acecainide has been researched along with procainamide in 213 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 163 (76.53) | 18.7374 |
| 1990's | 34 (15.96) | 18.2507 |
| 2000's | 11 (5.16) | 29.6817 |
| 2010's | 3 (1.41) | 24.3611 |
| 2020's | 2 (0.94) | 2.80 |
| Authors | Studies |
|---|---|
| Erhardt, PW; Hanna, RG; Lampe, JW; Lumma, WC; Sullivan, ME; Wong, SS | 1 |
| Akazawa, M; Inui, K; Masuda, S; Okuda, M; Saito, H; Urakami, Y | 1 |
| Akazawa, M; Inui, K; Okuda, M; Saito, H; Urakami, Y | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Jaillon, P; Winkle, RA | 1 |
| Atkinson, AJ; del Greco, F; Gibson, TP; Ivanovich, P; Nevin, MJ; Ruo, TI; Stec, GP; Thenot, JP | 1 |
| Bernstein, RE | 1 |
| Drayer, DE; Kluger, J; Koffler, D; Lahita, R; Reidenberg, MM | 1 |
| Hed, J; Karlsson, E; Sonnhag, C | 1 |
| Friedman, HS; Kim, HG | 1 |
| Kamath, BL; Reynolds, RD | 1 |
| Drayer, D; Kluger, J; Lahita, R; Reidenberg, M | 1 |
| Walberg, CB; Wan, SH | 1 |
| Huang, SK; Liu, XQ | 2 |
| Carnes, CA; Coyle, JD | 1 |
| Carnes, CA; Coyle, JD; Muir, WW; Schaal, SF | 1 |
| Brautigam, RT; Kutalek, SP; Nydegger, C; Porter, RS; Schuster, M | 1 |
| Ing, TS; Kar, PM; Kellner, K; Leehey, DJ | 1 |
| Koopman, WJ; Zacharias, W | 1 |
| Hudson, JL; Liebling, MR; Richardson, BC | 1 |
| Brogden, RN; Harron, DW | 1 |
| Arimori, K; Hashimoto, Y; Nakano, M | 1 |
| Annesley, T; vasBinder, E | 1 |
| Boudoulas, H; Coyle, JD; Lima, JJ | 1 |
| Huang, SK; Lu, DY; Lu, H; Lu, JF; Yang, JY | 1 |
| Deng, N; Huang, SK; Liu, XD | 1 |
| Stevenson, WG; Weiss, J | 1 |
| Roden, DM | 1 |
| Flowers, D; Keefe, D; Miura, DS; Somberg, JC; Torres, V; Williams, S; Wynn, J | 1 |
| Beirne, GJ; Moorthy, AV; Pitterle, ME; Raehl, CL | 1 |
| Bruguerolle, B; Jadot, G | 1 |
| Franz, MR; Liem, B; Nguyen, KP; Swerdlow, CD; Thomsen, G | 1 |
| Annesley, T; Davenport, R; Giacherio, D; Matz, K | 1 |
| Kusowska, J; Sienkiewicz, J | 1 |
| Ferguson, RK; Greenspan, AM; Porter, RS; Raja, RM; Rocci, ML; Vlasses, PH | 1 |
| Brady, ME; Rosansky, SJ | 1 |
| Braden, GL; Fitzgibbons, JP; Germain, MJ; Ledewitz, HM | 1 |
| King, LW; Lertora, JJ | 1 |
| Borensztejn, M; Dupeyron, JP; Guyon, F; Raphanaud, D | 1 |
| Bowmer, CJ; Dean, HG; Silberstein, DJ; Yates, MS | 1 |
| Borkan, SC | 1 |
| Baerman, JM; de Buitleir, M; DiCarlo, LA; Kou, WH; Krol, RB; Morady, F | 1 |
| Raja, RM | 1 |
| Beirne, GJ; Moorthy, AV; Raehl, CL | 1 |
| Brown, SA; Davis, CA; Davis, LE; McKiernan, BC; Papich, MG | 1 |
| Feld, G; Nademanee, K; Singh, BN | 1 |
| Donkor, KA; King, LW; Lertora, JJ | 1 |
| Josephson, MA; Singh, BN | 1 |
| Atkinson, AJ; Ruo, TI | 1 |
| Drayer, DE; Reidenberg, MM | 1 |
| Keefe, D; Miura, D; Somberg, J; Torres, V; Williams, S; Wynn, J | 1 |
| Brown, WW; Bruggensmith, P; Domoto, DT | 1 |
| Coyle, K; Josephson, MA; Schwab, M; Singh, BN | 1 |
| Deguchi, F; Fujii, T; Ito, K; Ohe, T; Shimomura, K | 1 |
| Hiraoka, E; Kanamori, N; Kataoka, K; Mishima, M; Oishi, M; Yamaji, A | 1 |
| Okumura, K; Waldo, AL | 1 |
| Atkinson, AJ; Belknap, SM; Jansyn, EM; Piergies, AA; Ruo, TI | 1 |
| Davis, RJ; Ferguson, RK; Mojaverian, P; Rocci, ML; Vlasses, PH | 1 |
| Mitnick, PD | 1 |
| Boudoulas, H; Coyle, JD; Lima, JJ; MacKichan, JJ | 1 |
| Hoffman, BF; Wu, KM | 1 |
| Boucher, M; Dubray, C; Duchêne-Marullaz, P; Paire, M | 1 |
| Gallastegui, J; Jung, D; Paloucek, FP; Rodvold, KA | 1 |
| Iwamoto, K; Koyama, I; Ozeki, S; Watanabe, J | 1 |
| Imai, H; Tamai, G; Yoshida, H | 1 |
| Dhruv, RA; Henry, PR | 1 |
| Alballa, RS; Jamali, F; Lemko, CH; Mehvar, R | 1 |
| Feld, GK; Singh, BN; Venkatesh, N | 1 |
| Adams, L; Heineman, WR; Hess, EV; Lunte, CE; Wheeler, JF | 1 |
| Gill, EW; Jones, A; Sim, E; Stanley, L | 1 |
| Atkinson, AJ; Piergies, AA; Ruo, TI | 1 |
| Cornacchia, E; Golbus, J; Hanash, S; Maybaum, J; Richardson, B; Strahler, J | 1 |
| Cefali, E; Harford, A; Poynor, W; Sica, DA; Small, R; Yonce, C | 1 |
| Chao, PD; Chen, HC; Chung, CH; Jiang, FM; Lai, MY | 1 |
| Kosoglou, T; Rocci, ML; Vlasses, PH | 1 |
| Arimori, K; Nakano, M | 1 |
| Audino, N; Burris, S; Haver, VM; Nelson, M | 1 |
| An, DK; Mao, FF; Olugo-Edege, GC; Zhang, SQ; Zhu, YP | 1 |
| Desai, T; Furukawa, T; Herscovici, H; Lister, JW; Moroe, K; Nogami, A; Rozanski, JJ; Sampsell, R | 1 |
| Furukawa, T; Takeuchi, J; Taniguchi, K | 1 |
| Ferguson, RK; Kosoglou, T; Rocci, ML; Vlasses, PH | 1 |
| Goodrich, S; Karol, MD | 1 |
| Barbey, JT; Black, JN; Cato, E; Coxe, DR; Echt, DS | 1 |
| Deaton, PR; Epstein, D; Ingram, LA; Kang, ES; Mirvis, DM | 1 |
| Andress, E; Chase, SL; Ferguson, RK; Greenspon, AJ; Kosoglou, T; Lottes, S; Rocci, ML; Vlasses, PH | 1 |
| Bauer, LA; Black, D; Gensler, A; Sprinkle, J | 1 |
| Atkinson, AJ; Breiter, HC; Connelly, TJ; Hsieh, AM; Hubler, GL; Juan, D; Piergies, AA; Ruo, TI; Sedek, GS | 1 |
| Knowlton, PW; Svensson, CK | 1 |
| Adams, LE; Budinsky, R; Donovan-Brand, R; Hess, EV; Roberts, SM; Skoulis, NP; Zimmer, H | 1 |
| Funck-Brentano, C; Light, RT; Lineberry, MD; Roden, DM; Woosley, RL; Wright, GM | 1 |
| Ebihara, A; Fujimura, A; Kajiyama, H; Kumagai, Y; Nakashima, H; Sugimoto, K | 1 |
| Kusowska, J | 1 |
| Kusowska, J; Polakowski, P | 1 |
| Kennedy, HL; Stratmann, HG; Walter, KE | 1 |
| Herre, JM; Thompson, JA | 1 |
| Carlson, RJ; Gottlieb, AJ; Meisner, DJ | 1 |
| Giardina, EG | 1 |
| Alvis, R; DeLosAngeles, A; Goldstein, S; Kramer, M; Raja, R | 1 |
| Ahmad, S | 1 |
| Gorczynski, RJ; Reynolds, RD | 1 |
| Drayer, D; Ellis, G; Hayes, J; Kluger, J; Lloyd, V; Reidenberg, M; Tyberg, T | 1 |
| Jaillon, P; Kates, RE; Rubenson, DS; Winkle, RA | 1 |
| Dextraze, P; Diamond, I; Griffiths, WC; Hayes, M; Mitchell, J | 1 |
| Amsterdam, EA; Gallaher, C; Henderson, GL; Low, RI; Mason, DT | 1 |
| Kamath, BL; Yacobi, A | 1 |
| Eudeikis, JR; Kushner, W; Lertora, JL; Stec, GP | 1 |
| Kamath, BL; Lai, CM; Look, ZM; Yacobi, A | 1 |
