Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin

8-hydroxy-2-(di-n-propylamino)tetralin and guanosine 5'-o-(3-thiotriphosphate)

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with guanosine 5'-o-(3-thiotriphosphate) in 75 studies

Research

Studies (75)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's24 (32.00)18.2507
2000's44 (58.67)29.6817
2010's7 (9.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Heller, PH; Levine, JD; Taiwo, YO1
Bertin, B; Breyer, RM; Freissmuth, M; Marullo, S; Schütz, W; Strosberg, AD1
Harrington, MA; Peroutka, SJ1
Ennis, C; Evans, N; Khawaja, X; Minchin, MC; Reilly, Y1
Bockaert, J; Harris, B; Jouin, P; Le Nguyen, D; McClue, S; Varrault, A1
Gettys, TW; Olsen, CL; Raymond, JR1
Chaput, C; Millan, MJ; Newman-Tancredi, A; Verrièle, L1
Hery, F; Pesce, G1
Hacksell, U; Höök, BB; Johansson, AM; Malmberg, A1
Batistini, A; Bevilacqua, G; Borsini, F; Cassano, GB; Ladinsky, H; Lucacchini, A; Marazziti, D; Naccarato, AG; Palego, L; Rotondo, A1
Beer, MS; Stanton, JA1
Bayliss, DA; Sadr, NN; Talley, EM1
Hayataka, K; O'Connor, MF; Parker, KK; Weber, JT1
Audinot-Bouchez, V; Chaput, C; Conte, C; Lavielle, G; Lochon, S; Millan, MJ; Newman-Tancredi, A; Verrièle, L1
Colpaert, FC; Pauwels, PJ; Tardif, S; Wurch, T2
Colpaert, FC; Dupuis, DS; Palmier, C; Pauwels, PJ1
Chattopadhyay, A; Harikumar, KG2
Dupuis, DS; Halazy, S; Pauwels, PJ; Perez, M1
Ferré, S; Fuxe, K; Owman, C; Rinken, A; Terasmaa, A1
Dupuis, DS; Hall, H; Pauwels, PJ; Radu, D1
Hećimović, H; Kelly, JS1
Audinot, V; Cussac, D; Dubuffet, T; Lavielle, G; Loutz, A; Millan, MJ; Newman-Tancredi, A1
Chaput, C; Millan, MJ; Newman-Tancredi, A; Rivet, J; Touzard, M; Verrièle, L1
McLoughlin, DJ; Strange, PG1
Carr, KD; Hiller, JM; Li, H; Meller, E1
Childers, SR; Selley, DE; Sim-Selley, LJ; Vogt, LJ; Xiao, R1
Collin, L; Ho, M; Price, GW; Riley, G; Scott, C; Selkirk, JV; Watson, J1
Branchek, TA; Calligaro, DO; Czachura, JF; Dreshfield-Ahmad, LJ; Evans, DC; Hemrick-Luecke, SK; Kallman, MJ; Kendrick, WT; Leander, JD; Nelson, DL; Overshiner, CD; Rasmussen, K; Wainscott, DB; Wolff, MC; Wong, DT; Xu, YC; Zgombick, JM1
Chattopadhyay, A; Harikumar, KG; John, PT1
Millan, MJ; Newman-Tancredi, A; Verrièle, L1
Durgam, H; Hensler, J1
Breese, GR; Knapp, DJ; Overstreet, DH; Sim-Selley, LJ1
Alper, RH; Mize, AL; Poisner, AM1
Assié, MB; Colpaert, FC; Cosi, C; Koek, W; Patoiseau, JF; Pauwels, PJ; Vacher, B1
