Compounds > 9-(2-hydroxy-3-nonyl)adenine

9-(2-hydroxy-3-nonyl)adenine and rolipram

9-(2-hydroxy-3-nonyl)adenine has been researched along with rolipram in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (18.75)18.2507
2000's7 (43.75)29.6817
2010's4 (25.00)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Bucki, A; Chłoń-Rzepa, G; Funk, P; Gawalska, A; Lemrová, B; Nowak, B; Pawłowski, M; Pociecha, K; Ručilová, V; Soural, M; Świerczek, A; Vanda, D; Wyska, E; Zadrożna, M; Zajdel, P1
Bourguignon, JJ; Désaubry, L; Lugnier, C; Raboisson, P; Wermuth, CG1
Hughes, RA; Manallack, DT; Thompson, PE1
Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X1
de Esch, IJ; de Graaf, C; Jansen, C; Kanev, GK; Kooistra, AJ; Leurs, R1
Chen, G; Ke, H; Kunz, S; Martinelli, S; Robinson, H; Seebeck, T; Wan, Y; Wang, H1
Harnett, MM; Houslay, MD; Lobban, M; Michie, AM; Müller, T1
Eisenbrand, G; Fürstenberger, G; Marko, D; Romanakis, K; Steinbauer, B; Zankl, H1
Brading, AF; Jones, OM; McC Mortensen, NJ1
O'Donnell, JM; Suvarna, NU1
Hernández, J; Juan-Fita, MJ; Vargas, ML1
Andersson, TP; Sköld, HN; Svensson, SP1
Cao, Q; Ding, YH; Ellenberger, T; Iffland, A; Kamath, AV; Kohls, D; Kothe, M; Low, S; Luan, J; Zhang, Y1
Adderley, SP; Bowles, EA; Ellsworth, ML; Sprague, RS; Sridharan, M; Stephenson, AH1
Arai, N; Hiramoto, K; Inui, M; Manganiello, VC; Morita, H; Murata, T; Shimizu, K; Tagawa, T1
Gergs, U; Laufs, U; Neumann, J; Voss, R; Werner, C1

Reviews

1 review(s) available for 9-(2-hydroxy-3-nonyl)adenine and rolipram

ArticleYear
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
    Journal of medicinal chemistry, 2005, May-19, Volume: 48, Issue:10

    Topics: Animals; Binding Sites; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Drug Design; Humans; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Quantitative Structure-Activity Relationship; Xanthines

2005

Other Studies

15 other study(ies) available for 9-(2-hydroxy-3-nonyl)adenine and rolipram

ArticleYear
New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases.
    European journal of medicinal chemistry, 2021, Jan-01, Volume: 209

    Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Female; Humans; Imidazoles; Inflammation; Male; Mice, Inbred BALB C; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pyridines; Rats, Wistar

2021
9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors.
    Journal of medicinal chemistry, 1997, Jun-06, Volume: 40, Issue:12

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenosine Deaminase Inhibitors; Anticonvulsants; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Isoenzymes; Muscle, Smooth, Vascular; Purines; Structure-Activity Relationship

1997
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship

2008
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
    Journal of medicinal chemistry, 2016, Aug-11, Volume: 59, Issue:15

    Topics: Databases, Protein; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship

2016
Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
    The Journal of biological chemistry, 2012, Apr-06, Volume: 287, Issue:15

    Topics: Amino Acid Sequence; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Design; Kinetics; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Sulfonamides; Surface Properties; Trypanosoma cruzi

2012
Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.
    Cellular signalling, 1996, Volume: 8, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Antibodies, Monoclonal; Binding, Competitive; CD3 Complex; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanosine Monophosphate; Humans; Isoenzymes; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phytohemagglutinins; Pyrrolidinones; Rabbits; Receptors, Antigen, T-Cell; Rolipram; Sensitivity and Specificity; Signal Transduction; Thymus Gland

1996
Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts.
    Cell biochemistry and biophysics, 1998, Volume: 28, Issue:2-3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Carcinoma; Cell Cycle; Cell Division; Cell Size; Cell Transformation, Neoplastic; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA Fragmentation; Isoenzymes; Keratinocytes; Mice; Papilloma; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Pteridines; Pyrrolidinones; Rolipram; Skin Neoplasms; Tumor Cells, Cultured

1998
Phosphodiesterase inhibitors cause relaxation of the internal anal sphincter in vitro.
    Diseases of the colon and rectum, 2002, Volume: 45, Issue:4

    Topics: Adenine; Aged; Aged, 80 and over; Anal Canal; Dipyridamole; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Isoquinolines; Male; Middle Aged; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Purinones; Rectum; Rolipram; Tetrahydroisoquinolines; Vinca Alkaloids

2002
Hydrolysis of N-methyl-D-aspartate receptor-stimulated cAMP and cGMP by PDE4 and PDE2 phosphodiesterases in primary neuronal cultures of rat cerebral cortex and hippocampus.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenosine; Animals; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 4; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Guanylate Cyclase; Hippocampus; N-Methylaspartate; Neurons; Nitric Oxide Donors; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rolipram

2002
Comparative actions of diazepam and other phosphodiesterase inhibitors on the effects of noradrenaline in rat myocardium.
    Pharmacology & toxicology, 2003, Volume: 93, Issue:1

    Topics: Adenine; Animals; Cyclic AMP; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Female; In Vitro Techniques; Isoenzymes; Male; Milrinone; Myocardial Contraction; Norepinephrine; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Xanthines

2003
Phosphoinositide 3-kinase is involved in Xenopus and Labrus melanophore aggregation.
    Cellular signalling, 2003, Volume: 15, Issue:12

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Androstadienes; Animals; Chromones; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Kinetics; Melanocyte-Stimulating Hormones; Melanophores; Melanosomes; Melatonin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Norepinephrine; Papaverine; Perciformes; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Rolipram; Signal Transduction; Wortmannin; Xenopus laevis

2003
Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system.
    Biochemistry, 2005, Jun-14, Volume: 44, Issue:23

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenine; Amino Acid Sequence; Binding Sites; Catalytic Domain; Cell-Free System; Crystallography, X-Ray; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Protein Binding; Protein Biosynthesis; Rolipram; Sequence Alignment; Substrate Specificity; Triticum

2005
Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
    Microcirculation (New York, N.Y. : 1994), 2011, Volume: 18, Issue:2

    Topics: Adenine; Adenosine Triphosphate; Cilostazol; Colforsin; Cyclic AMP; Enzyme Activation; Erythrocytes; Guanine Nucleotide Exchange Factors; Humans; Iloprost; In Vitro Techniques; Isoproterenol; Models, Biological; Naphthalenes; Phosphodiesterase Inhibitors; Protein Kinase C; Rolipram; Signal Transduction; Tetradecanoylphorbol Acetate; Tetrazoles; Thionucleotides

2011
Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells.
    Cellular signalling, 2014, Volume: 26, Issue:9

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Humans; Melanoma; RNA Interference; RNA, Small Interfering; Rolipram

2014
Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:6

    Topics: Adenine; Animals; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Heart Atria; Heart Rate; Histamine; Humans; Male; Mice; Mice, Transgenic; Phosphodiesterase Inhibitors; Quinolones; Receptors, Histamine H2; Rolipram

2021