Compounds > 8-oxo-7-8-dihydrodeoxyguanine

8-oxo-7-8-dihydrodeoxyguanine and 5-hydroxymethyluracil

8-oxo-7-8-dihydrodeoxyguanine has been researched along with 5-hydroxymethyluracil* in 1 studies

Other Studies

1 other study(ies) available for 8-oxo-7-8-dihydrodeoxyguanine and 5-hydroxymethyluracil

Article	Year
Urinary 5-hydroxymethyluracil and 8-oxo-7,8-dihydroguanine as potential biomarkers in patients with colorectal cancer. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2015, Volume: 20, Issue:5 Oxidative stress linked with chronic inflammation is associated with etiology of the colorectal cancer.. To assess the diagnostic utility of urinary excretion of oxidatively modified DNA bases/nucleoside: 8-oxo-7,8-dihydroguanine (8-oxoGua), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and 5-hydroxymethyluracil (5-hmUra).. Seventy-two healthy controls, 15 patients with adenomas and 56 colorectal cancer patients were recruited.. The receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for all markers tested separately was <0.7. The combination of these modifications showed better diagnostic power (AUC = 0.778 for 8-oxoGua + 8-oxodG)/5hmUra ratio).. Urinary DNA modifications may reflect the oxidative stress/chronic inflammation in colorectal cancer but diagnostic performance for early-detection is moderate. Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Biomarkers, Tumor; Colorectal Neoplasms; Female; Guanine; Humans; Male; Middle Aged; Pentoxyl	2015

Article

Year

Urinary 5-hydroxymethyluracil and 8-oxo-7,8-dihydroguanine as potential biomarkers in patients with colorectal cancer.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2015, Volume: 20, Issue:5

Oxidative stress linked with chronic inflammation is associated with etiology of the colorectal cancer.. To assess the diagnostic utility of urinary excretion of oxidatively modified DNA bases/nucleoside: 8-oxo-7,8-dihydroguanine (8-oxoGua), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) and 5-hydroxymethyluracil (5-hmUra).. Seventy-two healthy controls, 15 patients with adenomas and 56 colorectal cancer patients were recruited.. The receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for all markers tested separately was <0.7. The combination of these modifications showed better diagnostic power (AUC = 0.778 for 8-oxoGua + 8-oxodG)/5hmUra ratio).. Urinary DNA modifications may reflect the oxidative stress/chronic inflammation in colorectal cancer but diagnostic performance for early-detection is moderate.

Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Biomarkers, Tumor; Colorectal Neoplasms; Female; Guanine; Humans; Male; Middle Aged; Pentoxyl

2015