8-nitro-2--deoxyguanosine and 4-biphenylamine

4-Aminobiphenyl (4-ABP) which is primarily formed during tobacco combustion and overheated meat is a major carcinogen responsible for various cancers. Its adducted form, N-deoxyguanosine-C8-4-aminobiphenyl (dG-C8-4-ABP), has long been employed as a biomarker for assessment of the risk for cancer. In this review, the metabolism and carcinogenisity of 4-ABP will be discussed, followed by a discussion of the current common approaches of analyzing dG-C8-4-ABP. The major part of this review will be on the history and recent development of key methods for detection and quantitation of dG-C8-4-ABP in complex biological samples and their biological applications, from the traditional

Topics: Aminobiphenyl Compounds; Animals; Biomarkers; Chromatography, Liquid; Deoxyguanosine; Humans; Limit of Detection; Linear Models; Mass Spectrometry; Mice; Microfluidic Analytical Techniques; Occupational Exposure; Tissue Distribution