acebutolol and metoprolol

acebutolol has been researched along with metoprolol in 84 studies

Research

Studies (84)

Timeframe	Studies, this research(%)	All Research%
pre-1990	37 (44.05)	18.7374
1990's	13 (15.48)	18.2507
2000's	21 (25.00)	29.6817
2010's	10 (11.90)	24.3611
2020's	3 (3.57)	2.80

Authors

Authors	Studies
Carrupt, PA; el Tayar, N; Testa, B; Van de Waterbeemd, H	1
Carrupt, PA; Gaillard, P; Schambel, P; Testa, B	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Baker, JG	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Carrupt, PA; Guillarme, D; Henchoz, Y; Rudaz, S; Veuthey, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Bard, B; Carrupt, PA; Martel, S	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Akamatsu, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bucki, A; Głuch-Lutwin, M; Jaromin, A; Jastrzębska-Więsek, M; Kołaczkowski, M; Mordyl, B; Partyka, A; Siwek, A; Walczak, M; Wesołowska, A; Zagórska, A	1
Chubb, IW; Raine, AE	1
Gooren, L; Harms, HH; Hesse, C; Spoelstra, AJ; Verschoor, L	1
Kiechel, JR; Meier, J	1
Tannenbaum, H	1
Littler, WA; Stallard, TJ; Watson, RD	2
Godtlibsen, OB; Kayed, K	1
Newman, RJ	1
Hayashi, T; Ichinohe, T; Ikeda, S; Ikeda, Y; Kawaguchi, K; Kotake, C; Koya, Y; Onaka, H; Seo, T; Suyama, K	1
Abrignani, MG; Corda, M; Cosentino, F; Liquori, M; Novo, S; Pinto, A; Strano, A	1
Behr, U; Franz, IW; Ketelhut, R; Tönnesmann, U	2
Beudin, P; Ducher, JL; Gibert, J; Kantelip, JP; Lauxerois, M; Pechadre, JC; Sabot, C; Trolese, JF	1
Palkama, A; Raij, K; Uusitalo, H; Uusitalo, R	1
Jelnes, R; Svendsen, TL; Tønnesen, KH	2
Jackson, PR; Lewis, RV; Ramsay, LE	1
Fishbein, L; Jackson, CD	1
Tattersfield, AE; Thomas, MS	1
Antonaccio, MJ; DeForrest, JM; High, J; Sybertz, E	1
Czarnecka, D; Kawecka-Jaszcz, K; Kocemba, J; Skoczeń, M; Wojciechowska, M	1
Carlsen, JE; Heebøll-Nielsen, NC	1
al-Gohary, O; Lyal, J; Murray, JB	1
Höltermann, FP; Strasser, R; von Mengden, HJ	1
Coumel, P; Delhotal-Landes, B; Escoubet, B; Gourmel, B; Leclercq, JF; Maison-Blanche, P; Poirier, JM	1
Boucher, M; Duchene-Marullaz, P	1
Borer, JS; Moses, JW	1
Greefhorst, AP; van Herwaarden, CL	2
Brotelle, R; Colot, M; de Clavière, M; Heyndrickx, JP	1
Hatori, Y; Horii, M; Nakamura, Y; Nemoto, E; Otsuka, K; Sakai, T; Tsukiyama, H; Yamamoto, Y; Yamato, T; Yoshii, Y	1
Eisalo, A; Mänttäri, M	1
Auzépy, P; Boukara, N; Giudicelli, JF; Richard, C	1
Franz, IW; Gubba, A; Koch, G; Lohmann, FW	1
Jack, DB; Kendall, MJ; Quarterman, CP; Smith, SR; Zaman, R	1
Drayer, JI; Weber, MA	1
Jack, DB; Quarterman, CP; Wilkins, M	1
Jack, DB	1
Franz, IW; Koch, G; Lohmann, FW	1
Górecki, A; Ignatowska-Switalska, H; Januszewicz, A; Kochanowski, J; Lapiński, M; Opolski, G; Stolarz, P; Słomka, K; Wocial, B	1
Ambrosio, G; Chiariello, M; Chiariello, P; Napoli, C; Palumbo, G	1
Kuralay, E; Oztürk, OY; Süer, H; Tatar, H; Yorulmaz, FM	1
Klug, S; Merker, HJ; Neubert, D; Schwabe, R; Thiel, R	1
Iisalo, E; Kaila, T	1
Murakami, H; Nishimura, M; Urabe, K	1
Caldwell, GW; Evangelisto, M; Masucci, JA; White, R	1
Caldwell, GW; Demarest, K; Easlick, SM; Gunnet, J; Masucci, JA	1
Black, M; Cayenne, S; Cohen, TJ; Doolittle, S; Ibrahim, B; Quan, W	1
Foster, R; Lewanczuk, R; Mostafavi, S	1
Schröder, H	1
Abrahamowicz, M; Austin, PC; Eisenberg, MJ; Humphries, K; Pilote, L; Richard, H; Rinfret, S; Tu, J	1
Arima, Y; Hasegawa, C; Izawa, H; Kumazawa, T; Lee, XP; Sato, K; Umezawa, H	1
Armaković, S; Armaković, SJ; Setrajčić, IJ; Setrajčić, JP	1
Abdel-Rehim, M; Abuzooda, T; Amini, A	1
Abdel-Rehim, M; Dutta, J; Hadjmohammadi, MR; Karimiyan, H; Kunjali, KL; Moein, MM	1
Ansorge, M; Dovhunová, M; Galić, N; Habinovec, I; Pocrnić, M; Tesařová, E	1
Chen, YW; Chou, AK	1

