8-hydroxy-2-(di-n-propylamino)tetralin and mianserin

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with mianserin in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19906 (17.65)18.7374
1990's21 (61.76)18.2507
2000's5 (14.71)29.6817
2010's2 (5.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Glennon, RA2
Foulon, C; Kung, HF; Kung, MP1
Hamblin, MW; Jose, PA; Metcalf, MA; Monsma, FJ; Shen, Y; Sibley, DR1
Amlaiky, N; Hen, R; Plassat, JL1
Arrang, JM; Diaz, J; Leurs, R; Ruat, M; Schwartz, JC; Tardivel-Lacombe, J; Traiffort, E1
Audia, JE; Baez, M; Cohen, ML; Kursar, JD; Lucaites, VL; Nelson, DL; Nissen, JS; Schenck, KW; Wainscott, DB1
Dokhan, R; el Ahmad, Y; Laurent, E; Maillet, P; Ollivier, R; Talab, A; Teste, JF; Tran, G1
Chang, DJ; Eglen, RM; Jasper, JR; Kosaka, A; To, ZP1
Audinot, V; Boutin, JA; Cogé, F; Cussac, D; Dekeyne, A; Galizzi, JP; Gobert, A; Lejeune, F; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Rivet, JM1
Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D1
Buck, LB; Petrascheck, M; Ye, X1
Andres-Mach, M; Bączek, T; Belka, M; Czuczwar, SJ; Gomółka, AE; Herold, F; Jastrzębska-Więsek, M; Nowak, G; Partyka, A; Siwek, A; Stefanowicz, J; Słowiński, T; Turło, J; Ulenberg, S; Wesołowska, A; Wróbel, MZ; Zagaja, M; Żołnierek, M; Łuszczki, JJ1
Bączek, T; Belka, M; Bojarski, A; Herold, F; Kleps, J; Kozioł, AE; Król, M; Nowak, G; Siwek, A; Ślifirski, G; Stachowicz, K; Szewczyk, B; Turło, J; Ulenberg, S1
Miletic, V; Tan, H1
Akiyoshi, J; Ito, Y; Kojima, K; Miyamoto, T; Nagayama, H; Oba, A; Okada, K; Tsuchiyama, K; Yamada, K; Yamauchi, C1
Berendsen, HH; Broekkamp, CL2
De Boer, T; De Vos, CJ; Tonnaer, JA; Van Delft, AM1
Battista, PJ; Condon, WA; Rexroad, CE1
Jenner, P; Marsden, CD; Stewart, BR1
Peroutka, SJ1
Palacios, JM; Pazos, A; Probst, A1
Gudelsky, GA; Koenig, JI; Meltzer, HY1
Akiyoshi, J; Kuranaga, H; Mizobe, Y; Nagayama, H; Nakamura, M; Tsuchiyama, K1
Kreiss, DS; Lucki, I1
Hassan, AZ; Park, R; Saruhashi, Y; Young, W1
Lund, A; Mjellem, N1
de Boer, TH; Nefkens, F; van Delft, AM; van Helvoirt, A1
Rowe, PM1
Burrows, GD; McGrath, C; Norman, TR1
Aguerre, S; Chaouloff, F; Mormede, P1
Dekeyne, A; Girardon, S; Millan, MJ1
Pericić, D; Strac, DS; Vlainić, J1

Reviews

2 review(s) available for 8-hydroxy-2-(di-n-propylamino)tetralin and mianserin

ArticleYear
Central serotonin receptors as targets for drug research.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:1

    Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin

1987
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
    Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14

    Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists

2003

Other Studies

32 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and mianserin

ArticleYear
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.
    Journal of medicinal chemistry, 1993, May-14, Volume: 36, Issue:10

    Topics: Binding Sites; Dopamine Agents; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Salicylamides; Stereoisomerism; Tetrahydronaphthalenes

1993
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
    The Journal of biological chemistry, 1993, Aug-25, Volume: 268, Issue:24

    Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Cell Line; Cell Membrane; Cloning, Molecular; Cyclic AMP; Gene Expression; Kidney Tubules, Proximal; Lysergic Acid Diethylamide; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Radioligand Assay; Rats; Receptors, Serotonin; Recombinant Proteins; Serotonin; Transfection

