Crotaoprostrin and 2--hydroxychalcone

Crotaoprostrin has been researched along with 2--hydroxychalcone* in 1 studies

Other Studies

1 other study(ies) available for Crotaoprostrin and 2--hydroxychalcone

Article	Year
Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6 A series of 2'-hydroxychalcones has been synthesized and screened for their in vitro inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin production from lipopolysaccharide-treated RAW 264.7 cells. Structure-activity relationship study suggested that inhibitory activity against prostaglandin E(2) production was governed to a greater extent by the substituent on B ring of the chalcone, and most of the active compounds have at least two methoxy or benzyloxy groups on B ring. The relationship between chalcone structures and their PGE(2) inhibitory activities was also interpreted by docking study on cyclooxygenase-2. Topics: Animals; Cell Line; Chalcone; Chalcones; Chemistry, Pharmaceutical; Cyclooxygenase 2; Dinoprostone; Drug Design; Inflammation; Inhibitory Concentration 50; Lipopolysaccharides; Mice; Models, Chemical; Structure-Activity Relationship; Time Factors	2009

Article

Year

Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.

Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6

A series of 2'-hydroxychalcones has been synthesized and screened for their in vitro inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin production from lipopolysaccharide-treated RAW 264.7 cells. Structure-activity relationship study suggested that inhibitory activity against prostaglandin E(2) production was governed to a greater extent by the substituent on B ring of the chalcone, and most of the active compounds have at least two methoxy or benzyloxy groups on B ring. The relationship between chalcone structures and their PGE(2) inhibitory activities was also interpreted by docking study on cyclooxygenase-2.

Topics: Animals; Cell Line; Chalcone; Chalcones; Chemistry, Pharmaceutical; Cyclooxygenase 2; Dinoprostone; Drug Design; Inflammation; Inhibitory Concentration 50; Lipopolysaccharides; Mice; Models, Chemical; Structure-Activity Relationship; Time Factors

2009