abt 702 and adenosine kinase

abt 702 has been researched along with adenosine kinase in 23 studies

Research

Studies (23)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (34.78)	29.6817
2010's	11 (47.83)	24.3611
2020's	4 (17.39)	2.80

Authors

Authors	Studies
Alexander, K; Bhagwat, SS; Jarvis, MF; Jiang, M; Kohlhaas, K; Kowaluk, EA; Lee, CH; Williams, M; Yu, H	1
Bhagwat, SS; Cox, BF; Gomtsyan, A; Jarvis, MF; Jiang, M; Kowaluk, EA; Lee, CH; Lynch, JJ; McKie, J; Mikusa, J; Polakowski, J; Reinhart, G; Schweitzer, E; Williams, M; Wismer, CT; Zhu, CZ	1
Bhagwat, SS; Boyle, DL; Firestein, GS; Jarvis, MF; Kowaluk, EA; Lee, CH; Williams, M	1
Dickenson, AH; Jarvis, MF; Kowaluk, EA; Stanfa, LC; Suzuki, R; Williams, M	1
Bhagwat, SS; Cowart, M; Gfesser, G; Gu, YG; Jarvis, MF; Jiang, M; Kim, KH; Kowaluk, EA; Lee, CH; Perner, R; Stewart, AO; Williams, M	1
Alexander, KM; Bhagwat, SS; Chu, KL; Gomtsyan, A; Jarvis, MF; Jiang, MQ; Kim, KH; Koenig, JR; Kohlhaas, K; Kowaluk, EA; Lee, C; Mao, Y; Marsh, K; Matulenko, MA; McGaraughty, S; Mikusa, J; Muchmore, S; Perner, RJ; Pratt, JK; Stewart, AO; Wismer, CT; Yu, H; Zheng, GZ	1
Decker, MW; Jarvis, MF; Radek, RJ	1
Alexander, KM; Bhagwat, SS; DiDomenico, S; Frey, RR; Gomtsyan, A; Jakob, CL; Jarvis, MF; Jiang, M; Kohlhaas, KL; Kowaluk, EA; Lee, CH; Marsh, KC; Matulenko, MA; McGaraughty, S; Mikusa, J; Muchmore, SW; Paight, ES; Stewart, AO; Yu, H	1
Boison, D; Dharmawardana, N; Guo, CX; Housley, GD; Thorne, PR; Vlajkovic, SM; Wong, AC	1
Bache, RJ; Chen, Y; Fassett, JT; Hu, X; Lu, Z; Xu, X; Zhang, P	1
Boison, D; Guo, CX; Housley, GD; Paramananthasivam, V; Telang, R; Thorne, PR; Vlajkovic, SM; Wong, AC	1
Boison, D; Chen, JF; Lan, JQ; Lytle, N; Shen, HY; Singer, P; Wei, CJ; Williams-Karnesky, RL; Yee, BK	1
Bachtell, RK; Hobson, BD; Merritt, KE	1
Ahmad, S; Al-Gayyar, MM; Eissa, LA; El-Shishtawy, MM; Elsherbini, AM; Elsherbiny, NM; Fulzele, S; Liou, GI; Naime, M	1
Al-Shabrawey, M; Chadli, A; Elmarakby, AA; Elsherbiny, NM; Ibrahim, AS; Liou, GI; Pye, C	1
Ahmad, S; Bhatia, K; Elsherbini, AM; Elsherbiny, NM; Fulzele, S; Liou, GI	1
Ito, S; Kon, Y; Otsuguro, K; Otsuka, S; Tomonari, Y; Yamaguchi, S	1
An, X; Cao, W; Huang, Z; Li, Q; Liu, X; Wu, L; Xing, C; Yuan, Y; Zhang, A; Zhang, B	1
Bagi, Z; Czikora, I; Davila, A; Huo, Y; Kapuku, G; Li, J; Patel, V; Robinson, V; Su, H; Tian, Y; Weintraub, N	1
Bagi, Z; Czikora, I; Davila, A; Dong, G; Huo, Y; Kapuku, G; Li, J; S Weissman, A; Su, H; Tian, Y; Weinand, N; Xu, J	1
An, X; Cao, W; Dong, J; Duan, S; Huang, Z; Li, Q; Wan, H; Wu, L; Xing, C; Yuan, Y; Zhang, B	1
Cao, S; Chen, Y; Ma, J; Sun, S; Sun, Y; Wang, B; Wang, W; Wei, S; Xu, F; Xue, M; Yuan, Q; Zhai, X; Zhang, C; Zhang, Q	1
Fassett, E; Fassett, J; Friedl, K; Kollau, A; Mayer, B; Schrammel, A; Stessel, H; Teschl, E; Trummer, M; Wölkart, G	1

