Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin

8-hydroxy-2-(di-n-propylamino)tetralin and prazosin

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with prazosin in 61 studies

Research

Studies (61)

TimeframeStudies, this research(%)All Research%
pre-19907 (11.48)18.7374
1990's31 (50.82)18.2507
2000's15 (24.59)29.6817
2010's8 (13.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berardi, F; Colabufo, NA; Fiorentini, F; Ghiglieri, A; Govoni, S; Leopoldo, M; Olgiati, V; Perrone, R; Tortorella, V1
Alonso-Cires, L; Corcóstegui, R; Labeaga, L; Orjales, A1
Berardi, F; Caccia, C; Fornaretto, MG; Leopoldo, M; McArthur, RA; Perrone, R; Tortorella, V1
Berardi, F; Caccia, C; Colabufo, NA; Fornaretto, MG; Leopoldo, M; McArthur, RA; Perrone, R; Tortorella, V1
Barlocco, D; Cignarella, G; Leonardi, A; Mella, M; Montesano, F; Toma, L1
Barlocco, D; Cignarella, G; De Benedetti, PG; Fanelli, F; Giovannoni, MP; Leonardi, A; Montesano, F; Piaz, VD; Poggesi, E1
Betti, L; Botta, M; Corelli, F; Corsano, S; Floridi, M; Giannaccini, G; Maccari, L; Manetti, F; Strappaghetti, G; Tafi, A1
Betti, L; Botta, M; Floridi, M; Giannaccini, G; Manetti, F; Strappaghetti, G; Tafi, A1
Betti, L; Botta, M; Corelli, F; Floridi, M; Giannaccini, G; Maccari, L; Manetti, F; Strappaghetti, G1
Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO1
Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X1
Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG1
Colau, D; Dolusić, E; Frédérick, R; Larrieu, P; Masereel, B; Moineaux, L; Pilotte, L; Pochet, L; Stroobant, V; Van den Eynde, B; Wouters, J1
Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S1
Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L1
Bienkowski, P; Bucki, A; Jaśkowska, J; Kazek, G; Kowalski, P; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Mitka, K; Pawłowski, M; Siwek, A; Wasik, A; Wesołowska, A1
Bienkowski, P; Bucki, A; Jastrzębska-Więsek, M; Kazek, G; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Siwek, A; Śniecikowska, J; Wasik, A; Wesołowska, A1
Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E1
Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E1
Davis, JM; Pandey, GN; Pandey, SC; Piano, MR; Schwertz, DW1
Barrett, JE; Gleeson, S1
Ewing, FE; Furman, JS; Heym, JH; Howard, HR; Lowe, JA; Nagel, AA; Newman, ME; Schmidt, AW; Seeger, TF; Seymour, PA1
Bolaños, FJ; Gozlan, H; Hamon, M; Laporte, AM; Schechter, LE; Vergé, D1
Moser, PC1
Barrett, JE; Zhang, L1
Brown, CM; Kilpatrick, AT; MacKinnon, AC; McGrath, JC; Spedding, M1
Singer, EA; Valenta, B1
De Boer, T; De Vos, CJ; Tonnaer, JA; Van Delft, AM1
Beller, KD; Boer, R; Sanders, KH; Walter, B1
Backus, LI; Grahame-Smith, DG; Sharp, T1
Jackson, DA; White, SR1
Ramage, AG1
Friedman, E; Gillis, RA; Hamosh, P; Kellar, KJ; Mandal, AK; Pineo, SV1
Docherty, JR1
Berthold, H; Engel, G; Fozard, JR1
Arvidsson, LE; Gradin, K; Hedner, T; Hjorth, S; Persson, B; Pettersson, A1
Gonzales, DA; Peroutka, SJ; Shapiro, M1
Glennon, RA; Lyon, RA; Naiman, NA; Pierson, ME; Titeler, M; Weisberg, E1
Dykstra, LA; Powell, KR1
Ahrens, O; Flügge, G; Fuchs, E1
Hutson, PH; Middlemiss, DN; Wilkinson, LO1
Bowen, DM; Chessell, IP; Francis, PT; Pangalos, MN; Pearson, RC1
Critchley, DJ; Dourish, CT; Foden, ND; Liddle, CW; Middlefell, VC1
Bietti, G; Borsini, F; Ceci, A; Donetti, A1
de Boer, TH; Nefkens, F; van Delft, AM; van Helvoirt, A1
Kleven, MS; Koek, W; Prinssen, EP1
Bigl, V; Heider, M; Rossner, S; Schliebs, R1
Fernández, E; López-Rodríguez, ML; Morcillo, MJ; Murcia, M; Orensanz, L; Porras, E; Sanz, AM1
Audinot, V; Cistarelli, L; Gobert, A; Millan, MJ; Newman-Tancredi, A; Rivet, JM1
Giroux, N; Reader, TA; Rossignol, S1
Honda, M; Ono, H1
Deis, RP; Hole, D; Jahn, GA; Kalia, V; Wilson, CA1
Bardin, L; Colpaert, FC; Koek, W; Tarayre, JP1
Egashira, N; Fujioka, M; Fujiwara, M; Ishigami, N; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Yano, A1
Centurión, D; Gupta, S; MaassenVanDenBrink, A; Mehotra, S; Sánchez-López, A; Villalón, CM1
Scrogin, KE; Tiniakov, R1
López-Meraz, ML; Neri-Bazán, L; Rocha, L1
Allers, KA; Charette, G; Hajós, M; Jennings, K; Kocsis, B; Sharp, T; Sík, A1
Balsamo, A; Betti, L; Giannaccini, G; Nencetti, S; Orlandini, E; Rapposelli, S1
Doucet, EL; Godeheu, G; Hernández Vallejo, SJ; Houades, V; Lanteri, C; Salomon, L; Tassin, JP; Torrens, Y1
Bajwa, AK; Christian, BT; Hillmer, AT; Mukherjee, J; Pan, ML; Pandey, SK; Saigal, N; Wooten, DW1