| Calzadilla, S; Gupta, SD; Kamath, BL; Lai, CM; Look, ZM; Reynolds, RD; Yacobi, A | 1 |
| Higgins, SB; Oates, JA; Reele, SB; Roden, DM; Smith, RF; Wilkinson, GR; Woosley, RL | 1 |
| Asada, S; Muranishi, S; Nakae, H; Takada, K | 2 |
| Bigger, JT; Fenster, PE; Giardina, EG; Marcus, FI; Mayersohn, M; Perrier, D | 1 |
| Atkinson, AJ; Lertora, JJ; Morita, Y; Ruo, TI; Stec, GP; Thenot, JP | 1 |
| Camacho, M; Drayer, DE; Kluger, J; Reidenberg, MM | 1 |
| Grześkowiak, A; Lowicki, Z; Michałowska, D; Ochotny, R; Tomaszkiewicz, T; Wierzchowiecki, M | 1 |
| Jaillon, P; Kates, RE; Peters, F; Winkle, RA | 1 |
| Black, LA; Carney, DP; Carter, JE; Dutcher, JS; Erhardt, PW; Klein, LR | 1 |
| Atkinson, AJ; Henthorn, T; Morita, Y; Ruo, TI; Thenot, JP | 1 |
| Galeazzi, RL; Karlaganis, G; Omar-Amberg, C | 1 |
| Jaillon, P; Mason, JW; Peters, F; Rubenson, D; Winkle, RA | 1 |
| Dangman, KH; Hoffman, BF | 1 |
| Lalka, D; McNamara, PJ; Pieper, JA; Slaughter, RL; Wyman, MG | 1 |
| Durrani, M; Gupta, SD; Kamath, BL; Lai, CM; Stampfli, H; Yacobi, A | 1 |
| Drayer, DE; Kluger, J; Lahita, R; Reidenberg, MM | 1 |
| Amlie, JP; Landmark, K | 1 |
| Bach, PR; Larsen, JW | 1 |
| Durrani, MJ; Gupta, SD; Kamath, BL; Lai, CM; Yacobi, A | 1 |
| González, ER | 1 |
| Galeazzi, RL; Karlaganis, G; Pirovino, M | 1 |
| Reidenberg, MM | 2 |
| Freeman, RW; Uetrecht, JP; Woosley, RL | 1 |
| Badke, FR; Crawford, MH; Ludden, T; O'Rourke, RA; Walsh, RA | 1 |
| Lasky, FD; Wesley, JF | 1 |
| Drayer, DE; Kluger, J; Leech, S; Lloyd, V; Reidenberg, MM | 1 |
| Stearns, FM | 1 |
| Glezer, MG; Kholodov, LE; Sokolov, AV | 1 |
| Vyden, JK | 1 |
| Horner, H; Kluger, J; Reidenberg, MM | 1 |
| Atkinson, AJ; Ruo, TI; Stec, GP; Thenot, JP | 1 |
| Crawford, MH; Ludden, TM | 1 |
| Amon, KW; Crawford, MH; Kennedy, GT; Ludden, TM; O'Rourke, RA; Sodums, MT | 1 |
| Burmeister, WE; Calzadilla, SV; Drayer, DE; Lee, RJ; Reidenberg, MM; Reynolds, RD | 1 |
| Gupta, SD; Kamath, BL; Krasula, RW; Lai, CM; Stampfli, HF; Yacobi, A | 1 |
| Ho-Tung, P; Kessler, KM; Myerburg, RJ; Narayanan, S; Pickoff, A; Silver, J; Steele, B | 1 |
| McKinney, TD; Speeg, KV | 1 |
| Cunningham-Rundles, S; Tannen, RH | 1 |
| Cohen, J; Gaarder, T; Hurst, A; Jelliffe, RW; Rodman, JH | 1 |
| Howanitz, JH; Howanitz, PJ | 1 |
| Engel, TR | 1 |
| Basseches, PJ; DiGregorio, GJ | 1 |
| Heinzow, B; Somogyi, A | 1 |
| Frawley, VL; Ou, CN | 1 |
| Al-Hakiem, MH; Landon, J; Smith, DS | 1 |
| Bateman, DN | 1 |
| Hunt, S; Martins, J; Olshansky, B | 1 |
| Mirando, T; Zema, MJ | 1 |
| Glazier, H; Pittard, WB | 1 |
| Atkinson, AJ; Chao, GC; Kushner, W; Lertora, JJ; Nevin, MJ | 1 |
| Juma, Z; Saksena, S; Sung, RJ | 1 |
| Ferguson, RK; Greenspon, AJ; Porrini, KA; Rocci, ML; Vlasses, PH | 1 |
| Chen, ML; Chiou, WL; Lee, MG | 1 |
| Patel, CP | 1 |
| Kamath, BL; Lai, CM; Look, ZM; Stampfli, HF; Yacobi, A | 1 |
| Roden, DM; Woosley, RL | 2 |
| Heinzow, B; McLean, A; Somogyi, A | 1 |
| Kark, B; Keller, A; Sistovaris, N | 1 |
| Leskinen, O; Metsä-Ketelä, T; Ruosteenoja, R; Ylitalo, P | 1 |
| Boudoulas, H; Coyle, JD; Lima, JJ; MacKichan, JJ; Shields, BJ | 1 |
| Kroboth, PD; Mitchum, K; Puschett, JB | 1 |
| Christian, CD; Meredith, CG; Speeg, KV | 1 |
| Asada, A; Atkinson, AJ; Bowsher, DJ; Chow, MJ; Kushner, W; Murphy, JJ; Piergies, AA; Ruo, TI; Talano, JV | 1 |
| Matusewicz, W; Orszulak, DE | 1 |
| Hoyt, AM; Whitaker, JE | 1 |
| Matusewicz, W | 2 |
| Buxton, AE; Cassidy, DM; Doherty, JU; Josephson, ME; Marchlinski, FE; Vassallo, JA; Waxman, HL | 1 |
| Curry, RW; Grauer, K; Kravitz, L; Lopez, LM; Robinson, JD; Sands, CR | 1 |
| Duran, SH; Ellis, EJ; Malloy, M; Ravis, WR; Smyth, BG | 1 |
| Coyne, KS; Meimer, J; Nelson, SD | 1 |
| Lam, YW; Watkins, CE | 1 |
| Allen, NM; Page, RL | 1 |
| Cantilena, LR; Gibson, KF; Miller, CD; Oleshansky, MA | 1 |
| Ayer, LM; Edworthy, SM; Fritzler, MJ | 1 |
| Gleichmann, E; Goebel, C; Goebels, R; Kubicka-Muranyi, M; Uetrecht, J | 1 |
| Evans, MD; Herbert, KE; Hill, CM; Lunec, J | 1 |
| Bailie, GR; Low, CL; Phelps, KR | 1 |
| Eddington, ND; Kharidia, J | 1 |
| Borzak, S; Krepostman, A; Padhi, ID; Rudis, MI; Svensson, CK; Tisdale, JE; Ware, JA; Webb, CR; Zarowitz, BJ | 1 |
| Abel, RB; Forgue, ST; Smithers, JA; Uprichard, AC; Yang, BB | 1 |
| Padhi, ID; Svensson, CK; Tisdale, JE; Ware, JA | 1 |
| Chikazawa, S; Iwakawa, S; Kita, T; Komada, F; Okumura, K; Tanigawara, Y | 1 |
| Hadasová, E; Havel, J; Vargas, G | 1 |
| Bélanger, PM; Coquet, A; Fortin, A; Hamelin, BA; Lessard, E; Turgeon, J | 1 |
| Abel, RB; de Vries, TM; Eldon, MA; Koup, JR; Smithers, JA | 1 |
| Azzazy, HM; Chou, PP; Christenson, RH; Poklis, A; Shock, G | 1 |
| Adekoya, F; Eddington, ND; Kharidia, J | 1 |
| Boucher, M; Breysse, C; Chassaing, C; Herbet, A; Laborde, P | 1 |
| Ishii, K; Kubota, Y; Moriuchi, H; Nakahara, T; Sakamato, K; Shigenobu, K; Tanaka, Y; Yunoki, M | 1 |
| Ivars, F; Leanderson, T; Lindgren, H; Pero, RW | 1 |
| Bauer, LA; Black, DJ; Garrison, J; Hooton, TM; Lill, JS; Raisys, VA | 1 |
| Cannon, BC; Friedman, RA; Kertesz, NJ; Moffett, BS | 1 |
| Actor, JK; Dasgupta, A; Hovanetz, M; Olsen, M; Wells, A | 1 |
| Bonini, MG; Deterding, LJ; Ehrenshaft, M; Jiang, J; Mason, RP; Siraki, AG; Tomer, KB | 1 |
| Abdelhady, AM; Mohamed, AN; Overholser, BR; Sowinski, KM; Spencer, D; Tisdale, JE | 1 |
| Rosenbaum, AN; Vollmer, NJ; Wieruszewski, PM; Wittwer, ED | 1 |
| Oliveira, AC; Sigler, W | 1 |
11 review(s) available for acecainide and procainamide
| Article | Year |
|---|---|
Theoretical basis for interest in acetylprocainamide and clinical experiences with this new antiarrhythmic agent.
Topics: Acecainide; Acetylation; Animals; Arrhythmias, Cardiac; Isomerism; Kinetics; Procainamide | 1979 |
Combined high-efficiency hemodialysis and charcoal hemoperfusion in severe N-acetylprocainamide intoxication.
