8-hydroxynorcocaine has been researched along with cocaine in 11 studies
| Studies (8-hydroxynorcocaine) | Trials (8-hydroxynorcocaine) | Recent Studies (post-2010) (8-hydroxynorcocaine) | Studies (cocaine) | Trials (cocaine) | Recent Studies (post-2010) (cocaine) |
|---|---|---|---|---|---|
| 12 | 0 | 0 | 32,461 | 1,096 | 9,400 |
| Protein | Taxonomy | 8-hydroxynorcocaine (IC50) | cocaine (IC50) |
|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.338 | |
| Fatty acid-binding protein, heart | Homo sapiens (human) | 0.367 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0855 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0855 | |
| D | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 1.2861 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.4321 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0855 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.5442 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 0.8885 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 0.3796 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 5.541 | |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | 0.2 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.05 | |
| Transporter | Rattus norvegicus (Norway rat) | 3.2277 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alroy, J; Powers, JF; Shuster, L | 1 |
| Reith, ME; Wiener, HL | 1 |
| Benuck, M; Lajtha, A; Reith, ME | 1 |
| Kloss, MW; Rauckman, EJ; Rosen, GM | 2 |
| Freeman, RW; Harbison, RD; Teaf, CM | 1 |
| Casey, E; Shuster, L; Welankiwar, SS | 1 |
| Lloyd, RV; Mason, RP; Shuster, L | 1 |
| Evans, JE; Greenblatt, DJ; LeDuc, BW; Shuster, L; Sinclair, JF; Sinclair, PR | 1 |
| Bornheim, LM | 1 |
| Boelsterli, UA; Boess, F; Ndikum-Moffor, FM; Roberts, SM | 1 |
11 other study(ies) available for 8-hydroxynorcocaine and cocaine
| Article | Year |
|---|---|
Hepatic morphologic and biochemical changes induced by subacute cocaine administration in mice.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; Ribosomes | 1992 |
Differential effects of daily administration of cocaine on hepatic and cerebral glutathione in mice.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Brain; Cocaine; Cysteine; Glutathione; Liver; Male; Mice; Mice, Inbred C57BL; Peptides | 1990 |
Presence of the toxic metabolite N-hydroxy-norcocaine in brain and liver of the mouse.
Topics: Animals; Brain Chemistry; Chloramphenicol; Cocaine; Diazinon; Liver; Male; Mice; Mice, Inbred BALB C | 1988 |
Biotransformation of norcocaine to norcocaine nitroxide by rat brain microsomes.
Topics: Animals; Biotransformation; Brain; Cocaine; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; In Vitro Techniques; Kinetics; Male; Microsomes; Rats; Rats, Inbred Strains | 1984 |
Initiation of in vitro lipid peroxidation by N-hydroxynorcocaine and norcocaine nitroxide.
Topics: Animals; Cocaine; Cricetinae; Electron Spin Resonance Spectroscopy; Free Radicals; In Vitro Techniques; Kinetics; Lipid Peroxides; Male; Mice; Mice, Inbred DBA; Microsomes, Liver; NADP; Rats; Rats, Inbred F344; Species Specificity | 1982 |
Cocaine-induced hepatotoxicity: lipid peroxidation as a possible mechanism.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Lipid Peroxides; Male; Malondialdehyde; Mice; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital | 1984 |
Metabolism of cocaine and norcocaine to N-hydroxynorcocaine.
Topics: Animals; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 Enzyme Inhibitors; Male; Mass Spectrometry; Mice; Microsomes | 1983 |
Reexamination of the microsomal transformation of N-hydroxynorcocaine to norcocaine nitroxide.
Topics: Animals; Biotransformation; Brain; Cocaine; Electron Spin Resonance Spectroscopy; Female; In Vitro Techniques; Lipid Peroxides; Male; Microsomes; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Superoxides | 1993 |
Norcocaine and N-hydroxynorcocaine formation in human liver microsomes: role of cytochrome P-450 3A4.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases | 1993 |
Effect of cytochrome P450 inducers on cocaine-mediated hepatotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carboxylic Ester Hydrolases; Chemical and Drug Induced Liver Injury; Cocaine; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Isoenzymes; Liver; Male; Mice; Narcotics; Phencyclidine; Phenobarbital | 1998 |
Effects of cocaine and its oxidative metabolites on mitochondrial respiration and generation of reactive oxygen species.
Topics: Animals; Cell Respiration; Cocaine; Dopamine Uptake Inhibitors; In Vitro Techniques; Mice; Mice, Inbred ICR; Mitochondria; Reactive Oxygen Species; Rhodamines | 2000 |