9-methyl-7-bromoeudistomin d has been researched along with caffeine in 12 studies
*Caffeine: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. [MeSH]
*Caffeine: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. [MeSH]
| Studies (9-methyl-7-bromoeudistomin d) | Trials (9-methyl-7-bromoeudistomin d) | Recent Studies (post-2010) (9-methyl-7-bromoeudistomin d) | Studies (caffeine) | Trials (caffeine) | Recent Studies (post-2010) (caffeine) |
|---|---|---|---|---|---|
| 16 | 0 | 1 | 25,501 | 2,393 | 6,825 |
| Protein | Taxonomy | 9-methyl-7-bromoeudistomin d (IC50) | caffeine (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | 7.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (75.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, YI; Ishibashi, M; Kobayashi, J; Kobayashi, M; Momose, K; Nakamura, H; Ohizumi, Y; Seino, A | 1 |
| Furukawa, K; Ishibashi, M; Kobayashi, J; Kozutsumi, D; Ohizumi, Y; Takahashi, Y | 1 |
| Furukawa, K; Momose, K; Ohizumi, Y; Yamamoto, M; Yoshikawa, K | 1 |
| Adachi, M; Fang, YI; Kobayashi, J; Ohizumi, Y | 1 |
| Furukawa, K; Ishibashi, M; Ishiyama, H; Kobayashi, J; Kozutsumi, D; Ohizumi, Y; Takahashi, Y | 1 |
| Adachi, M; Fang, Y; Kobayashi, J; Ohizumi, Y; Yamakuni, T | 1 |
| Adachi, M; Kakubari, M; Ohizumi, Y | 2 |
| Henmi, S; Imaizumi, Y; Ohizumi, Y; Uyama, Y; Watanabe, M | 1 |
| Atsuki, K; Imaizumi, Y; Ohi, Y; Ohizumi, Y; Tori, Y; Watanabe, M | 1 |
| Ahmed, M; Bruton, JD; Frame, M; Furman, BL; Islam, MS; Lemmens, R; Persson-Sjögren, S; Pyne, NJ; Shi, CL; Westerblad, H | 1 |
| Copello, JA; Diaz-Sylvester, PL; Fleischer, S; Juettner, VV; Lv, Y; Porta, M | 1 |
12 other study(ies) available for 9-methyl-7-bromoeudistomin d and caffeine
| Article | Year |
|---|---|
9-methyl-7-bromoeudistomin D, a powerful radio-labelable Ca++ releaser having caffeine-like properties, acts on Ca(++)-induced Ca++ release channels of sarcoplasmic reticulum.
Topics: Animals; Binding Sites; Caffeine; Calcium; Calcium Channels; Carbolines; Magnesium; Muscles; Procaine; Rabbits; Ruthenium Red; Ryanodine; Sarcoplasmic Reticulum | 1991 |
4,6-Dibromo-3-hydroxycarbazole (an analogue of caffeine-like Ca2+ releaser), a novel type of inhibitor of Ca(2+)-induced Ca2+ release in skeletal muscle sarcoplasmic reticulum.
Topics: Animals; Caffeine; Calcium; Calcium Radioisotopes; Carbazoles; Carbolines; In Vitro Techniques; Ion-Selective Electrodes; Magnesium; Male; Muscle, Skeletal; Procaine; Rabbits; Ruthenium Red; Ryanodine; Sarcoplasmic Reticulum | 1995 |
[3H]9-Methyl-7-bromoeudistomin D, a caffeine-like powerful Ca2+ releaser, binds to caffeine-binding sites distinct from the ryanodine receptors in brain microsomes.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Brain; Caffeine; Calcium; Calcium Channels; Carbolines; Cholic Acids; Cyclic GMP; Detergents; Guinea Pigs; Inositol 1,4,5-Trisphosphate; Kinetics; Microsomes; Muscle Proteins; Procaine; Ruthenium Red; Ryanodine; Ryanodine Receptor Calcium Release Channel | 1995 |
High affinity binding of 9-[3H]methyl-7-bromoeudistomin D to the caffeine-binding site of skeletal muscle sarcoplasmic reticulum.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Caffeine; Calcium; Carbolines; Cell Membrane; Magnesium; Muscles; Procaine; Rabbits; Ruthenium Red; Ryanodine; Sarcoplasmic Reticulum | 1993 |
Structure-activity relationship of bromoeudistomin D, a powerful Ca2+ releaser in skeletal muscle sarcoplasmic reticulum.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Carbolines; Male; Muscle Proteins; Muscle, Skeletal; Rabbits; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Structure-Activity Relationship | 1995 |
Properties of the binding sites of [3H]9-methyl-7-bromoeudistomin D in bovine aortic smooth muscle microsomes.
Topics: Animals; Aorta; Binding Sites; Binding, Competitive; Caffeine; Carbolines; Cattle; Microsomes; Muscle, Smooth, Vascular | 1994 |
Tissue- and subcellular-distribution of the binding site of [3H]9- methyl-7-bromoeudistomin D, a potent caffeine-like Ca2+ releaser, in rabbits.
Topics: Animals; Binding Sites; Binding, Competitive; Caffeine; Calcium; Carbolines; Cell Membrane; Male; Organ Specificity; Rabbits; Subcellular Fractions | 1994 |
The specific binding site of 9-[3H]methyl-7-bromoeudistomin D, a caffeine-like Ca2+ releaser, in liver microsomes in distinct from that in skeletal sarcoplasmic reticulum.
Topics: Animals; Binding Sites; Caffeine; Calcium; Carbolines; In Vitro Techniques; Male; Microsomes, Liver; Muscles; Nucleotides; Procaine; Rabbits; Sarcoplasmic Reticulum | 1994 |
Effects of 9-methyl-7-bromoeudistomin D (MBED), a powerful Ca2+ releaser, on smooth muscles of the guinea pig.
Topics: Animals; Caffeine; Calcium; Carbolines; Guinea Pigs; Ileum; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Patch-Clamp Techniques | 1993 |
Imaging of Ca2+ release by caffeine and 9-methyl-7-bromoeudistomin D and the associated activation of large conductance Ca2+-dependent K+ channels in urinary bladder smooth muscle cells of the guinea pig.
Topics: Animals; Caffeine; Calcium; Carbolines; Guinea Pigs; Male; Microscopy, Confocal; Muscle, Smooth; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Potassium Channels; Urinary Bladder | 2001 |
Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Calcium; Carbolines; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Tumor Cells, Cultured | 2003 |
Eudistomin D and penaresin derivatives as modulators of ryanodine receptor channels and sarcoplasmic reticulum Ca2+ ATPase in striated muscle.
Topics: Animals; Caffeine; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium-Transporting ATPases; Carbolines; In Vitro Techniques; Indole Alkaloids; Lipid Bilayers; Microsomes; Muscle, Skeletal; Myocardium; Protein Binding; Rabbits; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 2014 |