8-nitroguanosine and 8-thioguanosine

8-nitroguanosine has been researched along with 8-thioguanosine* in 1 studies

Other Studies

1 other study(ies) available for 8-nitroguanosine and 8-thioguanosine

ArticleYear
Development of new 1,3-diazaphenoxazine derivatives (thioG-grasp) to covalently capture 8-thioguanosine.
    Molecules (Basel, Switzerland), 2015, Jan-09, Volume: 20, Issue:1

    The derivatives of 8-thioguanosine are thought to be included in the signal transduction system related to 8-nitroguanosine. In this study, we attempted to develop new 1,3-diazaphenoxazine (G-clamp) derivatives to covalently capture 8-thioguanosine (thioG-grasp). It was expected that the chlorine atom at the end of the linker would be displaced by the nucleophilic attack by the sulfur atom of 8-thioguanosine via multiple hydrogen-bonded complexes. The thioG-grasp derivative with a propyl linker reacted efficiently with 8-thioguanosine to form the corresponding adduct.

    Topics: Aza Compounds; Chromatography, High Pressure Liquid; Guanosine; Models, Molecular; Nitro Compounds; Oxazines; Thionucleosides; Time Factors

2015