Compounds > 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
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9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine and adefovir

9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine has been researched along with adefovir in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's13 (61.90)18.2507
2000's7 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrei, G; Balzarini, J; De Clercq, E; Dvoráková, H; Günter, J; Holý, A; Masojídková, M; Snoeck, R1
Andrei, G; Balzarini, J; De Clercq, E; Holý, A; Masojídková, M; Naesens, L; Snoeck, R; Votruba, I1
Cordeiro, MN; Fernández, F; García-Mera, X; Helguera, AM; Rodríguez-Borges, JE1
Andrei, G; Crance, JM; De Clercq, E; De Vos, R; Duraffour, S; Garin, D; Holy, A; Krecmerová, M; Snoeck, R; van Den Oord, J1
Andrei, G; Balzarini, J; Camarasa, MJ; de Castro, S; Naesens, L; Peromingo, MT; Snoeck, R; Velázquez, S1
Cerný, J; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Sedivá, K; Veselý, J; Vlach, J; Votruba, I1
Balzarini, J; De Clercq, E; Naesens, L1
De Clercq, E1
De Clercq, E; Konno, K; Mochizuki, S; Mori, S; Shigeta, S; Yokota, T1
De Clercq, E; Holý, A; Rosenberg, I1
Balestra, E; Balzarini, J; Caliò, R; De Clercq, E; Del Gobbo, V; Holy, A; Perno, CF; Sesa, F; Villani, N1
De Clercq, E; Kaminsky, R; Zweygarth, E1
Holý, A; Merta, A; Stĕtina, R; Votruba, I1
Konno, K; Shigeta, S; Sudo, K; Yokota, T1
Balzarini, J; De Clercq, E; Hatse, S; Naesens, L1
Bílá, V; Holý, A; Lesková, V; Mejsnarová, B; Otová, B; Sladká, M; Votruba, I1
Havel, J; Holý, A; Revilla, A; Vargas, G1
Downey, KM; Kramata, P1
De Clercq, E; Frison, E; Helliot, B; Lepoivre, P; Neyts, J; Panis, B; Swennen, R1
Croubels, S; De Backer, P; Garré, B; Nauwynck, H; Neyts, J; Nugent, J; van der Meulen, K1
Andrei, G; De Clercq, E; Fiten, P; Froeyen, M; Opdenakker, G; Snoeck, R1

Reviews

1 review(s) available for 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine and adefovir

ArticleYear
Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents.
    Drugs under experimental and clinical research, 1990, Volume: 16, Issue:7

    Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Purines; Pyrimidines; Retroviridae Infections; Virus Diseases

1990

Other Studies

20 other study(ies) available for 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine and adefovir

ArticleYear
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
    Journal of medicinal chemistry, 1999, Jun-17, Volume: 42, Issue:12

    Topics: Animals; Anti-HIV Agents; Antiviral Agents; Cell Line; DNA Viruses; HIV-1; HIV-2; Humans; Moloney murine sarcoma virus; Organophosphonates; Purine Nucleotides; Pyrimidine Nucleotides; Structure-Activity Relationship

1999
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
    Journal of medicinal chemistry, 2002, Apr-25, Volume: 45, Issue:9

    Topics: Animals; Anti-HIV Agents; Antineoplastic Agents; Antiviral Agents; Cell Division; Cell Line; Humans; Mice; Organophosphonates; Pyrimidine Nucleosides; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Virus Replication

2002
Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
    Journal of medicinal chemistry, 2007, Apr-05, Volume: 50, Issue:7

    Topics: Algorithms; Antineoplastic Agents; Databases, Factual; Discriminant Analysis; Models, Molecular; Nucleosides; Quantitative Structure-Activity Relationship

2007
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12

    Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Male; Mice; Microscopy, Electron, Transmission; Nucleosides; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Swiss 3T3 Cells; Virus Replication

2007
4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action.
    Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18

    Topics: Antiviral Agents; Cell Line; Cytomegalovirus; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Thymidine; Urea

2008
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro.
    Antiviral research, 1990, Volume: 13, Issue:6

    Topics: Adenine; Adenosine; Antiviral Agents; Cidofovir; Cytosine; DNA Viruses; Guanine; In Vitro Techniques; Nucleic Acid Synthesis Inhibitors; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Inhibitors; Ribonucleotide Reductases; Structure-Activity Relationship; Tubercidin

