9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine has been researched along with guanine in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cerný, J; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Sedivá, K; Veselý, J; Vlach, J; Votruba, I | 1 |
| Holý, A; Merta, A; Stĕtina, R; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L | 1 |
| Bílá, V; Holý, A; Lesková, V; Mejsnarová, B; Otová, B; Sladká, M; Votruba, I | 1 |
| Eckschlager, T; Franek, F; Holy, A; Votruba, I | 1 |
| Compton, ML; Paborsky, LR; Toole, JJ | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L; Segers, C; Verbeken, E; Waer, M | 1 |
| Downey, KM; Kramata, P | 1 |
| Holý, A; Horská, K; Krejcová, R; Votruba, I | 1 |
| Andrei, G; De Clercq, E; Holý, A; Horejsí, K; Pohl, R; Snoeck, R | 1 |
| Holý, A; Otová, B; Votruba, I | 1 |
| Holy, A; Hrdy, J; Otová, B; Votruba, I | 1 |
| Cvilink, V; Hájek, M; Holý, A; Mertlíková-Kaiserová, H; Votruba, I | 1 |
| Holý, A; Mertlíková-Kaiserová, H; Procházková, E; Rumlová, M; Tloušťová, E; Votruba, I | 1 |
| Holy, A; Mertlíková-Kaiserová, H; Nejedlá, M; Votruba, I | 1 |
1 review(s) available for 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine and guanine
| Article | Year |
|---|---|
[Acyclic nucleoside phosphonates as potential antineoplastic agents].
Topics: Adenine; Alanine; Animals; Antineoplastic Agents; Cell Line, Tumor; Guanine; Humans; Lymphoma, Non-Hodgkin; Nucleosides; Organophosphonates; Organophosphorus Compounds; Purines | 2008 |
14 other study(ies) available for 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine and guanine
| Article | Year |
|---|---|
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro.
Topics: Adenine; Adenosine; Antiviral Agents; Cidofovir; Cytosine; DNA Viruses; Guanine; In Vitro Techniques; Nucleic Acid Synthesis Inhibitors; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Inhibitors; Ribonucleotide Reductases; Structure-Activity Relationship; Tubercidin | 1990 |
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Topics: Adenine; Animals; Antiviral Agents; CHO Cells; Cricetinae; Cricetulus; Cytarabine; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Guanine; Organophosphonates; Organophosphorus Compounds; Zidovudine | 1993 |
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Survival; Cyclic AMP; Drug Resistance, Neoplasm; Guanine; Kinetics; Leukemia L1210; Mice; Organophosphonates; Organophosphorus Compounds; Purine Nucleotides; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Genotoxicity of purine acyclic nucleotide analogs.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Female; Guanine; Humans; Male; Molecular Structure; Mutagenicity Tests; Mutagens; Organophosphonates; Organophosphorus Compounds; Purines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tenofovir; Teratogens; Thioguanine | 1997 |
Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; DNA, Neoplasm; Drug Screening Assays, Antitumor; Guanine; HL-60 Cells; Humans; Leukemia, Myeloid; Organophosphorus Compounds; Tumor Cells, Cultured | 1999 |
9-(2-Phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9-(2-phosphonylmethoxyethyl)guanine (PMEG).
Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Deamination; Dideoxynucleosides; Guanine; Humans; Organophosphorus Compounds; Prodrugs; Rats; Tumor Cells, Cultured | 1999 |
9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.
Topics: Adenine; Animals; Antineoplastic Agents; Choriocarcinoma; Female; Guanine; Male; Organophosphonates; Organophosphorus Compounds; Pregnancy; Prodrugs; Rats; Tumor Cells, Cultured; Uterine Neoplasms | 1999 |
9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis.
Topics: Adenine; Antineoplastic Agents; Deoxyadenine Nucleotides; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; Guanine; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1999 |
Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes.
Topics: Adenine; Animals; Antineoplastic Agents; Guanine; Guanosine Monophosphate; Guanylate Kinases; Isoenzymes; Kinetics; Nucleoside-Phosphate Kinase; Organophosphorus Compounds; Phosphorylation; Substrate Specificity; Swine | 2000 |
Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity.
Topics: Adenine; Antiviral Agents; Cell Proliferation; Cytomegalovirus; Guanine; Herpesvirus 3, Human; Humans; Organophosphorus Compounds; Structure-Activity Relationship | 2006 |
In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG.
Topics: Adenine; Animals; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 1; Gene Expression Regulation, Neoplastic; Guanine; Lymphoma, T-Cell; Male; Neovascularization, Pathologic; Organophosphorus Compounds; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2009 |
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.
Topics: Adenine; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; In Situ Hybridization, Fluorescence; Organophosphorus Compounds; Proto-Oncogene Proteins c-myc; Reverse Transcriptase Polymerase Chain Reaction; RNA; Telomerase; Telomere; Time Factors | 2010 |
Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.
Topics: Adenine; Adenylate Kinase; Amino Acid Sequence; Antineoplastic Agents; Cells, Cultured; Drug Resistance, Neoplasm; Guanine; Guanylate Kinases; Humans; Molecular Sequence Data; Organophosphorus Compounds; Phosphorylation; Point Mutation | 2011 |
Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates.
Topics: Adenine; Antineoplastic Agents; Caspase 3; Cell Line, Tumor; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Guanine; HL-60 Cells; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Organophosphorus Compounds; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; RNA, Messenger | 2012 |