abecarnil has been researched along with diazepam in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 26 (83.87) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cook, JM; Dayer, CA; He, X; Huang, Q; Liu, R; Ma, C; McKernan, R; Wenger, GR; Yu, S | 1 |
| Clayton, T; Cook, J; DeLorey, TM; Furtmüller, R; Halliwell, RF; Harris, D; Huck, S; Sahbaie, P; Sieghart, W | 1 |
| Hönack, D; Löscher, W | 1 |
| Crabbe, JC | 1 |
| Andrews, JS; Jensen, LH; Kehr, W; Petersen, EN; Rettig, KJ; Schmiechen, R; Schneider, HH; Stephens, DN; Turner, JD; Turski, L | 1 |
| Hansen, JB; Jensen, LH; Löscher, W; Meldrum, BS; Patel, S; Petersen, EN; Schmiechen, R; Schneider, HH; Stephens, DN; Turski, L | 1 |
| Hönack, D; Löscher, W; Rundfeldt, C; Wlaź, P | 1 |
| Mehta, AK; Shank, RP | 1 |
| Schneider, HH; Sharonova, IN; Skrebitsky, VG; Stephens, DN; Vorobjev, VS | 1 |
| Biggio, G; Dazzi, L; Gessa, GL; Imperato, A; Motzo, C; Serra, M | 1 |
| Löscher, W | 1 |
| Akai, T; Nakada-Kometani, Y; Ozawa, M; Sugimachi, K; Yamaguchi, M | 1 |
| Biggio, G; Dazzi, L; Gessa, GL; Imperato, A; Serra, M | 1 |
| Schneider, HH; Stephens, DN; Steppuhn, KG; Turski, L | 1 |
| Stephens, DN; Turski, L | 1 |
| Biggio, G; Dazzi, L; Maira, G; Motzo, C; Sanna, A; Serra, M | 1 |
| Biggio, G; Ghiani, CA; Motzo, C; Porceddu, ML; Serra, M | 1 |
| Emmett-Oglesby, MW; Lytle, DA; Stephens, DN | 1 |
| Fink, H; Rex, A; Stephens, DN | 1 |
| Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD | 1 |
| Ebert, U; Hönack, D; Löscher, W; Rundfeldt, C | 1 |
| Contarino, A; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A | 2 |
| Bateson, AN; Holt, RA; Martin, IL | 1 |
| Anton, RF; Bianca, R; Kranzler, HR; McEvoy, JP; Moak, DH | 1 |
| Bienkowski, P; Iwinska, K; Jankowska, E; Kostowski, W; Stefanski, R | 1 |
| Biggio, G; Concas, A; Marino, G; Minei, R; Mostallino, MC; Pierobon, P; Porcu, P | 1 |
| Griebel, G; Perrault, G; Sanger, DJ | 1 |
| Aufdembrinke, B; DeMartinis, N; Rickels, K | 1 |
| Altruda, F; Eva, C; Oberto, A; Panzica, G | 1 |
| Depoortere, R; Jung, ME; Oglesby, MW | 1 |
1 review(s) available for abecarnil and diazepam
| Article | Year |
|---|---|
Abecarnil shows reduced tolerance development and dependence potential in comparison to diazepam: animal studies.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Dogs; Drug Tolerance; Substance-Related Disorders | 1993 |
2 trial(s) available for abecarnil and diazepam
| Article | Year |
|---|---|
A double-blind comparison of abecarnil and diazepam in the treatment of uncomplicated alcohol withdrawal.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Carbolines; Diazepam; Double-Blind Method; Humans; Male; Middle Aged; Substance Withdrawal Syndrome | 1997 |
A double-blind, placebo-controlled trial of abecarnil and diazepam in the treatment of patients with generalized anxiety disorder.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Anxiety Agents; Anxiety Disorders; Carbolines; Diazepam; Double-Blind Method; Female; Humans; Male; Middle Aged; Placebos | 2000 |
28 other study(ies) available for abecarnil and diazepam
| Article | Year |
|---|---|
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
Topics: Animals; Benzodiazepines; Carbolines; Cell Line; Columbidae; Conditioning, Operant; Crystallography, X-Ray; Humans; Indoles; Ligands; Male; Models, Molecular; Pyrimidines; Quinolones; Radioligand Assay; Receptors, GABA-A; Saimiri; Stereoisomerism; Structure-Activity Relationship | 2000 |
Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.
Topics: Animals; Behavior, Animal; Benzodiazepines; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Databases, Factual; Electrophysiology; Female; Ligands; Male; Memory; Mice; Models, Molecular; Molecular Structure; Oocytes; Protein Isoforms; Protein Subunits; Quantitative Structure-Activity Relationship; Receptors, GABA-A; Structure-Activity Relationship; Xenopus laevis | 2008 |
Withdrawal precipitation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Carbolines; Diazepam; Dogs; Female; Flumazenil; GABA-A Receptor Antagonists; Oxazepam; Substance Withdrawal Syndrome | 1992 |
Antagonism of ethanol withdrawal convulsions in Withdrawal Seizure Prone mice by diazepam and abecarnil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Ethanol; Female; Mice; Seizures; Substance Withdrawal Syndrome | 1992 |
Abecarnil, a metabolically stable, anxioselective beta-carboline acting at benzodiazepine receptors.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Diazepam; Female; Lorazepam; Male; Mice; Motor Activity; Punishment; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, Papio papio.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Interactions; Electromyography; Etorphine; Female; Gerbillinae; Male; Mice; Mice, Inbred DBA; Papio; Rats; Rats, Inbred Strains | 1990 |
Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Carbolines; Diazepam; Disease Models, Animal; Drug Tolerance; Male; Mice; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome | 1995 |
Interaction of abecarnil, bretazenil, and RO 19-8022 with diazepam-sensitive and -insensitive benzodiazepine sites in the rat cerebellum and cerebral cortex.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding Sites; Brain; Carbolines; Cell Membrane; Cerebellum; Cerebral Cortex; Diazepam; Male; Pyrrolidines; Quinolizines; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Abecarnil enhances GABA-induced currents in acutely isolated cerebellar Purkinje cells.
