Compounds > aceclofenac
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aceclofenac and dinoprostone

aceclofenac has been researched along with dinoprostone in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's6 (60.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de la Cruz, C; de Nicoläs, R; Egido, J; González, E; Herrero-Beaumont, G1
Hashimoto, S; Kaneda, N; Kawai, S; Koshino, T; Matsuzaki, T; Mizushima, Y; Okamoto, R; Yamazaki, R; Yokokura, T1
Hashimoto, S; Kawai, S; Koshino, T; Matsumoto, T; Matsuzaki, T; Mizushima, Y; Okamoto, R; Yamazaki, R; Yokokura, T1
Hashimoto, S; Ito, A; Kawai, S; Matsuzaki, T; Mizushima, Y; Yamazaki, R; Yokokura, T1
de Leval, X; Deby-Dupont, G; Delarge, J; Dogné, JM; Henrotin, Y; Mathy-Hartet, M; Mouithys-Mickalad, A; Reginster, JY1
Blanco, FJ; Fernández-Sueiro, JL; Galdo, F; Lema, B; López-Armada, MJ; Maneiro, E1
Alvarez-Soria, MA; Calvo, E; Egido, J; Hernández, M; Herrero-Beaumont, G; Largo, R; Sánchez-Pernaute, O; Santillana, J1
Aletras, AJ; Andonopoulos, AP; Giannopoulou, E; Gouvousis, PA; Panagiotopoulos, E; Syggelos, SA1
Alvarez-Soria, MA; Calvo, E; Egido, J; Herrero-Beaumont, G; Largo, R; Moreno-Rubio, J; Santillana, J1
Gilhotra, RM; Mathurm, M1

Trials

3 trial(s) available for aceclofenac and dinoprostone

ArticleYear
Long-term effect of nonsteroidal anti-inflammatory drugs on the production of cytokines and other inflammatory mediators by blood cells of patients with osteoarthritis.
    Agents and actions, 1994, Volume: 41, Issue:3-4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Diclofenac; Dinoprostone; Double-Blind Method; Female; Humans; Interleukin-1; Interleukin-6; Knee Joint; Leukotriene B4; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Osteoarthritis; Platelet Activating Factor; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

1994
Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac.
    Annals of the rheumatic diseases, 2006, Volume: 65, Issue:8

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blotting, Western; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Depression, Chemical; Diclofenac; Dinoprostone; Female; Gene Expression; Humans; Interleukin-1; Knee Joint; Male; Membrane Proteins; Osteoarthritis, Knee; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Synovial Membrane; Time Factors; Tumor Necrosis Factor-alpha

2006
Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis.
    Osteoarthritis and cartilage, 2008, Volume: 16, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Celecoxib; Chondrocytes; Cyclooxygenase 2; Diclofenac; Dinoprostone; Down-Regulation; Female; Humans; Interleukin-1; Male; Nitric Oxide; Osteoarthritis, Knee; Pyrazoles; Sulfonamides; Synovial Membrane

2008

Other Studies

7 other study(ies) available for aceclofenac and dinoprostone

ArticleYear
Aceclofenac blocks prostaglandin E2 production following its intracellular conversion into cyclooxygenase inhibitors.
    European journal of pharmacology, 1997, Jun-25, Volume: 329, Issue:2-3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Chromatography, Thin Layer; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Monocytes; Neutrophils; Prostaglandin-Endoperoxide Synthases; Synovial Membrane

1997
Hydrolytic activity is essential for aceclofenac to inhibit cyclooxygenase in rheumatoid synovial cells.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydrolysis; Immunoenzyme Techniques; Isoenzymes; Membrane Proteins; Microsomes; Prostaglandin-Endoperoxide Synthases; Synovial Membrane

1999
A major metabolite of aceclofenac, 4'-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2000, Volume: 49, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Dinoprostone; Enzyme Precursors; Extracellular Space; Humans; Interleukin-1; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Protease Inhibitors; RNA, Messenger; Synovial Membrane; Tissue Inhibitor of Metalloproteinase-1

2000
In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2001, Volume: 50, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chondrocytes; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Diclofenac; Dinoprostone; DNA; Humans; In Vitro Techniques; Inflammation Mediators; Interleukin-1; Isoenzymes; Membrane Proteins; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction

2001
Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.
    The Journal of rheumatology, 2001, Volume: 28, Issue:12

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cartilage, Articular; Cells, Cultured; Chondrocytes; Culture Media, Conditioned; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Humans; Insulin-Like Growth Factor I; Interleukin 1 Receptor Antagonist Protein; Lipopolysaccharides; Middle Aged; Nitric Oxide; Osteoarthritis, Knee; Piroxicam; Sialoglycoproteins; Tumor Necrosis Factor-alpha

2001
In vitro effects of non-steroidal anti-inflammatory drugs on cytokine, prostanoid and matrix metalloproteinase production by interface membranes from loose hip or knee endoprostheses.
    Osteoarthritis and cartilage, 2007, Volume: 15, Issue:5

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Cytokines; Diclofenac; Dinoprostone; Female; Hip Prosthesis; Humans; Indomethacin; Knee Prosthesis; Matrix Metalloproteinases; Middle Aged; Piroxicam; Tissue Inhibitor of Metalloproteinases

2007
Glycerogelatin-based ocular inserts of aceclofenac: physicochemical, drug release studies and efficacy against prostaglandin E₂-induced ocular inflammation.
    Drug delivery, 2011, Volume: 18, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Chemistry, Pharmaceutical; Cross-Linking Reagents; Delayed-Action Preparations; Diclofenac; Diffusion; Dinoprostone; Eye Diseases; Gelatin; Glycerol; Inflammation; Ophthalmic Solutions; Polymers; Rabbits; Vision, Ocular

2011