Reviews

6 review(s) available for acebutolol and metoprolol

Article	Year
Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists. Journal of medicinal chemistry, 1988, Volume: 31, Issue:11 Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Models, Molecular; Receptors, Adrenergic, beta; Structure-Activity Relationship	1988
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Comparative pharmacokinetics of beta-blockers]. La Nouvelle presse medicale, 1978, Sep-20, Volume: 7, Issue:31 Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Half-Life; Humans; Metoprolol; Oxprenolol; Pindolol; Practolol; Propranolol; Sotalol; Timolol	1978
[Long-term utilization of beta-blockers in arterial hypertension]. La Nouvelle presse medicale, 1978, Sep-20, Volume: 7, Issue:31 Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Blood Pressure; Coronary Disease; Drug Tolerance; Heart Rate; Humans; Hypertension; Metoprolol; Pindolol; Practolol; Time Factors	1978
A toxicological review of beta-adrenergic blockers. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1986, Volume: 6, Issue:3 Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Cocarcinogenesis; Ethanolamines; Female; Kinetics; Labetalol; Lethal Dose 50; Male; Metoprolol; Mice; Mutagens; Nadolol; Neoplasms, Experimental; Oxprenolol; Pindolol; Practolol; Propanolamines; Propranolol; Rats; Sotalol; Timolol	1986
Beta-adrenergic antagonists in the treatment of patients with heart disease. Disease-a-month : DM, 1981, Volume: 27, Issue:9 Topics: Acebutolol; Adrenergic beta-Agonists; Alprenolol; Animals; Arrhythmias, Cardiac; Bronchial Spasm; Cardiomyopathy, Hypertrophic; Coronary Disease; Female; Heart Diseases; Heart Failure; Humans; Hypertension; Metoprolol; Mitral Valve Prolapse; Mitral Valve Stenosis; Nadolol; Nervous System Diseases; Pindolol; Pregnancy; Pregnancy Complications, Cardiovascular; Propanolamines; Propranolol; Receptors, Adrenergic, beta; Structure-Activity Relationship; Timolol	1981

