contraceptives, Oral; Estrogens; Female; Humans; Pregnancy; Pregnancy Complications; Sulfates | 1994 |
Cisapride raises the bioavailability of paracetamol by inhibiting its glucuronidation in man.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Area Under Curve; Biological Availability; Cisapride; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Agents; Glucuronosyltransferase; Humans; Male; Statistics, Nonparametric | 2001 |
Effect of nizatidine on paracetamol and its metabolites in human plasma.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Area Under Curve; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Histamine H2 Antagonists; Humans; Male; Nizatidine | 2002 |
Paracetamol and metabolite pharmacokinetics in infants.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Infant; Male; Metabolic Clearance Rate; Pain, Postoperative | 2003 |
Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates.
Topics: Acetaminophen; Age Factors; Analgesics; Body Weight; Chromatography, High Pressure Liquid; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Linear Models; Metabolic Clearance Rate; Multivariate Analysis; Urination | 2005 |
Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Antineoplastic Agents; Benzoquinones; Child; Child, Preschool; Cysteine; Drug Administration Schedule; Drug Interactions; Humans; Imines; Infant; Neoplasms; Oxidation-Reduction | 2007 |
Pharmacokinetics of paracetamol and its metabolites in women at delivery and post-partum.
Topics: Acetaminophen; Administration, Intravenous; Adult; Analgesics, Non-Narcotic; Delivery, Obstetric; Dose-Response Relationship, Drug; Female; Humans; Metabolic Clearance Rate; Pain; Pain Measurement; Postpartum Period; Pregnancy | 2013 |
An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects.
Topics: Acetaminophen; Acetylcysteine; Adult; Area Under Curve; Dietary Supplements; Estradiol; gamma-Glutamyltransferase; Humans; Inactivation, Metabolic; Liver; Male; Pilot Projects; Plant Extracts; Raphanus; Treatment Outcome; Up-Regulation | 2014 |
Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen.
Topics: Acetaminophen; Adult; Amides; Analgesics, Non-Narcotic; Antiviral Agents; Drug Interactions; Female; Humans; In Vitro Techniques; Inhibitory Concentration 50; Male; Middle Aged; Pyrazines; Young Adult | 2015 |
Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants.
Topics: Acetaminophen; Body Weight; Child Development; Computer Simulation; Female; Humans; Infant; Infant, Newborn; Male; Metabolic Clearance Rate; Models, Biological; Up-Regulation | 2015 |
56 other study(ies) available for acetaminophen and acetaminophen sulfate ester
| Article | Year |
|---|---|
Uptake of a protein-bound polar compound, acetaminophen sulfate, by perfused rat liver.
Topics: Acetaminophen; Animals; Biological Transport; Carbon Radioisotopes; Chromium Radioisotopes; Iodine Radioisotopes; Kinetics; Liver; Male; Mathematics; Models, Biological; Perfusion; Protein Binding; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Serum Albumin; Tritium | 1992 |
The effect of malaria infection on paracetamol disposition in the rat.
Topics: Acetaminophen; Animals; Bile; Half-Life; Inactivation, Metabolic; Liver; Malaria; Male; Mice; Rats | 1991 |
In vivo microdialysis sampling for pharmacokinetic investigations.
Topics: Acetaminophen; Animals; Chromatography, Liquid; Dialysis; Dose-Response Relationship, Drug; Microchemistry; Rats; Rats, Inbred Strains; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1991 |
Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biliary Tract; Cricetinae; Cysteine; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; L-Iditol 2-Dehydrogenase; Liver; Male; Mesocricetus; Pregnenolone Carbonitrile | 1991 |
Dose-dependent intestinal glucuronidation and sulfation of acetaminophen in the rat in situ.
Topics: Acetaminophen; Animals; Biotransformation; Dose-Response Relationship, Drug; Glucose; Intestinal Mucosa; Male; Rats; Rats, Inbred Strains | 1990 |
Altered hepatobiliary disposition of acetaminophen metabolites after phenobarbital pretreatment and renal ligation: evidence for impaired biliary excretion and a diffusional barrier.
Topics: Acetaminophen; Animals; Bile; Bile Ducts; Diffusion; Kidney; Ligation; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
First-pass metabolism of acetaminophen in rats after low and high doses.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Disposition of phenacetin in rabbits pretreated orally and intraperitoneally with 3,4-benzpyrene.
