a 78773 has been researched along with hydroxyurea in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (83.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Awni, WM; Bell, RL; Bouska, J; Brooks, DW; Carter, GW; Dubé, L; Hansen, R; Lanni, C; Marsh, K; Stewart, AO | 1 |
| Bell, RL; Bouska, JB; Brooks, DW; Carter, GW; Harris, RR; Lanni, C; Malo, PE; Otis, ER; Stewart, AO | 1 |
| Bell, RL; Brooks, DW; Carter, GW; Hansen, R; Lanni, C; Malo, PE; Rubin, P; Stewart, AO | 1 |
| Currie, JL; Isakson, PC; Rao, TS; Shaffer, AF | 1 |
| Currie, JL; Isakson, PC; Kim, S; Rao, T; Shaffer, AF; Smith, WG; Thompson, JM | 1 |
| Fort, JJ; Li, R; Mayer, PT; Trivedi, JS | 1 |
| Bell, RL; Brooks, CD; Huang, R; Hulkower, KI; Otis, ER; Pollock, JS; Walsh, RE | 1 |
| Kearney, AS; McLoughlin, M; Palepu, NR | 1 |
| Bell, RL; Carter, GW; Harris, RR; Wilcox, D | 1 |
| Castonguay, A; Rioux, N | 1 |
| Anderson, GD; De Ciechi, PA; Keys, KL; Masferrer, JL | 1 |
| Funk, CD; Nair, DG | 1 |
12 other study(ies) available for a 78773 and hydroxyurea
| Article | Year |
|---|---|
Stereoselective metabolism of the 5-lipoxygenase inhibitor A-78773.
Topics: Animals; Humans; Hydroxyurea; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Microsomes, Liver; Neutrophils; Rats; Stereoisomerism; Tumor Cells, Cultured | 1994 |
Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Haplorhini; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Rats; Stereoisomerism | 1995 |
Preclinical and clinical activity of zileuton and A-78773.
Topics: Animals; Bronchial Spasm; Guinea Pigs; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Rats | 1993 |
Evaluation of 5-lipoxygenase inhibitors, zileuton, A-78773 and ICI-D-2138 in an ionophore (A-23187)-induced pleural inflammation model in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Disease Models, Animal; Drug Evaluation, Preclinical; Eicosanoids; Hydroxyurea; Leukotrienes; Lipoxygenase Inhibitors; Male; Pleurisy; Prostaglandins; Pyrans; Quinolones; Rats; Rats, Sprague-Dawley | 1993 |
Characterization of 5-lipoxygenase inhibitors in biochemical and functional in vivo assays.
Topics: Animals; Antigens; Blood Vessels; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Guinea Pigs; Humans; Hydroxyurea; Indomethacin; Lipoxygenase Inhibitors; Male; Pyrans; Quinolones; Rats; Skin | 1995 |
Polymorphism and crystallization behavior of Abbott-79175, a second-generation 5-lipoxygenase inhibitor.
Topics: Anti-Inflammatory Agents; Hydroxyurea; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Microscopy, Electron, Scanning; Solvents; X-Ray Diffraction | 1996 |
Leukotrienes do not regulate nitric oxide production in RAW 264.7 macrophages.
Topics: Animals; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Hydroxyurea; Interferon-gamma; Leukotriene B4; Leukotrienes; Lipopolysaccharides; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Second Messenger Systems; Toxicity Tests | 1996 |
Aqueous stability of SB 210661: kinetics and primary degradation mechanisms of an N-hydroxyurea-containing 5-lipoxygenase inhibitor.
Topics: Benzofurans; Drug Stability; Hydrogen-Ion Concentration; Hydroxyurea; Kinetics; Lipoxygenase Inhibitors; Urea; Water | 1998 |
The role of tissue mast cells in polyacrylamide gel-induced inflammation in mice.
Topics: Acrylic Resins; Animals; Anti-Inflammatory Agents; Dinoprostone; Hydroxyurea; Inflammation; Leukocyte Count; Leukotriene B4; Lipoxygenase Inhibitors; Mast Cells; Mice; Mice, Inbred BALB C; Neutrophils; Peroxidase | 1998 |
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
Topics: Animals; Anticarcinogenic Agents; Arachidonic Acid; Aspirin; Body Weight; Carcinogens; Drug Screening Assays, Antitumor; Female; Hydroxyurea; Indoles; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines | 1998 |
Combination therapies that inhibit cyclooxygenase-2 and leukotriene synthesis prevent disease in murine collagen induced arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arthritis, Experimental; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Epoxide Hydrolases; Humans; Hydroxyurea; Leukotriene B4; Leukotrienes; Male; Mice; Mice, Inbred DBA; Prostaglandins; Pyrazoles; RNA, Messenger; Sulfonamides | 2009 |
A cell-based assay for screening lipoxygenase inhibitors.
Topics: Acetamides; Cell Line; Drug Evaluation, Preclinical; Fluorenes; Humans; Hydroxyurea; Inhibitory Concentration 50; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Microscopy, Fluorescence; Phenyl Ethers | 2009 |