9-(2-aminoethoxy)phenoxazine and phenoxazine

9-(2-aminoethoxy)phenoxazine has been researched along with phenoxazine* in 2 studies

Other Studies

2 other study(ies) available for 9-(2-aminoethoxy)phenoxazine and phenoxazine

Article	Year
Binding affinities of oligonucleotides and PNAs containing phenoxazine and G-clamp cytosine analogues are unusually sequence-dependent. Organic letters, 2007, Oct-25, Volume: 9, Issue:22 Melting temperatures of DNA duplexes containing the phenoxazine (P) and G-clamp (X) cytosine analogues exhibited a strong and unusual dependence on the nucleoside flanking the modified nucleobase, and the same trend was observed in PNA-DNA duplexes incorporating X in the PNA chain. Molecular dynamics simulations of the DNA duplexes show that generalized stacking (including secondary interactions of the ammonium group of X) and hydrogen bonding are good descriptors of the different duplex stabilities. Topics: Base Sequence; Cytosine; Nucleic Acid Conformation; Oligonucleotides; Oxazines; Peptide Nucleic Acids	2007
High-affinity peptide nucleic acid oligomers containing tricyclic cytosine analogues. Organic letters, 2002, Dec-12, Volume: 4, Issue:25 [structure: see text] Peptide nucleic acid (PNA) monomers containing the tricyclic cytosine analogues phenoxazine, 9-(2-aminoethoxy)phenoxazine (G-clamp), and 9-(3-aminopropoxy)phenoxazine (propyl-G-clamp) have been synthesized. The modified nucleobases were incorporated into PNA oligomers using Boc-chemistry for solid-phase synthesis. PNAs containing single G-clamp modifications exhibit significantly enhanced affinity toward RNA and DNA targets relative to unmodified PNA while maintaining mismatch discrimination. These PNA G-clamp modifications exhibit the highest increase in affinity toward nucleic acid targets reported so far for PNA modifications. Topics: Cytosine; DNA; Molecular Structure; Oxazines; Peptide Nucleic Acids; RNA	2002

Article

Year

Binding affinities of oligonucleotides and PNAs containing phenoxazine and G-clamp cytosine analogues are unusually sequence-dependent.

Organic letters, 2007, Oct-25, Volume: 9, Issue:22

Melting temperatures of DNA duplexes containing the phenoxazine (P) and G-clamp (X) cytosine analogues exhibited a strong and unusual dependence on the nucleoside flanking the modified nucleobase, and the same trend was observed in PNA-DNA duplexes incorporating X in the PNA chain. Molecular dynamics simulations of the DNA duplexes show that generalized stacking (including secondary interactions of the ammonium group of X) and hydrogen bonding are good descriptors of the different duplex stabilities.

Topics: Base Sequence; Cytosine; Nucleic Acid Conformation; Oligonucleotides; Oxazines; Peptide Nucleic Acids

2007

High-affinity peptide nucleic acid oligomers containing tricyclic cytosine analogues.

Organic letters, 2002, Dec-12, Volume: 4, Issue:25

[structure: see text] Peptide nucleic acid (PNA) monomers containing the tricyclic cytosine analogues phenoxazine, 9-(2-aminoethoxy)phenoxazine (G-clamp), and 9-(3-aminopropoxy)phenoxazine (propyl-G-clamp) have been synthesized. The modified nucleobases were incorporated into PNA oligomers using Boc-chemistry for solid-phase synthesis. PNAs containing single G-clamp modifications exhibit significantly enhanced affinity toward RNA and DNA targets relative to unmodified PNA while maintaining mismatch discrimination. These PNA G-clamp modifications exhibit the highest increase in affinity toward nucleic acid targets reported so far for PNA modifications.

Topics: Cytosine; DNA; Molecular Structure; Oxazines; Peptide Nucleic Acids; RNA

2002