Page last updated: 2024-08-22

acadesine and adenosine

acadesine has been researched along with adenosine in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (8.33)	18.7374
1990's	30 (62.50)	18.2507
2000's	11 (22.92)	29.6817
2010's	2 (4.17)	24.3611
2020's	1 (2.08)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Kaminski, PM; Proctor, KG	1
Bullough, D; Galiñanes, M; Hearse, DJ; Mullane, KM	1
Barankiewicz, J; Gruber, HE; Jimenez, R; Magill, M; Ronlov, G	1
Barankiewicz, J; Gruber, HE; Jimenez, R; Uyesaka, J	1
Burrier, AC; Jeng, AY; Oei, HH	1
Engler, RL; Gruber, HE; Hoffer, ME; Laikind, PK; Lane, TA; McAllister, DR; Schmid-Schoenbein, GW	1
Gruber, HE; Laikind, PK; Seegmiller, JE	1
Hoffmeister, HM; Mauser, M; Nienaber, C; Schaper, W	1
Pasque, MK; Wechsler, AS	1
Eglen, RM; Flippin, LA; Kim, EJ; Lazar, DA; Leung, E; Seran, CS; Walsh, LK; Wong, EH	1
Bullough, D; Mullane, K	1
Burckhartt, B; Cohen, MV; Downey, JM; Mullane, KM; Tsuchida, A; Yang, XM	2
Bullough, DA; Firestein, GS; Magill, MJ; Mullane, KM	1
Gruber, HE	1
Hudspeth, DA; McGee, DS; Sato, H; Van Wylen, DG; Vinten-Johansen, J; Williams, MW; Zhao, ZQ	1
Auszura, LA; Davis, E; Mathew, JP; O'Connor, T; Rinder, CS; Smith, BR; Tracey, JB	1
Bullough, DA; Montag, A; Mullane, KM; Young, MA; Zhang, C	1
Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Morioka, T; Node, K; Sato, H; Takashima, S	1
Dai, HB; Friedman, M; Johnson, RG; Piana, RN; Sellke, FW; Wang, SY	1
Engler, RL	1
Downey, JM; Liu, GS; Mullane, K; Tsuchida, A	1
Mullane, K	1
Fabian, MJ; Fabian, TC; Proctor, KG; Yockey, JM	1
White, TD	1
Cheng, TO	1
Bouma, MG; Buurman, WA; van den Wildenberg, FA	1
Bache, RJ; Duncker, DJ; Ishibashi, Y; Klassen, C; Quebbeman, BB	1
Lee, HT	1
Richardt, G; Schreieck, J	1
Unkle, DW	1
Hori, M; Kitakaze, M; Kuzuya, T; Minamino, T; Mori, H; Node, K; Shinozaki, Y; Takashima, S	1
Hegge, JO; Lasley, RD; Mentzer , RM; Randhawa, MP	1
Davis, KA; Fabian, TC; Proctor, KG; Ragsdale, DN; Trenthem, LL	1
Proctor, KG; Ragsdale, DN	1
Carling, D; Fryer, LG; Parbu-Patel, A	1
Campàs, C; Gil, J; López, JM; Santidrián, AF	1
Barragán, M; Bellosillo, B; Campàs, C; Colomer, D; Gil, J; Lopez, JM; Santidrián, AF	1
Currie, AJ; Dale, N; Frenguelli, BG; Gadalla, AE; Hardie, DG; Hawley, SA; Hirst, W; Michel, AD; Pearson, T; Randall, A; Sheehan, M	1
Dietzel, C; Mangano, DT; Miao, Y; Tudor, IC	1
Kloner, RA	1
Baggott, JE; Morgan, SL	1
Bullinger, D; Fehm, T; Gleiter, CH; Kammerer, B; Laufer, S; Neubauer, H	1
Drew, BG; Kingwell, BA	1
Ambrosio, G; Ferguson, TB; Harrington, RA; Koglin, J; Lira, A; Newman, MF; Nussmeier, NA; Pearl, RG; Pitt, B; Reece, TL; Wechsler, AS; Weisel, RD; White, JA	1
Barbisan, PRT; Efstathiou, NE; Georgakopoulos, CD; Konstantinou, EK; Maidana, DE; Miller, JW; Moustafa, GA; Notomi, S; Vavvas, DG	1