Topics: Acecainide; Charcoal; Combined Modality Therapy; Hemoperfusion; Humans; Male; Middle Aged; Poisoning; Procainamide; Renal Dialysis | 1992 |
Acecainide (N-acetylprocainamide). A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cardiac arrhythmias.
Topics: Acecainide; Arrhythmias, Cardiac; Humans; Procainamide | 1990 |
Comparison of the pharmacokinetic and pharmacodynamic properties of procainamide and N-acetylprocainamide.
Topics: Acecainide; Arrhythmias, Cardiac; Electrophysiology; Hemodynamics; Humans; Procainamide | 1988 |
Procainamide: clinical pharmacology and efficacy against ventricular arrhythmias.
Topics: Acecainide; Administration, Oral; Animals; Arrhythmias, Cardiac; Electrocardiography; Heart; Humans; Injections, Intravenous; Kinetics; Lupus Erythematosus, Systemic; Procainamide | 1984 |
[Clinical pharmacokinetics and pharmacodynamics of novocainamide and its metabolite N-acetylnovocainamide].
Topics: Absorption; Acecainide; Biological Availability; Dose-Response Relationship, Drug; Hemodynamics; Humans; Hydrogen-Ion Concentration; Kidney; Kinetics; Methods; Myocardial Contraction; Procainamide; Protein Binding; Tissue Distribution | 1981 |
Antiarrhythmic drug monitoring.
Topics: Acecainide; Anti-Arrhythmia Agents; Disopyramide; Humans; Lidocaine; Phenytoin; Procainamide; Propranolol; Quinidine | 1981 |
The electropharmacology of acute drug testing using pacemakers.
Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Electrophysiology; Heart Conduction System; Humans; Myocardial Infarction; Pacemaker, Artificial; Procainamide; Sinoatrial Node; Tachycardia; Time Factors | 1982 |
Pharmacokinetics and metabolism of the benzamides.
Topics: Acecainide; Animals; Benzamides; Disease; Half-Life; Humans; Kinetics; Metoclopramide; Procainamide; Sulpiride | 1982 |
Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide.
Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Disopyramide; Drug Interactions; Electrocardiography; Electrophysiology; Humans; Kinetics; Procainamide; Quinidine | 1983 |
[Clinical pharmacology of procainamide and its active metabolite -N-acetylprocainamide].
Topics: Acecainide; Animals; Arrhythmias, Cardiac; Biological Availability; Biotransformation; Half-Life; Humans; Metabolic Clearance Rate; Mice; Procainamide; Rabbits | 1984 |
11 trial(s) available for acecainide and procainamide
| Article | Year |
|---|---|
Comparison of intravenous dosing regimens for maintaining steady-state procainamide levels during programmed ventricular stimulation.
Topics: Acecainide; Cardiac Pacing, Artificial; Humans; Immunoenzyme Techniques; Infusions, Intravenous; Injections, Intravenous; Middle Aged; Procainamide; Tachycardia, Ventricular; Ventricular Fibrillation | 1992 |
Interaction of steady-state procainamide with H2-receptor antagonists cimetidine and ranitidine.
Topics: Acecainide; Adult; Cimetidine; Drug Interactions; Humans; Intestinal Absorption; Male; Procainamide; Ranitidine | 1987 |
Ranitidine-induced changes in the renal and hepatic clearances of procainamide are correlated.
Topics: Acecainide; Adult; Drug Interactions; Humans; Kidney; Liver; Male; Metabolic Clearance Rate; Procainamide; Ranitidine | 1989 |
Trimethoprim inhibition of the renal clearance of procainamide and N-acetylprocainamide.
Topics: Acecainide; Adult; Drug Interactions; Electrocardiography; Humans; Kidney; Male; Metabolic Clearance Rate; Procainamide; Random Allocation; Reference Values; Trimethoprim | 1989 |
The clinical pharmacology and antiarrhythmic efficacy of acetylprocainamide in patients with arrhythmias.
Topics: Acecainide; Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Dose-Response Relationship, Drug; Echocardiography; Female; Half-Life; Heart Rate; Humans; Male; Middle Aged; Placebos; Procainamide | 1980 |
Antiarrhythmic efficacy, pharmacokinetics and safety of N-acetylprocainamide in human subjects: comparison with procainamide.
Topics: Acecainide; Adolescent; Adult; Aged; Ambulatory Care; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arteriosclerosis; Creatinine; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Procainamide | 1980 |
Clinical pharmacology and antiarrhythmic efficacy of N-acetylprocainamide.
Topics: Acecainide; Adult; Aged; Arrhythmias, Cardiac; Coronary Disease; Dose-Response Relationship, Drug; Electrocardiography; Eye Diseases; Female; Gastrointestinal Diseases; Humans; Kinetics; Male; Middle Aged; Procainamide; Urticaria | 1981 |
Efficacy and safety of N-acetylprocainamide in long-term treatment of ventricular arrhythmias.
Topics: Acecainide; Aged; Ambulatory Care; Analysis of Variance; Arrhythmias, Cardiac; Chromatography, High Pressure Liquid; Drug Evaluation; Electrocardiography; Half-Life; Heart Ventricles; Hospitalization; Humans; Long-Term Care; Middle Aged; Nausea; Procainamide; Stroke Volume | 1983 |
Inhibition of N-acetylation of procainamide and renal clearance of N-acetylprocainamide by para-aminobenzoic acid in humans.
Topics: 4-Aminobenzoic Acid; Acecainide; Acetylation; Administration, Oral; Adult; Anti-Arrhythmia Agents; Cross-Over Studies; Drug Interactions; Female; Humans; Injections, Intravenous; Kidney; Male; Procainamide; Sunscreening Agents | 1995 |
Pharmacokinetic and pharmacodynamic comparisons of twice daily and four times daily formulations of procainamide in patients with frequent ventricular premature depolarization.
Topics: Acecainide; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chemistry, Pharmaceutical; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Procainamide; Tablets; Ventricular Premature Complexes | 1996 |
Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.
Topics: Acecainide; Adult; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Ciprofloxacin; Cross-Over Studies; Drug Interactions; Female; Humans; Kidney; Levofloxacin; Male; Ofloxacin; Procainamide | 2005 |
191 other study(ies) available for acecainide and procainamide
| Article | Year |
|---|---|
Heterocyclic analogues of benzamide antiarrhythmic agents.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzamides; Chemical Phenomena; Chemistry; Dogs; Electrophysiology; In Vitro Techniques; Papillary Muscles; Purkinje Fibers; Structure-Activity Relationship | 1989 |
Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules.
Topics: Animals; Cell Line; Dogs; Kidney; Kidney Tubules; Kinetics; Membranes; Nephrons; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substrate Specificity; Tetraethylammonium; Transfection | 2001 |
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Cations; Cell Line; Cloning, Molecular; DNA, Complementary; Genetic Variation; Humans; Kidney; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tetraethylammonium; Tissue Distribution; Transfection | 2002 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Electrophysiologic comparative study of procainamide and N-acetylprocainamide in anesthetized dogs: concentration-response relationships.
Topics: Acecainide; Animals; Atrioventricular Node; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Female; Heart Conduction System; Heart Ventricles; Male; Procainamide; Sinoatrial Node | 1979 |
N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis.
Topics: Acecainide; Adult; Computers; Female; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Models, Biological; Procainamide; Renal Dialysis | 1979 |
Procainamide, acetylprocainamide, and drug-induced lupus erythematosus.
Topics: Acecainide; Humans; Immune Complex Diseases; Lupus Erythematosus, Systemic; Procainamide | 1979 |
Antibodies to nuclear antigens in patients treated with procainamide or acetylprocainamide.
Topics: Acecainide; Aged; Antibodies, Antinuclear; Antibody Formation; Cell Nucleus; DNA; DNA, Single-Stranded; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Procainamide | 1979 |
Procainamide-induced lupus erythematosus-like syndrome in relation to acetylator phenotype and plasma levels of procainamide.
Topics: Acecainide; Acetylation; Adult; Aged; Antibodies, Antinuclear; Female; Humans; Isoniazid; Lupus Erythematosus, Systemic; Male; Middle Aged; Phenotype; Procainamide; Sulfapyridine | 1979 |
Procainamide-induced sinus node dysfunction in patients with chronic renal failure.
Topics: Acecainide; Aged; Angina Pectoris; Arrhythmia, Sinus; Arrhythmias, Cardiac; Bradycardia; Female; Heart Failure; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Pacemaker, Artificial; Procainamide | 1979 |
N-acetylprocainamide and ischemia-induced ventricular fibrillation in the dog.
Topics: Acecainide; Animals; Blood Pressure; Coronary Disease; Dogs; Electrocardiography; Female; Heart Rate; Male; Procainamide; Time Factors; Ventricular Fibrillation | 1979 |
Clinical evaluation of the EMIT procainamide and N-acetylprocainamide assay.
Topics: Acecainide; Antibody Specificity; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Procainamide | 1979 |
[Effects of amiodarone on kinetics of procainamide and its major metabolite disposition in rabbit].
Topics: Acecainide; Amiodarone; Animals; Drug Interactions; Female; Male; Procainamide; Rabbits | 1992 |
Evaluation of very rapid emit Qst methods for measuring serum procainamide and N-acetylprocainamide concentrations.
Topics: Acecainide; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Humans; Immunoenzyme Techniques; Procainamide; Time Factors | 1992 |
Electrophysiologic interactions of procainamide and N-acetylprocainamide in isolated canine cardiac Purkinje fibers.
Topics: Acecainide; Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; In Vitro Techniques; Procainamide; Purkinje Fibers | 1992 |
Lupus-inducing drugs alter the structure of supercoiled circular DNA domains.
