Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin

8-hydroxy-2-(di-n-propylamino)tetralin and thiazoles

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with thiazoles in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's17 (60.71)18.2507
2000's7 (25.00)29.6817
2010's4 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bregna, DE; Dunn, RW; Geyer, HM; Hartman, HB; Hrib, NJ; Jurcak, JG; Roehr, JE; Rogers, KL; Rush, DK; Szczepanik, AM1
Bajjou, R; Chaouche-Teyara, K; Dabiré, H; De Nanteuil, G; Fournier, B; Laubie, M; Safar, M; Schmitt, H1
Ikeda, K; Ishibashi, T; Ishida, K; Kato, T; Nakamura, M; Ohno, Y1
Fozard, JR; Hoyer, D; McQuade, R; Sharp, T1
Fletcher, A; Marsden, CA; Mundey, MK1
Haj-Dahmane, S; Hamon, M; Lanfumey, L1
Fozard, JR; Hoyer, D; Schoeffter, P; Seiler, MP; Siegl, H; Stoll, A1
Herremans, AH; Mos, J; Olivier, B; Van Drimmelen, M; Van Hest, A1
Hoffmann, WE; Hyslop, DK; Piercey, MF1
De Vry, J; Glaser, T; Greuel, JM; Heine, HG; Mauler, F; Schmidt, B; Schohe-Loop, R; Sommermeyer, H1
Becquet, D; Deprez, P; François-Bellan, AM; Héry, F; Héry, M1
Blier, P; de Montigny, C; Dong, J1
Hijzen, TH; Joordens, RJ; Olivier, B1
De Leyn, P; Demedts, MG; Deneffe, G; Dupont, LJ; Pype, JL; Verleden, GM1
Adell, A; Artigas, F1
Ahn, KH; Hong, CY; Kim, HJ; Kim, JS; Kim, YZ; Lee, CH; Lee, SJ; Oh, JI; Park, HD; Park, TK1
Artigas, F; Casanovas, JM; Hervás, I1
Harkany, T; Horvath, KM; Keijser, J; Luiten, PG; Mulder, J; Nyakas, C; van der Meeberg, EK1
Adayev, T; Banerjee, P; Ray, I; Sobocki, T; Sondhi, R1
Bruins Slot, LA; Kleven, MS; Newman-Tancredi, A1
Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Okuno, R1
Fujita, Y; Hagiwara, H; Hashimoto, K; Ishima, T; Iyo, M; Kunitachi, S; Shirayama, Y1
King, JA; Shields, J1
Auclair, AL; Barret-Grévoz, C; Barreto, M; Depoortère, R; Kleven, MS; Newman-Tancredi, A1
Alvarez, E; Artigas, F; Celada, P; Cortés, R; Lladó-Pelfort, L; Oller, S; Pérez, V; Pérez-Egea, R; Portella, MJ; Puigdemont, D; Scorza, MC1
García, M; López, C; Martín, ML; Morán, A; Restrepo, B; San Román, L1
Bimpisidis, Z; Cenci, MA; Iderberg, H; Rylander, D1
Carlson, J; DeBold, JF; Hwa, LS; Miczek, KA; Quadros, IM; Shimamoto, A1

Trials

1 trial(s) available for 8-hydroxy-2-(di-n-propylamino)tetralin and thiazoles

ArticleYear
Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment.
    British journal of pharmacology, 2012, Volume: 167, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles

2012

Other Studies

27 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and thiazoles

ArticleYear
3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia.
    Journal of medicinal chemistry, 1992, Jul-10, Volume: 35, Issue:14

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Mice; Rats; Receptors, Dopamine; Receptors, Serotonin; Schizophrenia; Substrate Specificity; Tetrahydronaphthalenes; Thiazoles; Thiazolidines

1992
S14063: a new potent 5-HT1A receptor antagonist devoid of beta-adrenoceptor blocking properties.
    European journal of pharmacology, 1991, Oct-15, Volume: 203, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Benzothiazoles; Blood Pressure; Heart Rate; Male; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Tetrahydronaphthalenes; Thiazoles

