abienol and sclareol

abienol has been researched along with sclareol* in 2 studies

Reviews

1 review(s) available for abienol and sclareol

ArticleYear
Enzymes for synthetic biology of ambroxide-related diterpenoid fragrance compounds.
    Advances in biochemical engineering/biotechnology, 2015, Volume: 148

    Ambrox and related ambroxides are highly priced in the fragrance industry, and valued for their delicate odor and fixative properties. Historically, ambrox was obtained from ambergris, a waxy excretion produced by sperm whales, now an endangered species. Synthetic ambroxides have replaced ambergris in perfume manufacture. Plant labdane diterpenoids can serve as starting material for ambroxide synthesis. Among these, the diterpene alcohol sclareol is the major industrial precursor obtained from cultivated clary sage (Salvia sclarea). In plants, a large family of diterpene synthase (diTPS) enzymes controls key reactions in diterpenoid biosynthesis. Advanced metabolite profiling and high-throughput sequencing of fragrant and medicinal plants have accelerated discovery of novel diTPS functions, providing a resource for combinatorial synthetic biology and metabolic engineering approaches. This chapter highlights recent progress on the discovery, characterization, and engineering of plant diTPSs with potential uses in ambroxide production. It features biosynthesis of sclareol, cis-abienol, and diterpene resin acids, as sources of genes and enzymes for diterpenoid bioproducts.

    Topics: Acids; Alkyl and Aryl Transferases; Biotechnology; Diterpenes; Furans; Naphthalenes; Naphthols; Oxides; Plant Extracts; Plant Proteins; Saliva; Synthetic Biology; Systems Biology; Terpenes

2015

Other Studies

1 other study(ies) available for abienol and sclareol

ArticleYear
Identification of natural diterpenes that inhibit bacterial wilt disease in tobacco, tomato and Arabidopsis.
    Plant & cell physiology, 2012, Volume: 53, Issue:8

    The soil-borne bacterial pathogen Ralstonia solanacearum invades a broad range of plants through their roots, resulting in wilting of the plant, but no effective protection against this disease has been developed. Two bacterial wilt disease-inhibiting compounds were biochemically isolated from tobacco and identified as sclareol and cis-abienol, labdane-type diterpenes. When exogenously applied to their roots, sclareol and cis-abienol inhibited wilt disease in tobacco, tomato and Arabidopsis plants without exhibiting any antibacterial activity. Microarray analysis identified many sclareol-responsive genes in Arabidopsis roots, including genes encoding or with a role in ATP-binding cassette (ABC) transporters, and biosynthesis and signaling of defense-related molecules and mitogen-activated protein kinase (MAPK) cascade components. Inhibition of wilt disease by sclareol was attenuated in Arabidopsis mutants defective in the ABC transporter AtPDR12, the MAPK MPK3, and ethylene and abscisic acid signaling pathways, and also in transgenic tobacco plants with reduced expression of NtPDR1, a tobacco homolog of AtPDR12. These results suggest that multiple host factors are involved in the inhibition of bacterial wilt disease by sclareol-related compounds.

    Topics: Abscisic Acid; Anti-Bacterial Agents; Arabidopsis; Arabidopsis Proteins; ATP-Binding Cassette Transporters; Diterpenes; Ethylenes; Gene Expression Regulation, Plant; Microarray Analysis; Mitogen-Activated Protein Kinases; Mutation; Naphthols; Nicotiana; Plant Diseases; Plant Roots; Ralstonia solanacearum; Signal Transduction; Solanum lycopersicum; Structure-Activity Relationship

2012