8-methylguanosine has been researched along with 7-methylguanine* in 1 studies
1 other study(ies) available for 8-methylguanosine and 7-methylguanine
| Article | Year |
|---|---|
Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation.
Eukaryotic translation initiation factor 4E (eIF4E) is overexpressed in many cancers deregulating translational control of the cell cycle. mRNA 5' cap analogs targeting eIF4E are small molecules with the potential to counteract elevated levels of eIF4E in cancer cells. However, the practical utility of typical cap analogs is limited because of their reduced cell membrane permeability. Transforming the active analogs into their pronucleotide derivatives is a promising approach to overcome this obstacle. 7-Benzylguanosine monophosphate (bn Topics: Endoribonucleases; Eukaryotic Initiation Factor-4E; Genetic Variation; Guanine; Guanosine; Humans; Models, Molecular; Nerve Tissue Proteins; Nucleotide Motifs; Nucleotides; Phosphates; Protein Biosynthesis; RNA Cap Analogs; RNA, Messenger; Tryptamines | 2020 |