1991
Effects of chronic treatments with SM-9018, a potential atypical neuroleptic, on behavioral dopaminergic and serotonergic sensitivities in rats.
    General pharmacology, 1995, Volume: 26, Issue:3

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Dopamine; Haloperidol; Indoles; Isoindoles; Male; Motor Activity; Posture; Rats; Rats, Sprague-Dawley; Serotonin; Stereotyped Behavior; Thiazoles

1995
The novel 5-HT1A receptor antagonist, SDZ 216-525, decreases 5-HT release in rat hippocampus in vivo.
    British journal of pharmacology, 1993, Volume: 109, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Dialysis; Electrophysiology; GTP-Binding Proteins; Hippocampus; Indoles; Male; Neurons; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Thiazoles

1993
Effect of the putative 5-HT1A antagonists WAY100135 and SDZ 216-525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus.
    Neuropharmacology, 1994, Volume: 33, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Indoles; Male; Neurons; Piperazines; Raphe Nuclei; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles

1994
Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525.
    European journal of pharmacology, 1993, Nov-02, Volume: 249, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Chromans; Electrophysiology; Hippocampus; In Vitro Techniques; Indoles; Male; Piperazines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Spiro Compounds; Thiazoles

1993
SDZ 216-525, a selective and potent 5-HT1A receptor antagonist.
    European journal of pharmacology, 1993, Feb-15, Volume: 244, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Behavior, Animal; Brain; Dioxins; In Vitro Techniques; Indoles; Male; Phosphatidylinositols; Piperazines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Dopamine D2; Second Messenger Systems; Serotonin Antagonists; Spiro Compounds; Temperature; Thiazoles

1993
The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.
    European journal of pharmacology, 1997, May-01, Volume: 325, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Columbidae; Discrimination Learning; Fluvoxamine; Indoles; Pindolol; Piperazines; Pyridines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles

1997
Excitation of type II anterior caudate neurons by stimulation of dopamine D3 receptors.
    Brain research, 1997, Jul-11, Volume: 762, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminoquinolines; Animals; Benzothiazoles; Caudate Nucleus; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Haloperidol; Imidazoles; Neurons; Pramipexole; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Tetrahydronaphthalenes; Thiazoles

1997
Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Benzopyrans; Body Temperature; Cyclic AMP; Hippocampus; Humans; Male; Phosphatidylinositols; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Thiazoles

1998
Serotonin directly stimulates luteinizing hormone-releasing hormone release from GT1 cells via 5-HT7 receptors.
    Endocrine, 1997, Volume: 7, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Line, Transformed; Gonadotropin-Releasing Hormone; Indoles; Mice; Mice, Transgenic; Neurons; Polymerase Chain Reaction; Receptors, Serotonin; Ritanserin; RNA-Directed DNA Polymerase; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Tumor Cells, Cultured

1997
Full agonistic properties of BAY x 3702 on presynaptic and postsynaptic 5-HT1A receptors electrophysiological studies in the rat hippocampus and dorsal raphe.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Benzopyrans; Hippocampus; Male; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Thiazoles

1998
The effects of 5-HT1A receptor agonists, 5-HT1A receptor antagonists and their interaction on the fear-potentiated startle response.
    Psychopharmacology, 1998, Volume: 139, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Fear; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex, Startle; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles

1998
The effects of 8-hydroxy-2-(di-n-propylamino)tetralin on the cholinergic contraction in guinea pig and human airways in vitro.
    American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:5 Pt 1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Bronchi; Bronchoconstriction; Capsaicin; Cholinergic Fibers; Culture Techniques; Cyclohexane Monoterpenes; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Humans; Indoles; Ketanserin; Methysergide; Muscle Contraction; Muscle, Smooth; Neuropeptides; Pindolol; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Trachea; Tropisetron

1998
A microdialysis study of the in vivo release of 5-HT in the median raphe nucleus of the rat.
    British journal of pharmacology, 1998, Volume: 125, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Uptake Inhibitors; Animals; Benzopyrans; Male; Microdialysis; Piperazines; Pyridines; Quinolines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reserpine; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin; Thiazoles