Other Studies

61 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and prazosin

ArticleYear
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.
    Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6

    Topics: Animals; Chemical Phenomena; Chemistry, Physical; Guinea Pigs; Isomerism; Kinetics; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes

1995
New (2-methoxyphenyl)piperazine derivatives as 5-HT1A receptor ligands with reduced alpha 1-adrenergic activity. Synthesis and structure-affinity relationships.
    Journal of medicinal chemistry, 1995, Apr-14, Volume: 38, Issue:8

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Ligands; Male; Piperazines; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Structure-Activity Relationship

1995
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.
    Journal of medicinal chemistry, 1996, Aug-02, Volume: 39, Issue:16

    Topics: Animals; Buspirone; Mass Spectrometry; Molecular Structure; Piperazines; Protein Binding; Rats; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists

1996
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.
    Journal of medicinal chemistry, 1996, Dec-06, Volume: 39, Issue:25

    Topics: Magnetic Resonance Spectroscopy; Piperazines; Radioligand Assay; Receptors, Serotonin; Structure-Activity Relationship

1996
Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton.
    Journal of medicinal chemistry, 1999, Jan-14, Volume: 42, Issue:1

    Topics: Adrenergic Antagonists; Animals; Aorta, Thoracic; CHO Cells; Cricetinae; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pyridazines; Pyrroles; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship; Vas Deferens

1999
Phenylpiperazinylalkylamino substituted pyridazinones as potent alpha(1) adrenoceptor antagonists.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta; CHO Cells; Cricetinae; HeLa Cells; Humans; In Vitro Techniques; Ligands; Models, Molecular; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Pyridazines; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1

2001
Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives.
    Journal of medicinal chemistry, 2002, Aug-15, Volume: 45, Issue:17

    Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Imidazoles; In Vitro Techniques; Models, Molecular; Piperazines; Pyridazines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship

2002
alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus.
    Bioorganic & medicinal chemistry letters, 2003, Jan-20, Volume: 13, Issue:2

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Chemical Phenomena; Chemistry, Physical; Cyclization; Pyridazines; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT1

2003
Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety.
    Journal of medicinal chemistry, 2003, Jul-31, Volume: 46, Issue:16

    Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Ligands; Piperazines; Pyridazines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship

2003
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
    Journal of medicinal chemistry, 2005, Nov-03, Volume: 48, Issue:22