Topics: Acecainide; Animals; Antibodies; Canavanine; DNA, Superhelical; Electrophoresis, Agar Gel; Escherichia coli; Hydralazine; Lupus Erythematosus, Systemic; Plasmids; Procainamide | 1990 |
CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation.
Topics: Acecainide; Antibody Formation; Antigen-Presenting Cells; Antigens, CD; Antigens, Differentiation; Azacitidine; B-Lymphocytes; CD4-Positive T-Lymphocytes; Cell Differentiation; DNA; Histocompatibility Antigens; Humans; Hydroxyurea; Integrin beta1; Leukocyte Common Antigens; Methylation; Procainamide | 1990 |
Comparison of transport of procainamide and N-acetylprocainamide from blood into the intestinal lumen with that into the peritoneal cavity in rats.
Topics: Acecainide; Animals; Biological Transport; Intestinal Mucosa; Male; Peritoneal Dialysis; Procainamide; Rats; Rats, Inbred Strains | 1990 |
Liquid chromatographic analysis of mexiletine in serum, with alternate application to tocainide, procainamide, and N-acetylprocainamide.
Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Lidocaine; Mexiletine; Procainamide; Tocainide | 1991 |
[Combined pharmacokinetic and pharmacodynamic model analysis for procainamide and its metabolite].
Topics: Acecainide; Animals; Chromatography, Thin Layer; Female; Male; Models, Statistical; Procainamide; Rabbits | 1991 |
Acecainide pharmacokinetics in normal subjects of known acetylator phenotype.
Topics: Acecainide; Acetylation; Adult; Humans; Male; Phenotype; Procainamide | 1991 |
[Combined pharmacokinetic-pharmacodynamic model of procainamide in rabbits with induced ventricular fibrillation threshold (VFT) changes].
Topics: Acecainide; Animals; Female; Linear Models; Male; Mathematics; Procainamide; Rabbits; Ventricular Fibrillation | 1991 |
[Simultaneous predictions of disposition kinetics of procainamide and its metabolite N-acetylprocainamide in rat by a physiological pharmacokinetic model].
Topics: Acecainide; Animals; Female; Male; Models, Biological; Procainamide; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
Torsades de pointes due to n-acetylprocainamide.
Topics: Acecainide; Aged; Female; Humans; Kidney Failure, Chronic; Procainamide; Renal Dialysis; Tachycardia | 1985 |
Antiarrhythmic drugs. Clinical pharmacology of the old and the new agents.
Topics: Acecainide; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden; Delayed-Action Preparations; Disopyramide; Heart Arrest; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Procainamide; Resuscitation; Tocainide | 1985 |
Electrophysiologic evaluation of the antiarrhythmic effects of N-acetylprocainamide for ventricular tachycardia secondary to coronary artery disease.
Topics: Acecainide; Aged; Coronary Disease; Electrocardiography; Electrophysiology; Female; Heart Arrest; Heart Conduction System; Heart Ventricles; Hemodynamics; Humans; Male; Middle Aged; Procainamide; Tachycardia | 1985 |
Procainamide administration during continuous ambulatory peritoneal dialysis.
Topics: Acecainide; Humans; Male; Metabolic Clearance Rate; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Procainamide | 1985 |
Circadian changes in procainamide and N-acetylprocainamide kinetics in the rat.
Topics: Acecainide; Animals; Circadian Rhythm; Half-Life; Injections, Intraperitoneal; Kinetics; Male; Procainamide; Rats; Rats, Inbred Strains | 1985 |
N-acetylprocainamide, torsades de pointes, and hemodialysis.
Topics: Acecainide; Adult; Female; Glomerulonephritis; Humans; Procainamide; Renal Dialysis; Tachycardia | 1986 |
A high performance liquid chromatographic assay for tocainide with alternate application for the determination of lidocaine, procainamide, and N-acetylprocainamide.
Topics: Acecainide; Administration, Oral; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Lidocaine; Procainamide; Tocainide | 1986 |
[Preliminary evaluation of the anti-arrhythmia effect of 4-acylamino-N[2-diethylaminoethyl]benzamides (N-acyl derivatives of procainamide)].
Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Drug Evaluation; Drug Evaluation, Preclinical; Mice; Mice, Inbred Strains; Procainamide | 1985 |
Lethal accumulation of procainamide metabolite in severe renal insufficiency.
Topics: Acecainide; Aged; Electrocardiography; Female; Heart; Humans; Kidney Diseases; Male; Middle Aged; Procainamide | 1986 |
Procainamide toxicity in a patient with acute renal failure.
Topics: Acecainide; Acute Kidney Injury; Administration, Oral; Aged; Arrhythmias, Cardiac; Gentamicins; Hemoperfusion; Humans; Male; Procainamide; Renal Dialysis | 1986 |
Hemoperfusion for treatment of N-acetylprocainamide intoxication.
Topics: Acecainide; Hemoperfusion; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Procainamide; Renal Dialysis | 1986 |
Cardiovascular actions and pharmacokinetics of desethyl-N-acetylprocainamide in the dog.
Topics: Acecainide; Animals; Blood Pressure; Cardiovascular System; Dogs; Dose-Response Relationship, Drug; Heart Rate; Kinetics; Myocardial Contraction; Procainamide; Propranolol | 1986 |
High performance liquid chromatography of procainamide and N-acetylprocainamide in human blood plasma.
Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Procainamide; Spectrometry, Fluorescence | 1986 |
Effect of acute renal failure on the disposition and elimination of [3H]N-acetyl procainamide ethobromide in the rat.
Topics: Acecainide; Acute Kidney Injury; Animals; Bile; Biotransformation; Chromatography, Thin Layer; Injections, Intravenous; Jugular Veins; Kinetics; Liver; Male; Portal Vein; Procainamide; Rats; Rats, Inbred Strains | 1986 |
Hemoperfusion for N-acetylprocainamide intoxication.
Topics: Acecainide; Hemoperfusion; Humans; Procainamide; Tachycardia | 1986 |
Effects of incremental doses of procainamide on ventricular refractoriness, intraventricular conduction, and induction of ventricular tachycardia.
Topics: Acecainide; Aged; Cardiac Catheterization; Cardiac Pacing, Artificial; Dose-Response Relationship, Drug; Drug Evaluation; Electrocardiography; Female; Heart Conduction System; Heart Ventricles; Humans; Infusions, Intravenous; Male; Middle Aged; Procainamide; Prospective Studies; Tachycardia | 1986 |
Resin hemoperfusion for drug intoxication--an update.
Topics: Acecainide; Digoxin; Glutethimide; Hemoperfusion; Humans; Ion Exchange Resins; Poisoning; Polystyrenes; Polyvinyls; Procainamide; Theophylline | 1986 |
Procainamide pharmacokinetics in patients on continuous ambulatory peritoneal dialysis.
Topics: Acecainide; Adult; Aged; Half-Life; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Procainamide | 1986 |
Pharmacokinetics of procainamide hydrochloride in dogs.
Topics: Acecainide; Animals; Chromatography, High Pressure Liquid; Dogs; Female; Fluorescence Polarization; Half-Life; Immunoassay; Kinetics; Male; Procainamide | 1986 |
Arrhythmia control by selective lengthening of cardiac repolarization: role of N-acetylprocainamide, active metabolite of procainamide.
Topics: Acecainide; Action Potentials; Animals; Arrhythmias, Cardiac; Depression, Chemical; Dogs; Electrophysiology; Heart Conduction System; Humans; In Vitro Techniques; Procainamide | 1986 |
The inotropic actions of N-acetylprocainamide: blockade and reversal by propranolol.
Topics: Acecainide; Animals; Atropine; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Heart Rate; Muscle Contraction; Procainamide; Propranolol; Stimulation, Chemical | 1986 |
Hemodynamic effects of N-acetylprocainamide in man: comparison with other antiarrhythmic drugs.
Topics: Acecainide; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Blood Pressure; Calcium Channel Blockers; Cardiac Catheterization; Cardiac Output; Hemodynamics; Humans; Procainamide; Pulmonary Wedge Pressure; Stroke Volume | 1986 |
Pharmacokinetics of N-acetylprocainamide.
Topics: Acecainide; Biological Availability; Body Water; Erythrocytes; Half-Life; Hemodynamics; Humans; Intestinal Absorption; Kidney; Procainamide; Protein Binding | 1986 |
Procainamide, N-acetylprocainamide, antinuclear antibody and systemic lupus erythematosus.
Topics: Acecainide; Acetylation; Antibodies, Antinuclear; Humans; Lupus Erythematosus, Systemic; Procainamide | 1986 |
N-acetylprocainamide's antiarrhythmic action in patients with ventricular tachycardia.
Topics: Acecainide; Drug Evaluation; Electric Stimulation; Heart Ventricles; Humans; Infusions, Intravenous; Longitudinal Studies; Procainamide; Tachycardia | 1986 |
Removal of toxic levels of N-acetylprocainamide with continuous arteriovenous hemofiltration or continuous arteriovenous hemodiafiltration.
Topics: Acecainide; Aged; Blood; Humans; Kidney Diseases; Male; Middle Aged; Procainamide; Renal Dialysis; Ultrafiltration | 1987 |
Effects of intravenous N-acetylprocainamide on hemodynamics and left ventricular function in man.
Topics: Acecainide; Adult; Aged; Blood Pressure; Cardiac Catheterization; Depression, Chemical; Heart Ventricles; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contraction; Procainamide; Stroke Volume; Ventricular Function | 1987 |
[A case of torsade de pointes induced by N-acetyl procainamide].
