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9-(2,3-dihydroxypropyl)adenine, (s)-isomer and ribavirin

9-(2,3-dihydroxypropyl)adenine, (s)-isomer has been researched along with ribavirin in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19905 (16.67)18.7374
1990's1 (3.33)18.2507
2000's14 (46.67)29.6817
2010's10 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Balzarini, J; De Clercq, E; Dorland, E; Harrap, KR; Serafinowski, P1
Auclair, C; Balzarini, J; De Clercq, E; Debart, F; Gosselin, G; Le Ber, P; Mrani, D; Paoletti, C; Periguad, C; Rayner, B1
Balzarini, J; Calvo-Mateo, A; Camarasa, MJ; De Clercq, E; De las Heras, FG; Diaz-Ortiz, A1
Balzarini, J; De Clercq, E; Krowicki, K; Lown, JW1
Bergogne, MC; De Clercq, E; de Rudder, J; Gosselin, G; Imbach, JL1
Agarwal, KC; De Clercq, E; Hosmane, RS; Luo, JK; Parks, RE; Saunders, PP; Schneller, SW; Stoeckler, JD1
Carte, N; De Clercq, E; Guillerm, D; Guillerm, G; Lambert, C; Leize, E; Rogniaux, H; Van Dorsselaer, A; Vandenplas-Witkowki, C1
Chiacchio, MA; Corsaro, A; De Clercq, E; Iannazzo, D; Mastino, A; Piperno, A; Rescifina, A; Romeo, G; Romeo, R; Valveri, V1
Balzarini, J; De Clercq, E; Gazivoda, T; Kralj, M; Marjanović, M; Mintas, M; Pavelić, K; Raić-Malić, S1
Alvarez, K; Balzarini, J; Barral, K; Canard, B; Neyts, J; Priet, S; Sire, J1
Andrei, G; Balzarini, J; De Clercq, E; Holý, A; Krecmerová, M; Masojídková, M; Naesens, L; Neyts, J; Pískala, A; Snoeck, R1
Balzarini, J; Clercq, ED; Kralj, M; Makuc, D; Mintas, M; Pavelić, K; Plavec, J; Prekupec, S; Raić-Malić, S; Suman, L1
De Clercq, E; Küçükgüzel, I; Küçükgüzel, SG; Rollas, S; Tatar, E1
Andrei, G; Balzarini, J; De Clercq, E; Gazivoda, T; Kralj, M; Mintas, M; Pavelić, K; Raić-Malić, S; Snoeck, R; Sokcević, M; Suman, L1
Andrei, G; Balzarini, J; De Clercq, E; Holý, A; Krecmerová, M; Masojídková, M; Naesens, L; Neyts, J; Pohl, R; Snoeck, R1
De Clercq, E; Gawin, R; Koszytkowska-Stawińska, M; Naesens, L1
Balzarini, J; De Clercq, E; Judge, V; Kumar, P; Narang, R; Narasimhan, B; Sharma, D1
Balzarini, J; Brancale, A; Cirilli, R; Coluccia, A; Giordano, C; La Regina, G; La Torre, F; Lavecchia, A; Maga, G; Novellino, E; Piscitelli, F; Samuele, A; Sansone, A; Silvestri, R; Zanoli, S1
Andrei, G; Bayrak, OF; De Clercq, E; Güniz Küçükgüzel, S; Karakuş, S; Küçükgüzel, I; Pannecouque, C; Sahin, F; Snoeck, R1
Andrei, G; Balzarini, J; Baraka, MM; el-Sabbagh, OI; Ibrahim, SM; Pannecouque, C; Rashad, AA; Snoeck, R1
Balzarini, J; Bhargava, A; De Clercq, E; Rai, D; Singh, RK; Yadav, D1
Balzarini, J; De Clercq, E; Judge, V; Kumar, D; Narang, R; Narasimhan, B; Sangwan, S1
De Clercq, E; Ganguly, S; Kumar, KS; Veerasamy, R1
Balzarini, J; De Clercq, E; Dewan, SK; Kumar, P; Narasimhan, B; Pannecouque, C; Yadav, S1
Balzarini, J; Głowacka, IE; Piotrowska, DG1
Balzarini, J; Bharatam, PV; Chibale, K; Kaur, H; Little, S; Singh, K1
Balzarini, J; Chibale, K; Kaur, H; Singh, K1
Balzarini, J; Singh, K1
Andrei, G; Kraljević Pavelić, S; Makuc, D; Martinović, T; Mintas, M; Pavelić, K; Plavec, J; Schols, D; Snoeck, R; Stipković Babić, M; Wittine, K1
Balzarini, J; De Clercq, E; Karki, SS; Kulkarni, AA; Kumar, S; Veliyath, SK1