Trials

20 trial(s) available for acebutolol and metoprolol

Article	Year
Effects of the beta-adrenoceptor antagonists acebutolol and metoprolol on sleep pattern in normal subjects. European journal of clinical pharmacology, 1977, Dec-16, Volume: 12, Issue:5 Topics: Acebutolol; Adult; Electroencephalography; Female; Humans; Male; Mental Recall; Metoprolol; Placebos; Propanolamines; Sleep; Task Performance and Analysis; Time Factors	1977
Comparison of the antilipolytic effect of metoprolol, acebutolol, and propranolol in man. British medical journal, 1977, Sep-03, Volume: 2, Issue:6087 Topics: Acebutolol; Adult; Fatty Acids, Nonesterified; Humans; Insulin; Lipid Metabolism; Male; Metoprolol; Propanolamines; Propranolol	1977
Regression of structural vascular changes after chronic treatment in hypertensives. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1991, Volume: 9, Issue:6 Topics: Acebutolol; Adult; Aged; Blood Pressure; Captopril; Female; Hemodynamics; Humans; Hypertension; Labetalol; Leg; Male; Metoprolol; Middle Aged; Regional Blood Flow; Vascular Resistance	1991
[Regression of left ventricular hypertrophy in hypertensive patients under long-term therapy with antihypertensive agents]. Deutsche medizinische Wochenschrift (1946), 1990, Apr-20, Volume: 115, Issue:16 Topics: Acebutolol; Adult; Antihypertensive Agents; Atenolol; Cardiomegaly; Female; Gallopamil; Humans; Hypertension; Male; Metoprolol; Middle Aged; Nifedipine; Time Factors	1990
[Regression of left heart hypertrophy in hypertensive patients as a result of antihypertensive therapy]. Zeitschrift fur Kardiologie, 1989, Volume: 78 Suppl 5 Topics: Acebutolol; Adult; Antihypertensive Agents; Atenolol; Cardiac Output; Cardiac Volume; Cardiomegaly; Drug Therapy, Combination; Echocardiography; Enalapril; Female; Gallopamil; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Nifedipine	1989
[Central effects of five beta-adrenergic receptor blockers in healthy volunteers: a quantitative EEG study]. Neurophysiologie clinique = Clinical neurophysiology, 1989, Volume: 19, Issue:1 Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Brain; Carteolol; Electroencephalography; Humans; Male; Metoprolol; Monitoring, Physiologic; Pindolol; Sotalol	1989
Is adrenergic betareceptor blockade contraindicated in patients with intermittent claudication? Acta medica Scandinavica. Supplementum, 1985, Volume: 693 Topics: Acebutolol; Adrenergic beta-Antagonists; Aged; Blood Pressure; Female; Humans; Intermittent Claudication; Locomotion; Male; Metoprolol; Middle Aged	1985
Comparison of beta-adrenoceptor selectivity of acebutolol and its metabolite diacetolol with metoprolol and propranolol in normal man. European journal of clinical pharmacology, 1986, Volume: 29, Issue:6 Topics: Acebutolol; Adrenergic beta-Antagonists; Airway Resistance; Dose-Response Relationship, Drug; Heart Rate; Humans; Isoproterenol; Metoprolol; Physical Exertion; Propranolol; Receptors, Adrenergic, beta	1986
[Comparative effects of metoprolol and acebutolol in primary arterial hypertension]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1988, Sep-05, Volume: 43, Issue:36 Topics: Acebutolol; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged	1988
[A randomized comparison between acebutolol and metoprolol in 215 patients with hypertension. Significance of the self-stimulating effect and awareness of the occurrence of adverse effects]. Ugeskrift for laeger, 1988, Apr-11, Volume: 150, Issue:15 Topics: Acebutolol; Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Random Allocation	1988