1993
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
    Molecular pharmacology, 1993, Volume: 44, Issue:2

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists

1993
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Sep-15, Volume: 90, Issue:18

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; CHO Cells; Cricetinae; Cyclic AMP; DNA; Genomic Library; Kinetics; Lysergic Acid Diethylamide; Mianserin; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Organ Specificity; Rats; Receptors, Serotonin; Restriction Mapping; Serotonin; Serotonin Receptor Agonists; Transfection

1993
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
    Molecular pharmacology, 1993, Volume: 43, Issue:3

    Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Temperature

1993
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
    Journal of medicinal chemistry, 1997, Mar-14, Volume: 40, Issue:6

    Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Binding, Competitive; Colforsin; Cyclic AMP; Electrophysiology; Enzyme Activation; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Piperazines; Protein Binding; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship

1997
Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b).
    British journal of pharmacology, 1997, Volume: 122, Issue:1

    Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cyclic AMP; DNA, Complementary; Humans; Molecular Sequence Data; Placenta; Radioligand Assay; Rats; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid

1997
Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic tr
    Synapse (New York, N.Y.), 2000, Volume: 35, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Body Temperature; Frontal Lobe; Guinea Pigs; Hippocampus; Humans; Mice; Neurons; Piperoxan; Pyrroles; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Swine; Synaptic Transmission; Yohimbine

2000
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:2

    Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists

2004
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
    Nature, 2007, Nov-22, Volume: 450, Issue:7169

    Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevity; Methiothepin; Mianserin; Octopamine; Receptors, Biogenic Amine; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Signal Transduction; Starvation

2007
Synthesis and biological investigation of new equatorial (β) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile.
    Bioorganic & medicinal chemistry, 2016, 09-15, Volume: 24, Issue:18

    Topics: Animals; Antipsychotic Agents; Benzene Derivatives; Dopamine D2 Receptor Antagonists; Male; Mice; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Serotonin 5-HT2 Receptor Antagonists; Stereoisomerism; Structure-Activity Relationship; Tropanes

2016
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT
    European journal of medicinal chemistry, 2019, Mar-15, Volume: 166

    Topics: Animals; Chemistry Techniques, Synthetic; Drug Design; Ligands; Mice; Pyrimidines; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Tryptamines

2019
Diverse actions of 5-hydroxytryptamine on frog spinal dorsal horn neurons in vitro.
    Neuroscience, 1992, Volume: 49, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Dioxanes; Electric Stimulation; Evoked Potentials; Female; In Vitro Techniques; Ketanserin; Kinetics; Male; Membrane Potentials; Methysergide; Mianserin; Neurons; Rana pipiens; Serotonin; Serotonin Antagonists; Spinal Cord; Spiro Compounds; Synapses; Tetrodotoxin; Tropanes

1992
Corticosterone response to 8-OH-DPAT after chronic administration of antidepressants.
    The Japanese journal of psychiatry and neurology, 1991, Volume: 45, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Corticosterone; Desipramine; Dose-Response Relationship, Drug; Doxepin; Male; Mianserin; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes

1991
Attenuation of 5-HT1A and 5-HT2 but not 5-HT1C receptor mediated behaviour in rats following chronic treatment with 5-HT receptor agonists, antagonists or anti-depressants.
    Psychopharmacology, 1991, Volume: 105, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Male; Mianserin; Penile Erection; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes; Tranylcypromine

1991
Neurochemical studies with the potential antipsychotic compound trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H- dibenz[2,3:6,7]oxepino[4,5-c]pyrrolidine maleate.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Autonomic Nervous System; Benzazepines; Brain Chemistry; Corpus Striatum; Cyclic AMP; Dibenzocycloheptenes; Dibenzoxepins; Heterocyclic Compounds, 4 or More Rings; In Vitro Techniques; Male; Membranes; Mianserin; Prazosin; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Serotonin; Tetrahydronaphthalenes; Yohimbine

1990
Mechanisms involved in the action of serotonin-induced stimulation of progesterone production by bovine luteal cells in vitro.
    Molecular and cellular endocrinology, 1987, Volume: 51, Issue:1-2

    Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cattle; Corpus Luteum; Estrus; Female; In Vitro Techniques; Ketanserin; Mianserin; Progesterone; Receptors, Serotonin; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes

1987
Induction of purposeless chewing behaviour in rats by 5-HT agonist drugs.
    European journal of pharmacology, 1989, Mar-14, Volume: 162, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Male; Methiothepin; Methoxydimethyltryptamines; Mianserin; Parasympatholytics; Piperazines; Propranolol; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes

1989
Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex.
    Journal of neurochemistry, 1986, Volume: 47, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Frontal Lobe; Indoles; Methysergide; Mianserin; Piperazines; Rats; Serotonin; Tetrahydronaphthalenes

1986
Serotonin receptors in the human brain--III. Autoradiographic mapping of serotonin-1 receptors.
    Neuroscience, 1987, Volume: 21, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aged, 80 and over; Autoradiography; Brain; Ergolines; Female; Humans; Male; Mianserin; Middle Aged; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes

1987
Selective desensitization of serotonin (5-HT) receptor-mediated hyperthermia by mianserin and other 5-HT antagonists.
    Neuropharmacology, 1987, Volume: 26, Issue:7A

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Dose-Response Relationship, Drug; Fever; Male; Mianserin; Pyrazines; Rats; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes

1987
Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:1

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Cerebral Cortex; Depression; Hydroxyindoleacetic Acid; Kinetics; Male; Membranes; Mianserin; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin

1994
Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Autoreceptors; Corpus Striatum; Fluoxetine; Hippocampus; Male; Mianserin; Rats; Rats, Sprague-Dawley; Serotonin

1995
Excitatory and inhibitory effects of serotonin on spinal axons.
    Neuroscience, 1994, Volume: 61, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Axons; Electric Stimulation; Female; Male; Mianserin; Quipazine; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord

1994
Chronic, combined treatment with desipramine and mianserin: enhanced 5-HT1A receptor function and altered 5-HT1A/5-HT2 receptor interaction in rats.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Body Temperature; Body Weight; Desipramine; Drinking Behavior; Hippocampus; Male; Mianserin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Serotonin; Serotonin Receptor Agonists; Spinal Cord

1993
Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Corpus Striatum; Dioxanes; Hippocampus; Idazoxan; Imidazoles; Male; Mianserin; Mirtazapine; Norepinephrine; Prazosin; Rats; Rats, Wistar; Serotonin; Tetrodotoxin

1996
Indirect in vivo 5-HT1A-agonistic effects of the new antidepressant mirtazapine.
    Psychopharmacology, 1997, Volume: 133, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Conditioning, Operant; Fluoxetine; Male; Mianserin; Mice; Mice, Inbred ICR; Mirtazapine; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Taste

1997
How do antidepressants work?
    Molecular medicine today, 1995, Volume: 1, Issue:9

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Brain; Desipramine; Fluoxetine; Humans; Mianserin; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin

1995
Neurochemical effects of the enantiomers of mirtazapine in normal rats.
    European journal of pharmacology, 1998, Sep-04, Volume: 356, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Body Temperature; Injections, Intraperitoneal; Ketanserin; Male; Mianserin; Mirtazapine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin Antagonists; Stereoisomerism

1998
GR 127935 and (+)-WAY 100135 do not affect TFMPP-induced inhibition of 5-HT synthesis in the midbrain and hippocampus of Wistar-Kyoto rats.
    Neuropharmacology, 1998, Volume: 37, Issue:9

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Hippocampus; Idazoxan; Ketanserin; Male; Mesencephalon; Mianserin; Nerve Endings; Oxadiazoles; Piperazines; Rats; Rats, Inbred WKY; Rats, Wistar; Reserpine; Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Species Specificity; Tryptophan Hydroxylase

1998
Discriminative stimulus properties of the novel serotonin (5-HT)2C receptor agonist, RO 60-0175: a pharmacological analysis.
    Neuropharmacology, 1999, Volume: 38, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Conditioning, Operant; Ethylamines; Fluorobenzenes; Indoles; Male; Mianserin; Piperazines; Piperidines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes

1999
Zimelidine decreases seizure susceptibility in stressed mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2006, Volume: 113, Issue:12

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Ketanserin; Male; Mianserin; Mice; Mice, Inbred CBA; Phenols; Picrotoxin; Piperazines; Pyridines; Seizures; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Stress, Psychological; Sulfonamides; Swimming; Zimeldine

2006