8-nitroguanine and 3-(thymin-1--yl)-2-propenal

8-nitroguanine has been researched along with 3-(thymin-1--yl)-2-propenal* in 1 studies

Other Studies

1 other study(ies) available for 8-nitroguanine and 3-(thymin-1--yl)-2-propenal

Article	Year
Effects of carbon dioxide/bicarbonate on induction of DNA single-strand breaks and formation of 8-nitroguanine, 8-oxoguanine and base-propenal mediated by peroxynitrite. FEBS letters, 1996, Dec-09, Volume: 399, Issue:1-2 Carbon dioxide has been reported to react with peroxynitrite (ONOO-), a strong oxidant and nitrating agent, to form an ONO2CO2- adduct, altering the reactivity characteristic of peroxynitrite. We found that bicarbonate (0-10 mM) caused a dose-dependent increase of up to 6-fold in the formation of 8-nitroguanine in calf-thymus DNA incubated with 0.1 mM peroxynitrite, whereas it produced no apparent effect on 8-oxoguanine formation. In contrast, bicarbonate inhibited peroxynitrite-induced strand breakage in plasmid pBR322 DNA and thymine-propenal formation from thymidine. We conclude that C02/HCO3- reacts with peroxynitrite to form a potent nitrating agent, but also to inactivate hydroxyl-radical-like activity of peroxynitrous acid. Topics: Animals; Bicarbonates; Carbon Dioxide; Cattle; DNA Damage; DNA, Single-Stranded; Guanine; Nitrates; Thymine	1996

Article

Year

Effects of carbon dioxide/bicarbonate on induction of DNA single-strand breaks and formation of 8-nitroguanine, 8-oxoguanine and base-propenal mediated by peroxynitrite.

FEBS letters, 1996, Dec-09, Volume: 399, Issue:1-2

Carbon dioxide has been reported to react with peroxynitrite (ONOO-), a strong oxidant and nitrating agent, to form an ONO2CO2- adduct, altering the reactivity characteristic of peroxynitrite. We found that bicarbonate (0-10 mM) caused a dose-dependent increase of up to 6-fold in the formation of 8-nitroguanine in calf-thymus DNA incubated with 0.1 mM peroxynitrite, whereas it produced no apparent effect on 8-oxoguanine formation. In contrast, bicarbonate inhibited peroxynitrite-induced strand breakage in plasmid pBR322 DNA and thymine-propenal formation from thymidine. We conclude that C02/HCO3- reacts with peroxynitrite to form a potent nitrating agent, but also to inactivate hydroxyl-radical-like activity of peroxynitrous acid.

Topics: Animals; Bicarbonates; Carbon Dioxide; Cattle; DNA Damage; DNA, Single-Stranded; Guanine; Nitrates; Thymine

1996