The effects of acebutolol and metoprolol on walking distances and distal blood pressure in hypertensive patients with intermittent claudication. Acta medica Scandinavica, 1986, Volume: 219, Issue:2 Topics: Acebutolol; Aged; Blood Pressure; Clinical Trials as Topic; Female; Hemodynamics; Humans; Hypertension; Intermittent Claudication; Locomotion; Male; Metoprolol; Middle Aged; Random Allocation	1986
Comparison of four beta-blockers as assessed by 24-hour ECG recording. Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:4 Topics: Acebutolol; Administration, Oral; Adult; Blood Pressure; Dose-Response Relationship, Drug; Drug Evaluation; Electrocardiography; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Nadolol; Propanolamines; Propranolol; Random Allocation	1986
Comparative study of the ventilatory effects of three beta 1-selective blocking agents in asthmatic patients. European journal of clinical pharmacology, 1981, Volume: 20, Issue:6 Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Asthma; Atenolol; Bronchi; Clinical Trials as Topic; Heart Rate; Humans; Male; Metoprolol; Pulmonary Ventilation; Respiration; Terbutaline; Vital Capacity	1981
A comparison of two cardioselective beta-blockers with different ancillary properties in the treatment of hypertension. Acta medica Scandinavica. Supplementum, 1982, Volume: 668 Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines	1982
beta-adrenoceptor blockade and physical activity: cardiovascular and metabolic aspects. Acta medica Scandinavica. Supplementum, 1983, Volume: 672 Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Blood Glucose; Catecholamines; Hemodynamics; Humans; Hypertension; Lactates; Lactic Acid; Lipolysis; Male; Metoprolol; Oxygen Consumption; Physical Exertion; Pindolol; Pituitary Hormones, Anterior; Respiration	1983
Single-agent and combination therapy of essential hypertension. American heart journal, 1984, Volume: 108, Issue:2 Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aldosterone; Blood Pressure; Diuretics; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propranolol; Renin-Angiotensin System	1984
Ventilatory and haemodynamic effects of terbutaline infusion during beta 1-selective blockade with metoprolol and acebutolol in asthmatic patients. European journal of clinical pharmacology, 1982, Volume: 23, Issue:3 Topics: Acebutolol; Adult; Asthma; Clinical Trials as Topic; Double-Blind Method; Female; Forced Expiratory Volume; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Peak Expiratory Flow Rate; Propanolamines; Respiration; Terbutaline	1982
Effects of short-term and long-term treatment with cardio-selective and non-selective beta-receptor blockade on carbohydrate and lipid metabolism and on plasma catecholamines at rest and during exercise. Clinical science (London, England : 1979), 1981, Volume: 61 Suppl 7 Topics: Acebutolol; Adult; Blood Glucose; Dopamine; Epinephrine; Humans; Hypertension; Lipids; Long-Term Care; Metoprolol; Pindolol; Propanolamines	1981
Beneficial effects of beta-adrenergic blockade in coronary artery surgery: clinical research. Cardiovascular surgery (London, England), 1993, Volume: 1, Issue:4 Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Cardiotonic Agents; Coronary Artery Bypass; Coronary Disease; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Postoperative Complications; Premedication	1993
Selectivity of acebutolol, atenolol, and metoprolol in healthy volunteers estimated by the extent the drugs occupy beta 2-receptors in the circulating plasma. Journal of clinical pharmacology, 1993, Volume: 33, Issue:10 Topics: Acebutolol; Administration, Oral; Adult; Animals; Atenolol; Double-Blind Method; Humans; Male; Metoprolol; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Time Factors	1993

