Page last updated: 2024-08-22

9-anilinoacridine and amsacrine

9-anilinoacridine has been researched along with amsacrine in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (26.19)	18.7374
1990's	11 (26.19)	18.2507
2000's	12 (28.57)	29.6817
2010's	5 (11.90)	24.3611
2020's	3 (7.14)	2.80

Authors

Authors	Studies
Baguley, BC; Cain, BF; Denny, WA	1
Atwell, GJ; Cain, BF; Denny, WA	1
Atwell, GJ; Cain, BF; Denny, WA; Hansch, C; Leo, A; Panthananickal, A	1
Denny, WA; Henry, DR; Jurs, PC	1
Croft, SL; Denny, WA; Figgitt, DP; Gamage, SA; Mauel, J; Ralph, RK; Ransijn, A; Snowdon, D; Wojcik, SJ; Yardley, V	1
Cain, BF; Denny, WA; Roberts, PB	1
Baguley, BC; Ferguson, LR; Iwamoto, Y; Pearson, A	1
Denny, WA; Ferguson, LR; Iwamoto, Y; Kurita, A; Pogai, HB; Uzuhashi, T; Yangihara, Y	1
Baguley, BC; Denny, WA; Johnson, P; Lee, HH; McFadyen, WD; Palmer, BD; Wakelin, LP; Wickham, G	1
Ames, JR; Kovacic, P; Ryan, MD	1
Klopman, G; Macina, OT	1
Atwell, GJ; Baguley, BC; Denny, WA; Rewcastle, GW	1
Baguley, BC; Nash, R	1
Baguley, BC; Ferguson, LR	1
Baguley, BC; Denny, WA; Robertson, IG	1
Khan, MN; Kuliya-Umar, AF	1
Denny, WA; Figgitt, DP; Gamage, SA; Ralph, RK	1
Chavalitshewinkoon, P; Denny, W; Figgitt, D; Gamage, S; Ralph, R; Wilairat, P	1
Denny, W; Figgitt, D; Gamage, S; Mauël, J; Ralph, R; Ransijn, A; Wojcik, S	1
Denny, WA; Gao, H; Garg, R; Hansch, C	1
Madden, B; McClean, S; McGown, AT; Searcey, M; Wakelin, LP	1
Boyd, M; Denny, WA; Fan, JY; Ohms, SJ	1
Auparakkitanon, S; Wilairat, P	1
Beal, PA; Carlson, CB	2
Chen, IL; Chen, YL; Lu, CM; Tsao, LT; Wang, JP	1
Baguley, BC; Jacintho, JD; Kovacic, P; Wakelin, LP	1
Auparakkitanon, S; Denny, WA; Noonpakdee, W; Ralph, RK; Wilairat, P	1
Bacherikov, VA; Chen, CH; Chou, TC; Dong, HJ; Lin, YW; Su, TL; Tsai, TJ	1
Bacherikov, VA; Chen, CH; Chou, TC; Dong, HJ; Lee, RZ; Lin, YW; Liu, LF; Su, TL; Tsai, TJ; Zhang, X	1
Alonso, C; Castilla, J; Fuertes, MA; Nguewa, PA; Pérez, JM	1
Chen, YT; Chou, TC; Kakadiya, R; Kapuriya, K; Kapuriya, N; Lee, TC; Naliapara, Y; Shah, A; Su, TL; Tsai, TH; Wu, YT; Zhang, X	1
Chen, CH; Chou, TC; Kakadiya, R; Kapuriya, N; Lin, YW; Su, TL; Tsai, TJ; Zhang, X	1
Chauhan, PM; Kumar, A; Puri, SK; Raja Kumar, S; Srivastava, K	1
Hrubý, M; Kaňková, D; Kovář, J; Sedláček, O; Studenovský, M; Svoboda, J; Ulbrich, K; Větvička, D	1
Jubie, S; Kalirajan, R; Kulshrestha, V; Sankar, S	1
Cheng, P; Luo, T; Wang, J; Wang, Z; Zhang, Y; Zhao, J	1
Gaurav, K; Gowramma, B; Kalirajan, R; Pandiselvi, A; Sankar, S	1
Balachandran, P; Gowramma, B; Kalirajan, R; Pandiselvi, A	1
Egarmina, K; Gellerman, G; Grynszpan, F; Hershkovitz-Rokah, O; Shpilberg, O; Tuchinsky, H; Walunj, D	1
Byran, G; Gomathi, S; Rajagopal, K; Sri, VB	1
Chen, ZS; Gupta, P; Kumar, RV; Kwon, CH	1

