a-40926 and maltodextrin

a-40926 has been researched along with maltodextrin* in 1 studies

Other Studies

1 other study(ies) available for a-40926 and maltodextrin

Article	Year
High-yield production of lipoglycopeptide antibiotic A40926 using a mutant strain Nonomuraea sp. DP-13 in optimized medium. Preparative biochemistry & biotechnology, 2016, Volume: 46, Issue:2 The lipoglycopeptide antibiotic A40926 produced by Nonomuraea sp. is a complex of structurally related components differing in the fatty acid moiety. Besides showing an intrinsic antibacterial activity, A40926 is the precursor of the semisynthetic antibiotic Dalvance. In this work, A40926 production by a mutant strain Nonomuraea sp. DP-13 was investigated. It was found that A40926 production was markedly promoted by using poorly assimilated carbon source maltodextrin and nitrogen source soybean meal. Addition of Cu(2+) resulted in a stimulation of A40926 production, but Co(2+) had an inhibitory effect. L-Leucine addition greatly improved total A40926 production and modified the complex composition toward factor B0. An optimized production medium IM-3 was developed and a maximum A40926 production of 1096 mg/L was obtained in the 10-L fermenter. This was the highest A40926 productivity so far reported. Topics: Actinomycetales; Anti-Bacterial Agents; Bioreactors; Carbon; Culture Media; Fermentation; Glycine max; Industrial Microbiology; Leucine; Metals; Mutation; Nitrogen; Polysaccharides; Teicoplanin	2016

Article

Year

High-yield production of lipoglycopeptide antibiotic A40926 using a mutant strain Nonomuraea sp. DP-13 in optimized medium.

Preparative biochemistry & biotechnology, 2016, Volume: 46, Issue:2

The lipoglycopeptide antibiotic A40926 produced by Nonomuraea sp. is a complex of structurally related components differing in the fatty acid moiety. Besides showing an intrinsic antibacterial activity, A40926 is the precursor of the semisynthetic antibiotic Dalvance. In this work, A40926 production by a mutant strain Nonomuraea sp. DP-13 was investigated. It was found that A40926 production was markedly promoted by using poorly assimilated carbon source maltodextrin and nitrogen source soybean meal. Addition of Cu(2+) resulted in a stimulation of A40926 production, but Co(2+) had an inhibitory effect. L-Leucine addition greatly improved total A40926 production and modified the complex composition toward factor B0. An optimized production medium IM-3 was developed and a maximum A40926 production of 1096 mg/L was obtained in the 10-L fermenter. This was the highest A40926 productivity so far reported.

Topics: Actinomycetales; Anti-Bacterial Agents; Bioreactors; Carbon; Culture Media; Fermentation; Glycine max; Industrial Microbiology; Leucine; Metals; Mutation; Nitrogen; Polysaccharides; Teicoplanin

2016