Other Studies

30 other study(ies) available for 9-(2,3-dihydroxypropyl)adenine, (s)-isomer and ribavirin

ArticleYear
Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
    Journal of medicinal chemistry, 1992, Nov-27, Volume: 35, Issue:24

    Topics: Animals; Antiviral Agents; Cell Line; HIV-1; Humans; Methyltransferases; Molecular Structure; Rabbits; S-Adenosylhomocysteine; Simplexvirus; Vaccinia virus; Vesicular stomatitis Indiana virus

1992
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:5

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; DNA; Guanidines; Humans; Mice; Netropsin; Oligopeptides; Tumor Cells, Cultured

1989
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:8

    Topics: Antiviral Agents; Chemical Phenomena; Chemistry; HIV; Microbial Sensitivity Tests; Moloney murine sarcoma virus; Nucleosides

1989
Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:7

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line; Distamycins; Drug Evaluation, Preclinical; Guanidines; Humans; Indicators and Reagents; Leukemia L1210; Mice; Netropsin; Oligopeptides; Pyrroles; Structure-Activity Relationship; Vaccinia virus

1986
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:2

    Topics: Animals; Antiviral Agents; Cell Division; Lethal Dose 50; Mice; Nucleosides; Rabbits

1986
Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cell Division; Cell Line; Cricetinae; Cricetulus; Erythrocytes; Escherichia coli; Female; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Indicators and Reagents; Microbial Sensitivity Tests; Ovary; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Viruses

1984
Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
    Journal of medicinal chemistry, 2001, Aug-16, Volume: 44, Issue:17

    Topics: Adenosylhomocysteinase; Amino Acid Sequence; Antiviral Agents; Cell Line; Chromatography, Liquid; Enzyme Inhibitors; Humans; Hydrolases; Models, Molecular; Molecular Sequence Data; NAD; Placenta; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Thionucleosides

2001
Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
    Journal of medicinal chemistry, 2006, Jan-26, Volume: 49, Issue:2

    Topics: Animals; Anthracenes; Antineoplastic Agents; Antiviral Agents; Apoptosis; Cell Line, Tumor; Chlorocebus aethiops; DNA; DNA Viruses; Drug Screening Assays, Antitumor; fas Receptor; Humans; Intercalating Agents; Isoxazoles; Phenanthrenes; Polycyclic Aromatic Hydrocarbons; Pyrenes; RNA Viruses; Stereoisomerism; Structure-Activity Relationship; Vero Cells

2006
The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
    Bioorganic & medicinal chemistry, 2007, Jan-15, Volume: 15, Issue:2

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Ascorbic Acid; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Fibroblasts; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Pyrimidines; Structure-Activity Relationship; Uracil; Viruses

2007
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
    Journal of medicinal chemistry, 2006, Dec-28, Volume: 49, Issue:26

    Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Boranes; Boron Compounds; Chlorocebus aethiops; DNA Viruses; HIV-1; Humans; In Vitro Techniques; Nucleosides; Organophosphonates; Phosphates; RNA Viruses; Structure-Activity Relationship; Vero Cells; Virus Replication

2006
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
    Journal of medicinal chemistry, 2007, Mar-08, Volume: 50, Issue:5

    Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Cidofovir; Cytosine; DNA Viruses; Humans; Mice; Organophosphonates; Retroviridae; RNA Viruses; Stereoisomerism; Structure-Activity Relationship; Triazines

2007
Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
    Journal of medicinal chemistry, 2007, Jun-28, Volume: 50, Issue:13

    Topics: Animals; Antiviral Agents; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; Cytostatic Agents; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Conformation; Molecular Mimicry; Positron-Emission Tomography; Pyrimidine Nucleosides; Pyrimidines; Structure-Activity Relationship

2007
Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:2

    Topics: Animals; Antitubercular Agents; Antiviral Agents; Cell Line; Drug Evaluation, Preclinical; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Thiourea; Triazoles

2008
Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
    Journal of medicinal chemistry, 2007, Aug-23, Volume: 50, Issue:17

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Ascorbic Acid; Cell Line; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Mice; Pyrimidines; Pyrimidinones; Stereoisomerism; Structure-Activity Relationship