Reviews

8 review(s) available for acadesine and adenosine

Article	Year
Metabolic intervention to affect myocardial recovery following ischemia. Annals of surgery, 1984, Volume: 200, Issue:1 Topics: Adenine; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Citric Acid Cycle; Coronary Circulation; Coronary Disease; Fructosediphosphates; Glucose; Glycogen; Heart; Humans; Inosine; Myocardium; Oxidative Phosphorylation; Ribonucleosides; Ribose	1984
Harnessing an endogenous cardioprotective mechanism: cellular sources and sites of action of adenosine. Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Carrier Proteins; Dogs; Endothelium, Vascular; Energy Metabolism; Guinea Pigs; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rabbits; Rats; Receptors, Purinergic P1; Reperfusion Injury; Ribonucleosides; Signal Transduction	1995
Acadesine: preclinical overview. Advances in experimental medicine and biology, 1994, Volume: 370 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Vessels; Dogs; Heart; Heart Transplantation; Muscle, Smooth, Vascular; Myocardial Stunning; Rats; Ribonucleosides	1994
Harnessing nature's own cardiac defense mechanism with acadesine, an adenosine regulating agent: importance of the endothelium. Journal of cardiac surgery, 1994, Volume: 9, Issue:3 Suppl Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Endothelium, Vascular; Heart; Humans; Myocardial Reperfusion Injury; Myocardial Stunning; Ribonucleosides	1994
Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury. Cardiovascular research, 1993, Volume: 27, Issue:1 Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Dogs; Guinea Pigs; Humans; Myocardial Reperfusion Injury; Myocardium; Rats; Ribonucleosides	1993
The anti-inflammatory potential of adenosine in ischemia-reperfusion injury: established and putative beneficial actions of a retaliatory metabolite. Shock (Augusta, Ga.), 1997, Volume: 8, Issue:5 Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular System; Enzyme Inhibitors; Humans; Ischemic Preconditioning; Nucleosides; Receptors, Purinergic P1; Reperfusion Injury; Ribonucleosides	1997
Mechanisms of ischemic preconditioning and clinical implications for multiorgan ischemic-reperfusion injury. Journal of cardiothoracic and vascular anesthesia, 1999, Volume: 13, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; Anesthesia; Animals; Humans; Ischemic Preconditioning; Liver; Reperfusion Injury; Ribonucleosides; Surgical Procedures, Operative; Thoracic Surgical Procedures	1999
Acadesine, an adenosine-regulating agent with the potential for widespread indications. Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:12 Topics: Adenosine; Aminoimidazole Carboxamide; Coronary Artery Bypass; Diabetes Mellitus; Humans; Infusions, Intravenous; Leukemia, Lymphocytic, Chronic, B-Cell; Myocardial Reperfusion Injury; Ribonucleosides	2008

Trials

4 trial(s) available for acadesine and adenosine

Article	Year
Effects of acadesine on the incidence of myocardial infarction and adverse cardiac outcomes after coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Anesthesiology, 1995, Volume: 83, Issue:4 Topics: Adenosine; Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Double-Blind Method; Female; Hemodynamics; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Ribonucleosides; Ventricular Function, Left	1995
Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery, 1995, Volume: 109, Issue:3 Topics: Adenosine; Aminoimidazole Carboxamide; Cardiopulmonary Bypass; CD18 Antigens; Female; Humans; Macrophage-1 Antigen; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Cytoadhesin; Ribonucleosides; Up-Regulation	1995
Post-reperfusion myocardial infarction: long-term survival improvement using adenosine regulation with acadesine. Journal of the American College of Cardiology, 2006, Jul-04, Volume: 48, Issue:1 Topics: Adenosine; Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Preoperative Care; Ribonucleosides; Risk Factors; Survival Rate	2006
Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial. JAMA, 2012, Jul-11, Volume: 308, Issue:2 Topics: Adenosine; Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Coronary Artery Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Perioperative Period; Reperfusion Injury; Ribonucleosides; Stroke; Ventricular Dysfunction, Left	2012