Collin, L; Davies, CH; Day, NC; Gaster, L; Harries, MH; Heightman, T; Kendall, I; Middlemiss, DN; Parker, C; Price, GW; Randall, AD; Roberts, C; Scott, C; Soffin, E; Watson, J; Wyman, P1
Battaglia, G; D'Souza, D; Garcia, F; Muma, NA; Raap, DK; Van de Kar, LD; Zhang, Y1
Cryan, JF; Dalvi, A; Lucki, I; Manning, DR; Page, ME; Saucy, B; Sullivan, A1
Duncan, MJ; Hensler, JG1
Castro, M; del Olmo, E; Diaz, A; Pazos, A1
Alper, RH; Mize, AL1
Hensler, JG; Ladenheim, EE; Lyons, WE1
Colpaert, FC; Pauwels, PJ1
Chattopadhyay, A; Pucadyil, TJ1
Chattopadhyay, A; Harikumar, KG; Kalipatnapu, S; Pucadyil, TJ1
Chattopadhyay, A; Harikumar, KG; Jafurulla, M; Kalipatnapu, S; Pucadyil, TJ1
Assié, MB; Cosi, C; Danty, N; Leduc, N; Newman-Tancredi, A; Ormière, AM1
Bartoszyk, GD; Dawson, LA; Hagan, JJ; Hill, M; Hughes, ZA; Langmead, CJ; Middlemiss, DN; Starr, KR1
Burnett, A; Goldstein, E; Parker, KK; Russo, EB; Thiagaraj, HV; Thompson, CM1
Chen, R; Hamilton, R; Jordan, S; Kikuchi, T; Koprivica, V; Tottori, K; Whitehead, RE1
Odagaki, Y; Toyoshima, R1
Burnett, A; Hall, B; Parker, KK; Russo, EB1
Assié, MB; Carilla-Durand, E; Cosi, C; Leduc, N; Maraval, M; Newman-Tancredi, A; Ormiere, AM1
Chattopadhyay, A; Jafurulla, M; Pucadyil, TJ1
Dean, B; Gray, L; Scarr, E1
Lin, H; Saisch, SG; Strange, PG1
Alonso, A; Dickson, CT; Ma, L; Shalinsky, MH1
Assié, MB; Cussac, D; Leduc, N; Martel, JC; Newman-Tancredi, A; Ormière, AM1
Advani, T; Hensler, JG; Monteggia, LM1
Betti, L; Fabbrini, L; Fabiani, O; Giannaccini, G; Giusiani, M; Giusti, L; Lucacchini, A; Macchia, M; Martini, C; Mascia, G; Palego, L; Pirone, A1
Aso, E; Castro, E; Maldonado, R; Martín, M; Mato, S; Pazos, A; Valverde, O1
Cussac, D; Heusler, P; Loock, T; Newman-Tancredi, A1
Burke, TF; Hensler, JG; Rossi, DV1
Castro, E; Del Olmo, E; Díaz, A; Pazos, A; Rodriguez-Gaztelumendi, A1
Barrondo, S; Sallés, J1
Charnay, Y; Fagret, D; Ginovart, N; Hamon, M; Hen, R; Ibáñez, V; Lanfumey, L; Millet, P; Moulin-Sallanon, M; Perret, P1
Gass, P; Hensler, JG; Vogt, MA1
Castro, E; Pazos, A; Valdizán, EM1
Ailhaud, MC; Croville, G; Cussac, D; Heusler, P; Rauly-Lestienne, I; Tardif, S; Tourette, A1
Goeldner, C; Kieffer, BL; Lutz, PE; Pradhan, AA1
Dulawa, SC; Masten, VL; Shanahan, NA; Velez, LP1
Alper, RH; Raddatz, R1
Amigó, J; Castro, E; Compan, V; Díaz, A; Martín, A; Pazos, A; Pilar-Cuéllar, F; Vidal, R1
Bandari, S; Chattopadhyay, A; Jafurulla, M; Pucadyil, TJ1

