Isoliquiritigenin-4-4--dimethyl-ether has been researched along with isoliquiritigenin* in 1 studies
1 other study(ies) available for Isoliquiritigenin-4-4--dimethyl-ether and isoliquiritigenin
| Article | Year |
|---|---|
Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.
A series of new isoliquiritigenin (ISL) derivatives were synthesized and evaluated as dual inhibitors for amyloid-beta (Aβ) aggregation and 5-lipoxygenase (5-LO). It was found that all these synthetic compounds inhibited Aβ (1-42) aggregation effectively with their IC₅₀ values ranged from 2.2 ± 1.5 μM to 23.8 ± 2.0 μM. These derivatives also showed inhibitory activity to 5-LO with their IC50 values ranged from 6.1 ± 0.1 μM to 35.9 ± 0.3 μM. Their structure-activity relationships (SAR) and mechanisms of inhibitions were studied. This study provided potentially important information for further development of ISL derivatives as multifunctional agents for Alzheimer's disease (AD) treatment. Topics: Amyloid beta-Peptides; Antineoplastic Agents; Antioxidants; Arachidonate 5-Lipoxygenase; Cell Line, Tumor; Chalcones; Chemistry Techniques, Synthetic; Humans; Lipoxygenase Inhibitors; Molecular Docking Simulation; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Structure-Activity Relationship | 2013 |