8-tert-butyl-6,7-dihydropyrrolo(3,2-e)-5-methylpyrazolo(1,5-a)pyrimidine-3-carbonitrile has been researched along with indomethacin in 2 studies
| Studies (8-tert-butyl-6,7-dihydropyrrolo(3,2-e)-5-methylpyrazolo(1,5-a)pyrimidine-3-carbonitrile) | Trials (8-tert-butyl-6,7-dihydropyrrolo(3,2-e)-5-methylpyrazolo(1,5-a)pyrimidine-3-carbonitrile) | Recent Studies (post-2010) (8-tert-butyl-6,7-dihydropyrrolo(3,2-e)-5-methylpyrazolo(1,5-a)pyrimidine-3-carbonitrile) | Studies (indomethacin) | Trials (indomethacin) | Recent Studies (post-2010) (indomethacin) |
|---|---|---|---|---|---|
| 15 | 0 | 0 | 29,527 | 1,838 | 3,396 |
| Protein | Taxonomy | 8-tert-butyl-6,7-dihydropyrrolo(3,2-e)-5-methylpyrazolo(1,5-a)pyrimidine-3-carbonitrile (IC50) | indomethacin (IC50) |
|---|---|---|---|
| Chain A, membrane-associated prostaglandin E synthase-2 | Macaca fascicularis (crab-eating macaque) | 1000 | |
| Prostaglandin-H2 D-isomerase | Mus musculus (house mouse) | 1.1 | |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | 5.8 | |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | 0.9994 | |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | 0.7764 | |
| Cytochrome c oxidase subunit 2 | Homo sapiens (human) | 0.34 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 0.5605 | |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | 0.004 | |
| Interleukin-8 | Homo sapiens (human) | 0.05 | |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | 0.004 | |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | 6 | |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | 5 | |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | 0.011 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 0.4848 | |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | 0.2 | |
| Thromboxane-A synthase | Homo sapiens (human) | 0.1 | |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | 0.082 | |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | 4.5 | |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | 5.7 | |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | 0.2 | |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | 0.2 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 1.5128 | |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | 0.5504 | |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | 3.4486 | |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | 0.2 | |
| C-X-C chemokine receptor type 3 | Homo sapiens (human) | 0.05 | |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | 8.97 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 3.4647 | |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | 0.4233 | |
| Solute carrier family 22 member 6 | Homo sapiens (human) | 3 | |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | 0.49 | |
| Rho-associated protein kinase 2 | Rattus norvegicus (Norway rat) | 7.7 | |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | 0.5461 | |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | 0.96 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akata, T; Kuriyama, H; Nakashima, M | 1 |
| Inazu, M; Tujitani, M | 1 |
2 other study(ies) available for 8-tert-butyl-6,7-dihydropyrrolo(3,2-e)-5-methylpyrazolo(1,5-a)pyrimidine-3-carbonitrile and indomethacin
| Article | Year |
|---|---|
Effects on the rabbit coronary artery of LP-805, a new type of releaser of endothelium-derived relaxing factor and a K+ channel opener.
Topics: Acetylcholine; Action Potentials; Animals; Coronary Vessels; Glyburide; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Potassium Channels; Pyrazoles; Pyrimidines; Rabbits; Vasodilator Agents | 1992 |
Effect of LP-805, a releaser of endothelium-derived nitric oxide, on systemic vasodilatation in vivo.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypotension; Indomethacin; Injections, Intravenous; Male; Nitric Oxide; Nitroarginine; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 1993 |