Reviews

2 review(s) available for 9-anilinoacridine and amsacrine

Article	Year
Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress? Current medicinal chemistry, 2003, Volume: 10, Issue:24 Topics: Acridines; Amsacrine; Antineoplastic Agents; DNA; Electron Transport; Humans; Intercalating Agents; Neoplasms; Oxidative Stress	2003
Anticancer compounds as leishmanicidal drugs: challenges in chemotherapy and future perspectives. Current medicinal chemistry, 2008, Volume: 15, Issue:5 Topics: Amsacrine; Animals; Antineoplastic Agents; Antiprotozoal Agents; Apoptosis; Humans; Leishmania; Leishmaniasis; Meglumine; Meglumine Antimoniate; Organometallic Compounds; Organoplatinum Compounds; Oxyquinoline; Phospholipids; Topoisomerase II Inhibitors	2008

Article

Year

Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress?

Current medicinal chemistry, 2003, Volume: 10, Issue:24

Topics: Acridines; Amsacrine; Antineoplastic Agents; DNA; Electron Transport; Humans; Intercalating Agents; Neoplasms; Oxidative Stress

2003

Anticancer compounds as leishmanicidal drugs: challenges in chemotherapy and future perspectives.

Current medicinal chemistry, 2008, Volume: 15, Issue:5

Topics: Amsacrine; Animals; Antineoplastic Agents; Antiprotozoal Agents; Apoptosis; Humans; Leishmania; Leishmaniasis; Meglumine; Meglumine Antimoniate; Organometallic Compounds; Organoplatinum Compounds; Oxyquinoline; Phospholipids; Topoisomerase II Inhibitors

