8-nitro-2--deoxyguanosine has been researched along with nitroaniline* in 1 studies
*nitroaniline: RN given refers to cpd with unspecified locant for nitro moiety [MeSH]
*nitroaniline: RN given refers to cpd with unspecified locant for nitro moiety [MeSH]
1 other study(ies) available for 8-nitro-2--deoxyguanosine and nitroaniline
Article | Year |
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Structure of an Unusual Tetracyclic Deoxyguanosine Adduct: Implications for Frameshift Mutagenicity of
Nitroaromatic compounds represent a major class of industrial chemicals that are also found in nature. Polycyclic derivatives are regarded as potent mutagens and carcinogens following bioactivation to produce nitrenium electrophiles that covalently modify DNA to afford N-linked C8-2'-deoxyguanosine (C8-dG) lesions that can induce frameshift mutations, especially in CpG repeat sequences. In contrast, their monocyclic counterparts typically exhibit weak mutagenicity or a lack thereof, despite also undergoing bioactivation to afford N-linked C8-dG adducts. Recently, it has been reported that cyano substitution can greatly increase the mutagenicity of nitroaniline derivatives that are components of azo dyes. The basis of this "cyano effect" may be rooted in the formation of a novel polycyclic adduct arising from initial formation of the N-linked C8-dG adduct followed by a cyclization process involving N7 of dG and the Topics: Aniline Compounds; Density Functional Theory; Deoxyguanosine; DNA Adducts; Frameshift Mutation; Molecular Conformation; Molecular Dynamics Simulation | 2020 |