Reviews

1 review(s) available for 8-hydroxy-2-(di-n-propylamino)tetralin and guanosine 5'-o-(3-thiotriphosphate)

ArticleYear
Selective breeding of 5-HT(1A) receptor-mediated responses: application to emotion and receptor action.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Breeding; Emotions; Guanosine 5'-O-(3-Thiotriphosphate); Hypothermia; Mice; Mice, Knockout; Rats; Rats, Mutant Strains; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists

2000

Trials

1 trial(s) available for 8-hydroxy-2-(di-n-propylamino)tetralin and guanosine 5'-o-(3-thiotriphosphate)

ArticleYear
Further characterisation of [3H]8-hydroxy-2-(di-N-propylamino)tetralin binding sites in human brain postmortem.
    Neurochemistry international, 1997, Volume: 30, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Analysis of Variance; Binding Sites; Binding, Competitive; Cations, Divalent; Cerebral Cortex; Corpus Striatum; Female; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Kinetics; Male; Membranes; Middle Aged; Radioligand Assay; Serotonin Receptor Agonists

1997

Other Studies

73 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and guanosine 5'-o-(3-thiotriphosphate)

ArticleYear
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
    Neuroscience, 1992, Volume: 48, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes

1992
Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits.
    The Journal of biological chemistry, 1992, Apr-25, Volume: 267, Issue:12

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amino Acid Sequence; Binding, Competitive; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Molecular Sequence Data; Plasmids; Receptors, Serotonin; Recombinant Proteins; Signal Transduction; Tetrahydronaphthalenes

1992
Modulation of 5-hydroxytryptamine1A receptor density by nonhydrolyzable GTP analogues.
    Journal of neurochemistry, 1990, Volume: 54, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine Triphosphate; Animals; Cell Membrane; Cerebral Cortex; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Models, Theoretical; Rats; Receptors, Serotonin; Tetrahydronaphthalenes; Thionucleotides

1990
Characterisation of the binding of [3H]WAY-100635, a novel 5-hydroxytryptamine1A receptor antagonist, to rat brain.
    Journal of neurochemistry, 1995, Volume: 64, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Brain; Cations, Divalent; Cations, Monovalent; Guanosine 5'-O-(3-Thiotriphosphate); Male; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Temperature; Tritium

1995
5-Hydroxytryptamine1A receptor synthetic peptides. Mechanisms of adenylyl cyclase inhibition.
    The Journal of biological chemistry, 1994, Jun-17, Volume: 269, Issue:24

    Topics: 3T3 Cells; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Clone Cells; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hippocampus; Humans; Kinetics; Male; Mice; Molecular Sequence Data; Moths; Peptide Fragments; Pertussis Toxin; Protein Structure, Secondary; Rats; Rats, Wistar; Receptors, Serotonin; Virulence Factors, Bordetella

1994
Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha.
    Biochemistry, 1993, Oct-19, Volume: 32, Issue:41

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Antibody Specificity; Cell Membrane; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Immune Sera; Immunoblotting; Immunosorbent Techniques; Molecular Sequence Data; Peptide Fragments; Receptors, Serotonin

1993
S 15535 and WAY 100,635 antagonise 5-HT-stimulated [35S]GTP gamma S binding at cloned human 5-HT1A receptors.
    European journal of pharmacology, 1996, Jun-20, Volume: 307, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stimulation, Chemical; Tritium

1996
Resolution of multiple affinity states of 5-hydroxytryptamine-1A receptors labelled by [3H]-8-hydroxy-2-(di-n-propilamino) tetralin in rat hippocampal membranes.
    General pharmacology, 1996, Volume: 27, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Dopamine Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Membranes; Rats; Receptors, Serotonin; Serotonin Receptor Agonists; Spiperone; Thermodynamics

1996
Novel (R)-2-amino-5-fluorotetralins: dopaminergic antagonists and inverse agonists.
    Journal of medicinal chemistry, 1996, Oct-25, Volume: 39, Issue:22

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine Agonists; Dopamine Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Raclopride; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Salicylamides; Tetrahydronaphthalenes

1996
Characterisation of a cloned human 5-HT1A receptor cell line using [35S]GTP gamma S binding.
    European journal of pharmacology, 1997, Feb-12, Volume: 320, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Cell Line; Clone Cells; Cystamine; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tritium

1997
Postnatal development of serotonergic innervation, 5-HT1A receptor expression, and 5-HT responses in rat motoneurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Jun-01, Volume: 17, Issue:11