Other Studies

58 other study(ies) available for acebutolol and metoprolol

Article	Year
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models. Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1 Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes	1996
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. British journal of pharmacology, 2005, Volume: 144, Issue:3 Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Algorithms; Animals; Cell Line; CHO Cells; Cricetinae; Dioxoles; Humans; Propanolamines; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists. Journal of medicinal chemistry, 2008, Feb-14, Volume: 51, Issue:3 Topics: Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Chromatography, Liquid; Mathematics; Pharmaceutical Preparations; Software	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography. Journal of medicinal chemistry, 2009, May-28, Volume: 52, Issue:10 Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia. European journal of medicinal chemistry, 2022, Apr-05, Volume: 233 Topics: Animals; Antipsychotic Agents; Dementia; Humans; Ligands; Mice; Phosphoric Diester Hydrolases; Serotonin	2022
Long term beta-adrenergic blockade reduces tyrosine hydroxylase and dopamine beta-hydroxylase activities in sympathetic ganglia. Nature, 1977, May-19, Volume: 267, Issue:5608 Topics: Acebutolol; Adrenergic beta-Antagonists; Animals; Blood Pressure; Dopamine beta-Hydroxylase; Ganglia, Autonomic; Metoprolol; Neural Pathways; Practolol; Propranolol; Rabbits; Time Factors; Tyrosine 3-Monooxygenase	1977
Blockade of isoprenaline-induced changes in plasma free fatty acids, immunoreactive insulin levels and plasma renin activity in healthy human subjects, by propranolol, pindolol, practolol, atenolol, metoprolol and acebutolol. British journal of clinical pharmacology, 1978, Volume: 5, Issue:1 Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Fatty Acids, Nonesterified; Heart Rate; Humans; Insulin; Isoproterenol; Male; Metoprolol; Pindolol; Practolol; Propranolol; Renin	1978
Effects of beta-adrenoreceptor antagonists on sino-aortic baroreflex sensitivity and blood pressure in hypertensive man. Clinical science (London, England : 1979), 1979, Volume: 57, Issue:3 Topics: Acebutolol; Adolescent; Adrenergic beta-Agonists; Adult; Aging; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Physical Exertion; Pressoreceptors; Propranolol; Sinoatrial Node; Time Factors	1979
Influence of once-daily administration of beta-adrenoceptor antagonists on arterial pressure and its variability. Lancet (London, England), 1979, Jun-09, Volume: 1, Issue:8128 Topics: Acebutolol; Activities of Daily Living; Adolescent; Adult; Bed Rest; Blood Pressure; Circadian Rhythm; Diastole; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Physical Exertion; Propanolamines; Propranolol; Sleep; Systole	1979
[The effect of acebutolol and metoprolol on noninvasive ambulatory blood pressure monitoring system in essential hypertension]. Kokyu to junkan. Respiration & circulation, 1992, Volume: 40, Issue:9 Topics: Acebutolol; Adult; Aged; Blood Pressure; Blood Pressure Monitors; Circadian Rhythm; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged	1992
Comparison of the effects of adrenergic agonists and alpha-, beta 1-, beta 2-antagonists on the intraocular pressure and adenylate cyclase activity in the ciliary processes of the rabbit. Acta ophthalmologica, 1985, Volume: 63, Issue:1 Topics: Acebutolol; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Ciliary Body; Intraocular Pressure; Isoproterenol; Labetalol; Metoprolol; Rats; Timolol; Water	1985
Side-effects of beta-blockers assessed using visual analogue scales. European journal of clinical pharmacology, 1985, Volume: 28 Suppl Topics: Acebutolol; Adrenergic beta-Antagonists; Analysis of Variance; Atenolol; Dreams; Fatigue; Humans; Hypertension; Metoprolol; Oxprenolol; Propranolol	1985
Antihypertensive effects of 12 beta adrenoceptor antagonists in conscious spontaneously hypertensive rats: relationship to changes in plasma renin activity, heart rate and sympathetic nerve function. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1 Topics: Acebutolol; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Blood Pressure; Decerebrate State; Heart; Heart Rate; Hypertension; Isoproterenol; Levobunolol; Male; Metoprolol; Oxprenolol; Propranolol; Rats; Rats, Inbred SHR; Renin; Sympathetic Nervous System; Sympathomimetics; Time Factors	1986
