9-deazainosine and 3-deazaguanosine

9-deazainosine has been researched along with 3-deazaguanosine* in 1 studies

Other Studies

1 other study(ies) available for 9-deazainosine and 3-deazaguanosine

Article	Year
Activity of purine analogs against Leishmania donovani in vivo. Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:1 The dose of orally administered 9-deazainosine calculated to suppress 50% of Leishmania donovani amastigotes in hamster livers was 19 mg/kg (body weight) per day; 96 to 99% of Leishmania organisms were eliminated from the liver and spleen of squirrel monkeys by 50 mg/kg per day. Because these activities were greater than that of the experimental clinical agent allopurinol and comparable to that of the classical agent parenteral pentavalent antimony, 9-deazainosine should be considered for clinical development for visceral leishmaniasis. Topics: Administration, Oral; Allopurinol; Animals; Cricetinae; Formycins; Guanosine; Injections, Intramuscular; Inosine; Leishmania donovani; Leishmaniasis, Visceral; Liver; Male; Meglumine; Meglumine Antimoniate; Mesocricetus; Organometallic Compounds; Saimiri; Spleen	1987

Article

Year

Activity of purine analogs against Leishmania donovani in vivo.

Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:1

The dose of orally administered 9-deazainosine calculated to suppress 50% of Leishmania donovani amastigotes in hamster livers was 19 mg/kg (body weight) per day; 96 to 99% of Leishmania organisms were eliminated from the liver and spleen of squirrel monkeys by 50 mg/kg per day. Because these activities were greater than that of the experimental clinical agent allopurinol and comparable to that of the classical agent parenteral pentavalent antimony, 9-deazainosine should be considered for clinical development for visceral leishmaniasis.

Topics: Administration, Oral; Allopurinol; Animals; Cricetinae; Formycins; Guanosine; Injections, Intramuscular; Inosine; Leishmania donovani; Leishmaniasis, Visceral; Liver; Male; Meglumine; Meglumine Antimoniate; Mesocricetus; Organometallic Compounds; Saimiri; Spleen

1987