9-deazaadenosine and isocytosine

9-deazaadenosine has been researched along with isocytosine* in 1 studies

Other Studies

1 other study(ies) available for 9-deazaadenosine and isocytosine

Article	Year
Design and synthesis of novel SATE derivatives of acyclic isocytosine and 9-deazaadenine C-nucleosides. Nucleosides, nucleotides & nucleic acids, 2010, Volume: 29, Issue:3 This article describes a very simple route for synthesizing novel lipophilic phosphate bis(t-bu-SATE) prodrugs of acyclic cyclobutylated C-nucleosides such as isocytosine 12 and 9-deazaadenine 19, which were prepared from 1,1-gem cyclobutyl dicarboxylate. Synthesized compounds were evaluated as potential antiviral agents against HIV virus. Some phosphate SATE prodrugs were more active against HIV than parent nucleosides. Topics: Anti-HIV Agents; Cytosine; Drug Design; HIV-1; Microbial Sensitivity Tests; Molecular Structure; Prodrugs; Stereoisomerism; Structure-Activity Relationship; Tubercidin; Zidovudine	2010

Article

Year

Design and synthesis of novel SATE derivatives of acyclic isocytosine and 9-deazaadenine C-nucleosides.

Nucleosides, nucleotides & nucleic acids, 2010, Volume: 29, Issue:3

This article describes a very simple route for synthesizing novel lipophilic phosphate bis(t-bu-SATE) prodrugs of acyclic cyclobutylated C-nucleosides such as isocytosine 12 and 9-deazaadenine 19, which were prepared from 1,1-gem cyclobutyl dicarboxylate. Synthesized compounds were evaluated as potential antiviral agents against HIV virus. Some phosphate SATE prodrugs were more active against HIV than parent nucleosides.

Topics: Anti-HIV Agents; Cytosine; Drug Design; HIV-1; Microbial Sensitivity Tests; Molecular Structure; Prodrugs; Stereoisomerism; Structure-Activity Relationship; Tubercidin; Zidovudine

2010