acetaminophen has been researched along with 3-hydroxyacetanilide in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Kapur, S; Rosario, M; Selassie, CD; Verma, RP | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Morrone, LA; Pimpinella, G; Romanelli, L; Valeri, P | 1 |
| Bjørge, C; Holme, JA; Hongslo, JK; Nelson, SD | 1 |
| Myers, TG; Nelson, SD; Rashed, MS; Tirmenstein, MA | 1 |
| Jollow, DJ; Price, VF; Roberts, SA | 1 |
| Nelson, SD; Tirmenstein, MA | 2 |
| Esterline, RL; Ji, S | 1 |
| Nelson, EB | 1 |
| Hinson, JA; Matthews, AM; Pumford, NR; Roberts, DW | 1 |
| Hinson, JA; Pumford, NR; Roberts, SM; Salminen, WF | 1 |
| Bae, MA; Pie, JE; Song, BJ | 1 |
| Benet, LZ; Burlingame, AL; Qiu, Y | 1 |
| Bruschi, SA; Campbell, JS; Chen, W; Fausto, N; Franklin, CC; Nelson, SD; Pierce, RH; Tonge, RP | 1 |
| Bora, RS; Khattar, SK; Malik, R; Priyadarsiny, P; Rahman, S; Saini, KS; Seshaiah, A; Shingatgeri, VM; Udupa, V | 1 |
| Bleumink, R; Boon, L; Fiechter, D; Hassing, I; Kwast, LM; Ludwig, IS; Pieters, RH | 1 |
| Abdelmegeed, MA; Banerjee, A; Hardwick, JP; Jang, S; Song, BJ | 1 |
| Howell, BA; Siler, SQ; Watkins, PB | 1 |
| He, Z; Li, J; Li, X; Li, Y; Qian, X; Wan, Y; Xia, W; Xu, L; Xu, S; Zheng, T | 1 |
21 other study(ies) available for acetaminophen and 3-hydroxyacetanilide
| Article | Year |
|---|---|
Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Activation; Mice; Molecular Conformation; Phenols; Quantitative Structure-Activity Relationship; Vinblastine | 2005 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Ocular disposition of acetaminophen and its metabolites following intravenous administration in rabbits.
Topics: Acetaminophen; Acetanilides; Analgesics; Animals; Blood; Cerebrospinal Fluid; Eye; Glucuronates; Injections, Intravenous; Male; Rabbits | 1991 |
Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes.
Topics: Acetaminophen; Acetanilides; Animals; Benzoquinones; Cell Survival; Cells, Cultured; Glutathione; Hydroquinones; Imines; Liver; Male; Mice; Protein Binding; Quinones; Trypan Blue | 1991 |
Acetaminophen and protein thiol modification.
Topics: Acetaminophen; Acetanilides; Animals; Benzoquinones; Binding Sites; Glutathione; Imines; In Vitro Techniques; Liver; Mice; Proteins; Sulfhydryl Compounds | 1991 |
Acetaminophen structure-toxicity studies: in vivo covalent binding of a nonhepatotoxic analog, 3-hydroxyacetanilide.
Topics: Acetaminophen; Acetanilides; Analgesics; Animals; Binding Sites; Carbon Radioisotopes; Cricetinae; Glutathione; Kidney; Kinetics; Liver; Male; Mesocricetus; Muscles; Organ Specificity; Structure-Activity Relationship; Tritium | 1990 |
Acetaminophen-induced oxidation of protein thiols. Contribution of impaired thiol-metabolizing enzymes and the breakdown of adenine nucleotides.
Topics: Acetaminophen; Acetanilides; Adenine Nucleotides; Analgesics; Animals; Cytosol; Glutathione Peroxidase; Kinetics; Liver; Male; Mice; Oxidation-Reduction; Proteins; Reference Values; Sulfhydryl Compounds; Sulfurtransferases; Xanthine Dehydrogenase; Xanthine Oxidase | 1990 |
Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver.