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles

2005
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship

2008
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship

2008
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.
    Journal of medicinal chemistry, 2011, Aug-11, Volume: 54, Issue:15

    Topics: Animals; Antineoplastic Agents; Biological Availability; Cell Line; Drug Design; Enzyme Inhibitors; Humans; Immunologic Factors; Indoles; Kinetics; Mice; Neoplasms; Structure-Activity Relationship; Tryptophan Oxygenase

2011
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
    European journal of medicinal chemistry, 2013, Volume: 63

    Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship

2013
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
    Bioorganic & medicinal chemistry, 2013, May-15, Volume: 21, Issue:10

    Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship

2013
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
    Journal of medicinal chemistry, 2014, Jun-12, Volume: 57, Issue:11

    Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides

2014
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
    European journal of medicinal chemistry, 2015, Mar-06, Volume: 92

    Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming

2015
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine

2016
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
    Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

    Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship

2017
Effect of ethanol administration and withdrawal on serotonin receptor subtypes and receptor-mediated phosphoinositide hydrolysis in rat brain.
    Alcoholism, clinical and experimental research, 1992, Volume: 16, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Withdrawal Delirium; Alcoholism; Animals; Calcimycin; Cerebral Cortex; Hippocampus; Hydrolysis; Lysergic Acid Diethylamide; Male; Norepinephrine; Phosphatidylinositols; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Signal Transduction

1992
Discriminative stimulus effects of 8-OH-DPAT in pigeons: antagonism studies with the putative 5-HT1A receptor antagonists BMY 7378 and NAN-190.
    European journal of pharmacology, 1992, Jul-07, Volume: 217, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Indoles; Pindolol; Piperazines; Prazosin; Serotonin Antagonists

1992
1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Behavior, Animal; Dopamine Antagonists; Haloperidol; Ketanserin; Locomotion; Male; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tetrahydronaphthalenes

1991
[3H]5-methyl-urapidil labels 5-HT1A receptors and alpha 1-adrenoceptors in the rat CNS. In vitro binding and autoradiographic studies.
    European journal of pharmacology, 1991, May-30, Volume: 198, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Autoradiography; Binding, Competitive; Brain; In Vitro Techniques; Kinetics; Male; Membranes; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes

1991
The effect of putative 5-HT1A receptor antagonists on 8-OH-DPAT-induced hypothermia in rats and mice.
    European journal of pharmacology, 1991, Feb-07, Volume: 193, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Dioxanes; Dose-Response Relationship, Drug; Hypothermia, Induced; Male; Mice; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes

1991
Involvement of 5-HT1A activity in the discriminative stimulus effects of imipramine.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Columbidae; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Imipramine; Male; Piperazines; Prazosin; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes

1991
Heterogeneity of alpha 2-adrenoceptors in rat cortex but not human platelets can be defined by 8-OH-DPAT, RU 24969 and methysergide.
    British journal of pharmacology, 1990, Volume: 99, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood Platelets; Cerebral Cortex; Guanosine Triphosphate; In Vitro Techniques; Indoles; Kinetics; Male; Methysergide; Naphthalenes; Oxymetazoline; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Species Specificity; Tetrahydronaphthalenes; Yohimbine

1990
Hypotensive effects of 8-hydroxy-2-(di-n-propylamino)tetralin and 5-methylurapidil following stereotaxic microinjection into the ventral medulla of the rat.
    British journal of pharmacology, 1990, Volume: 99, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Blood Pressure; Dioxanes; Dopamine Antagonists; Heart Rate; Male; Medulla Oblongata; Microinjections; Naphthalenes; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Spiperone; Spiro Compounds; Stereotaxic Techniques; Tetrahydronaphthalenes

1990
Neurochemical studies with the potential antipsychotic compound trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Autonomic Nervous System; Benzazepines; Brain Chemistry; Corpus Striatum; Cyclic AMP; Dibenzocycloheptenes; Dibenzoxepins; Heterocyclic Compounds, 4 or More Rings; In Vitro Techniques; Male; Membranes; Mianserin; Prazosin; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Serotonin; Tetrahydronaphthalenes; Yohimbine

