9-diazomethylanthracene has been researched along with imidapril* in 1 studies
1 other study(ies) available for 9-diazomethylanthracene and imidapril
| Article | Year |
|---|---|
Highly sensitive determination of imidapril, a new angiotensin I-converting enzyme inhibitor, and its active metabolite in human plasma and urine using high-performance liquid chromatography with fluorescent labelling reagent.
A method for the simultaneous determination of imidapril and its active metabolite in human plasma and urine has been developed using high-performance liquid chromatography with a fluorescent labelling reagent, 9-anthryldiazomethane. Imidapril and its active metabolite were extracted from human plasma and urine using a solid-phase extraction cartridge (Bond Elut C18). Two compounds in the eluate were derivatized with 9-anthryldiazomethane and purified with a solid-phase extraction cartridge (Bond Elut SI). The derivatives were analysed using high-performance liquid chromatography with fluorometry. The detection limits of imidapril and its active metabolite were 0.2 ng/ml in plasma and 10 ng/ml in urine. This method could be applied to the pharmacokinetic study of imidapril. Topics: Angiotensin-Converting Enzyme Inhibitors; Anthracenes; Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; Imidazoles; Imidazolidines; Male; Molecular Structure; Reproducibility of Results; Spectrometry, Fluorescence | 1993 |