Other Studies

36 other study(ies) available for acadesine and adenosine

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Extracellular and intracellular actions of adenosine and related compounds in the reperfused rat intestine. Circulation research, 1992, Volume: 71, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Aminoimidazole Carboxamide; Animals; Dipyridamole; Intestines; Male; Purinergic Antagonists; Rats; Rats, Inbred Strains; Receptors, Purinergic; Reperfusion Injury; Ribonucleosides; Theophylline	1992
Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart. Circulation, 1992, Volume: 86, Issue:2 Topics: Abdomen; Adenine Nucleotides; Adenosine; Aminoimidazole Carboxamide; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Heart Transplantation; Magnesium; Male; Myocardial Contraction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Potassium Chloride; Rats; Rats, Inbred Lew; Ribonucleosides; Sodium Chloride; Time Factors; Transplantation, Heterotopic	1992
Alteration of purine metabolism by AICA-riboside in human B lymphoblasts. Archives of biochemistry and biophysics, 1990, Nov-01, Volume: 282, Issue:2 Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; B-Lymphocytes; Cell Division; Cell Line; Humans; Phosphoribosyl Pyrophosphate; Purines; Ribonucleosides; Ribosemonophosphates	1990
Regulation of adenosine concentrations by acadesine (AICA-riboside) in human B-lymphoblasts. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; B-Lymphocytes; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Kinetics; Ribonucleosides	1991
5-Amino-4-imidazolecarboxamide riboside raises adenosine in perfused hypoxic rat heart. European journal of pharmacology, 1991, Oct-29, Volume: 204, Issue:1 Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Cardiac Output; Coronary Circulation; Heart; Hypoxia; Inosine; Male; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Ribonucleosides	1991
Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury. Circulation, 1989, Volume: 80, Issue:5 Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Cells, Cultured; Collateral Circulation; Coronary Circulation; Dogs; Granulocytes; Imidazoles; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Ribonucleosides; Superoxides	1989
Detection of 5'-phosphoribosyl-4-(N-succinylcarboxamide)-5-aminoimidazole in urine by use of the Bratton-Marshall reaction: identification of patients deficient in adenylosuccinate lyase activity. Analytical biochemistry, 1986, Volume: 156, Issue:1 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Chromatography, High Pressure Liquid; Creatinine; Ethylenediamines; Humans; Imidazoles; Lyases; Purine-Pyrimidine Metabolism, Inborn Errors; Reagent Strips; Ribonucleosides; Ribonucleotides; Spectrophotometry	1986
Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog. Circulation research, 1985, Volume: 56, Issue:2 Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Biopsy, Needle; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Female; Heart; Hemodynamics; Imidazoles; Male; Myocardium; Perfusion; Ribonucleosides; Ribose; Time Factors	1985
Enhancement of adenosine A1 receptor functions by benzoylthiophenes in guinea pig tissues in vitro. Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:2 Topics: Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Electric Stimulation; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Muscle Contraction; Myocardial Contraction; Peptides; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Ribonucleosides; Thienopyridines; Thiophenes; Wasp Venoms	1995
Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits. Cardiovascular research, 1995, Volume: 29, Issue:5 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rabbits; Ribonucleosides; Time Factors; Ventricular Fibrillation	1995
Adenosine activates A2 receptors to inhibit neutrophil adhesion and injury to isolated cardiac myocytes. Journal of immunology (Baltimore, Md. : 1950), 1995, Sep-01, Volume: 155, Issue:5 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Cell Adhesion; Cells, Cultured; Dogs; Heart Injuries; Myocardium; Neutrophils; Receptors, Purinergic P1; Ribonucleosides	1995