1990
Is blockade of alpha 1-adrenoceptors favourable in hypotension induced by stimulation of serotonin1A receptors in conscious dogs?
    Drugs, 1990, Volume: 40 Suppl 4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Heart Rate; Male; Piperazines; Prazosin; Rats; Receptors, Serotonin; Stimulation, Chemical; Swine; Tetrahydronaphthalenes

1990
Behavioural evidence for a functional interaction between central 5-HT2 and 5-HT1A receptors.
    British journal of pharmacology, 1990, Volume: 100, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Haloperidol; Ketanserin; Male; Methoxydimethyltryptamines; Piperidines; Prazosin; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Stereotyped Behavior; Tetrahydronaphthalenes

1990
Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons.
    Neuropharmacology, 1990, Volume: 29, Issue:9

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; In Vitro Techniques; Injections, Intravenous; Iontophoresis; Ketanserin; Male; Methysergide; Microelectrodes; Motor Neurons; Piperidines; Prazosin; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Spinal Cord; Tetrahydronaphthalenes

1990
Are drugs that act both on serotonin receptors and alpha 1-adrenoceptors more potent hypotensive agents than those that act only on alpha 1-adrenoceptors?
    Journal of cardiovascular pharmacology, 1988, Volume: 11 Suppl 1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Cats; Cinanserin; Ergolines; Ketanserin; Male; Metergoline; Piperidines; Prazosin; Receptors, Adrenergic, alpha; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Sympathetic Nervous System; Tetrahydronaphthalenes

1988
Importance of central nervous system serotonin-1A receptors for mediating the hypotensive effect of urapidil.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antihypertensive Agents; Blood Pressure; Cats; Heart Rate; Medulla Oblongata; Piperazines; Prazosin; Receptors, Serotonin; Respiration; Spiperone; Tetrahydronaphthalenes

1989
An investigation of the effects of intravenous injection of the 5-hydroxytryptamine 2 receptor antagonists ketanserin and LY 53857 on blood pressure in anesthetized spontaneously hypertensive rats.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Ergolines; Heart Rate; Hypertension; Ketanserin; Male; Prazosin; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes; Xylazine

1989
5-HT1 receptor agonists attenuate the naloxone-induced jumping behaviour in morphine-dependent mice.
    European journal of pharmacology, 1989, Mar-14, Volume: 162, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Buspirone; Dioxanes; Female; Fenclonine; Idazoxan; Indoles; Mice; Morphine Dependence; Naloxone; Prazosin; Receptors, Serotonin; Tetrahydronaphthalenes

1989
Cardiovascular effects in the Sprague-Dawley rat of 8-hydroxy-2(di-N-propylamino) tetralin, a selective 5-hydroxytryptamine receptor agonist.
    The Journal of pharmacy and pharmacology, 1985, Volume: 37, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Atropine; Blood Pressure; Heart Rate; Hemodynamics; Injections, Intravenous; Injections, Intraventricular; Male; Methiothepin; Naphthalenes; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes; Time Factors

1985
Modulation of postdecapitation convulsions in rats by alpha-adrenergic and 5-hydroxytryptamine1A agents.
    Experimental neurology, 1987, Volume: 96, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Animals; Buspirone; Death; Dioxanes; Male; Prazosin; Pyrimidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Seizures; Serotonin; Tetrahydronaphthalenes; Yohimbine

1987
NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).
    European journal of pharmacology, 1988, Sep-23, Volume: 154, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Conditioning, Operant; Discrimination Learning; Naphthalenes; Piperazines; Prazosin; Rats; Serotonin Antagonists; Tetrahydronaphthalenes

1988
The role of serotonin in the effects of opioids in squirrel monkeys responding under a titration procedure: I. Kappa opioids.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Analgesics; Animals; Drug Interactions; Electric Stimulation; Male; Prazosin; Pyrrolidines; Receptors, Opioid, kappa; Saimiri; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

1995
Monoamine receptors in the amygdaloid complex of the tree shrew (Tupaia belangeri).
    The Journal of comparative neurology, 1994, May-22, Volume: 343, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Autoradiography; Iodocyanopindolol; Pindolol; Prazosin; Receptors, Biogenic Amine; Tupaiidae; Yohimbine

1994
5-HT1A receptor activation increases hippocampal acetylcholine efflux and motor activity in the guinea pig: agonist efficacy influences functional activity in vivo.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Biological Transport; Guinea Pigs; Hippocampus; Male; Microdialysis; Motor Activity; Prazosin; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