Adsorption of antihypertensives by suspensoids. Part 2. The adsorption of acebutolol, metoprolol, nadolol, oxprenolol, and timolol by attapulgite, charcoal, kaolin and magnesium trisilicate. Pharmaceutica acta Helvetiae, 1988, Volume: 63, Issue:1 Topics: Acebutolol; Adsorption; Antihypertensive Agents; Charcoal; Kaolin; Magnesium; Magnesium Compounds; Magnesium Silicates; Metoprolol; Nadolol; Oxprenolol; Silicic Acid; Silicon; Silicon Compounds; Timolol	1988
[Echocardiography studies of the relevance and intrinsic activity of beta blockers in the human]. Medizinische Klinik (Munich, Germany : 1983), 1986, Oct-31, Volume: 81, Issue:22 Topics: Acebutolol; Adult; Echocardiography; Hemodynamics; Humans; Metoprolol; Myocardial Contraction	1986
Acebutolol, metoprolol and propranolol in conscious dogs with chronic heart-block: chronotropic effects and relation between depression of ventricular activity and beta-adrenoceptor blocking potency. British journal of pharmacology, 1980, Volume: 70, Issue:2 Topics: Acebutolol; Adrenergic beta-Antagonists; Animals; Blood Pressure; Depression, Chemical; Dogs; Female; Heart Block; Heart Rate; Male; Metoprolol; Propranolol	1980
Variability in the preventive action of the B-blockers on genetic hypertension in the rat. Paroi arterielle, 1980, Volume: 6, Issue:4 Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; Male; Metoprolol; Oxprenolol; Pindolol; Practolol; Propranolol; Rats; Rats, Inbred Strains; Species Specificity; Time Factors	1980
Possible significance of the pharmacological differentiation of beta-blocking agents in hemodynamic effects in essential hypertension. Japanese circulation journal, 1983, Volume: 47, Issue:3 Topics: Acebutolol; Adrenergic beta-Antagonists; Atenolol; Carteolol; Hemodynamics; Humans; Hypertension; Metoprolol; Oxprenolol; Propranolol	1983
[Acute poisoning caused by beta blockers in the adult. Apropos of 7 cases]. Annales de cardiologie et d'angeiologie, 1983, Volume: 32, Issue:4 Topics: Acebutolol; Adolescent; Adrenergic beta-Antagonists; Adult; Alcohol Drinking; Bradycardia; Coma; Dose-Response Relationship, Drug; Female; Humans; Male; Metoprolol; Middle Aged; Oxprenolol; Propranolol; Seizures	1983
Beta-adrenoceptor blocker pharmacokinetics and the oral contraceptive pill. British journal of clinical pharmacology, 1984, Volume: 17 Suppl 1 Topics: Acebutolol; Adrenergic beta-Antagonists; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Drug Interactions; Female; Humans; Kinetics; Metoprolol; Oxprenolol; Propranolol; Time Factors	1984
Lack of evidence for polymorphism in metoprolol metabolism. British journal of clinical pharmacology, 1983, Volume: 16, Issue:2 Topics: Acebutolol; Adult; Biotransformation; Half-Life; Humans; Metoprolol; Polymorphism, Genetic	1983
Statistical analysis of polymorphic drug metabolism data using the Rosin Rammler Sperling Weibull distribution. European journal of clinical pharmacology, 1983, Volume: 25, Issue:4 Topics: Acebutolol; Africa; Debrisoquin; Humans; Isoniazid; Metoprolol; Polymorphism, Genetic; Sparteine; Statistics as Topic	1983
Elevated plasma atrial natriuretic peptide concentrations in hypertensive patients with acute myocardial infarction. Journal of cardiovascular risk, 1995, Volume: 2, Issue:1 Topics: Acebutolol; Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Cardiac Output, Low; Creatine Kinase; Creatinine; Echocardiography; Female; Furosemide; Heart Atria; Heart Ventricles; Humans; Hypertension; Isoenzymes; Male; Metoprolol; Middle Aged; Myocardial Infarction; Nifedipine; Potassium; Sodium	1995
[Protection by blockers against human low density lipoprotein peroxidation induced by oxygen free radicals]. Giornale italiano di cardiologia, 1994, Volume: 24, Issue:4 Topics: Acebutolol; Adrenergic beta-Antagonists; Free Radicals; Humans; In Vitro Techniques; Lipid Peroxidation; Lipoproteins, LDL; Malondialdehyde; Metoprolol; Propranolol	1994
Toxicity of beta-blockers in a rat whole embryo culture: concentration-response relationships and tissue concentrations. Archives of toxicology, 1994, Volume: 68, Issue:6 Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryonic and Fetal Development; In Vitro Techniques; Metoprolol; Pindolol; Propranolol; Rats; Rats, Wistar	1994
Relation between dynamic midventricular obstruction and unexplained chest pain in patients with normal echocardiograms at rest. The American journal of cardiology, 1996, Nov-01, Volume: 78, Issue:9 Topics: Acebutolol; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angina Pectoris; Atenolol; Dobutamine; Echocardiography, Doppler, Color; Female; Humans; Male; Metoprolol; Middle Aged; Rest; Ventricular Outflow Obstruction	1996
