9-PAHSA and stearic-acid

9-PAHSA has been researched along with stearic-acid* in 1 studies

Other Studies

1 other study(ies) available for 9-PAHSA and stearic-acid

Article	Year
Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β-Cell Apoptosis. Journal of medicinal chemistry, 2020, 11-12, Volume: 63, Issue:21 The field of bioactive lipids is ever expanding with discoveries of novel lipid molecules that promote human health. Adopting a lipidomic-assisted approach, two new families of previously unrecognized saturated hydroxy fatty acids (SHFAs), namely, hydroxystearic and hydroxypalmitic acids, consisting of isomers with the hydroxyl group at different positions, were identified in milk. Among the various regio-isomers synthesized, those carrying the hydroxyl at the 7- and 9-positions presented growth inhibitory activities against various human cancer cell lines, including A549, Caco-2, and SF268 cells. In addition, 7- and 9-hydroxystearic acids were able to suppress β-cell apoptosis induced by proinflammatory cytokines, increasing the possibility that they can be beneficial in countering autoimmune diseases, such as type 1 diabetes. 7-( Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Chromatography, High Pressure Liquid; Cytokines; Fatty Acids; Gene Expression; Humans; Insulin-Secreting Cells; Milk; STAT3 Transcription Factor; Stearic Acids; Stereoisomerism; Tandem Mass Spectrometry	2020

Article

Year

Saturated Hydroxy Fatty Acids Exhibit a Cell Growth Inhibitory Activity and Suppress the Cytokine-Induced β-Cell Apoptosis.

Journal of medicinal chemistry, 2020, 11-12, Volume: 63, Issue:21

The field of bioactive lipids is ever expanding with discoveries of novel lipid molecules that promote human health. Adopting a lipidomic-assisted approach, two new families of previously unrecognized saturated hydroxy fatty acids (SHFAs), namely, hydroxystearic and hydroxypalmitic acids, consisting of isomers with the hydroxyl group at different positions, were identified in milk. Among the various regio-isomers synthesized, those carrying the hydroxyl at the 7- and 9-positions presented growth inhibitory activities against various human cancer cell lines, including A549, Caco-2, and SF268 cells. In addition, 7- and 9-hydroxystearic acids were able to suppress β-cell apoptosis induced by proinflammatory cytokines, increasing the possibility that they can be beneficial in countering autoimmune diseases, such as type 1 diabetes. 7-(

Topics: Animals; Apoptosis; Cell Line; Cell Proliferation; Chromatography, High Pressure Liquid; Cytokines; Fatty Acids; Gene Expression; Humans; Insulin-Secreting Cells; Milk; STAT3 Transcription Factor; Stearic Acids; Stereoisomerism; Tandem Mass Spectrometry

2020