1994
Localisation of muscarinic (m1) and other neurotransmitter receptors on corticofugal-projecting pyramidal neurones.
    Brain research, 1993, Dec-31, Volume: 632, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Cerebral Cortex; Functional Laterality; gamma-Aminobutyric Acid; Glycoproteins; Kainic Acid; Male; N-Glycosyl Hydrolases; Neurons; Neurotoxins; Pirenzepine; Plant Lectins; Plant Proteins; Prazosin; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, Muscarinic; Receptors, Neurotransmitter; Receptors, Serotonin; Ribosome Inactivating Proteins, Type 2; Ricin; Tritium

1993
Effects of the selective 5-HT1A receptor antagonist WAY100135 and its enantiomers on 8-OH-DPAT-induced hyperglycaemia in conscious rats.
    European journal of pharmacology, 1994, Mar-11, Volume: 254, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Glucose; Dose-Response Relationship, Drug; Hyperglycemia; Male; Piperazines; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Serotonin Receptor Agonists; Stereoisomerism

1994
BIMT 17, a 5-HT1A receptor agonist/5-HT2A receptor antagonist, directly activates postsynaptic 5-HT inhibitory responses in the rat cerebral cortex.
    Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Antidepressive Agents; Benzimidazoles; Binding, Competitive; Buspirone; Cerebral Cortex; Dose-Response Relationship, Drug; In Vitro Techniques; Iontophoresis; Male; Microelectrodes; Neurons; Piperazines; Prazosin; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes

1995
Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Corpus Striatum; Dioxanes; Hippocampus; Idazoxan; Imidazoles; Male; Mianserin; Mirtazapine; Norepinephrine; Prazosin; Rats; Rats, Wistar; Serotonin; Tetrodotoxin

1996
Effects of dopamine antagonists in a two-way active avoidance procedure in rats: interactions with 8-OH-DPAT, ritanserin, and prazosin.
    Psychopharmacology, 1996, Volume: 128, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Avoidance Learning; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Prazosin; Raclopride; Rats; Rats, Sprague-Dawley; Ritanserin; Salicylamides; Serotonin Agents

1996
Basal forebrain cholinergic immunolesion by 192IgG-saporin: evidence for a presynaptic location of subpopulations of alpha 2- and beta-adrenergic as well as 5-HT2A receptors on cortical cholinergic terminals.
    Neurochemical research, 1997, Volume: 22, Issue:8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholinesterase; Animals; Antibodies, Monoclonal; Autoradiography; Cerebral Cortex; Cholinergic Fibers; Dihydroalprenolol; Immunotoxins; Isotope Labeling; Ketanserin; Male; N-Glycosyl Hydrolases; Prazosin; Presynaptic Terminals; Prosencephalon; Radioligand Assay; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Receptors, Presynaptic; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Ribosome Inactivating Proteins, Type 1; Saporins; Tritium; Yohimbine

1997
Synthesis and structure-activity relationships of a new model of arylpiperazines. 3.1 2-[omega-(4-arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: study of the influence of the terminal amide fragment on 5-
    Journal of medicinal chemistry, 1997, Aug-01, Volume: 40, Issue:16

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antihypertensive Agents; Cerebral Cortex; In Vitro Techniques; Models, Chemical; Piperazines; Prazosin; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Structure-Activity Relationship

1997
Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release.
    Neuroscience, 1998, Volume: 84, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Dopamine; Dopamine Agonists; Frontal Lobe; Guanabenz; Guinea Pigs; Homeostasis; Idazoxan; Imidazoles; Indoles; Isoindoles; Male; Medetomidine; Models, Neurological; Motor Activity; Norepinephrine; Oxadiazoles; Piperazines; Prazosin; Raclopride; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Serotonin

1998
Autoradiographic study of alpha1- and alpha2-noradrenergic and serotonin1A receptors in the spinal cord of normal and chronically transected cats.
    The Journal of comparative neurology, 1999, Apr-12, Volume: 406, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Autoradiography; Cats; Denervation; Idazoxan; Isomerism; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Receptors, Serotonin; Reference Values; Serotonin Receptor Agonists; Spinal Cord