1990
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo.
    Antiviral research, 1991, Volume: 16, Issue:1

    Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Cell Transformation, Viral; Drug Administration Schedule; Injections, Intraperitoneal; Mice; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental

1991
Phosphonylmethoxyalkyl derivatives of purine as inhibitors of human hepatitis B virus DNA synthesis.
    Nucleic acids symposium series, 1990, Issue:22

    Topics: Adenine; Antiviral Agents; DNA Replication; DNA, Viral; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured

1990
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo.
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:2

    Topics: Adenine; Animals; Antiviral Agents; Brain Diseases; Herpes Simplex; Injections; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mice, Hairless; Mice, Nude; Organophosphonates; Organophosphorus Compounds; Vaccinia

1989
Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates.
    Antiviral research, 1994, Volume: 23, Issue:1

    Topics: Adenine; Animals; Antiviral Agents; Interferons; Killer Cells, Natural; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Organophosphonates; Organophosphorus Compounds; Time Factors

1994
Antitrypanosomal activity of phosphonylmethoxyalkylpurines.
    The Journal of parasitology, 1994, Volume: 80, Issue:6

    Topics: Adenine; Animals; Cidofovir; Cytosine; Female; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Purines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma congolense; Trypanosomiasis, African

1994
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
    Neoplasma, 1993, Volume: 40, Issue:6

    Topics: Adenine; Animals; Antiviral Agents; CHO Cells; Cricetinae; Cricetulus; Cytarabine; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Guanine; Organophosphonates; Organophosphorus Compounds; Zidovudine

1993
Colorimetric assay system for screening antiviral compounds against hepatitis B virus.
    Microbiology and immunology, 1996, Volume: 40, Issue:2

    Topics: Adenine; Antiviral Agents; Base Sequence; Colorimetry; DNA Primers; DNA, Viral; Drug Evaluation, Preclinical; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Molecular Sequence Data; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured

1996
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
    Biochimica et biophysica acta, 1998, Mar-12, Volume: 1402, Issue:1

    Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Survival; Cyclic AMP; Drug Resistance, Neoplasm; Guanine; Kinetics; Leukemia L1210; Mice; Organophosphonates; Organophosphorus Compounds; Purine Nucleotides; Structure-Activity Relationship; Tumor Cells, Cultured

1998
Genotoxicity of purine acyclic nucleotide analogs.
    Folia biologica, 1997, Volume: 43, Issue:6

    Topics: Adenine; Animals; Antiviral Agents; Cell Line; Female; Guanine; Humans; Male; Molecular Structure; Mutagenicity Tests; Mutagens; Organophosphonates; Organophosphorus Compounds; Purines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tenofovir; Teratogens; Thioguanine

1997
Capillary electrophoresis separation of the new anti-AIDS agents 9-(2-phosphonylmethoxyethyl)adenine and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine in mixtures with some monoribonucleotides or the most common deoxynucleotides.
    Electrophoresis, 1998, Volume: 19, Issue:16-17

    Topics: Adenine; Anti-HIV Agents; Electrophoresis, Capillary; Organophosphonates; Ribonucleotides

1998
9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis.
    Molecular pharmacology, 1999, Volume: 56, Issue:6

    Topics: Adenine; Antineoplastic Agents; Deoxyadenine Nucleotides; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; Guanine; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured

1999
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.).
    Antiviral research, 2003, Volume: 59, Issue:2

    Topics: Adenine; Antiviral Agents; Badnavirus; Musa; Organophosphonates; Organophosphorus Compounds; Plant Diseases; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication

2003
In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet.
    Veterinary microbiology, 2007, May-16, Volume: 122, Issue:1-2

    Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Drug Resistance, Viral; Epithelial Cells; Foscarnet; Ganciclovir; Herpesvirus 1, Equid; Horses; Lung; Organophosphonates

2007
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions.
    Antiviral therapy, 2007, Volume: 12, Issue:5

    Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Cidofovir; Cytosine; Disease Models, Animal; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Enzyme Inhibitors; Exodeoxyribonucleases; Foscarnet; Genotype; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice; Models, Molecular; Mutation; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Phenotype; Protein Binding; Protein Conformation; Vero Cells; Viral Proteins; Virulence

2007