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Animals; Animals, Newborn; Calcium Channel Blockers; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Hypoglossal Nerve; Immunohistochemistry; In Situ Hybridization; Motor Neurons; Neural Inhibition; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Radioligand Assay; Raphe Nuclei; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Serotonin; Serotonin Receptor Agonists; Spider Venoms; Tritium

1997
Rabbit cerebral cortex 5HT1a receptors.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1997, Volume: 117, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; CHO Cells; Cricetinae; Dioxanes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Propranolol; Rabbits; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Sesquiterpenes; Spiro Compounds; Tritium

1997
Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Binding, Competitive; Cell Membrane; Cricetinae; Dihydroergotamine; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; In Vitro Techniques; Indoles; Lisuride; Methysergide; Migraine Disorders; Piperazines; Piperidines; Pizotyline; Propranolol; Propylamines; Protein Binding; Pyridines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Recombinant Proteins; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Tryptamines

1997
Stimulated [35S]GTP gamma S binding by 5-HT1A receptor agonists in recombinant cell lines. Modulation of apparent efficacy by G-protein activation state.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Binding, Competitive; Cell Line; Cell Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; HeLa Cells; Humans; Ligands; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists

1997
Autoradiography of serotonin 5-HT1A receptor-activated G proteins in guinea pig brain sections by agonist-stimulated [35S]GTPgammaS binding.
    Journal of neurochemistry, 1998, Volume: 70, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Brain Chemistry; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Hippocampus; Male; Oxadiazoles; Piperazines; Raphe Nuclei; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Septal Nuclei; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tryptamines

1998
Metal ion and guanine nucleotide modulations of agonist interaction in G-protein-coupled serotonin1A receptors from bovine hippocampus.
    Cellular and molecular neurobiology, 1998, Volume: 18, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding Sites; Binding, Competitive; Cations, Divalent; Cations, Monovalent; Cattle; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists

1998
Dimerization of 8-OH-DPAT increases activity at serotonin 5-HT1A receptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 358, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Dimerization; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; HeLa Cells; Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists

1998
Serotonergic agonists behave as partial agonists at the dopamine D2 receptor.
    Neuroreport, 1999, Feb-25, Volume: 10, Issue:3

    Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Butaclamol; Cell Membrane; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Raclopride; Receptors, Dopamine D2; Salicylamides; Serotonin; Serotonin Receptor Agonists

1999
Autoradiographic studies of 5-HT1A-receptor-stimulated [35S]GTPgammaS-binding responses in the human and monkey brain.
    The European journal of neuroscience, 1999, Volume: 11, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Macaca fascicularis; Male; Oxadiazoles; Piperazines; Piperidines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tritium; Tryptamines

1999
Okadaic acid antagonizes the inhibitory action of internal GTP-gamma-S on the calcium current of dorsal raphe neurons but not that of 5-HT1A receptor activation.
    Annals of the New York Academy of Sciences, 1999, Apr-30, Volume: 868

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Barium; Calcium Channels; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Neurons; Okadaic Acid; Phosphorylation; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1

1999
Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonist.
    Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Pyrroles; Pyrrolidines; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Sulpiride; Tetrahydronaphthalenes; Transfection

1999
Differential discrimination of G-protein coupling of serotonin(1A) receptors from bovine hippocampus by an agonist and an antagonist.
    FEBS letters, 1999, Sep-03, Volume: 457, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Cattle; Cell Membrane; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Piperazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction

1999
The 5HT(1A) receptor ligand, S15535, antagonises G-protein activation: a [35S]GTPgammaS and [3H]S15535 autoradiography study.
    European journal of pharmacology, 1999, Nov-19, Volume: 384, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Binding, Competitive; Brain; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Ligands; Male; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tritium

1999
Mechanisms of agonism and inverse agonism at serotonin 5-HT1A receptors.
    Journal of neurochemistry, 2000, Volume: 74, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Osmolar Concentration; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Sodium

