Compounds > acadesine
Page last updated: 2024-08-22

acadesine and metformin

acadesine has been researched along with metformin in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (21.43)29.6817
2010's10 (71.43)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Chen, J; Chen, L; Fu, S; He, L; Lei, L; Liu, Z; Long, C; Ma, L; Pei, H; Peng, A; Pu, Y; Ran, Y; Tang, M1
Chen, SB; Hu, YT; Huang, SL; Huang, ZS; Li, C; Li, QJ; Ou, TM; Rao, Y; Song, BB; Song, QQ; Tan, JH; Wang, HG; Xu, YH; Xu, Z; Ye, JM; Yu, H; Zhong, GP1
Shakulov, RS1
Choudhury, GG; Feliers, D; Foretz, M; Kasinath, BS; Lee, MJ; Mahimainathan, L; Mariappan, MM; Musi, N; Sataranatarajan, K; Viollet, B; Weinberg, JM1
Bertini, F; Camici, M; Garcia-Gil, M; Pesi, R; Tozzi, MG; Voccoli, V1
Bandyopadhyay, G; Braun, U; Farese, RV; Foufelle, F; Hainault, I; Kahn, R; Leitges, M; Longnus, SL; Miura, A; Nimal, S; Sajan, MP; Standaert, ML; Van Obberghen, E1
Bilodeau-Goeseels, S; Kastelic, JP; Panich, PL1
Crabb, DW; Liangpunsakul, S; Lu, C; Sozio, MS; Zeng, Y1
Chang, JW; Kim, JH; Kim, JS; Kim, SB; Lee, JH; Lee, SK; Park, JS1
Dembitz, V; Lalic, H; Visnjic, D1
Miyamoto, L1
Abdullahi, A; Auger, C; Jeschke, MG; Knuth, CM; Parousis, A; Samadi, O1

Reviews

2 review(s) available for acadesine and metformin

ArticleYear
The Role of AMPK/mTOR Modulators in the Therapy of Acute Myeloid Leukemia.
    Current medicinal chemistry, 2019, Volume: 26, Issue:12

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Clinical Trials as Topic; Humans; Leukemia, Myeloid, Acute; Metformin; Ribonucleosides; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2019
[AMPK as a Metabolic Intersection between Diet and Physical Exercise].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2018, Volume: 138, Issue:10

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biphenyl Compounds; Diet; Drug Discovery; Eating; Exercise; Exercise Therapy; Humans; Hypoglycemic Agents; Isoenzymes; Metabolic Diseases; Metformin; Molecular Targeted Therapy; Muscle Contraction; Pyrones; Ribonucleosides; Thiophenes

2018

Other Studies

12 other study(ies) available for acadesine and metformin

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Synthesis and lipid-lowering evaluation of 3-methyl-1H-purine-2,6-dione derivatives as potent and orally available anti-obesity agents.
    European journal of medicinal chemistry, 2014, Nov-24, Volume: 87

    Topics: 3T3-L1 Cells; Administration, Oral; Animals; Anti-Obesity Agents; Biological Availability; Diet, High-Fat; Hypolipidemic Agents; Mice; Purines

2014
Discovery of a promising agent IQZ23 for the treatment of obesity and related metabolic disorders.
    European journal of medicinal chemistry, 2020, Apr-15, Volume: 192

    Topics: 3T3-L1 Cells; Animals; Anti-Obesity Agents; Cell Differentiation; Cells, Cultured; Cholesterol; Diet, High-Fat; Dose-Response Relationship, Drug; Drug Discovery; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Molecular Structure; Obesity; Structure-Activity Relationship

2020
AMPK or ZMPK?
    Medical hypotheses, 2006, Volume: 67, Issue:3

    Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Enzyme Activation; Humans; Isopentenyladenosine; Metformin; Models, Biological; Phosphorylation; Protein Kinases; Ribonucleosides; Ribonucleotides

2006
A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.
    American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glucose; Hypertrophy; Intracellular Signaling Peptides and Proteins; Kidney; Metformin; Multienzyme Complexes; Phosphoproteins; Protein Serine-Threonine Kinases; Rats; Ribonucleosides; Transforming Growth Factor beta

2007
5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway.
    Nucleosides, nucleotides & nucleic acids, 2006, Volume: 25, Issue:9-11

    Topics: Aminoimidazole Carboxamide; Apoptosis; Caspase 9; Cell Line, Tumor; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Fluorescent Dyes; Humans; Metformin; Mitochondria; Neuroblastoma; Purines; Ribonucleosides; Tetrazolium Salts; Thiazoles

2006
AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.
    American journal of physiology. Endocrinology and metabolism, 2010, Volume: 298, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Enzyme Activation; Enzyme Activators; Extracellular Signal-Regulated MAP Kinases; Glucose Transport Proteins, Facilitative; Hypoglycemic Agents; In Vitro Techniques; Isoenzymes; Male; Metformin; Mice; Mice, Knockout; Muscle Fibers, Skeletal; Physical Conditioning, Animal; Protein Kinase C; Rats; Ribonucleosides; Second Messenger Systems; Signal Transduction

2010
Activation of AMP-activated protein kinase may not be involved in AICAR- and metformin-mediated meiotic arrest in bovine denuded and cumulus-enclosed oocytes in vitro.
    Zygote (Cambridge, England), 2011, Volume: 19, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cattle; Cumulus Cells; Female; Meiosis; Metformin; Oocytes; Phosphorylation; Purines; Ribonucleosides; Roscovitine

2011
Activated AMPK inhibits PPAR-{alpha} and PPAR-{gamma} transcriptional activity in hepatoma cells.
    American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 301, Issue:4

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Liver Neoplasms; Metformin; PPAR alpha; PPAR gamma; Rats; Ribonucleosides; Rosiglitazone; Thiazolidinediones; Transcriptional Activation

2011
AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition.
    American journal of physiology. Renal physiology, 2013, Mar-15, Volume: 304, Issue:6

    Topics: Albumins; Aldosterone; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Cell Line; Epithelial-Mesenchymal Transition; Glucose; Heme Oxygenase-1; Humans; Metformin; NADPH Oxidase 4; NADPH Oxidases; Nephrosclerosis; Pyrazoles; Pyrimidines; Reactive Oxygen Species; Ribonucleosides; Thioredoxins; Transforming Growth Factor beta

2013
Metformin prevents the pathological browning of subcutaneous white adipose tissue.
    Molecular metabolism, 2019, Volume: 29

    Topics: Acetyl-CoA Carboxylase; Adipocytes, Beige; Adipose Tissue, White; Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Burns; Disease Models, Animal; Humans; Lipolysis; Metformin; Mice; Mice, Inbred C57BL; Mitochondria; Okadaic Acid; Oxidative Phosphorylation; Protein Phosphatase 2; Ribonucleosides; Sterol Esterase; Subcutaneous Fat

2019