Evaluation of the immobilized artificial membrane phosphatidylcholine. Drug discovery column for high-performance liquid chromatographic screening of drug-membrane interactions. Journal of chromatography. A, 1998, Mar-27, Volume: 800, Issue:2 Topics: Acebutolol; Acetonitriles; Adrenergic beta-Antagonists; Alprenolol; Aniline Compounds; Atenolol; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Membranes, Artificial; Metoprolol; Models, Chemical; Osmolar Concentration; Oxprenolol; Phosphatidylcholines; Pindolol; Propranolol; Reproducibility of Results; Timolol	1998
In vitro permeability of eight beta-blockers through Caco-2 monolayers utilizing liquid chromatography/electrospray ionization mass spectrometry. Journal of mass spectrometry : JMS, 1998, Volume: 33, Issue:7 Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Atenolol; Biological Availability; Caco-2 Cells; Cell Membrane Permeability; Chromatography, Liquid; Epithelial Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Mass Spectrometry; Metoprolol; Molecular Structure; Oxprenolol; Pindolol; Propranolol; Research Design; Timolol	1998
The effects of intrinsic sympathomimetic activity on beta-blocker efficacy for treatment of neurocardiogenic syncope. The Journal of invasive cardiology, 1999, Volume: 11, Issue:7 Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Female; Humans; Male; Metoprolol; Middle Aged; Pindolol; Retrospective Studies; Sympathomimetics; Syncope, Vasovagal; Tilt-Table Test	1999
Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats. Biopharmaceutics & drug disposition, 2000, Volume: 21, Issue:4 Topics: Acebutolol; Adrenergic beta-Antagonists; Animals; Cardiac Output; Coronary Vessels; Kidney; Liver; Male; Metoprolol; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Spleen; Stomach; Sympathetic Nervous System; Sympathomimetics	2000
[Antihypertensive therapy with left cardiac insufficiency]. Medizinische Monatsschrift fur Pharmazeuten, 2005, Volume: 28, Issue:12 Topics: Acebutolol; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diuretics; Heart Failure; Heart Function Tests; Humans; Hypertension; Male; Metoprolol; Middle Aged; Thiazides; Ventricular Dysfunction, Left	2005
A population-based analysis of the class effect of beta-blockers after myocardial infarction. American heart journal, 2007, Volume: 153, Issue:2 Topics: Acebutolol; Adrenergic beta-Antagonists; Aged; Atenolol; Female; Humans; Male; Metoprolol; Myocardial Infarction	2007
Simultaneous determination of beta-blockers in human plasma using liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC, 2008, Volume: 22, Issue:7 Topics: Acebutolol; Adrenergic beta-Antagonists; Chromatography, Liquid; Humans; Labetalol; Linear Models; Metoprolol; Pindolol; Propranolol; Sensitivity and Specificity; Tandem Mass Spectrometry	2008
Active components of frequently used β-blockers from the aspect of computational study. Journal of molecular modeling, 2012, Volume: 18, Issue:9 Topics: Acebutolol; Adrenergic beta-Antagonists; Atenolol; Computer Simulation; Hardness; Humans; Hydrocarbons, Aromatic; Magnetic Resonance Spectroscopy; Metoprolol; Models, Molecular; Molecular Conformation; Static Electricity	2012
Graphite-based microextraction by packed sorbent for online extraction of β-blockers from human plasma samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015, Jun-15, Volume: 992 Topics: Acebutolol; Adrenergic beta-Antagonists; Chromatography, Liquid; Graphite; Humans; Limit of Detection; Linear Models; Metoprolol; Reproducibility of Results; Solid Phase Microextraction	2015
Graphene Oxide/Polyethylene Glycol-Stick for Thin Film Microextraction of β-Blockers from Human Oral Fluid by Liquid Chromatography-Tandem Mass Spectrometry. Molecules (Basel, Switzerland), 2019, Oct-11, Volume: 24, Issue:20 Topics: Acebutolol; Adrenergic beta-Antagonists; Body Fluids; Chromatography, Liquid; Graphite; Humans; Limit of Detection; Metoprolol; Mouth; Nanocomposites; Polyethylene Glycols; Solid Phase Microextraction; Tandem Mass Spectrometry	2019
Chiral separation of beta-blockers by high-performance liquid chromatography and determination of bisoprolol enantiomers in surface waters. Arhiv za higijenu rada i toksikologiju, 2020, Mar-01, Volume: 71, Issue:1 Topics: Acebutolol; Adrenergic beta-Antagonists; Atenolol; Bisoprolol; Chromatography, High Pressure Liquid; Labetalol; Metoprolol; Water	2020
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat. Neurological research, 2023, Volume: 45, Issue:4 Topics: Acebutolol; Analgesia; Anesthetics, Local; Animals; Bupivacaine; Butoxamine; Carteolol; Dose-Response Relationship, Drug; Epinephrine; Metoprolol; Oxprenolol; Pain; Rats; Rats, Sprague-Dawley	2023