2000
5-Hydroxytryptamine(1A) receptor-stimulated [(35)S]GTPgammaS binding in rat brain: absence of regional differences in coupling efficiency.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Brain; Dose-Response Relationship, Drug; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Phenoxybenzamine; Piperazines; Protein Binding; Pyridines; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tryptamines

2000
Region-specific changes in 5-HT(1A) receptor-activated G-proteins in rat brain following chronic buspirone.
    European journal of pharmacology, 2000, Feb-18, Volume: 389, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Buspirone; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1

2000
5-HT(1A) receptor agonist-antagonist binding affinity difference as a measure of intrinsic activity in recombinant and native tissue systems.
    British journal of pharmacology, 2000, Volume: 130, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone

2000
The novel 5-Hydroxytryptamine(1A) antagonist LY426965: effects on nicotine withdrawal and interactions with fluoxetine.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Body Temperature; Columbidae; Corticosterone; Depression; Discrimination Learning; Drug Interactions; Fluoxetine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lip; Male; Microdialysis; Neurons; Nicotine; Piperidines; Posture; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex, Startle; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Smoking Cessation; Substance Withdrawal Syndrome; Sulfur Radioisotopes

2000
Role of disulfides and sulfhydryl groups in agonist and antagonist binding in serotonin1A receptors from bovine hippocampus.
    Cellular and molecular neurobiology, 2000, Volume: 20, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Binding Sites; Cattle; Cell Membrane; Dithiothreitol; Ethylmaleimide; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Kinetics; Ligands; Piperazines; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium

2000
Differential modulation by GTPgammaS of agonist and inverse agonist binding to h5-HT(1A) receptors revealed by [3H]-WAY100,635.
    British journal of pharmacology, 2001, Volume: 132, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Ligands; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists

2001
Regulation of 5-HT(1A) receptor-stimulated [35S]-GtpgammaS binding as measured by quantitative autoradiography following chronic agonist administration.
    British journal of pharmacology, 2001, Volume: 132, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Image Processing, Computer-Assisted; Male; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Synapses

2001
Estrogens act in rat hippocampus and frontal cortex to produce rapid, receptor-mediated decreases in serotonin 5-HT(1A) receptor function.
    Neuroendocrinology, 2001, Volume: 73, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Diethylstilbestrol; Estradiol; Estrogen Antagonists; Estrogens; Estrogens, Non-Steroidal; Female; Frontal Lobe; Fulvestrant; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Time Factors

2001
5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential.
    European journal of pharmacology, 2001, May-25, Volume: 420, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Antidepressive Agents; Binding, Competitive; Buspirone; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Male; Motor Activity; Piperazines; Piperidines; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming

2001
SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue.
    British journal of pharmacology, 2001, Volume: 133, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Aged; Aged, 80 and over; Animals; Autoradiography; Binding, Competitive; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Indoles; Mesencephalon; Middle Aged; Neurons; Piperazines; Pyridines; Radioligand Assay; Raphe Nuclei; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tritium

2001
Real-time analysis of dopamine: antagonist interactions at recombinant human D2long receptor upon modulation of its activation state.
    British journal of pharmacology, 2001, Volume: 134, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alternative Splicing; Animals; Binding, Competitive; Butaclamol; Calcium; CHO Cells; Clozapine; Cricetinae; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Genotype; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Lisuride; Mutation; Plasmids; Receptors, Dopamine; Receptors, Dopamine D2; Recombinant Proteins; Sulfur Radioisotopes; Time Factors

2001
Characterization of the functional heterologous desensitization of hypothalamic 5-HT(1A) receptors after 5-HT(2A) receptor activation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Oct-15, Volume: 21, Issue:20

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Amphetamines; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Fluorobenzenes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hypothalamus; Male; Membrane Proteins; Oxytocin; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists

2001
Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Benzofurans; Brain Chemistry; Cell Line; Extracellular Space; Female; Fluoxetine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Microdialysis; Piperazines; Prefrontal Cortex; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Swimming; Vilazodone Hydrochloride