1998
Pharmacological characterization of LB50016, N-(4-amino)butyl 3-phenylpyrrolidine derivative, as a new 5-HT1A receptor agonist.
    Archives of pharmacal research, 1999, Volume: 22, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Anti-Anxiety Agents; Antidepressive Agents; Body Temperature; Corticosterone; Cyclic S-Oxides; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles

1999
Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex.
    Neuroreport, 1999, May-14, Volume: 10, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Benzopyrans; Male; Neurons; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synapses; Thiazoles

1999
Oral post-lesion administration of 5-HT(1A) receptor agonist repinotan hydrochloride (BAY x 3702) attenuates NMDA-induced delayed neuronal death in rat magnocellular nucleus basalis.
    Neuroscience, 2001, Volume: 108, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Administration, Oral; Animals; Apoptosis; Basal Nucleus of Meynert; Behavior, Animal; Benzopyrans; Choline O-Acetyltransferase; Excitatory Amino Acid Agonists; Male; Memory; N-Methylaspartate; Neurons; Neuroprotective Agents; Parietal Lobe; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles

2001
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
    Biochimica et biophysica acta, 2003, Apr-07, Volume: 1640, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apoptosis; Benzopyrans; Calcium; Caspase 3; Caspase Inhibitors; Cell Line; Enzyme Activation; Hydrogen Peroxide; Mice; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Protein Kinase C; Protein Kinase C-alpha; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles

2003
Effects of novel antipsychotics with mixed D(2) antagonist/5-HT(1A) agonist properties on PCP-induced social interaction deficits in the rat.
    Neuropharmacology, 2005, Volume: 49, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Dioxanes; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Interpersonal Relations; Male; Phencyclidine; Piperazines; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Remoxipride; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Tropanes

2005
Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder.
    Journal of pharmacological sciences, 2005, Volume: 99, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Haloperidol; Indoles; Isoindoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT1A; Risperidone; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles

2005
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2008, Volume: 18, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Body Temperature; Cognition Disorders; Dose-Response Relationship, Drug; Drug Interactions; Injections, Subcutaneous; Isoindoles; Male; Mice; Mice, Inbred ICR; Pattern Recognition, Visual; Phencyclidine; Piperazines; Protein Binding; Pyridines; Receptor, Serotonin, 5-HT1A; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Time Factors

2008
The role of 5-HT1A receptors in the behavioral responses associated with innate fear.
    Behavioral neuroscience, 2008, Volume: 122, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Psychological; Corticosterone; Dose-Response Relationship, Drug; Fear; Freezing Reaction, Cataleptic; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Thiazoles

2008
Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys.
    Behavioural brain research, 2009, Nov-05, Volume: 203, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Benzamides; Benzodiazepines; Benzoxazoles; Catalepsy; Clozapine; Dibenzothiazepines; Dioxanes; Dopamine Antagonists; Female; Haloperidol; Macaca fascicularis; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Remoxipride; Risperidone; Serotonin Receptor Agonists; Thiazoles; Tropanes; Video Recording

2009
The cyclooxygenase and nitric oxide synthesis/pathways mediate the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in long-term diabetic pithed rats.
    Pharmacology, 2012, Volume: 90, Issue:3-4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alloxan; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Piperazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Serotonin; Signal Transduction; Sympathetic Nervous System; Thiazoles

2012
Modulating mGluR5 and 5-HT1A/1B receptors to treat l-DOPA-induced dyskinesia: effects of combined treatment and possible mechanisms of action.
    Experimental neurology, 2013, Volume: 250

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antiparkinson Agents; Dopamine Agonists; Drug Synergism; Dyskinesia, Drug-Induced; Levodopa; Parkinsonian Disorders; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptors, Dopamine D1; Serotonin Receptor Agonists; Thiazoles

2013
Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:12

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Alcohol Drinking; Animals; Central Nervous System Agents; Central Nervous System Depressants; Dorsal Raphe Nucleus; Ethanol; Mice; Neural Pathways; Prefrontal Cortex; Pyridazines; Pyrimidines; Pyrroles; Receptor, Serotonin, 5-HT1A; Receptors, Corticotropin-Releasing Hormone; Self Administration; Serotonin; Serotonin 5-HT1 Receptor Agonists; Thiazoles

2014