2008

Other Studies

40 other study(ies) available for 9-anilinoacridine and amsacrine

Article	Year
Potenial antitumor agents. 28. Deoxyribonucleic acid polyintercalating agents. Journal of medicinal chemistry, 1978, Volume: 21, Issue:7 Topics: Acridines; Animals; Antineoplastic Agents; Bacteriophages; DNA; DNA, Superhelical; DNA, Viral; Leukemia L1210; Leukemia, Experimental; Mice; Nucleic Acid Conformation; Structure-Activity Relationship	1978
Potential antitumor agents. 17. 9-Anilino-10-methylacridinium salts. Journal of medicinal chemistry, 1976, Volume: 19, Issue:6 Topics: Acridines; Aniline Compounds; Animals; Antineoplastic Agents; Leukemia L1210; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Quaternary Ammonium Compounds; Structure-Activity Relationship	1976
Potential antitumor agents. 36. Quantitative relationships between experimental antitumor activity, toxicity, and structure for the general class of 9-anilinoacridine antitumor agents. Journal of medicinal chemistry, 1982, Volume: 25, Issue:3 Topics: Aminoacridines; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chemistry, Physical; Electrons; Kinetics; Models, Chemical; Molecular Conformation; Structure-Activity Relationship	1982
Structure-antitumor activity relationships of 9-anilinoacridines using pattern recognition. Journal of medicinal chemistry, 1982, Volume: 25, Issue:8 Topics: Aminoacridines; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Models, Molecular; Molecular Conformation; Pattern Recognition, Automated; Structure-Activity Relationship	1982
Structure-activity relationships for the antileishmanial and antitrypanosomal activities of 1'-substituted 9-anilinoacridines. Journal of medicinal chemistry, 1997, Aug-01, Volume: 40, Issue:16 Topics: Amsacrine; Animals; Antiprotozoal Agents; Humans; Leishmania donovani; Leishmania major; Macrophages; Mice; Mice, Inbred CBA; Models, Chemical; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Tumor Cells, Cultured	1997
Radiosensitization of E. coli B/r by 9-anilinoacridines. British journal of cancer, 1979, Volume: 40, Issue:4 Topics: Aminoacridines; Amsacrine; Cobalt Radioisotopes; DNA Repair; DNA, Bacterial; Escherichia coli; Oxygen; Radiation-Sensitizing Agents; Structure-Activity Relationship	1979
Photo-enhancement of the mutagenicity of 9-anilinoacridine derivatives related to the antitumour agent amsacrine. Mutation research, 1992, Volume: 268, Issue:1 Topics: Acridines; Aminoacridines; Amsacrine; Antineoplastic Agents; Dose-Response Relationship, Drug; Frameshift Mutation; Light; Mutagenicity Tests; Mutagens; Oxidation-Reduction; Proflavine; Salmonella typhimurium	1992
Mutagenic activities of azido analogues of amsacrine and other 9-anilinoacridines in Salmonella typhimurium and their enhancement by photoirradiation. Mutation research, 1992, Volume: 280, Issue:4 Topics: Amsacrine; DNA Damage; Electrophoresis, Agar Gel; Frameshift Mutation; Light; Mutagens; Photochemistry; Plasmids; Salmonella typhimurium	1992
DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridine. Journal of medicinal chemistry, 1990, Volume: 33, Issue:11 Topics: Alkylating Agents; Amsacrine; Animals; Chelating Agents; Chemical Phenomena; Chemistry; Cisplatin; Diamines; DNA; Drug Resistance; Ethylenediamines; Leukemia P388; Magnetic Resonance Spectroscopy; Molecular Structure; Organoplatinum Compounds; Spectrophotometry, Ultraviolet	1990
Electron transfer-oxy radical mechanism for anti-cancer agents: 9-anilinoacridines. Anti-cancer drug design, 1987, Volume: 2, Issue:1 Topics: Amsacrine; Antineoplastic Agents; DNA Damage; Electron Transport; Free Radicals; Oxidation-Reduction; Structure-Activity Relationship	1987
Computer-automated structure evaluation of antileukemic 9-anilinoacridines. Molecular pharmacology, 1987, Volume: 31, Issue:4 Topics: Amsacrine; Animals; Antineoplastic Agents; Computer Simulation; Leukemia L1210; Software; Structure-Activity Relationship	1987
Potential antitumor agents. 42. Structure-activity relationships for acridine-substituted dimethyl phosphoramidate derivatives of 9-anilinoacridine. Journal of medicinal chemistry, 1984, Volume: 27, Issue:8 Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; DNA; Female; Leukemia L1210; Leukemia P388; Male; Mathematics; Mice; Structure-Activity Relationship	1984
Antitumour activity of substituted 9-anilinoacridines--comparison of in vivo and in vitro testing systems. European journal of cancer, 1981, Volume: 17, Issue:6 Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; DNA, Neoplasm; Dose-Response Relationship, Drug; Leukemia L1210; Mice; Mice, Inbred DBA	1981