2002
Aging alters in a region-specific manner serotonin transporter sites and 5-HT(1A) receptor-G protein interactions in hamster brain.
    Neuropharmacology, 2002, Volume: 43, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Autoradiography; Binding, Competitive; Brain; Carrier Proteins; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mesocricetus; Nerve Tissue Proteins; Paroxetine; Piperazines; Pyridines; Raphe Nuclei; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists

2002
Chronic fluoxetine induces opposite changes in G protein coupling at pre and postsynaptic 5-HT1A receptors in rat brain.
    Neuropharmacology, 2003, Volume: 44, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Autoreceptors; Brain; Fluoxetine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Organ Specificity; Radioligand Assay; Rats; Rats, Wistar; Receptors, Presynaptic; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Synapses

2003
Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17beta-estradiol in vitro requires protein kinases A and C.
    Neuroendocrinology, 2002, Volume: 76, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Carbazoles; Cell Membrane; Culture Techniques; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Indoles; Naphthalenes; Ovariectomy; Phosphorylation; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Staurosporine

2002
Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF (+/-) mice.
    Journal of neurochemistry, 2003, Volume: 85, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Autoradiography; Behavior, Animal; Binding, Competitive; Brain-Derived Neurotrophic Factor; Choice Behavior; Ethanol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heterozygote; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Raphe Nuclei; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Self Administration; Serotonin Receptor Agonists

2003
Ca2+ responses in Chinese hamster ovary-K1 cells demonstrate an atypical pattern of ligand-induced 5-HT1A receptor activation.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Calcium; CHO Cells; Cricetinae; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Sulfur Radioisotopes

2003
Cholesterol modulates ligand binding and G-protein coupling to serotonin(1A) receptors from bovine hippocampus.
    Biochimica et biophysica acta, 2004, May-27, Volume: 1663, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; beta-Cyclodextrins; Cattle; Cell Membrane; Cholesterol; Cyclodextrins; Dose-Response Relationship, Drug; Fluorescence Polarization; Fluorescent Dyes; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Tritium

2004
Ligand binding characteristics of the human serotonin1A receptor heterologously expressed in CHO cells.
    Bioscience reports, 2004, Volume: 24, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Binding Sites; Binding, Competitive; Cell Membrane; CHO Cells; Clone Cells; Cricetinae; Cricetulus; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Ligands; Piperazines; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Sensitivity and Specificity; Serotonin Antagonists; Serotonin Receptor Agonists; Transfection; Tritium

2004
Role of cholesterol in ligand binding and G-protein coupling of serotonin1A receptors solubilized from bovine hippocampus.
    Biochemical and biophysical research communications, 2005, Feb-25, Volume: 327, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cattle; Cell Membrane; Cholesterol; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Hippocampus; Ligands; Protein Binding; Receptor, Serotonin, 5-HT1A; Solubility

2005
Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia.
    The international journal of neuropsychopharmacology, 2005, Volume: 8, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Antipsychotic Agents; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Phosphorus Isotopes; Protein Binding; Rats; Receptor, Serotonin, 5-HT1A; Recombinant Proteins; Serotonin Antagonists; Signal Transduction; Tritium

2005
Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.
    European journal of pharmacology, 2005, Mar-07, Volume: 510, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzofurans; Benzylamines; Binding, Competitive; Cell Membrane; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Frontal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Indoles; Male; Microdialysis; Norepinephrine; Paroxetine; Piperazines; Piperidones; Pyridines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfur Radioisotopes; Time Factors; Tritium; Vilazodone Hydrochloride

2005
Binding properties of dipropyltryptamine at the human 5-HT1a receptor.
    Pharmacology, 2005, Volume: 74, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Molecular Structure; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Serotonin; Sulfur Radioisotopes; Transfection; Tritium; Tryptamines

2005
In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors.
    European journal of pharmacology, 2005, Jul-11, Volume: 517, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Autoradiography; Binding, Competitive; Buspirone; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Frontal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Male; Middle Aged; Pindolol; Piperazines; Pyridines; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfur Radioisotopes