Acadesine reduces myocardial infarct size by an adenosine mediated mechanism. Cardiovascular research, 1995, Volume: 29, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Circulation; Extracellular Space; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Rabbits; Receptors, Purinergic P1; Regional Blood Flow; Ribonucleosides; Theophylline	1995
Adenosine-mediated inhibition of platelet aggregation by acadesine. A novel antithrombotic mechanism in vitro and in vivo. The Journal of clinical investigation, 1994, Volume: 94, Issue:4 Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Aspirin; Blood Physiological Phenomena; Coronary Thrombosis; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Erythrocytes; Humans; Male; Plasma; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Regional Blood Flow; Ribonucleosides; Theophylline; Tubercidin	1994
AICA riboside improves myocardial ischemia in coronary microembolization in dogs. The American journal of physiology, 1994, Volume: 267, Issue:4 Pt 2 Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Aminoimidazole Carboxamide; Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Cytosol; Dogs; Energy Metabolism; Myocardial Ischemia; Myocardium; Oxygen Consumption; Ribonucleosides; Thromboembolism	1994
Adenosine and AICA-riboside fail to enhance microvascular endothelial preservation. The Annals of thoracic surgery, 1994, Volume: 58, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Blood; Bradykinin; Calcimycin; Cardioplegic Solutions; Cardiopulmonary Bypass; Coronary Vessels; Endothelium, Vascular; Female; Heart Arrest, Induced; Male; Muscle, Smooth, Vascular; Myocardial Reperfusion Injury; Nitroprusside; Ribonucleosides; Swine	1994
Acadesine extends the window of protection afforded by ischaemic preconditioning. Cardiovascular research, 1994, Volume: 28, Issue:3 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rabbits; Ribonucleosides; Theophylline; Time Factors	1994
Acadesine lowers temporal threshold for the myocardial infarct size limiting effect of preconditioning. Cardiovascular research, 1993, Volume: 27, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Rabbits; Receptors, Purinergic; Ribonucleosides; Time Factors	1993
Acadesine and lipopolysaccharide-evoked pulmonary dysfunction after resuscitation from traumatic shock. Surgery, 1996, Volume: 119, Issue:3 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Capillary Permeability; Hydrocortisone; Leukocyte Count; Lipopolysaccharides; Lung; Resuscitation; Ribonucleosides; Shock, Traumatic; Swine; Tumor Necrosis Factor-alpha	1996
Potentiation of excitatory amino acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine. European journal of pharmacology, 1996, May-06, Volume: 303, Issue:1-2 Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoimidazole Carboxamide; Animals; Cerebral Cortex; Drug Synergism; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Ribonucleosides	1996
Adenosine and K(+)-induced Ca2+ loading. The Annals of thoracic surgery, 1997, Volume: 64, Issue:2 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Calcium; Cardioplegic Solutions; Humans; Myocardial Reperfusion Injury; Myocardium; Potassium; Ribonucleosides	1997
Acadesine increases blood flow in the collateralized heart during exercise. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Collateral Circulation; Coronary Circulation; Dogs; Female; Heart; Hemodynamics; Infusions, Intravenous; Male; Myocardial Ischemia; Physical Conditioning, Animal; Ribonucleosides	1998
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart. Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1 Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiography; Enzyme Inhibitors; Hypoxanthine; Inosine; Male; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Ribonucleosides; Theophylline; Thioinosine; Thiophenes; Time Factors; Ventricular Fibrillation; Xanthines	1999
The unorthodox and orthodox: the therapeutic role of acadesine after traumatic injury and sepsis. Critical care medicine, 1999, Volume: 27, Issue:3 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Hemodynamics; Humans; Microcirculation; Ribonucleosides; Sepsis; Shock, Hemorrhagic; Swine; Wounds and Injuries	1999
Improvement by 5-amino-4-imidazole carboxamide riboside of the contractile dysfunction that follows brief periods of ischemia through increases in ecto-5-nucleotidase activity and adenosine release in canine hearts. Japanese circulation journal, 1999, Volume: 63, Issue:7 Topics: 5'-Nucleotidase; Adenosine; Aminoimidazole Carboxamide; Animals; Dogs; Hemodynamics; Myocardial Contraction; Myocardial Ischemia; Myocardium; Purinergic P1 Receptor Antagonists; Reperfusion; Ribonucleosides	1999
Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig. Canadian journal of physiology and pharmacology, 1999, Volume: 77, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Circulation; Extracellular Space; Female; Heart; Male; Myocardial Stunning; Perfusion; Renal Dialysis; Ribonucleosides; Swine	1999
Endogenous adenosine and secondary injury after chest trauma. The Journal of trauma, 2000, Volume: 49, Issue:5 Topics: Acidosis; Adenosine; Aminoimidazole Carboxamide; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Hemodynamics; Hypercapnia; Inflammation; Leukocyte Count; Peroxidase; Ribonucleosides; Survival Analysis; Swine; Thoracic Injuries; Wounds, Nonpenetrating	2000
Acadesine and intestinal barrier function after hemorrhagic shock and resuscitation. Critical care medicine, 2000, Volume: 28, Issue:12 Topics: Adenosine; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Blood Flow Velocity; Capillary Permeability; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fluid Therapy; Formycins; Ileum; Intestinal Mucosa; Ischemia; Laser-Doppler Flowmetry; Male; Resuscitation; Ribonucleosides; Shock, Hemorrhagic; Swine	2000
Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside. FEBS letters, 2002, Nov-06, Volume: 531, Issue:2 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Kinetics; Multienzyme Complexes; Muscle, Skeletal; Protein Kinases; Protein Serine-Threonine Kinases; Ribonucleosides; Ribonucleotides	2002
5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved. The Biochemical journal, 2003, Mar-15, Volume: 370, Issue:Pt 3 Topics: Adenosine; Affinity Labels; Amino Acid Chloromethyl Ketones; Aminoimidazole Carboxamide; Apoptosis; Caspases; Cyclic AMP-Dependent Protein Kinases; Cytochrome c Group; Enzyme Inhibitors; Humans; Jurkat Cells; Phosphorylation; Ribonucleosides; Thioinosine	2003
Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood, 2003, May-01, Volume: 101, Issue:9 Topics: Adenosine; Amino Acid Chloromethyl Ketones; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antimetabolites, Antineoplastic; Apoptosis; B-Lymphocytes; Caspases; Cyclic AMP-Dependent Protein Kinases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Neoplastic Stem Cells; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Ribonucleosides; Ribonucleotides; T-Lymphocytes; Tubercidin; Tumor Cells, Cultured	2003
AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. Journal of neurochemistry, 2004, Volume: 88, Issue:5 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Male; Multienzyme Complexes; Nucleoside Transport Proteins; Nucleotides; Protein Serine-Threonine Kinases; Rats; Receptors, Purinergic P1; Ribonucleosides; Stress, Physiological; Synaptic Transmission	2004
Moving preconditioning from bench to bedside. Journal of the American College of Cardiology, 2006, Jul-04, Volume: 48, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Artery Bypass; Humans; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Reperfusion Injury; Ribonucleosides; Survival Rate	2006
Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2007, Volume: 31, Issue:2 Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Antirheumatic Agents; Arthritis, Experimental; Biomarkers; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purines; Rats; Ribonucleosides	2007
Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling. BMC biochemistry, 2007, Nov-29, Volume: 8 Topics: Adenosine; Aminoimidazole Carboxamide; Biomarkers, Tumor; Breast Neoplasms; Cell Line; Cell Line, Tumor; Epithelial Cells; Female; Guanosine; Humans; Imidazoles; Ions; Mammary Glands, Human; Metabolic Networks and Pathways; Ribonucleosides; Ribose; S-Adenosylmethionine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Uridine	2007
Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells. PloS one, 2020, Volume: 15, Issue:12 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Cells, Cultured; Complement Activation; Complement C3; Humans; Macular Degeneration; Phosphorylation; Retinal Pigment Epithelium; Retinal Pigments; Ribonucleosides; Ribonucleotides; Tumor Necrosis Factor-alpha	2020