Compounds > acetaminophen

acetaminophen and 3-nitrotyrosine

acetaminophen has been researched along with 3-nitrotyrosine in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.53)18.2507
2000's11 (57.89)29.6817
2010's6 (31.58)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Halliwell, B; Kaur, H; Whiteman, M1
Hinson, JA; Mayeux, PR; Pike, SL; Pumford, NR1
Ault, SG; Hinson, JA; Michael, SL; Pumford, NR1
Bucci, TJ; Hinson, JA; Irwin, LK; Mayeux, PR; Michael, SL; Pumford, NR; Warbritton, AR1
Farhood, A; Ho, YS; Jaeschke, H; Knight, TR1
Abril, ER; Bethea, NW; Ito, Y; McCuskey, RS1
Hinson, JA; James, LP; Mayeux, PR1
Hinson, JA; Jaeschke, H; James, LP; Knight, TR; McCullough, SS1
Hirose, M; Iijima, M; Ishii, Y; Ito, R; Iwasaki, Y; Nakazawa, H; Nishikawa, A; Saito, K; Umemura, T1
Lei, XG; Zhu, JH1
Aregullin, M; Lei, XG; McClung, JP; Roneker, CA; Zhu, JH1
Lei, XG; McClung, JP; Ripoll, DR; Roneker, CA; Sun, Q; Thannhauser, TW; Zhang, S; Zhang, X; Zhu, JH1
Inoue, T; Ishii, Y; Nishikawa, A; Okamura, T; Tasaki, M; Umemura, T1
Choi, J; Jang, SI; Kim, SZ; Park, KH; Shin, JH1
Irie, T; Irikura, M; Ishitsuka, Y; Iwawaki, T; Kondo, Y; Miyata, K; Oike, Y; Shimizu, D; Tomishima, Y1
Liu, C; Liu, S; Meng, F; Pang, Q; Song, S; Wu, Q; Zhang, J; Zhang, R; Zhou, L1
Anraku, M; Hirayama, F; Iohara, D; Irie, T; Ishitsuka, Y; Uekama, K; Umezaki, Y1
Bajt, ML; Du, K; Jaeschke, H; McGill, MR; Xie, Y1
Jiang, Z; Melzig, MF; Wang, J; Xie, W; Zhang, X1

Reviews

1 review(s) available for acetaminophen and 3-nitrotyrosine

ArticleYear
Acetaminophen-induced hepatotoxicity.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:12

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Cytokines; Humans; Kupffer Cells; Liver Diseases; Mitochondria, Liver; Oxidative Stress; Tyrosine

2003

Other Studies

18 other study(ies) available for acetaminophen and 3-nitrotyrosine

ArticleYear
Protection against peroxynitrite dependent tyrosine nitration and alpha 1-antiproteinase inactivation by some anti-inflammatory drugs and by the antibiotic tetracycline.
    Annals of the rheumatic diseases, 1996, Volume: 55, Issue:6

    Topics: Acetaminophen; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Flufenamic Acid; Free Radical Scavengers; Humans; Mesalamine; Nitrates; Pancreatic Elastase; Penicillamine; Phenylbutazone; Tetracycline; Tyrosine

1996
Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice.
    Chemical research in toxicology, 1998, Volume: 11, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Biotransformation; Liver; Male; Mice; Nitrates; Nitric Oxide; Proteins; Tyrosine

1998
Western blot analysis for nitrotyrosine protein adducts in livers of saline-treated and acetaminophen-treated mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 53, Issue:2

    Topics: Acetaminophen; Adjuvants, Immunologic; Analgesics, Non-Narcotic; Animals; Blotting, Western; Cattle; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Hemocyanins; Immunoenzyme Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Nitrates; Protein Binding; Proteins; Rabbits; Serum Albumin, Bovine; Sodium Chloride; Tyrosine

2000
Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity.
    Nitric oxide : biology and chemistry, 2001, Volume: 5, Issue:5

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Gene Deletion; Immunoenzyme Techniques; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Tyrosine

2001
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Glutathione; Immunohistochemistry; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Necrosis; Peroxynitrous Acid; Serum Albumin, Bovine; Tyrosine

2002
Role of nitric oxide in hepatic microvascular injury elicited by acetaminophen in mice.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 286, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Capillaries; Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Glutathione; Immunohistochemistry; Kupffer Cells; Liver; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine

2004
Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress.
    Free radical research, 2003, Volume: 37, Issue:12

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Hepatocytes; Hydrogen Peroxide; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine

2003
Determination of nitrotyrosine and tyrosine by high-performance liquid chromatography with tandem mass spectrometry and immunohistochemical analysis in livers of mice administered acetaminophen.
    Journal of pharmaceutical and biomedical analysis, 2006, Jun-16, Volume: 41, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chromatography, High Pressure Liquid; Liver; Male; Mass Spectrometry; Mice; Tyrosine

2006
Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hepatocytes; Imines; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine

2006
Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity.
    The Biochemical journal, 2006, Nov-01, Volume: 399, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Biotransformation; Body Weight; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Resistance; Enzyme Induction; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Imines; Liver Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine

2006
Role of copper,zinc-superoxide dismutase in catalyzing nitrotyrosine formation in murine liver.
    Free radical biology & medicine, 2008, Sep-01, Volume: 45, Issue:5

    Topics: Acetaminophen; Animals; Catalysis; Cattle; Genotype; Lipopolysaccharides; Liver; Mice; Mice, Knockout; Nitrogen; Nitrogen Oxides; Substrate Specificity; Superoxide Dismutase; Tyrosine

2008
Dietary catechol causes increased oxidative DNA damage in the livers of mice treated with acetaminophen.
    Toxicology, 2009, Sep-19, Volume: 263, Issue:2-3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaminophen; Alanine Transaminase; Animals; Catechols; Chemical and Drug Induced Liver Injury; Deoxyguanosine; Diet; DNA Damage; Glutathione; Immunohistochemistry; Inflammation; Liver; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Oxidation-Reduction; Time Factors; Transaminases; Tyrosine

2009
The ameliorative effects of L-2-oxothiazolidine-4-carboxylate on acetaminophen-induced hepatotoxicity in mice.
    Molecules (Basel, Switzerland), 2013, Mar-18, Volume: 18, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Aldehydes; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; Caspase 3; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Glutathione; Glutathione Peroxidase; Liver; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Necrosis; Oxidative Stress; Pyrrolidonecarboxylic Acid; Thiazolidines; Tyrosine

2013
Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.
    Pharmacological research, 2014, Volume: 87

    Topics: Acetaminophen; Alanine Transaminase; Ammonia; Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; DNA Fragmentation; DNA-Binding Proteins; Glutathione; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Transgenic; Phenylbutyrates; Protective Agents; Proto-Oncogene Proteins; Regulatory Factor X Transcription Factors; Transcription Factor CHOP; Transcription Factors; Tyrosine; X-Box Binding Protein 1

2014
Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice.
    Scientific reports, 2015, Jan-29, Volume: 5

    Topics: Acetaminophen; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytokines; Disease Susceptibility; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Glutathione; Hepatocytes; Hypoxia-Inducible Factor 1, alpha Subunit; JNK Mitogen-Activated Protein Kinases; Liver; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Receptor, Serotonin, 5-HT2B; Serotonin; Time Factors; Transcription, Genetic; Tryptophan Hydroxylase; Tyrosine

2015
Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-Ī²-cyclodextrin nanoparticles for the treatment of a liver injury induced by anĀ overdose of acetaminophen.
    Biomaterials, 2015, Volume: 45

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetaminophen; Animals; Antioxidants; Benzothiazoles; beta-Cyclodextrins; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Fullerenes; Glutathione; Hydrophobic and Hydrophilic Interactions; Hydroxylation; Liver; Male; Mice, Inbred C57BL; Nanoparticles; Nitric Oxide; Oxidative Stress; Particle Size; Peroxynitrous Acid; Picrates; Protective Agents; Solubility; Static Electricity; Sulfonic Acids; Tyrosine

2015
Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2015, Volume: 81

    Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Overdose; Endonucleases; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Resveratrol; Stilbenes; Tyrosine

2015
Protective effect of hyperoside against acetaminophen (APAP) induced liver injury through enhancement of APAP clearance.
    Chemico-biological interactions, 2016, Feb-25, Volume: 246

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Liver; Male; Mice; NF-E2-Related Factor 2; Oxidative Stress; Quercetin; RNA, Messenger; Sulfotransferases; Tyrosine

2016