2007
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
    Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23

    Topics: Antiviral Agents; Cell Line; Cytosine; DNA Viruses; Drug Resistance, Viral; Esters; Humans; Magnetic Resonance Spectroscopy; Prodrugs; Retroviridae; RNA Viruses; Stereoisomerism; Structure-Activity Relationship

2007
Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.
    Bioorganic & medicinal chemistry, 2008, Sep-15, Volume: 16, Issue:18

    Topics: Animals; Antiviral Agents; Aza Compounds; Catalysis; Cell Line; DNA Viruses; Drug Resistance, Viral; Humans; Hydrogenation; Nucleosides; Palladium; Pyrimidine Nucleosides; RNA Viruses; Structure-Activity Relationship; Sulfanilamide; Sulfanilamides

2008
Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Aspergillus niger; Bacillus subtilis; Candida albicans; Cells, Cultured; Chlorocebus aethiops; Drug Design; Escherichia coli; HeLa Cells; Herpesvirus 1, Human; Humans; Imidazoles; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Vero Cells

2009
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
    Journal of medicinal chemistry, 2009, Apr-09, Volume: 52, Issue:7

    Topics: Amino Acids; Animals; Anti-HIV Agents; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Cell Proliferation; Cytostatic Agents; Drug Resistance, Viral; Enterovirus B, Human; HIV Reverse Transcriptase; HIV-1; Humans; Hydrophobic and Hydrophilic Interactions; Indoles; Lymphocytes; Mice; Models, Molecular; Molecular Conformation; Mutation; Protein Binding; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Sulfones; Virus Replication

2009
Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Sulfonamides; Thiourea; Viruses

2009
Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; HeLa Cells; Humans; Microbial Sensitivity Tests; Pyrazoles; Structure-Activity Relationship; Thiazoles; Vero Cells; Viruses

2009
Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Anti-Bacterial Agents; Antiviral Agents; Bacteria; Cells, Cultured; Curcumin; Dipeptides; Fatty Acids; Folic Acid; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure

2010
Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:7

    Topics: Anti-Infective Agents; Antiviral Agents; Bacteria; Benzylidene Compounds; Fungi; HeLa Cells; Humans; Hydrazines; Microbial Sensitivity Tests; Quantitative Structure-Activity Relationship; Viruses

2010
Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:11

    Topics: Antiviral Agents; Cell Line; Drug Evaluation, Preclinical; Humans; Magnetic Resonance Spectroscopy; Quinazolines; Schiff Bases; Spectrophotometry, Infrared

2010
4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:12

    Topics: Animals; Anti-Infective Agents; Benzenesulfonates; Cell Survival; Cells, Cultured; Chlorocebus aethiops; Dogs; Fungi; Gram-Negative Bacteria; Gram-Positive Bacteria; HeLa Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Quantitative Structure-Activity Relationship; Stereoisomerism; Structure-Activity Relationship; Vero Cells; Viruses

2010
Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
    European journal of medicinal chemistry, 2012, Volume: 47, Issue:1

    Topics: Animals; Antiviral Agents; Cell Line; Cytostatic Agents; Drug Design; Humans; Inhibitory Concentration 50; Mice; Nucleotides; Triazoles; Viruses

2012
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
    European journal of medicinal chemistry, 2012, Volume: 52

    Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; DNA; Dogs; Heme; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Plasmodium falciparum; Protoporphyrins; Pyrimidines; Structure-Activity Relationship; Viruses

2012
Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
    European journal of medicinal chemistry, 2013, Volume: 66

    Topics: Antimalarials; Antiviral Agents; Cell Line; Chemistry Techniques, Synthetic; DNA; Heme; Humans; Plasmodium falciparum; Pyrimidines; Structure-Activity Relationship

2013
Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
    European journal of medicinal chemistry, 2013, Volume: 67

    Topics: Animals; Antiviral Agents; Cells, Cultured; Chlorocebus aethiops; Dogs; Dose-Response Relationship, Drug; HeLa Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Pyrimidinones; Stereoisomerism; Structure-Activity Relationship; Vero Cells; Viruses

2013
Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.
    European journal of medicinal chemistry, 2015, Sep-18, Volume: 102

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Ascorbic Acid; Cell Line; Cell Proliferation; Cytomegalovirus; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fibroblasts; Humans; Mice; Microbial Sensitivity Tests; Molecular Structure; Purines; Structure-Activity Relationship

2015
Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
    Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2013, Volume: 22, Issue:4

    Topics:

2013