Induction of petite formation in Saccharomyces cerevisiae by experimental antitumour agents. Structure--activity relationships for 9-anilinoacridines. Mutation research, 1981, Volume: 90, Issue:4 Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Kinetics; Leukemia L1210; Mice; Mutagens; Mutation; Saccharomyces cerevisiae; Structure-Activity Relationship	1981
Inhibition of T4 bacteriophage yield by 9-anilinoacridines; comparison with in vivo antitumour activity. European journal of cancer, 1980, Volume: 16, Issue:9 Topics: Acridines; Aminoacridines; Amsacrine; Animals; DNA, Viral; Dose-Response Relationship, Drug; Leukemia L1210; Mice; Structure-Activity Relationship; T-Phages	1980
Kinetics and mechanism of general acid-catalysed thiolytic cleavage of 9-anilinoacridine. Bioorganic & medicinal chemistry, 1995, Volume: 3, Issue:7 Topics: Acids; Amsacrine; Antineoplastic Agents; Catalysis; Hydrogen-Ion Concentration; Hydrolysis; Hydroxylamines; Kinetics; Mercaptoethanol; Structure-Activity Relationship; Sulfhydryl Compounds	1995
Structure-activity relationships of 9-anilinoacridines as inhibitors of human DNA topoisomerase II. Anti-cancer drug design, 1994, Volume: 9, Issue:3 Topics: Amsacrine; Cell Line; Humans; Structure-Activity Relationship; Topoisomerase II Inhibitors	1994
Structure-activity relationships and modes of action of 9-anilinoacridines against chloroquine-resistant Plasmodium falciparum in vitro. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:3 Topics: Amsacrine; Animals; Antimalarials; Cell Line; Chloroquine; Drug Resistance, Microbial; Humans; Leukemia, T-Cell; Plasmodium falciparum; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tumor Cells, Cultured	1993
9-Anilinoacridines as potential antileishmanial agents. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:5 Topics: Amsacrine; Animals; Antiprotozoal Agents; Cell Line; Humans; Leishmania tropica; Leishmaniasis, Cutaneous; Macrophages; Mice; Mice, Inbred DBA; Tumor Cells, Cultured	1993
Quantitative structure-activity relationships (QSAR) for 9-anilinoacridines: a comparative analysis. Chemico-biological interactions, 1998, Nov-27, Volume: 116, Issue:3 Topics: Amsacrine; Animals; Antineoplastic Agents; Drug Design; Kinetics; Leukemia L1210; Mice; Structure-Activity Relationship	1998
Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anti-cancer drug design, 1998, Volume: 13, Issue:8 Topics: Acridines; Amsacrine; Antineoplastic Agents; DNA; DNA Footprinting; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Intercalating Agents; Picolinic Acids; Pyridones; Tumor Cells, Cultured	1998
DNA adducts of 9-anilinoacridine mustards: characterization by NMR. Chemical research in toxicology, 1999, Volume: 12, Issue:12 Topics: Amsacrine; Animals; Base Sequence; Cattle; DNA Adducts; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Molecular Structure; Spectrometry, Mass, Fast Atom Bombardment	1999
Cleavage of DNA induced by 9-anilinoacridine inhibitors of topoisomerase II in the malaria parasite Plasmodium falciparum. Biochemical and biophysical research communications, 2000, Mar-16, Volume: 269, Issue:2 Topics: Amsacrine; Animals; DNA, Protozoan; Enzyme Inhibitors; Plasmodium falciparum; Topoisomerase II Inhibitors	2000
Solid-phase synthesis of acridine-peptide conjugates and their analysis by tandem mass spectrometry. Organic letters, 2000, May-18, Volume: 2, Issue:10 Topics: Acridines; Amsacrine; Indicators and Reagents; Models, Molecular; Molecular Structure; Peptides; Spectrometry, Mass, Secondary Ion	2000
Point of attachment and sequence of immobilized peptide-acridine conjugates control affinity for nucleic acids. Journal of the American Chemical Society, 2002, Jul-24, Volume: 124, Issue:29 Topics: Amino Acids; Amsacrine; Combinatorial Chemistry Techniques; Peptide Library; Peptides; RNA	2002
Synthesis and antiinflammatory evaluation of 9-anilinoacridine and 9-phenoxyacridine derivatives. Journal of medicinal chemistry, 2002, Oct-10, Volume: 45, Issue:21 Topics: Acridines; Amsacrine; Aniline Compounds; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Degranulation; Cells, Cultured; Drug Screening Assays, Antitumor; Humans; Macrophages; Mast Cells; Mice; Neutrophils; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	2002