2005
5-HT1A receptor-mediated G protein activation assessed by [35S]GTPgammaS binding in rat cerebral cortex.
    European journal of pharmacology, 2005, Oct-03, Volume: 521, Issue:1-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hippocampus; Magnesium Chloride; Male; Piperazines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium Chloride; Sulfur Radioisotopes

2005
Agonistic properties of cannabidiol at 5-HT1a receptors.
    Neurochemical research, 2005, Volume: 30, Issue:8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Cannabidiol; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Rats; Receptors, Cell Surface; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists

2005
Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release.
    European journal of pharmacology, 2006, Mar-27, Volume: 535, Issue:1-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antipsychotic Agents; Aripiprazole; Benzoxazoles; Binding, Competitive; Cell Line; Clozapine; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Male; Piperazines; Prolactin; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Spodoptera; Sulfur Radioisotopes; Tropanes

2006
Prolonged treatment with ligands affects ligand binding to the human serotonin(1A) receptor in Chinese hamster ovary cells.
    Cellular and molecular neurobiology, 2006, Volume: 26, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Cell Membrane; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Piperazines; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Receptor Agonists

2006
Serotonin 1a receptor and associated G-protein activation in schizophrenia and bipolar disorder.
    Psychiatry research, 2006, Aug-30, Volume: 143, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Bipolar Disorder; Brain Mapping; Female; Frontal Lobe; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Middle Aged; Parietal Lobe; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Schizophrenia; Sex Characteristics; Signal Transduction

2006
Assays for enhanced activity of low efficacy partial agonists at the D(2) dopamine receptor.
    British journal of pharmacology, 2006, Volume: 149, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; CHO Cells; Cricetinae; Dopamine Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Meglumine; Receptors, Dopamine D2; Sodium

2006
Effects of serotonin on the intrinsic membrane properties of layer II medial entorhinal cortex neurons.
    Hippocampus, 2007, Volume: 17, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Algorithms; Anesthetics, Local; Animals; Cell Membrane; Cell Shape; Entorhinal Cortex; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Piperazines; Pyridines; Pyrimidines; Rats; Rats, Long-Evans; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin

2007
Native rat hippocampal 5-HT1A receptors show constitutive activity.
    Molecular pharmacology, 2007, Volume: 71, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; Piperazines; Pyridines; Rats; Receptor, Serotonin, 5-HT1A

2007
Regulation of serotonin-1A receptor function in inducible brain-derived neurotrophic factor knockout mice after administration of corticosterone.
    Biological psychiatry, 2007, Sep-01, Volume: 62, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Inflammatory Agents; Autoradiography; Brain-Derived Neurotrophic Factor; Corticosterone; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Male; Mice; Mice, Knockout; Piperazines; Protein Binding; Pyridines; Raphe Nuclei; Receptor, Serotonin, 5-HT1A; Serotonin Antagonists; Serotonin Receptor Agonists

2007
Short-term effects of 3,4-methylen-dioxy-metamphetamine (MDMA) on 5-HT(1A) receptors in the rat hippocampus.
    Neurochemistry international, 2007, Volume: 51, Issue:8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amphetamine; Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Dopamine Agents; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; N-Methyl-3,4-methylenedioxyamphetamine; Radioligand Assay; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission; Time Factors

2007
CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A/C receptors.
    Journal of neurochemistry, 2007, Volume: 103, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Autoradiography; Behavior, Animal; Body Temperature; Female; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Knockout; Protein Binding; Receptor, Cannabinoid, CB1; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists

2007
Antipsychotics differ in their ability to internalise human dopamine D2S and human serotonin 5-HT1A receptors in HEK293 cells.
    European journal of pharmacology, 2008, Feb-26, Volume: 581, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Antipsychotic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Quinpirole; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2

2008
Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by citalopram and escitalopram.
    European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Binding, Competitive; Citalopram; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Imipramine; In Vitro Techniques; Male; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists

2008
WAY100635 prevents the changes induced by fluoxetine upon the 5-HT1A receptor functionality.
    Neuropharmacology, 2008, Volume: 55, Issue:8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Brain; Drug Interactions; Fluoxetine; Guanosine 5'-O-(3-Thiotriphosphate); Male; Piperazines; Protein Binding; Pyridines; Radioisotopes; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors

2008
Allosteric modulation of 5-HT(1A) receptors by zinc: Binding studies.
    Neuropharmacology, 2009, Volume: 56, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cerebral Cortex; Chlorides; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Inhibitory Concentration 50; Male; Numerical Analysis, Computer-Assisted; Piperazines; Protein Binding; Pyridines; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium; Zinc Compounds

2009
Acute and chronic effects of citalopram on 5-HT1A receptor-labeling by [18F]MPPF and -coupling to receptors-G proteins.
    Synapse (New York, N.Y.), 2009, Volume: 63, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Brain; Citalopram; Fluorine Radioisotopes; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Knockout; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists

2009
Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice.
    Psychoneuroendocrinology, 2010, Volume: 35, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Corticosterone; Guanosine 5'-O-(3-Thiotriphosphate); Heterozygote; Hippocampus; Male; Mice; Mice, Transgenic; Protein Binding; Receptor, Serotonin, 5-HT1A; Receptors, Glucocorticoid; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists

2010
Agonist-dependent modulation of G-protein coupling and transduction of 5-HT1A receptors in rat dorsal raphe nucleus.
    The international journal of neuropsychopharmacology, 2010, Volume: 13, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Buspirone; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Raphe Nuclei; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Signal Transduction

2010
Actions of the prototypical 5-HT1A receptor agonist 8-OH-DPAT at human alpha2-adrenoceptors: (+)8-OH-DPAT, but not (-)8-OH-DPAT is an alpha2B subtype preferential agonist.
    European journal of pharmacology, 2010, Aug-25, Volume: 640, Issue:1-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-2 Receptor Agonists; Animals; CHO Cells; Cricetinae; Cricetulus; Electric Conductivity; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Serotonin 5-HT1 Receptor Agonists; Stereoisomerism

2010
Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2011, Volume: 21, Issue:11

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Dose-Response Relationship, Drug; Drug Administration Schedule; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Morphine; Narcotics; Prefrontal Cortex; Protein Binding; Raphe Nuclei; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Sulfur Radioisotopes; Time Factors

2011
Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice.
    Biological psychiatry, 2011, Dec-01, Volume: 70, Issue:11

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Clomipramine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Female; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Iodocyanopindolol; Isotopes; Mice; Mice, Inbred BALB C; Neural Inhibition; Obsessive-Compulsive Disorder; Prefrontal Cortex; Receptor, Serotonin, 5-HT1B; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Swimming; Time Factors

2011
Agonist-stimulated [35S]GTPγS binding.
    Current protocols in pharmacology, 2007, Volume: Chapter 2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hippocampus; Rats; Receptor, Serotonin, 5-HT1A; Sulfur Radioisotopes

2007
The absence of 5-HT
    Neuropharmacology, 2016, Volume: 111

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anhedonia; Animals; Antidepressive Agents, Second-Generation; Anxiety; Autoreceptors; Axl Receptor Tyrosine Kinase; Brain-Derived Neurotrophic Factor; Depression; Fluoxetine; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Hypothermia; Mice; Mice, Knockout; Neuronal Plasticity; Olfactory Bulb; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Serotonin, 5-HT1A; Receptor, trkB; Receptors, Serotonin, 5-HT4

2016
Sphingolipids modulate the function of human serotonin
    Biochimica et biophysica acta. Biomembranes, 2017, Volume: 1859, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bacterial Proteins; Cell Membrane; CHO Cells; Cricetulus; Gene Deletion; Gene Expression Regulation; Genes, Reporter; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Luminescent Proteins; Membrane Lipids; Receptor, Serotonin, 5-HT1A; Serine C-Palmitoyltransferase; Serotonin 5-HT1 Receptor Agonists; Signal Transduction; Sphingosine

2017