Topics: Acecainide; Humans; Male; Middle Aged; Procainamide; Tachycardia | 1987 |
Simultaneous determination of procainamide and N-acetylprocainamide in serum by gas chromatography with nitrogen-selective detection.
Topics: Acecainide; Adult; Arrhythmias, Cardiac; Chromatography, Gas; Humans; Indicators and Reagents; Kinetics; Male; Nitrogen; Procainamide | 1987 |
Effects of N-acetylprocainamide on experimental atrial flutter and atrial electrophysiologic properties in conscious dogs with sterile pericarditis: comparison with the effects of quinidine.
Topics: Acecainide; Animals; Atrial Flutter; Consciousness; Differential Threshold; Dogs; Electrophysiology; Heart; Heart Atria; Heart Conduction System; Pericarditis; Procainamide; Quinidine; Refractory Period, Electrophysiological; Time Factors | 1987 |
Effect kinetics of N-acetylprocainamide-induced QT interval prolongation.
Topics: Acecainide; Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Ventricles; Humans; Kinetics; Male; Middle Aged; Procainamide | 1987 |
Food-induced gastric retention and absorption of sustained-release procainamide.
Topics: Acecainide; Adult; Biological Availability; Delayed-Action Preparations; Food; Gastric Emptying; Humans; Intestinal Absorption; Kinetics; Male; Procainamide | 1987 |
N-acetylprocainamide toxicity.
Topics: Acecainide; Blood; Humans; Procainamide; Renal Dialysis; Ultrafiltration | 1987 |
Reversed-phase liquid chromatography method for measurement of procainamide and three metabolites in serum and urine: percent of dose excreted as deethyl metabolites.
Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Kinetics; Procainamide; Quality Control | 1987 |
Effect of procainamide and N-acetylprocainamide on atrial flutter: studies in vivo and in vitro.
Topics: Acecainide; Action Potentials; Animals; Atrial Flutter; Dogs; Electrocardiography; Humans; In Vitro Techniques; Membrane Potentials; Procainamide | 1987 |
Comparative effects of procainamide and its N-acetylated metabolite in conscious dogs with atrioventricular block: plasma concentration-response relationships.
Topics: Acecainide; Animals; Blood Pressure; Cardiac Pacing, Artificial; Dogs; Dose-Response Relationship, Drug; Female; Heart Block; Heart Rate; Male; Procainamide | 1987 |
Mandibular and parotid salivary excretion of procainamide and N-acetylprocainamide after intravenous administration of procainamide to rats.
Topics: Acecainide; Animals; Injections, Intravenous; Male; Parotid Gland; Procainamide; Rats; Rats, Inbred Strains; Saliva; Submandibular Gland | 1987 |
High-performance liquid chromatographic drug analysis by direct injection of whole blood samples. II. Determination of hydrophilic drugs.
Topics: Acecainide; Animals; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Procainamide; Rabbits | 1987 |
More-sensitive enzyme-multiplied immunoassay technique for procainamide and N-acetylprocainamide in plasma, serum, and urine.
Topics: Acecainide; Autoanalysis; Humans; Immunoenzyme Techniques; Procainamide | 1988 |
Longer plasma half-life for procainamide utilizing a very sensitive high performance liquid chromatography assay.
Topics: Acecainide; Administration, Oral; Chromatography, High Pressure Liquid; Half-Life; Humans; Monitoring, Physiologic; Procainamide | 1988 |
Effects of N-acetylprocainamide and recainam in the pharmacologic conversion and suppression of experimental canine atrial flutter: significance of changes in refractoriness and conduction.
Topics: Acecainide; Anesthesia; Animals; Anti-Arrhythmia Agents; Atrial Flutter; Dogs; Electrocardiography; Electrophysiology; Heart Conduction System; Phenylurea Compounds; Procainamide | 1988 |
Electrochemical determination of N-oxidized procainamide metabolites and functional assessment of effects on murine cells in vitro.
Topics: Acecainide; Animals; Ascorbic Acid; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; Cysteine; DNA; Electrochemistry; Electrolysis; Glutathione; Hydrogen-Ion Concentration; Kinetics; Mice; Oxidation-Reduction; Procainamide; Rats; Spectrophotometry; Spleen | 1988 |
Metabolites of procainamide and practolol inhibit complement components C3 and C4.
Topics: Acecainide; Complement C3; Complement C4; Humans; Practolol; Procainamide; Protein Binding | 1988 |
N-acetylprocainamide is a less potent inducer of T cell autoreactivity than procainamide.
Topics: Acecainide; Autoantibodies; Autoimmune Diseases; Chromatography, High Pressure Liquid; DNA; Humans; Hydralazine; In Vitro Techniques; Methylation; Phthalazines; Procainamide; T-Lymphocytes | 1988 |
Pharmacokinetics of procainamide in continuous ambulatory peritoneal dialysis.
Topics: Acecainide; Adult; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Procainamide | 1988 |
Dose dependent effect of cimetidine on procainamide disposition in man.
Topics: Acecainide; Adult; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Procainamide | 1988 |
Trimethoprim alters the disposition of procainamide and N-acetylprocainamide.
Topics: Acecainide; Acetylation; Adult; Creatinine; Drug Interactions; Humans; Hydrogen-Ion Concentration; Male; Metabolic Clearance Rate; Procainamide; Trimethoprim | 1988 |
Transport of procainamide and N-acetylprocainamide from blood into the intestinal lumen and intestinal dialysis by oral activated charcoal in rats with acute renal failure.
Topics: Acecainide; Acute Kidney Injury; Administration, Oral; Animals; Biliary Tract; Charcoal; Intestinal Mucosa; Male; Peritoneal Dialysis; Procainamide; Rats; Rats, Inbred Strains; Urinary Tract | 1988 |
Four fluorescence polarization immunoassays for therapeutic drug monitoring evaluated.
Topics: Acecainide; Fluorescence Polarization; Humans; Immunoassay; Phenytoin; Procainamide; Quality Control; Quinidine | 1989 |
[High performance liquid chromatographic method for determination of procainamide and its active metabolites, N-acetylprocainamide in serum].
Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Procainamide | 1988 |
Rapid assessment of rate and antiarrhythmic drug effect on the myocardium using asymmetric biphasic pulse stimulation.
Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Endocardium; Evoked Potentials; Heart; Heart Rate; Procainamide | 1989 |
The use of evoked endocardial response for assessment of antiarrhythmic drug effects on myocardium.
Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Electrodes; Endocardium; Evoked Potentials; Procainamide; Time Factors | 1988 |
Metabolite formation pharmacokinetics: rate and extent of metabolite formation determined by deconvolution.
Topics: Acecainide; Biotransformation; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Procainamide | 1988 |
Evaluation of antiarrhythmic drugs on defibrillation energy requirements in dogs. Sodium channel block and action potential prolongation.
Topics: Acecainide; Action Potentials; Animals; Anti-Arrhythmia Agents; Cesium; Dogs; Electric Countershock; Lidocaine; Procainamide; Quaternary Ammonium Compounds; Sodium Channels; Ventricular Fibrillation | 1989 |
Procainamide N-acetyltransferase: modulation by clofibrate and a microsomal form.
Topics: Acecainide; Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Clofibrate; Cytosol; In Vitro Techniques; Liver; Microsomes, Liver; Organ Size; Procainamide; Proteins; Rats; Rats, Inbred Strains; Subcellular Fractions | 1989 |
Influence of age, renal function and heart failure on procainamide clearance and n-acetylprocainamide serum concentrations.
Topics: Acecainide; Aged; Aging; Creatinine; Female; Heart Failure; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Procainamide; Tachycardia | 1989 |
Pharmacokinetics of N-acetylprocainamide in patients profiled with a stable isotope method.
Topics: Absorption; Acecainide; Aged; Carbon Isotopes; Humans; Male; Metabolic Clearance Rate; Middle Aged; Procainamide | 1989 |
Effect of the immunomodulator tilorone on the in vivo acetylation of procainamide in the rat.
Topics: Acecainide; Acetylation; Adjuvants, Immunologic; Animals; Fluorenes; Male; Procainamide; Rats; Rats, Inbred Strains; Tilorone | 1989 |
Procainamide hydroxylamine lymphocyte toxicity--I. Evidence for participation by hemoglobin.
Topics: Acecainide; Animals; Ascorbic Acid; Carbon Monoxide; Chemical Phenomena; Chemistry; Hemoglobins; In Vitro Techniques; Liver; Lymphocytes; Male; Methemoglobin; Monocytes; Procainamide; Rats; Rats, Inbred Strains; Spleen; Thymidine | 1989 |
Pharmacokinetic and pharmacodynamic interaction of N-acetyl procainamide and procainamide in humans.
Topics: Acecainide; Acetylation; Adult; Aged; Arrhythmias, Cardiac; Drug Interactions; Electrocardiography; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Phenotype; Procainamide | 1989 |
Chronopharmacokinetic studies of pranoprofen and procainamide.
Topics: Acecainide; Adult; Benzopyrans; Female; Humans; Male; Procainamide; Propionates | 1989 |
[A new anti-arrhythmia drug. II. Comparative studies of the effects of a new acyl derivative of procainamide, procainamide and N-acetylprocainamide on blood pressure and the electrocardiogram in rabbits].
Topics: Acecainide; Animals; Arrhythmias, Cardiac; Blood Pressure; Drug Evaluation, Preclinical; Electrocardiography; Heart Rate; Procainamide; Rabbits | 1989 |
[New anti-arrhythmia drug. III. Comparative studies of the effects of N-propionylprocainamide, procainamide and N-acetylprocainamide on hemodynamics and cardiac blood flow].