Topics: Animals; Carbolines; Cells, Cultured; Chloride Channels; Diazepam; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Male; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA; Time Factors | 1995 |
Modulation of basal and stress-induced release of acetylcholine and dopamine in rat brain by abecarnil and imidazenil, two anxioselective gamma-aminobutyric acidA receptor modulators.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Benzodiazepines; Carbolines; Diazepam; Dopamine; Ethanol; GABA Modulators; Hippocampus; Imidazoles; Male; Midazolam; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stress, Physiological | 1995 |
Chronic pharmacological activities of the novel anxiolytic beta-carboline abecarnil in rats.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Drinking Behavior; Male; Memory; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 1994 |
Differential effects of abecarnil on basal release of acetylcholine and dopamine in the rat brain.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Brain; Carbolines; Diazepam; Dopamine; Flumazenil; GABA-A Receptor Agonists; Hippocampus; Male; Microdialysis; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 1994 |
Long-term treatment with abecarnil does not induce diazepam-like dependence in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Electromyography; Male; Mice; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Effect of the beta-carboline abecarnil on spinal reflexes in mice and on muscle tone in genetically spastic rats: a comparison with diazepam.
Topics: Animals; Anticonvulsants; Carbolines; Diazepam; Disease Models, Animal; Electromyography; Female; Male; Mice; Mice, Inbred Strains; Muscle Spasticity; Muscle Tonus; Parasympatholytics; Rats; Rats, Wistar; Reflex; Spinal Cord | 1993 |
Enhancement of acetylcholine release by flumazenil in the hippocampus of rats chronically treated with diazepam but not with imidazenil or abecarnil.
Topics: Acetylcholine; Animals; Anticonvulsants; Benzodiazepines; Carbolines; Diazepam; Flumazenil; GABA Modulators; Hippocampus; Imidazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Antagonism of isoniazid-induced convulsions by abecarnil in mice tolerant to diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; GABA Modulators; Imidazoles; Isoniazid; Male; Mice; Seizures | 1995 |
Discriminative stimulus effects of midazolam and abecarnil in rats treated chronically with diazepam or abecarnil.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbolines; Conditioning, Operant; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Male; Midazolam; Rats | 1995 |
"Anxiolytic" action of diazepam and abecarnil in a modified open field test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Diazepam; Dose-Response Relationship, Drug; Eating; Exploratory Behavior; Male; Motor Activity; Rats; Rats, Wistar | 1996 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diazepam; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; Kindling, Neurologic; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Pentylenetetrazole; Quinazolines; Rats; Rats, Wistar; Seizures | 1996 |
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbolines; Clobazam; Clonazepam; Diazepam; Drug Tolerance; GABA-A Receptor Agonists; Ligands; Male; Mice; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1996 |
Abecarnil, a beta-carboline derivative, does not exhibit anticonvulsant tolerance or withdrawal effects in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Binding Sites; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Seizures; Substance Withdrawal Syndrome | 1996 |
Chronic treatment with diazepam or abecarnil differently affects the expression of GABAA receptor subunit mRNAs in the rat cortex.
Topics: Animals; Carbolines; Cerebral Cortex; Chromatography, High Pressure Liquid; Densitometry; Diazepam; GABA Modulators; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger | 1996 |
Differences between BDZ1 selective and non-selective GABAA/BDZ receptor ligands in discriminative stimulus and EtOH intake/preference paradigms.
Topics: Alcohol Drinking; Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; GABA Agents; Hypnotics and Sedatives; Ligands; Male; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Zolpidem | 1996 |
Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Carbolines; Cerebral Cortex; Chemoreceptor Cells; Clonazepam; Desoxycorticosterone; Diazepam; Feeding Behavior; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutathione; Hydra; Neurotransmitter Agents; Pregnanolone; Progesterone; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
Study of the modulatory activity of BZ (omega) receptor ligands on defensive behaviors in mice: evaluation of the importance of intrinsic efficacy and receptor subtype selectivity.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Benzodiazepinones; Carbolines; Diazepam; Escape Reaction; Male; Mice; Motor Activity; Rats; Receptors, GABA-A | 1999 |
Abecarnil enhances recovery from diazepam tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Carbolines; Cell Membrane; Cerebral Cortex; Clonazepam; Diazepam; Drug Interactions; Drug Tolerance; Flumazenil; Imidazoles; Ligands; Male; Mice; Receptors, GABA-A; Seizures; Tritium | 1999 |
Chronic modulation of the GABA(A) receptor complex regulates Y1 receptor gene expression in the medial amygdala of transgenic mice.
Topics: Allosteric Regulation; Amygdala; Animals; Anti-Anxiety Agents; Carbolines; Diazepam; GABA Modulators; Gene Expression Regulation; Male; Mice; Mice, Transgenic; Receptors, GABA-A; Receptors, Neuropeptide Y | 2000 |
Use of negatively reinforcing electrical brain stimulation to detect conventional and nonconventional anxiolytics as well as an anxiogenic drug.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Buspirone; Carbolines; Convulsants; Diazepam; Electric Stimulation; Electrodes; Flumazenil; GABA Modulators; Male; Pentylenetetrazole; Rats; Rats, Long-Evans; Reinforcement, Psychology | 2001 |