Page last updated: 2024-09-03

a 63162 and indomethacin

a 63162 has been researched along with indomethacin in 8 studies

Compound Research Comparison

Studies
(a 63162)
Trials
(a 63162)
Recent Studies (post-2010)
(a 63162)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
310029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomya 63162 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (87.50)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Atluru, D; Atluru, S; Erickson, HH; McVey, DS; Olsen, SC1
Anthony, MN; Krause, PJ; Maderazo, EG; Sha'afi, RI; Woronick, CL1
Barnes, PJ; Crawley, DE; Evans, TW; Liu, SF1
Jaworek, J; Konturek, SJ1
Leff, AR; Muñoz, NM1
Baranowski, S; Cozzi, PJ; Hamann, KJ; Leff, AR; Munoz, NM; Solway, J; Vita, A1
Juhn, SK; Kim, Y; Less, C; Lin, J; Ondrey, F1
Ehrlich, K; Peskar, BA; Peskar, BM; Schuligoi, R1

Other Studies

8 other study(ies) available for a 63162 and indomethacin

ArticleYear
Inhibition of equine mononuclear cell proliferation and leukotriene B4 synthesis by a specific 5-lipoxygenase inhibitor, A-63162.
    American journal of veterinary research, 1992, Volume: 53, Issue:6

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetamides; Animals; Calcimycin; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Horses; Indomethacin; Interleukin-2; Isoquinolines; Leukocytes, Mononuclear; Leukotriene B4; Lipoxygenase Inhibitors; Lymphocyte Activation; Phenyl Ethers; Phytohemagglutinins; Piperazines; Protein Kinase Inhibitors

1992
Characterization of a direct effect of phorbol myristate acetate on human neutrophil cell membrane using 31D8 monoclonal antibody.
    Journal of leukocyte biology, 1992, Volume: 51, Issue:3

    Topics: Acetamides; Antibodies, Monoclonal; Antigens; Betamethasone; Cell Membrane; Enzyme Inhibitors; Humans; Indoles; Indomethacin; Leukotriene Antagonists; Lipoxygenase Inhibitors; Neutrophils; Oxidants; Phenyl Ethers; Phorbol Esters; Protein Kinase C; Tetradecanoylphorbol Acetate

1992
Endothelium-dependent nonadrenergic, noncholinergic neural relaxation in guinea pig pulmonary artery.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2

    Topics: Acetamides; Adenosine Triphosphate; Animals; Arginine; Atropine; Autonomic Nervous System; Capsaicin; Chymotrypsin; Drug Interactions; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle, Smooth, Vascular; omega-N-Methylarginine; Phenyl Ethers; Propranolol; Prostaglandin Endoperoxides, Synthetic; Pulmonary Artery; Vasoactive Intestinal Peptide

1992
Effects of prostaglandin of E, F and I series, leukotriene C and platelet activating factor on amylase release from isolated rat pancreatic acini.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1993, Volume: 44, Issue:4

    Topics: Acetamides; Amylases; Animals; Bethanechol Compounds; Ceruletide; Chromones; Dinoprostone; Epoprostenol; Indomethacin; Isoquinolines; Leukotriene C4; Male; Pancreas; Phenyl Ethers; Platelet Activating Factor; Prostaglandin Antagonists; Prostaglandins; Prostaglandins F; Prostaglandins F, Synthetic; Pyridinium Compounds; Rats; Rats, Wistar; Tetrahydroisoquinolines

1993
Blockade of eosinophil migration by 5-lipoxygenase and cyclooxygenase inhibition in explanted guinea pig trachealis.
    The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetamides; Acetylcholine; Animals; Arachidonate 5-Lipoxygenase; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Eosinophils; Guinea Pigs; Indomethacin; Kinetics; Lipoxygenase Inhibitors; Male; N-Formylmethionine Leucyl-Phenylalanine; Phenyl Ethers; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Trachea

1995
Activation of tracheal smooth muscle responsiveness by fMLP-treated HL-60 cells and neutrophils.
    The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 1

    Topics: Acetamides; Acetylcholine; Animals; Bronchoconstriction; Cell Communication; Cell Survival; Guinea Pigs; Humans; Immunohistochemistry; Indomethacin; Leukemia, Myeloid; Lipoxygenase; Lipoxygenase Inhibitors; Male; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenyl Ethers; Prostaglandin-Endoperoxide Synthases; Trachea; Tumor Cells, Cultured

1993
Effect of lipoxygenase inhibition on mucous glycoprotein secretion from chinchilla middle ear epithelial cells in vitro.
    The Annals of otology, rhinology, and laryngology, 1996, Volume: 105, Issue:11

    Topics: Acetamides; Animals; Arachidonic Acid; Cells, Cultured; Chinchilla; Cyclooxygenase Inhibitors; Ear, Middle; Epithelium; Glycoproteins; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Phenyl Ethers; Platelet Activating Factor

1996
Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats.
    Pharmacology, 2009, Volume: 84, Issue:5

    Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Animals; Annexins; Anti-Ulcer Agents; Celecoxib; Cyclooxygenase Inhibitors; Dexamethasone; Drug Synergism; Flavanones; Fluorenes; Gastric Mucosa; Glucocorticoids; Indoles; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Male; Oligopeptides; Phenyl Ethers; Prostaglandin Antagonists; Pyrazoles; Rats; Rats, Wistar; Receptors, Formyl Peptide; Receptors, Lipoxin; Reperfusion Injury; Sulfonamides

2009