Other Studies

23 other study(ies) available for abt 702 and adenosine kinase

Article	Year
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects i The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3 Topics: Adenosine Kinase; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Male; Mice; Morpholines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1	2000
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3 Topics: Adenosine Kinase; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diabetes Mellitus, Experimental; Edema; Enzyme Inhibitors; Formaldehyde; Hemodynamics; Hyperalgesia; Male; Morpholines; Motor Activity; Pain; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Streptozocin	2000
Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:2 Topics: Adenosine; Adenosine Kinase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biotransformation; Blotting, Northern; Bone and Bones; Cell Nucleus; Enzyme Inhibitors; Freund's Adjuvant; Gene Expression Regulation, Enzymologic; Indicators and Reagents; Male; Matrix Metalloproteinases; Morpholines; Pyrimidines; Rats; Rats, Inbred Lew	2001
The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury. British journal of pharmacology, 2001, Volume: 132, Issue:7 Topics: Adenosine Kinase; Animals; Behavior, Animal; Carrageenan; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Hot Temperature; Inflammation; Ligation; Male; Morpholines; Neurons; Pain; Peripheral Nerve Injuries; Peripheral Nerves; Posterior Horn Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves	2001
Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. Journal of medicinal chemistry, 2001, Jun-21, Volume: 44, Issue:13 Topics: Adenosine Kinase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Enzyme Inhibitors; Formaldehyde; Humans; Models, Molecular; Molecular Conformation; Morpholines; Pain Measurement; Pyrimidines; Rats; Tumor Cells, Cultured	2001
Pyridopyrimidine analogues as novel adenosine kinase inhibitors. Bioorganic & medicinal chemistry letters, 2001, Aug-20, Volume: 11, Issue:16 Topics: Adenosine Kinase; Enzyme Inhibitors; Models, Molecular; Molecular Conformation; Morpholines; Pyrimidines; Structure-Activity Relationship	2001
The adenosine kinase inhibitor ABT-702 augments EEG slow waves in rats. Brain research, 2004, Nov-05, Volume: 1026, Issue:1 Topics: Adenosine Kinase; Analysis of Variance; Animals; Brain; Dose-Response Relationship, Drug; Electroencephalography; Male; Morpholines; Purinergic P1 Receptor Agonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Sleep, REM; Spectrum Analysis; Time Factors; Wakefulness	2004
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors. Bioorganic & medicinal chemistry, 2007, Feb-15, Volume: 15, Issue:4 Topics: Adenosine Kinase; Animals; Binding Sites; Crystallography, X-Ray; Inhibitory Concentration 50; Mice; Morpholines; Protein Binding; Protein Conformation; Pyrimidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2007
Role of adenosine kinase in cochlear development and response to noise. Journal of neuroscience research, 2010, Volume: 88, Issue:12 Topics: Adenosine Kinase; Animals; Animals, Newborn; Cell Differentiation; Cochlea; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Hearing Loss, Noise-Induced; Male; Morpholines; Noise; Nucleotides; Pyrimidines; Rats; Rats, Wistar	2010
Adenosine kinase regulation of cardiomyocyte hypertrophy. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:5 Topics: Adenosine; Adenosine Kinase; AMP-Activated Protein Kinase Kinases; Animals; Cells, Cultured; Enzyme Inhibitors; Hypertrophy; Models, Animal; Morpholines; Myocytes, Cardiac; Protein Kinases; Pyrimidines; raf Kinases; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Signal Transduction; TOR Serine-Threonine Kinases	2011
Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss. Experimental gerontology, 2011, Volume: 46, Issue:11 Topics: Adenosine Kinase; Animals; Cochlea; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hair Cells, Auditory; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Morpholines; Presbycusis; Pyrimidines	2011
Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia. The Journal of clinical investigation, 2012, Volume: 122, Issue:7 Topics: Adenosine; Adenosine Kinase; Amphetamines; Animals; Antipsychotic Agents; Basal Ganglia; Cell Transplantation; Cells, Cultured; Cognition Disorders; Cricetinae; Disease Models, Animal; Endophenotypes; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Psychotic Disorders; Pyrimidines; Receptor, Adenosine A2A; Schizophrenia; Schizophrenic Psychology	2012
Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats. Neuropharmacology, 2012, Volume: 63, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Cocaine; Dopamine Agonists; Dopamine Uptake Inhibitors; Male; Microinjections; Morpholines; Motor Activity; Nucleus Accumbens; Phenethylamines; Pyrimidines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2; Receptors, Purinergic P1; Stimulation, Chemical	2012
ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy. Life sciences, 2013, Jul-30, Volume: 93, Issue:2-3 Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine Kinase; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Inhibitors; Equilibrative Nucleoside Transporter 1; Glycated Serum Albumin; Glycation End Products, Advanced; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred C57BL; Microglia; Molecular Targeted Therapy; Morpholines; Oxidative Stress; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Retinitis; Serum Albumin; Tumor Necrosis Factor-alpha	2013
Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms. Pharmacological research, 2014, Volume: 85 Topics: Adenosine Kinase; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Cell Line; Dextrans; Diabetes Mellitus, Experimental; Endothelial Cells; Fluorescein-5-isothiocyanate; Humans; Kidney; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Proteinuria; Pyrimidines; Thiobarbituric Acid Reactive Substances; Transcription Factor RelA	2014
Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy. Journal of neuroimmunology, 2014, Dec-15, Volume: 277, Issue:1-2 Topics: Adenosine; Adenosine Kinase; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Equilibrative Nucleoside Transporter 1; Imidazoles; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Morpholines; Neurotoxicity Syndromes; Nitric Oxide Synthase Type I; Optic Nerve Injuries; Oxidative Stress; Pyridines; Pyrimidines; Retina	2014
An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat. Neuropharmacology, 2015, Volume: 97 Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Adenosine Kinase; Analgesics; Animals; Animals, Newborn; Enzyme Inhibitors; Membrane Potentials; Morpholines; Motor Neurons; Neural Pathways; Nociceptive Pain; Pyrimidines; Reflex; Spinal Cord; Tissue Culture Techniques; Xanthines	2015
Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity. American journal of physiology. Renal physiology, 2019, 07-01, Volume: 317, Issue:1 Topics: Acute Kidney Injury; Adenosine; Adenosine Kinase; Animals; Apoptosis; Cell Line; Cisplatin; Disease Models, Animal; Humans; Inflammation Mediators; Kidney; Male; Mice, Inbred C57BL; Morpholines; Oxidative Stress; Protein Kinase Inhibitors; Pyrimidines; Reactive Oxygen Species; Receptors, Purinergic P1; Signal Transduction; Up-Regulation	2019
Adenosine Kinase Inhibition Augments Conducted Vasodilation and Prevents Left Ventricle Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction. Circulation. Heart failure, 2019, Volume: 12, Issue:8 Topics: Adenosine Kinase; Animals; Diastole; Disease Models, Animal; Enzyme Inhibitors; Female; Heart Failure; Humans; Male; Microvessels; Middle Aged; Morpholines; Pyrimidines; Rats; Rats, Zucker; Stroke Volume; Vascular Resistance; Vasodilation; Ventricular Dysfunction, Left; Ventricular Function, Left	2019
Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction. Microcirculation (New York, N.Y. : 1994), 2020, Volume: 27, Issue:6 Topics: Adenosine Kinase; Animals; Diastole; Male; Mice; Mice, Knockout; Microvessels; Morpholines; Pyrimidines; Rats; Rats, Zucker; Vasodilation; Ventricular Dysfunction, Left	2020
Adenosine kinase inhibition attenuates ischemia reperfusion-induced acute kidney injury. Life sciences, 2020, Sep-01, Volume: 256 Topics: Acute Kidney Injury; Adenosine Kinase; Adult; Animals; Apoptosis; Cell Line; Cobalt; Enzyme Inhibitors; Female; Humans; Inflammation; Inosine; Kidney Tubules; Male; Mice, Inbred C57BL; Morpholines; Necrosis; Oxidative Stress; Pyrimidines; Reperfusion Injury	2020
Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury. Journal of cellular and molecular medicine, 2021, Volume: 25, Issue:6 Topics: Adenosine Kinase; Animals; Apoptosis; Biomarkers; Disease Management; Disease Models, Animal; Disease Susceptibility; Enzyme Inhibitors; Mice; Mitochondria; Morpholines; Myocardial Reperfusion Injury; Myocytes, Cardiac; Necroptosis; Pyrimidines; Rats; Reactive Oxygen Species	2021
Adenosine kinase (ADK) inhibition with ABT-702 induces ADK protein degradation and a distinct form of sustained cardioprotection. European journal of pharmacology, 2022, Jul-15, Volume: 927 Topics: Adenosine Kinase; Animals; Cardiotonic Agents; Heart; Mice; Morpholines; Myocardium; Proteolysis; Pyrimidines; Receptors, Purinergic P1	2022