Topics: Acetaminophen; Administration, Oral; Animals; Benzo(a)pyrene; Enzyme Induction; Injections, Intraperitoneal; Liver; Male; Phenacetin; Rabbits | 1989 |
Acetaminophen metabolism in vivo by pregnant, fetal, and neonatal guinea pigs.
Topics: Acetaminophen; Animals; Animals, Newborn; Biotransformation; Female; Fetus; Guinea Pigs; Pregnancy; Pregnancy, Animal | 1989 |
Estimation of phenolic conjugation by colonic mucosa.
Topics: Acetaminophen; Colon; Dialysis; Humans; Intestinal Mucosa; Phenols; Rectum | 1989 |
Paracetamol disposition and metabolite kinetics in patients with chronic renal failure.
Topics: Acetaminophen; Adult; Aged; Female; Half-Life; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Time Factors | 1989 |
A method for the preparation of calibration curves for acetaminophen glucuronide and acetaminophen sulfate in rabbit urine without use of authentic compounds in high-performance liquid chromatography.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Male; Rabbits; Reference Values | 1987 |
Acetaminophen sulfation deficit in obese rats overfed an energy-dense cafeteria diet.
Topics: Acetaminophen; Animals; Biotransformation; Kinetics; Male; Obesity; Rats; Rats, Inbred Strains | 1987 |
Toxicological studies in a Distalgesic addict.
Topics: Acetaminophen; Adult; Dextropropoxyphene; Drug Combinations; Humans; Kinetics; Male; Substance-Related Disorders | 1986 |
Influence of advanced age on the formation and elimination of acetaminophen metabolites by male rats.
Topics: Acetaminophen; Aging; Animals; Biotransformation; Kinetics; Male; Rats; Rats, Inbred F344 | 1986 |
A high resolution proton nuclear magnetic resonance approach to the study of hepatocyte and drug metabolism. Application to acetaminophen.
Topics: Acetaminophen; Animals; Deuterium; In Vitro Techniques; Kinetics; Liver; Magnetic Resonance Spectroscopy; Rats; Rats, Inbred Strains | 1985 |
Micro high-performance liquid chromatographic assay of acetaminophen and its major metabolites in plasma and urine.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Humans | 1985 |
The estimation of paracetamol and its major metabolites in both plasma and urine by a single high-performance liquid chromatography assay.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Cysteine; Humans; Spectrophotometry, Ultraviolet | 1994 |
The effect of garlic extract on human metabolism of acetaminophen.
Topics: Acetaminophen; Adult; Allyl Compounds; Carcinogens; Garlic; Half-Life; Humans; Inactivation, Metabolic; Male; Metabolic Clearance Rate; Neoplasms; Plant Extracts; Plants, Medicinal; Sulfides | 1994 |
The disposition of paracetamol and its conjugates during multiple dosing in patients with end-stage renal failure maintained on haemodialysis.
Topics: Acetaminophen; Administration, Oral; Adult; Cysteine; Drug Administration Schedule; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis | 1993 |
The misuse of urinary metabolite excretion data in drug metabolism studies.
Topics: Acetaminophen; Asian People; Genetic Variation; Humans; White People | 1993 |
Effect of lipid-free total parenteral nutrition on hepatic drug conjugation in rats.
Topics: Acetaminophen; Animals; Enteral Nutrition; Glucuronosyltransferase; Liver; Male; Parenteral Nutrition, Total; Rats; Rats, Sprague-Dawley | 1996 |
Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biological Availability; Camelus; Chromatography, High Pressure Liquid; Computer Simulation; Female; Glucuronates; Goats; Injections, Intramuscular; Injections, Intravenous; Species Specificity; Statistics as Topic | 1996 |
Inhibition of the hepatic uptake of paracetamol sulphate by anionic compounds.
Topics: Acetaminophen; Animals; Anions; Cholic Acid; Cholic Acids; Coloring Agents; Drug Interactions; Liver; Male; Nitrobenzenes; Perfusion; Probenecid; Rats; Rats, Wistar; Sulfates; Sulfobromophthalein; Uricosuric Agents | 1997 |
NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat.
Topics: Acetaminophen; Acetylation; Animals; Deuterium; Magnetic Resonance Spectroscopy; Male; Phenacetin; Rats; Rats, Sprague-Dawley | 1997 |
Metabolic changes of acetaminophen after intravenous administration to rats pretreated with 2-(allylthio)pyrazine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Inactivation, Metabolic; Male; Pyrazines; Rats; Rats, Sprague-Dawley | 1998 |
Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates.
Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gestational Age; Half-Life; Humans; Infant, Newborn; Infant, Premature; Male; Pain Measurement; Regression Analysis; Statistics, Nonparametric; Time Factors | 1999 |
Sulphation deficit in "low-functioning" autistic children: a pilot study.
Topics: Acetaminophen; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Autistic Disorder; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Food; Humans; Male; Metabolism, Inborn Errors; Pilot Projects; Sulfates | 1999 |
Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats.
Topics: Acetaminophen; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Bicarbonates; Biliary Tract; Biological Transport; Cell Membrane; Hydrogen-Ion Concentration; Liver; Male; Membrane Potentials; Membrane Transport Proteins; Models, Biological; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Perfusion; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2000 |
Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen.
Topics: Acetaminophen; Adult; Aged; Antibodies; Blood Platelets; Female; Glucuronides; Humans; Male; Middle Aged; Naproxen; Platelet Glycoprotein GPIIb-IIIa Complex; Purpura, Thrombocytopenic, Idiopathic | 2001 |
Disposition of acetaminophen and indocyanine green in cystic fibrosis-knockout mice.
Topics: Acetaminophen; Animals; Cystic Fibrosis; Indocyanine Green; Male; Mice; Mice, Knockout; Models, Animal; Organ Specificity | 2000 |
The effects of phytoestrogenic isoflavones on the formation and disposition of paracetamol sulfate in the isolated perfused rat liver.
Topics: Acetaminophen; Animals; Estrogens, Non-Steroidal; Isoflavones; Liver; Male; Perfusion; Phytoestrogens; Plant Preparations; Rats; Rats, Sprague-Dawley | 2003 |
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites.
Topics: Acetaminophen; Allyl Compounds; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Branched DNA Signal Amplification Assay; Drug Resistance, Multiple; Kidney; Liver; Male; Mitochondrial Proteins; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; Ribosomal Proteins; RNA, Messenger; Saccharomyces cerevisiae Proteins; Stilbenes; Sulfides; Thiones; Thiophenes; Time Factors | 2003 |
The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high-performance liquid chromatography assay.
Topics: Acetaminophen; Chromatography, High Pressure Liquid; Humans | 2004 |
Effect of taurine on biliary excretion and metabolism of acetaminophen in male hamsters.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bile; Cricetinae; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Male; Mesocricetus; Taurine; Time Factors | 2004 |
Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.
Topics: Acetaminophen; Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; In Vitro Techniques; Kinetics; Liver; Male; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Perfusion; Rats; Rats, Wistar; Tetrahydroisoquinolines | 2005 |
Spectrophotometric determination of paracetamol in urine with tetrahydroxycalix[4]arene as a coupling reagent and preconcentration with triton X-114 using cloud point extraction.
Topics: Acetaminophen; Aminophenols; Drugs, Chinese Herbal; Indicators and Reagents; Octoxynol; Polyethylene Glycols; Spectrophotometry; Surface-Active Agents; Temperature | 2006 |
A pharmacokinetic study of paracetamol in Thai beta-thalassemia/HbE patients.
Topics: Acetaminophen; Adult; Area Under Curve; beta-Thalassemia; Bilirubin; Cysteine; Female; Glucuronosyltransferase; Humans; Male; Middle Aged | 2006 |
Effects of combined UDP-glucuronosyltransferase (UGT) 1A1*28 and 1A6*2 on paracetamol pharmacokinetics in beta-thalassemia/HbE.
Topics: Acetaminophen; Adult; Analgesics; Area Under Curve; Asian People; beta-Thalassemia; Female; Glucuronosyltransferase; Half-Life; Hemoglobin E; Humans; Male; Metabolic Clearance Rate; Middle Aged; Polymorphism, Genetic | 2007 |
Development of an HPLC-MS/MS method for the selective determination of paracetamol metabolites in mouse urine.
Topics: Acetaminophen; Animals; Chromatography, High Pressure Liquid; Male; Mice; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation.
Topics: Acetaminophen; Adult; Chromatography, High Pressure Liquid; Cross-Over Studies; Cysteine; Dose-Response Relationship, Drug; Female; Humans; Male; Molecular Structure; Pain; Time; Young Adult | 2009 |
Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.
