Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin

8-hydroxy-2-(di-n-propylamino)tetralin and u-50488

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with u-50488 in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (36.36)18.2507
2000's3 (27.27)29.6817
2010's4 (36.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X1
Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG1
Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S1
Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L1
Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E1
Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E1
Heller, PH; Levine, JD; Taiwo, YO1
Bhargava, HN; Reddy, VP1
Dykstra, LA; Powell, KR1
Morgan, D; Picker, MJ1
Mogil, JS; Nemmani, KV1

Other Studies

11 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and u-50488

ArticleYear
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship

2008
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship

2008
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
    European journal of medicinal chemistry, 2013, Volume: 63

    Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship

2013
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
    Bioorganic & medicinal chemistry, 2013, May-15, Volume: 21, Issue:10

    Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship

2013
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine

2016
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
    Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

    Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship

2017
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
    Neuroscience, 1992, Volume: 48, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes

1992
Abstinence from U-50,488H, a kappa-opiate receptor agonist, decreases the binding of [3H]DPAT to 5-HT1A receptors in the hypothalamus of the rat.
    Neuropharmacology, 1992, Volume: 31, Issue:12

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding Sites; Brain; Down-Regulation; Drug Tolerance; Hypothermia; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Spinal Cord

1992
The role of serotonin in the effects of opioids in squirrel monkeys responding under a titration procedure: I. Kappa opioids.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Analgesics; Animals; Drug Interactions; Electric Stimulation; Male; Prazosin; Pyrrolidines; Receptors, Opioid, kappa; Saimiri; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

1995
Discriminative stimulus effects of the 5HT1A agonist 8-OH-DPAT: attenuation by mu but not by kappa opioids.
    Psychopharmacology, 1995, Volume: 122, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Benzomorphans; Discrimination Learning; Drug Therapy, Combination; Fentanyl; Male; Morphine; Narcotics; Pyrimidines; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin Receptor Agonists

1995
Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia.
    Neuropharmacology, 2003, Volume: 44, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Fenclonine; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Morphine; Pain Threshold; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Serotonin Agents; Serotonin Antagonists

2003