8-thioguanosine and 8-hydroxyguanosine

8-thioguanosine has been researched along with 8-hydroxyguanosine* in 2 studies

Other Studies

2 other study(ies) available for 8-thioguanosine and 8-hydroxyguanosine

Article	Year
Leishmania amazonensis infection is reduced in macrophages treated with guanine ribonucleosides. Acta tropica, 1998, Jun-15, Volume: 70, Issue:1 Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Guanosine; Leishmania mexicana; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Thionucleosides	1998
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells. Journal of medicinal chemistry, 1985, Volume: 28, Issue:9 A variety of 8-substituted guanosine and 2'-deoxyguanosine derivatives were synthesized and tested as inducers of the differentiation of Friend murine erythroleukemia cells in culture. The most active agents in the guanosine series were 8-substituted-N(CH3)2, -NHCH3, -NH2, -OH, and -SO2CH3, which caused 68, 42, 34, 33, and 30% of erythroleukemia cells to attain benzidine positivity, a functional measure of maturation, at concentrations of 5, 1, 0.4, 5, and 5 mM, respectively. The 8-OH derivative of the 2'-deoxyguanosine series produced comparable activity, causing 62% benzidine-positive cells at a level of 0.2 mM. These findings indicate that 8-substituted analogues of guanosine and 2'-deoxyguanosine have the potential to terminate leukemia cell proliferation through conversion to end-stage differentiated cells. Topics: Animals; Antineoplastic Agents; Cell Differentiation; Chemical Phenomena; Chemistry; Deoxyguanosine; Friend murine leukemia virus; Guanosine; Hypoxanthine Phosphoribosyltransferase; Leukemia, Erythroblastic, Acute; Mice; Structure-Activity Relationship	1985

Article

Year

Leishmania amazonensis infection is reduced in macrophages treated with guanine ribonucleosides.

Acta tropica, 1998, Jun-15, Volume: 70, Issue:1

Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Guanosine; Leishmania mexicana; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Thionucleosides

1998

8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells.

Journal of medicinal chemistry, 1985, Volume: 28, Issue:9

A variety of 8-substituted guanosine and 2'-deoxyguanosine derivatives were synthesized and tested as inducers of the differentiation of Friend murine erythroleukemia cells in culture. The most active agents in the guanosine series were 8-substituted-N(CH3)2, -NHCH3, -NH2, -OH, and -SO2CH3, which caused 68, 42, 34, 33, and 30% of erythroleukemia cells to attain benzidine positivity, a functional measure of maturation, at concentrations of 5, 1, 0.4, 5, and 5 mM, respectively. The 8-OH derivative of the 2'-deoxyguanosine series produced comparable activity, causing 62% benzidine-positive cells at a level of 0.2 mM. These findings indicate that 8-substituted analogues of guanosine and 2'-deoxyguanosine have the potential to terminate leukemia cell proliferation through conversion to end-stage differentiated cells.

Topics: Animals; Antineoplastic Agents; Cell Differentiation; Chemical Phenomena; Chemistry; Deoxyguanosine; Friend murine leukemia virus; Guanosine; Hypoxanthine Phosphoribosyltransferase; Leukemia, Erythroblastic, Acute; Mice; Structure-Activity Relationship

1985