Topics: Acetaminophen; Adaptor Proteins, Signal Transducing; Animals; Bile; Biotransformation; Carrier Proteins; Cytoskeletal Proteins; Gene Knockdown Techniques; Guinea Pigs; Kelch-Like ECH-Associated Protein 1; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; NF-E2-Related Factor 2 | 2009 |
Alteration in metabolism and toxicity of acetaminophen upon repeated administration in rats.
Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Analgesics, Non-Narcotic; Animals; Anisoles; Aspartate Aminotransferases; Cysteine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Injections, Intraperitoneal; L-Iditol 2-Dehydrogenase; Liver; Microsomes, Liver; Nitrophenols; Rats; Rats, Sprague-Dawley | 2009 |
Pharmacokinetics of intravenous paracetamol in elderly patients.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Aging; Analgesia; Analgesics, Non-Narcotic; Area Under Curve; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Female; Genotype; Glomerular Filtration Rate; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Sex Characteristics; Young Adult | 2011 |
Investigating paracetamol pharmacokinetics using venous and capillary blood and saliva sampling.
Topics: Acetaminophen; Adult; Area Under Curve; Capillaries; Chromatography, High Pressure Liquid; Female; Humans; Middle Aged; Reference Values; Reproducibility of Results; Saliva; Veins; Young Adult | 2012 |
Simultaneous LC-MS/MS quantitation of acetaminophen and its glucuronide and sulfate metabolites in human dried blood spot samples collected by subjects in a pilot clinical study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Chromatography, Reverse-Phase; Dried Blood Spot Testing; Humans; Limit of Detection; Methanol; Pilot Projects; Reference Standards; Solid Phase Extraction; Tandem Mass Spectrometry | 2012 |
Detection and follow-up, after partial liver resection, of the urinary paracetamol metabolites by proton NMR spectroscopy.
Topics: Acetaminophen; Analgesics; Benzoquinones; Female; Humans; Imines; Liver; Magnetic Resonance Spectroscopy; Male; Middle Aged | 2014 |
First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bioreactors; Caco-2 Cells; Cells, Cultured; Equipment Design; Humans; Intestinal Absorption; Intestinal Mucosa; Liver; Microfluidic Analytical Techniques; Models, Biological; Permeability; Rats | 2014 |
Establishment of a model of acetaminophen-induced hepatotoxicity in different weekly-aged ICR mice.
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Animals; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred ICR | 2015 |
Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Bile Canaliculi; Biotransformation; Child; Cohort Studies; Fatty Liver; Female; Humans; Liver; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Pilot Projects; Protein Transport; Up-Regulation | 2015 |
Quantitative Method for Simultaneous Analysis of Acetaminophen and 6 Metabolites.
Topics: Acetaminophen; Aminophenols; Calibration; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Plasma; Reproducibility of Results; Tandem Mass Spectrometry | 2017 |
Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI.
Topics: Acetaminophen; Animals; Benzoquinones; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Glutathione; Imines; Liver; Male; Mice, Inbred C57BL; Spatio-Temporal Analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2018 |
Transplacental transport of paracetamol and its phase II metabolites using the ex vivo placenta perfusion model.
Topics: Acetaminophen; Adult; Female; Fetus; Gestational Age; Humans; In Vitro Techniques; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy | 2019 |
Immobilizing sulfotransferase 1A1 on magnetic microparticles and their evaluation using capillary electrophoresis.
Topics: Acetaminophen; Arylsulfotransferase; Electrophoresis, Capillary; Enzymes, Immobilized; Humans; Hydrogen-Ion Concentration; Limit of Detection; Linear Models; Magnets; Microspheres; Reproducibility of Results | 2019 |
Rapid detection and quantification of paracetamol and its major metabolites using surface enhanced Raman scattering.
Topics: Acetaminophen; Glucuronides; Gold; Humans; Metal Nanoparticles; Sodium Chloride; Spectrum Analysis, Raman; Water; Young Adult | 2023 |
Detection of Distinct Distributions of Acetaminophen and Acetaminophen-Cysteine in Kidneys up to 10 μm Resolution and Identification of a Novel Acetaminophen Metabolite Using an AP-MALDI Imaging Mass Microscope.
Topics: Acetaminophen; Cysteine; Kidney; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2023 |