Antimalarial 9-anilinoacridine compounds directed at hematin. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:12 Topics: Amsacrine; Animals; Antimalarials; Chloroquine; Erythrocytes; Hemin; Hemolysis; Humans; In Vitro Techniques; Plasmodium falciparum; Protein Binding; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Topoisomerase II Inhibitors	2003
Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Amsacrine; Animals; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Injections, Intravenous; Mice; Mice, Nude; Nitrogen Mustard Compounds; Paclitaxel; Structure-Activity Relationship; Tumor Cells, Cultured; Vinblastine; Xenograft Model Antitumor Assays	2004
Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity. Bioorganic & medicinal chemistry, 2005, Jun-02, Volume: 13, Issue:12 Topics: Alkylating Agents; Amsacrine; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Nude; Neoplasms; Remission Induction; Structure-Activity Relationship; Xenograft Model Antitumor Assays	2005
Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage. Bioorganic & medicinal chemistry, 2008, May-15, Volume: 16, Issue:10 Topics: Acridines; Amsacrine; Aniline Mustard; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Molecular Structure; Rats; Stereoisomerism; Urea; Xenograft Model Antitumor Assays	2008
Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings. European journal of medicinal chemistry, 2009, Volume: 44, Issue:7 Topics: Amsacrine; Aniline Compounds; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Mustard Compounds; Precursor Cell Lymphoblastic Leukemia-Lymphoma	2009
Synthesis of 9-anilinoacridine triazines as new class of hybrid antimalarial agents. Bioorganic & medicinal chemistry letters, 2009, Dec-15, Volume: 19, Issue:24 Topics: Amsacrine; Animals; Antimalarials; Mice; Plasmodium falciparum; Triazines	2009
Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation. Bioorganic & medicinal chemistry, 2012, Jul-01, Volume: 20, Issue:13 Topics: Amsacrine; Antineoplastic Agents; Cell Line, Tumor; Cell Nucleus; Cell Survival; DNA; Drug Carriers; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Intercalating Agents; Microscopy, Fluorescence; Polymers; Water	2012
Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer activities as topoisomerase II inhibitors. European journal of medicinal chemistry, 2012, Volume: 56 Topics: Amsacrine; Animals; Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Mice; Models, Molecular; Molecular Structure; Oxazines; Structure-Activity Relationship; Topoisomerase II Inhibitors	2012
Synthesis and preliminary biological evaluation of polyamine-aniline acridines as P-glycoprotein inhibitors. Medicinal chemistry (Shariqah (United Arab Emirates)), 2014, Volume: 10, Issue:5 Topics: Amsacrine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Humans; K562 Cells; Polyamines	2014
Novel Thiazine Substituted 9-Anilinoacridines: Synthesis, Antitumour Activity and Structure Activity Relationships. Anti-cancer agents in medicinal chemistry, 2019, Volume: 19, Issue:11 Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Male; Mice; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship; Thiazines; Tumor Cells, Cultured	2019
In-silico Design, ADMET Screening, MM-GBSA Binding Free Energy of Some Novel Isoxazole Substituted 9-Anilinoacridines as HER2 Inhibitors Targeting Breast Cancer. Current drug research reviews, 2019, Volume: 11, Issue:2 Topics: Amsacrine; Antineoplastic Agents; Breast Neoplasms; Computer Simulation; Drug Design; Ethacridine; Female; Humans; Hydrogen Bonding; Isoxazoles; Models, Molecular; Molecular Dynamics Simulation; Receptor, ErbB-2; Structure-Activity Relationship; Tamoxifen	2019
Expedient synthesis and anticancer evaluation of dual-action 9-anilinoacridine methyl triazene chimeras. Chemical biology & drug design, 2021, Volume: 97, Issue:2 Topics: Amsacrine; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; Intercalating Agents; Structure-Activity Relationship; Topoisomerase II Inhibitors; Triazenes	2021
Pyrazole Substituted 9-Anilinoacridines as HER2 Inhibitors Targeting Breast Cancer - An in-silico approach. Current drug research reviews, 2022, Volume: 14, Issue:1 Topics: Amsacrine; Breast Neoplasms; Female; Humans; Ligands; Molecular Docking Simulation; Pyrazoles	2022
Synthesis and Anticancer Evaluation of Sulfur Containing 9-anilinoacridines. Recent patents on anti-cancer drug discovery, 2022, Volume: 17, Issue:1 Topics: Amsacrine; Antineoplastic Agents; DNA Topoisomerases, Type II; Humans; Molecular Docking Simulation; Sulfur; Topoisomerase II Inhibitors	2022