1999
Differential effects of (R)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats.
    European journal of pharmacology, 1999, Jun-04, Volume: 373, Issue:2-3

    Topics: 5,6-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Male; Norepinephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Reflex, Monosynaptic; Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Spiro Compounds; Stereoisomerism

1999
Receptors and neurotransmitters involved in the dual modulation of prolactin release by the serotoninergic system in pregnant and lactating rats.
    Journal of reproduction and fertility, 1999, Volume: 116, Issue:2

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amphetamines; Analysis of Variance; Animals; Brain Chemistry; Dopamine; Female; Fenclonine; Fenfluramine; Gestational Age; Ketanserin; Metoprolol; Norepinephrine; p-Chloroamphetamine; Prazosin; Pregnancy; Pregnancy, Animal; Prolactin; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction

1999
In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia.
    European journal of pharmacology, 2001, Jun-08, Volume: 421, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Nociceptors; Pain; Pain Measurement; Piperazines; Prazosin; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists

2001
Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: involvement of 5-HT1A receptors in the dorsal hippocampus in rats.
    Brain research, 2006, Jan-19, Volume: 1069, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Hippocampus; Male; Maze Learning; Memory Disorders; Microinjections; Phenols; Piperazines; Prazosin; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin Antagonists; Sulfonamides

2006
Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.
    European journal of pharmacology, 2006, Mar-27, Volume: 535, Issue:1-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Buspirone; Clozapine; Decerebrate State; Dose-Response Relationship, Drug; Drug Interactions; Ergotamine; Heart Rate; Ketanserin; Lisuride; Male; Metergoline; Methiothepin; Methysergide; Phenylephrine; Piperazines; Pizotyline; Prazosin; Pyridines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Serotonin Receptor Agonists; Yohimbine

2006
The serotonin 5-Hydroxytryptaphan1A receptor agonist, (+)8-hydroxy-2-(di-n-propylamino)-tetralin, stimulates sympathetic-dependent increases in venous tone during hypovolemic shock.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Central Venous Pressure; Heart Rate; Male; Prazosin; Quinolizines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Shock; Sympathetic Nervous System

2006
Indorenate modifies a1-adrenergic and benzodiazepine receptor binding in the rat brain: an autoradiography study.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:9

    Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Autoradiography; Binding, Competitive; Brain; Dopamine Agonists; Flunitrazepam; In Vitro Techniques; Male; Prazosin; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-1; Receptors, GABA-A

2006
Neurochemical identification of stereotypic burst-firing neurons in the rat dorsal raphe nucleus using juxtacellular labelling methods.
    The European journal of neuroscience, 2007, Volume: 25, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic alpha-Antagonists; Animals; Biotin; Brain Chemistry; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Neurons; Piperazines; Prazosin; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Streptavidin; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase

2007
Synthesis and 5-HT2A, 5-HT1A and alpha1-binding affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) benzyl oximes.
    Archiv der Pharmazie, 2007, Volume: 340, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Ketanserin; Ligands; Molecular Structure; Oximes; Piperazines; Prazosin; Protein Binding; Pyridines; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Succinates

2007
Inhibition of monoamine oxidases desensitizes 5-HT1A autoreceptors and allows nicotine to induce a neurochemical and behavioral sensitization.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jan-28, Volume: 29, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Behavior, Animal; Brain Chemistry; Drug Combinations; Fluorobenzenes; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nicotine; Nicotinic Agonists; Phenols; Piperazines; Prazosin; Pyridines; Raphe Nuclei; Receptor, Serotonin, 5-HT1A; Serotonin Antagonists; Serotonin Receptor Agonists; Tranylcypromine

2009
Comparative assessment of (18) F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species: Rodents, nonhuman primates, and humans.
    The Journal of comparative neurology, 2016, May-01, Volume: 524, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-1 Receptor Antagonists; Animals; Brain; Brain Mapping; Dose-Response Relationship, Drug; Female; Fourier Analysis; Humans; Image Processing, Computer-Assisted; Macaca mulatta; Male; Mice; Mice, Inbred BALB C; Piperazines; Positron-Emission Tomography; Prazosin; Protein Binding; Pyridines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists

2016