Topics: Acecainide; Animals; Arrhythmias, Cardiac; Coronary Circulation; Drug Evaluation, Preclinical; Female; Hemodynamics; Male; Procainamide; Rabbits | 1989 |
Torsade de pointes associated with elevated N-acetylprocainamide levels.
Topics: Acecainide; Humans; Male; Middle Aged; Procainamide; Tachycardia | 1985 |
Polymorphic ventricular tachycardia and ventricular fibrillation due to N-acetyl procainamide.
Topics: Acecainide; Aged; Electrocardiography; Heart Ventricles; Humans; Male; Procainamide; Tachycardia; Ventricular Fibrillation | 1985 |
Thrombocytopenia following sustained-release procainamide.
Topics: Acecainide; Acetylation; Adult; Aged; Antibodies, Antinuclear; Delayed-Action Preparations; Humans; Lupus Erythematosus, Systemic; Middle Aged; Phenotype; Procainamide; Thrombocytopenia; Time Factors | 1985 |
Resin hemoperfusion for severe N-acetylprocainamide toxicity in patients with renal failure.
Topics: Acecainide; Aged; Arrhythmias, Cardiac; Female; Hemoperfusion; Humans; Kidney Failure, Chronic; Male; Procainamide; Resins, Plant | 1984 |
Procainamide, NAPA and systemic lupus.
Topics: Acecainide; Animals; Dogs; Humans; Lupus Erythematosus, Systemic; Procainamide | 1980 |
Comparison of the autonomic effects of procainamide and N-acetylprocainamide in the dog.
Topics: Acecainide; Acetylcholine; Animals; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Autonomic Nervous System; Blood Pressure; Carotid Arteries; Dogs; Epinephrine; Female; Heart Rate; Hindlimb; Isoproterenol; Male; Phenylephrine; Procainamide; Vagus Nerve | 1980 |
Intravenous N-acetylprocainamide disposition kinetics in coronary artery disease.
Topics: Acecainide; Adult; Aged; Coronary Disease; Creatinine; Female; Half-Life; Humans; Infusions, Parenteral; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Procainamide | 1980 |
Assay of serum procainamide and N-acetylprocainamide: a comparison of emit and reverse-phase high-performance liquid chromatography.
Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Procainamide | 1980 |
Comparison of high-performance liquid chromatography with an enzyme multiplied immunoassay technique for the analysis of serum procainamide and N-acetylprocainamide.
Topics: Acecainide; Arrhythmias, Cardiac; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Immunoenzyme Techniques; Lidocaine; Procainamide; Quinidine | 1980 |
Half-life of N-acetylprocainamide in rats.
Topics: Acecainide; Animals; Half-Life; Kinetics; Male; Procainamide; Rats | 1980 |
The hemodynamic actions of N-acetylprocainamide in dogs: kinetics of effects and plasma concentration--response relationships.
Topics: Acecainide; Animals; Blood Pressure; Cardiac Output; Depression, Chemical; Dogs; Heart Rate; Heart Ventricles; Hemodynamics; Myocardial Contraction; Procainamide; Stimulation, Chemical; Stroke Volume; Vasodilation | 1980 |
Determination of procainamide and N-acetylprocainamide in biological fluids by high-pressure liquid chromatography.
Topics: Acecainide; Animals; Chromatography, High Pressure Liquid; Dogs; Humans; Procainamide; Rats; Species Specificity | 1980 |
Effect of coronary artery ligation on the pharmacokinetics of N-acetylprocainamide in dogs.
Topics: Acecainide; Animals; Coronary Vessels; Dogs; Half-Life; Kinetics; Ligation; Male; Procainamide | 1980 |
Transport rates of hepatic uptake and biliary excretion of an organic cation, acetyl procainamide ethobromide.
Topics: Acecainide; Animals; Bile; In Vitro Techniques; Indocyanine Green; Kinetics; Liver; Male; Procainamide; Rats | 1980 |
Efficacy, plasma concentrations and adverse effects of a new sustained release procainamide preparation.
Topics: Acecainide; Acetylation; Adult; Aged; Anti-Arrhythmia Agents; Antibodies, Antinuclear; Arrhythmias, Cardiac; Female; Gastrointestinal Diseases; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Nervous System Diseases; Phenotype; Procainamide | 1980 |
Kinetics of N-acetylprocainamide deacetylation.
Topics: Acecainide; Adult; Humans; Kinetics; Male; Metabolic Clearance Rate; Procainamide | 1980 |
Aging and renal clearance of procainamide and acetylprocainamide.
Topics: Acecainide; Adult; Aged; Aging; Child; Creatinine; Humans; Metabolic Clearance Rate; Middle Aged; Procainamide | 1980 |
Pharmacokinetic studies of procainamide (PA) and N-acetylprocainamide (NAPA) in healthy subjects.
Topics: Acecainide; Acetylation; Adolescent; Adult; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Phenotype; Procainamide | 1980 |
Analysis of procainamide hydrochloride and acecainide hydrochloride in rat feed.
Topics: Acecainide; Animal Feed; Animals; Chromatography, Gas; Procainamide; Rats | 1980 |
Identification of desethyl procainamide in patients: a new metabolite of procainamide.
Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Humans; Metabolic Clearance Rate; Mice; Procainamide; Respiration; Structure-Activity Relationship | 1981 |
N-Acetyl-procainamide kinetics in the elderly.
Topics: Acecainide; Aged; Humans; Kinetics; Middle Aged; Models, Biological; Procainamide; Saliva | 1981 |
Electrophysiologic effects of N-acetylprocainamide in human beings.
Topics: Acecainide; Atrial Function; Atrioventricular Node; Blood Pressure; Bundle of His; Electrocardiography; Electrophysiology; Female; Heart; Heart Conduction System; Humans; Male; Middle Aged; Procainamide; Sinoatrial Node; Ventricular Function | 1981 |
In vivo and in vitro antiarrhythmic and arrhythmogenic effects of N-acetyl procainamide.
Topics: Acecainide; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Dogs; Heart Block; Heart Rate; Heart Ventricles; In Vitro Techniques; Ligation; Membrane Potentials; Procainamide; Purkinje Fibers | 1981 |
Factors influencing serum protein binding of lidocaine in humans.
Topics: Acecainide; Blood Proteins; Bupivacaine; Disopyramide; Humans; Lidocaine; Orosomucoid; Procainamide; Propranolol; Protein Binding; Quinidine; Serum Albumin | 1981 |
Bioavailability of N-acetylprocainamide from mixed diet in rats.
Topics: Acecainide; Administration, Oral; Animals; Biological Availability; Diet; Intestinal Absorption; Male; Procainamide; Rats | 1981 |
Acetylprocainamide therapy in patients with previous procainamide-induced lupus syndrome.
Topics: Acecainide; Aged; Antibodies, Antinuclear; Arrhythmias, Cardiac; Female; Humans; Lupus Vulgaris; Male; Middle Aged; Procainamide | 1981 |
N-acetylprocainamide induced changes in refractoriness and monophasic action potentials of the dog heart in situ.
Topics: Acecainide; Action Potentials; Animals; Dogs; Female; Heart; Heart Conduction System; Heart Ventricles; Male; Procainamide; Ventricular Function | 1981 |
Stability of standard curves prepared for EMIT homogeneous enzyme immunoassay kits stored at room temperature after reconstitution.
Topics: Acecainide; Gentamicins; Humans; Lidocaine; Procainamide; Reagent Kits, Diagnostic; Reference Standards; Theophylline | 1980 |
Pharmacokinetics of procainamide and N-acetylprocainamide in rats.
Topics: Acecainide; Animals; Half-Life; Kinetics; Male; Models, Biological; Procainamide; Rats | 1981 |
Alter drug structure--avert induced lupus.
Topics: Acecainide; Arrhythmias, Cardiac; Female; Humans; Lupus Erythematosus, Systemic; Male; Procainamide; Structure-Activity Relationship | 1981 |
[Steady-state plasma and saliva concentrations of procainamide and N-acetyl-procainamide after a sustained release preparation].
Topics: Acecainide; Adult; Aged; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Procainamide; Saliva; Statistics as Topic | 1980 |
The chemical induction of systemic lupus erythematosus and lupus-like illnesses.
Topics: Acecainide; Acetylation; Adult; Female; Humans; Hydralazine; Hydrazines; Isoniazid; Lupus Erythematosus, Systemic; Lupus Vulgaris; Lymphocytes; Phenotype; Procainamide; Time Factors | 1981 |
The implications of procainamide metabolism to its induction of lupus.
Topics: Acecainide; Acetylation; Animals; Antibodies, Antinuclear; Antibody Formation; Humans; Hydroxylamines; Lupus Erythematosus, Systemic; Mice; Phenotype; Procainamide; Time Factors | 1981 |
Hemodynamic effects of n-acetylprocainamide compared with procainamide in conscious dogs.
Topics: Acecainide; Animals; Autonomic Nerve Block; Dogs; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Hexamethonium Compounds; Niacin; Nicotinic Acids; Procainamide; Reserpine; Sympathetic Nervous System | 1981 |
High performance liquid chromatographic analysis of the antiarrhythmic drugs procainamide, disopyramide, quinidine, propranolol and metabolites from serum extracts.
Topics: Acecainide; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Disopyramide; Humans; Procainamide; Propranolol; Pyridines; Quinidine; Spectrophotometry, Ultraviolet | 1981 |
Pharmacokinetic study on saturated hepato-biliary transport of acetyl procainamide ethobromide.