Topics: Acetaminophen; Acetanilides; Analgesics; Animals; Calcium; Calcium-Transporting ATPases; Cell Membrane; Glutathione; Glutathione Disulfide; Homeostasis; Isomerism; Kinetics; Liver; Male; Mice; Mitochondria, Liver; Reference Values; Subcellular Fractions | 1989 |
Metabolic alterations resulting from the inhibition of mitochondrial respiration by acetaminophen in vivo.
Topics: Acetaminophen; Acetanilides; Animals; Blood Glucose; Female; Lactates; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Inbred Strains | 1989 |
The pharmacology and toxicology of meta-substituted acetanilide I: acute toxicity of 3-hydroxyacetanilide in mice.
Topics: Acetaminophen; Acetanilides; Animals; Glutathione; Lethal Dose 50; Liver; Male; Mice; Transaminases | 1980 |
Comparison of covalent binding of acetaminophen and the regioisomer 3'-hydroxyacetanilide to mouse liver protein.
Topics: Acetaminophen; Acetanilides; Analgesics; Animals; Blotting, Western; Immune Sera; Liver; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Protein Binding | 1997 |
Immunochemical comparison of 3'-hydroxyacetanilide and acetaminophen binding in mouse liver.
Topics: Acetaminophen; Acetanilides; Allyl Compounds; Animals; Cobalt; Cytochrome P-450 CYP2E1 Inhibitors; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred Strains; Microsomes; Protein Binding; Rats; Sulfides | 1998 |
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.
Topics: Acetaminophen; Acetanilides; Analgesics; Analgesics, Non-Narcotic; Androstadienes; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cytochrome c Group; Cytochrome P-450 CYP2E1; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glioma; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Thiazoles; Time Factors; Tumor Cells, Cultured; Wortmannin | 2001 |
Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry.
Topics: Acetaminophen; Acetanilides; Analgesics, Non-Narcotic; Animals; Autoradiography; Electrophoresis, Gel, Two-Dimensional; Liver; Mass Spectrometry; Mice; Mice, Inbred C57BL; Proteins | 2001 |
Cell culture model for acetaminophen-induced hepatocyte death in vivo.
Topics: Acetaminophen; Acetanilides; Animals; Apoptosis; Caspases; Cell Nucleus; Cell Size; Hepatocytes; Peptide Hydrolases; Tumor Cells, Cultured | 2002 |
Differential gene expression analysis of a known hepatotoxin, N-acetyl-p-amino-phenol (APAP) as compared to its non-toxic analog, N-acetyl-m-amino-phenol (AMAP) in mouse liver.
Topics: Acetaminophen; Acetanilides; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; gamma-Glutamyltransferase; Gene Expression Profiling; L-Lactate Dehydrogenase; Liver; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis | 2008 |
Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA.
Topics: Acetaminophen; Acetanilides; Adjuvants, Immunologic; Administration, Oral; Animals; Antibody Formation; Carbamazepine; Drug Evaluation, Preclinical; Drug Hypersensitivity; Female; Injections, Epidural; Local Lymph Node Assay; Metformin; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Ofloxacin; Ovalbumin | 2011 |
Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury.
Topics: Acetaminophen; Acetanilides; Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Mice; Mitochondria, Liver; Nitrates; Oxidative Stress; Proteins; Superoxide Dismutase | 2013 |
Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice.
Topics: Acetaminophen; Acetanilides; Animals; Benzoquinones; Biotransformation; Chemical and Drug Induced Liver Injury; Computer Simulation; Cytochrome P-450 CYP2E1; Imines; Isomerism; Liver; Mice; Models, Biological; Systems Biology | 2014 |
Urinary paracetamol (4-acetaminophenol) and its isomer 2-acetaminophenol of Chinese pregnant women: Exposure characteristics and association with oxidative stress biomarkers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaminophen; Biomarkers; China; Female; Humans; Oxidative Stress; Pharmaceutical Preparations; Pregnancy; Pregnant Women | 2022 |