8-hydroxyguanosine has been researched along with pyrene* in 1 studies
1 other study(ies) available for 8-hydroxyguanosine and pyrene
| Article | Year |
|---|---|
Synthesis of new derivatives of 8-oxoG-clamp for better understanding the recognition mode and improvement of selective affinity.
8-Oxoguanosine (8-oxoG) is a representative metabolite derived by the oxidation of guanosine (G) and is regarded as a marker of oxidative stress in the cells. We previously reported the 8-oxoG-clamp as the first fluorescent probe for detection of 8-oxoG. In this study, new 8-oxoG-clamp derivatives having a variety of N-functional groups were synthesized and their recognition properties were investigated. The sp(3) oxygen atom of the carbamate unit was revealed to play a significant role in the hydrogen bonding interactions, and the pyrene group produced higher stability with 8-oxoG compared with the original 8-oxoG-clamp. Topics: Binding Sites; Biomarkers; Fluorescent Dyes; Guanosine; Hydrogen Bonding; Oxidative Stress; Pyrenes | 2010 |