Topics: Acecainide; Animals; Bile; Biological Transport; Kinetics; Liver; Male; Procainamide; Rats; Rats, Inbred Strains | 1981 |
Long-term antiarrhythmic therapy with acetylprocainamide.
Topics: Acecainide; Acetylation; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arthritis, Rheumatoid; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Female; Heart Failure; Humans; Long-Term Care; Male; Middle Aged; Procainamide; Systole; Tachycardia; Ventricular Fibrillation | 1981 |
Determination of procainamide and N-acetylprocainamide by "high-performance" liquid chromatography.
Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Procainamide | 1981 |
Acecainide for ventricular arrhythmias.
Topics: Acecainide; Arrhythmias, Cardiac; Heart Ventricles; Humans; Procainamide | 1982 |
Effects of procainamide and N-acetylprocainamide on myocardial contractility in ischemic isolated rabbit hearts.
Topics: Acecainide; Animals; Coronary Disease; Disease Models, Animal; Epinephrine; Male; Myocardial Contraction; Procainamide; Rabbits; Reserpine; Tyramine | 1981 |
Plasma concentrations of desethyl N-acetylprocainamide in patients treated with procainamide and N-acetylprocainamide.
Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Procainamide | 1981 |
N-Acetylprocainamide kinetics after single and repeated oral doses.
Topics: Acecainide; Administration, Oral; Adult; Aged; Cardiomyopathies; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Kidney; Kinetics; Male; Middle Aged; Procainamide; Time Factors | 1982 |
Hemodynamic effects of N-acetylprocainamide in heart disease.
Topics: Acecainide; Administration, Oral; Blood Pressure; Female; Heart Diseases; Heart Rate; Hemodynamics; Humans; Infusions, Parenteral; Male; Procainamide | 1982 |
Comparison of antiarrhythmic effects of procainamide, N-acetylprocainamide, and p-hydroxy-N-(3-diethylaminopropyl)benzamide.
Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Coronary Circulation; Dogs; Heart; Kinetics; Male; Mice; Mice, Inbred ICR; Procainamide; Structure-Activity Relationship | 1982 |
Disposition study of procainamide and N-acetylprocainamide during subacute administration in rats.
Topics: Acecainide; Animals; Biological Availability; Dose-Response Relationship, Drug; Eating; Female; Male; Procainamide; Rats; Rats, Inbred Strains; Sex Factors | 1982 |
Simultaneous quantitation of quinidine, procainamide, and N-acetylprocainamide in serum by gas-liquid chromatography with a nitrogen-phosphorus selective detector.
Topics: Acecainide; Chromatography, Gas; Heart Arrest; Humans; Immunoenzyme Techniques; Procainamide; Quinidine | 1982 |
Cimetidine and procainamide secretion by proximal tubules in vitro.
Topics: Absorption; Acecainide; Animals; Carbon Dioxide; Chromatography, High Pressure Liquid; Cimetidine; Guanidines; Hypothermia; Kidney Tubules, Proximal; Kinetics; Ouabain; Probenecid; Procainamide; Quinidine; Rabbits | 1982 |
Inhibition of Con A mitogenesis by serum from procainamide-treated patients and patients with systemic lupus erythematosus.
Topics: Acecainide; Antibodies; Binding, Competitive; Concanavalin A; Humans; Immunoglobulin G; In Vitro Techniques; Lupus Erythematosus, Systemic; Lymphocyte Activation; Procainamide | 1982 |
N-Acetylprocainamide kinetics and clinical response during repeated dosing.
Topics: Acecainide; Aged; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Kinetics; Male; Middle Aged; Procainamide | 1982 |
Excretion of procainamide into bile and saliva in rats with chronic renal failure.
Topics: Acecainide; Animals; Bile; Kidney Failure, Chronic; Male; Procainamide; Rats; Rats, Inbred Strains; Saliva | 1982 |
Cimetidine reduces procainamide elimination.
Topics: Acecainide; Cimetidine; Drug Interactions; Guanidines; Humans; Kidney; Procainamide | 1982 |
Theophylline, dyphylline, caffeine, acetaminophen, salicylate, acetylsalicylate, procainamide, and N-acetylprocainamide determined in serum with a single liquid-chromatographic assay.
Topics: Acecainide; Acetaminophen; Aspirin; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Humans; Pharmaceutical Preparations; Procainamide; Salicylates; Salicylic Acid; Theophylline | 1982 |
Development of Fluoroimmunoassays for the determination of individual or combined levels of procainamide and N-acetylprocainamide in serum.
Topics: Acecainide; Animals; Chromatography, Gas; Cross Reactions; Female; Fluorescent Antibody Technique; Humans; Immune Sera; Immunoassay; Procainamide; Rabbits; Sheep | 1982 |
N-acetyl procainamide causing torsades de pointes.
Topics: Acecainide; Aged; Anti-Arrhythmia Agents; Drug Therapy, Combination; Electrocardiography; Female; Humans; Procainamide; Tachycardia | 1982 |
Serum drug concentrations in patients with ischemic heart disease after administration of a sustained release procainamide preparation.
Topics: Acecainide; Administration, Oral; Adult; Aged; Coronary Disease; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Procainamide | 1983 |
Procainamide excretion in human milk.
Topics: Acecainide; Adult; Arrhythmias, Cardiac; Female; Humans; Infant, Newborn; Male; Milk, Human; Postpartum Period; Pregnancy; Pregnancy Complications, Cardiovascular; Procainamide | 1983 |
Electrophysiologic properties and antiarrhythmic mechanisms of intravenous N-acetylprocainamide in patients with ventricular dysrhythmias.
Topics: Acecainide; Adult; Aged; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiology; Female; Heart Conduction System; Humans; Male; Middle Aged; Procainamide; Tachycardia | 1983 |
Immediate-release and sustained-release procainamide: bioavailability at steady state in cardiac patients.
Topics: Acecainide; Aged; Arrhythmias, Cardiac; Biological Availability; Capsules; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Procainamide; Tablets; Time Factors | 1983 |
Pharmacokinetics of drugs in blood III: Metabolism of procainamide and storage effect of blood samples.
Topics: Acecainide; Adult; Blood Preservation; Chromatography, High Pressure Liquid; Humans; Kinetics; Procainamide; Specimen Handling | 1983 |
Improved liquid chromatographic determination of procainamide and N-acetylprocainamide in serum.
Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Procainamide | 1983 |
Age-related pharmacokinetics of N-acetylprocainamide in rats.
Topics: Acecainide; Administration, Oral; Aging; Animals; Injections, Intravenous; Kinetics; Procainamide; Rats; Tissue Distribution | 1983 |
Importance of metabolites in antiarrhythmic therapy.
Topics: Acecainide; Agranulocytosis; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Encainide; Humans; Procainamide; Propranolol; Quinidine | 1983 |
Cimetidine-procainamide pharmacokinetic interaction in man: evidence of competition for tubular secretion of basic drugs.
Topics: Absorption; Acecainide; Adult; Cimetidine; Drug Interactions; Half-Life; Humans; Kidney Tubules; Kinetics; Male; Metabolic Clearance Rate; Procainamide | 1983 |
Thin-layer chromatographic determination of procainamide and N-acetylprocainamide in human serum and urine at single-dose levels.
Topics: Acecainide; Adult; Biological Availability; Chromatography, Thin Layer; Half-Life; Humans; Kinetics; Male; Procainamide; Spectrophotometry, Ultraviolet | 1983 |
Aromatic amines and the pathogenesis of lupus erythematosus.
Topics: Acecainide; Acetylation; Amines; Anti-Arrhythmia Agents; Humans; Hydrazines; Lupus Erythematosus, Systemic; Male; Middle Aged; Phenotype; Procainamide | 1983 |
Significance of acetylator phenotype in pharmacokinetics and adverse effects of procainamide.
Topics: Acecainide; Acetylation; Adult; Aged; Antibodies, Antinuclear; Arrhythmias, Cardiac; Delayed-Action Preparations; Female; Humans; Kinetics; Male; Middle Aged; Myocardial Infarction; Phenotype; Procainamide | 1983 |
Fluoroimmunoassays for procainamide and N-acetylprocainamide compared with a liquid-chromatographic method.
Topics: Acecainide; Chromatography, High Pressure Liquid; Fluorescent Antibody Technique; Humans; Kinetics; Methods; Procainamide; Time Factors | 1984 |
Use of procainamide in chronic ambulatory peritoneal dialysis: report of a case.
Topics: Acecainide; Acetylation; Arrhythmias, Cardiac; Half-Life; Heart Ventricles; Humans; Kidney; Liver; Male; Middle Aged; Peritoneal Dialysis; Peritoneal Dialysis, Continuous Ambulatory; Procainamide | 1984 |
Cimetidine inhibits renal procainamide clearance.
Topics: Acecainide; Adult; Cimetidine; Drug Interactions; Glomerular Filtration Rate; Humans; Kidney; Male; Metabolic Clearance Rate; Procainamide | 1984 |
Torsade de pointes induced by N-acetylprocainamide.
Topics: Acecainide; Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Kinetics; Procainamide; Tachycardia | 1984 |
Colorimetric determination of procainamide in injectable preparations.
Topics: Acecainide; Chemical Phenomena; Chemistry; Colorimetry; Copper; Hydrogen-Ion Concentration; Injections; Procainamide | 1984 |
[Comparative studies of the hemodynamic effects of procainamide and N-acetylprocainamide in rabbits].
Topics: Acecainide; Animals; Blood Pressure; Cardiac Volume; Female; Heart Rate; Hemodynamics; Male; Procainamide; Rabbits | 1984 |
[Hemodynamic and electrocardiographic studies of the interaction of N-acetylprocainamide and procainamide with digoxin in rabbits].
Topics: Acecainide; Animals; Blood Pressure; Cardiac Volume; Digoxin; Drug Interactions; Electrocardiography; Female; Heart Rate; Hemodynamics; Male; Procainamide; Rabbits | 1984 |
Comparative electrophysiologic effects of intravenous and oral procainamide in patients with sustained ventricular arrhythmias.
Topics: Acecainide; Administration, Oral; Adult; Aged; Cardiac Pacing, Artificial; Electrophysiology; Female; Humans; Injections, Intravenous; Male; Middle Aged; Procainamide; Tachycardia; Ventricular Fibrillation | 1984 |
Ventricular ectopy.
Topics: Acecainide; Administration, Oral; Adult; Age Factors; Aged; Cardiac Complexes, Premature; Delayed-Action Preparations; Electrocardiography; Female; Half-Life; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Male; Middle Aged; Procainamide; Quinidine | 1984 |
The pharmacokinetics and pharmacodynamics of procainamide in horses after intravenous administration.
Topics: Acecainide; Animals; Electrocardiography; Fluorescence Polarization Immunoassay; Half-Life; Heart; Horses; Infusions, Intravenous; Procainamide | 1994 |
The discordant influences of infarct healing on the electrophysiologic effects of procainamide and N-acetylprocainamide.
Topics: Acecainide; Animals; Dogs; Electrophysiology; Heart; Heart Conduction System; Myocardial Infarction; Procainamide; Refractory Period, Electrophysiological | 1995 |
Fluorescence polarization immunoassay of quinidine, procainamide, and N-acetylprocainamide using Cobas-FP reagents.
Topics: Acecainide; Drug Monitoring; Enzyme Multiplied Immunoassay Technique; Fluorescence Polarization Immunoassay; Humans; Procainamide; Quinidine; Reagent Kits, Diagnostic | 1993 |
Procainamide administration during pregnancy.
Topics: Acecainide; Administration, Oral; Adult; Cardiac Pacing, Artificial; Female; Humans; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Trimester, Third; Procainamide; Tachycardia, Ventricular | 1993 |
Procainamide-induced myasthenia-like weakness and dysphagia.
Topics: Acecainide; Deglutition Disorders; Humans; Male; Middle Aged; Muscular Diseases; Procainamide | 1993 |
Effect of procainamide and hydralazine on poly (ADP-ribosylation) in cell lines.
Topics: Acecainide; Cell Line, Transformed; Humans; Hydralazine; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Procainamide; Tumor Cells, Cultured | 1993 |
T lymphocytes ignore procainamide, but respond to its reactive metabolites in peritoneal cells: demonstration by the adoptive transfer popliteal lymph node assay.
Topics: Acecainide; Acetylation; Animals; Female; Humans; Hydroxylation; Immunologic Memory; Lymph Nodes; Mice; Mice, Inbred A; Mice, Inbred C57BL; Peritoneal Cavity; Phagocytes; Procainamide; Spleen; T-Lymphocytes | 1993 |
Application of capillary electrophoresis to the in vitro assessment of drug metabolism.
Topics: Acecainide; Ascorbic Acid; Culture Media; Electrophoresis, Capillary; Evaluation Studies as Topic; Humans; In Vitro Techniques; Leukocytes; Peroxidase; Pharmaceutical Preparations; Procainamide | 1995 |
Relative efficacy of haemoperfusion, haemodialysis and CAPD in the removal of procainamide and NAPA in a patient with severe procainamide toxicity.
Topics: Acecainide; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Diabetic Nephropathies; Hemoperfusion; Humans; Male; Metabolic Clearance Rate; Peritoneal Dialysis, Continuous Ambulatory; Procainamide; Renal Dialysis | 1996 |
Application of computer-assisted radiotelemetry in the pharmacokinetic and pharmacodynamic modeling of procainamide and N-acetylprocainamide.
Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Cardiovascular System; Electrocardiography; Male; Procainamide; Rats; Rats, Sprague-Dawley; Telemetry | 1996 |
Comparison of fluorescence polarization immunoassay with liquid chromatography for quantification of procainamide and N-acetylprocainamide in urine.
Topics: Acecainide; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Fluorescence Polarization Immunoassay; Humans; Procainamide; Reproducibility of Results | 1996 |
Genotyping of N-acetylation polymorphism and correlation with procainamide metabolism.
Topics: Acecainide; Acetylation; Adult; Aged; Arylamine N-Acetyltransferase; Base Sequence; DNA; Female; Fluorescence Polarization Immunoassay; Genotype; Heterozygote; Homozygote; Humans; Japan; Male; Middle Aged; Molecular Sequence Data; Platelet Aggregation Inhibitors; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Procainamide | 1997 |
Direct determination of procainamide and N-acetylprocainamide by capillary zone electrophoresis in pharmaceutical formulations and urine.
Topics: Acecainide; Animals; Anti-Arrhythmia Agents; Capsules; Chemistry, Pharmaceutical; Electrochemistry; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Molecular Structure; Procainamide; Rats; Spectrophotometry | 1997 |
Improved high-performance liquid chromatographic assay for the determination of procainamide and its N-acetylated metabolite in plasma: application to a single-dose pharmacokinetic study.
Topics: Acecainide; Acetylation; Anti-Arrhythmia Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Procainamide; Regression Analysis; Spectrophotometry, Ultraviolet | 1998 |
Effect of age, gender, and race on steady state procainamide pharmacokinetics after administration of procanbid sustained-release tablets.
Topics: Acecainide; Administration, Oral; Adult; Aged; Aging; Anti-Arrhythmia Agents; Asian People; Black People; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Procainamide; Racial Groups; Sex Characteristics; Tablets; Ventricular Premature Complexes; White People | 1998 |
Multicenter evaluation of the Abbott AxSYM procainamide and N-acetylprocainamide assays: comparison with Abbott TDx/TDxFLx, Syva EMIT 2000, DuPont ACA, and HPLC methods.
Topics: Acecainide; Calibration; Chromatography, High Pressure Liquid; Fluorescence Polarization Immunoassay; Humans; Procainamide; Reagent Kits, Diagnostic; Reference Values; Reproducibility of Results; Sensitivity and Specificity | 1998 |
The influence of moderate and chronic exercise training on the pharmacokinetics of procainamide and N-acetylprocainamide.
Topics: Acecainide; Animals; Male; Physical Conditioning, Animal; Procainamide; Rats; Rats, Sprague-Dawley | 1998 |
Cardiac anticholinergic effects of procainamide and its N-acetylated metabolite: experimental pharmacological and radioligand binding studies.
Topics: Acecainide; Acetylation; Animals; Anti-Arrhythmia Agents; Binding, Competitive; Blood Pressure; Bradycardia; Cholinergic Antagonists; Dogs; Female; Heart; Male; Myocardium; Nervous System; Procainamide; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Muscarinic; Vagus Nerve | 1998 |
Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle.
Topics: Acecainide; Animals; Barium; Cattle; Dose-Response Relationship, Drug; In Vitro Techniques; Methacholine Chloride; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Peptides; Potassium; Potassium Channel Blockers; Potassium Channels; Procainamide; Trachea | 2001 |
N-substituted benzamides inhibit nuclear factor-kappaB and nuclear factor of activated T cells activity while inducing activator protein 1 activity in T lymphocytes.
Topics: Acecainide; Benzamides; CD40 Ligand; Cell Nucleus; DNA-Binding Proteins; Enzyme Activation; Humans; Interleukin-2; Jurkat Cells; NF-kappa B; NF-kappa B p50 Subunit; NFATC Transcription Factors; Nuclear Proteins; Procainamide; Promoter Regions, Genetic; T-Lymphocytes; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic | 2001 |
Therapeutic levels of intravenous procainamide in neonates: a retrospective assessment.
Topics: Acecainide; Anti-Arrhythmia Agents; Creatinine; Dose-Response Relationship, Drug; Gestational Age; Humans; Infant, Newborn; Infusions, Intravenous; Metabolic Clearance Rate; Procainamide; Retrospective Studies | 2006 |
Drug-herb interaction: effect of St John's wort on bioavailability and metabolism of procainamide in mice.
Topics: Acecainide; Animals; Anthracenes; Biological Availability; Female; Herb-Drug Interactions; Hypericum; Mice; Perylene; Procainamide | 2007 |
Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis.
Topics: Acecainide; Ascorbic Acid; Cell Line, Tumor; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Free Radicals; Granulocytes; Humans; Hydrogen Peroxide; Ions; Mass Spectrometry; Molecular Structure; Peroxidase; Procainamide | 2008 |
Pharmacokinetic modeling and simulation of procainamide and N-acetylprocainamide in a patient receiving continuous renal replacement therapy: a novel approach to guide renal dose adjustments.
Topics: Acecainide; Adult; Anti-Arrhythmia Agents; Humans; Male; Models, Biological; Procainamide; Renal Insufficiency, Chronic; Renal Replacement Therapy; Tachycardia, Ventricular | 2013 |
Procainamide pharmacokinetics during extracorporeal membrane oxygenation.
Topics: Acecainide; Adult; Arrhythmias, Cardiac; Extracorporeal Membrane Oxygenation; Humans; Procainamide; Tachycardia, Ventricular | 2023 |
Molecular basis of the different effects of procainamide and N-acetylprocainamide on the maximum upstroke velocity and half-decay time of the cardiac action potential in guinea pig papillary muscle.
Topics: Acecainide; Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Guinea Pigs; Mice; Papillary Muscles; Procainamide; Rats | 2023 |