Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin

8-hydroxy-2-(di-n-propylamino)tetralin and gamma-aminobutyric acid

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with gamma-aminobutyric acid in 45 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.44)18.7374
1990's15 (33.33)18.2507
2000's15 (33.33)29.6817
2010's12 (26.67)24.3611
2020's1 (2.22)2.80

Authors

AuthorsStudies
Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X1
Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG1
Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S1
Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L1
Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E1
Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E1
Fernández-Guasti, A; López-Rubalcava, C; Saldívar, A1
Blier, P; Bouchard, C1
Davidoff, RA; Gharagozloo, A; Hackman, JC; Holohean, AM1
Bendotti, C; Garattini, S; Invernizzi, R; Mennini, T; Samanin, R1
Ghazi, H; Osborne, NN1
Empson, RM; Heinemann, U; Schmitz, D1
Ashby, CR; Wang, RY; Zhang, JY1
Katsuki, H; Kawahara, F; Saito, H1
Bowen, DM; Chessell, IP; Francis, PT; Pangalos, MN; Pearson, RC1
Blier, P; De Montigny, C; Lista, A2
Gale, K; Pasini, A; Tortorella, A1
Abrahams, J; Ciporen, J; Sakuma, J; Young, W1
Matsuyama, S; Nei, K; Tanaka, C1
Andersson, G; Enerbäck, C; Engel, JA; Söderpalm, B1
Blier, P; de Montigny, C; Mongeau, R; Weiss, M1
Bischoff, AM; Lalley, PM; Pierrefiche, O; Richter, DW; Schmidt-Garcon, P1
Abe, K; Edagawa, Y; Saito, H1
Blier, P; Haddjeri, N; Lucas, G1
Akaike, N; Kishimoto, K; Koyama, S1
Yan, QS; Yan, SE1
Blier, P; Szabo, ST1
Chung, JH; Kim, CJ; Kim, EH; Kim, SA; Kim, YJ; Shin, MC1
Ichikawa, T; Kodama, N; Matsumoto, M; Sakuma, J; Sasaki, T; Tiwari, P; Young, W1
Mogil, JS; Nemmani, KV1
Cannizzaro, C; Cannizzaro, E; Gagliano, M; Martire, M; Mineo, A; Monastero, R; Provenzano, G1
Flügge, G; Palchaudhuri, M1
Hurley, LM1
Chen, YH; Hou, LL; Wang, JJ1
Han, TH; Im, JH; Jeon, BH; Jo, JY; Kang, G; Lee, KS; Lee, SY; Park, JB; Ryu, PD1
Congleton, MR; Duncan, MJ1
McCarley, RW1
Artigas, F; Celada, P; Ghisi, V; Lladó-Pelfort, L; Santana, N1
Albrechet-Souza, L; Almada, RC; Brandão, ML1
Bastian, G; Bourgoin, S; Hamon, M; Kayser, V; Michot, B1
Hasser, EM; Kline, DD; Ostrowski, D; Ostrowski, TD1
Almada, RC; Brandão, ML; Coimbra, NC1
Cruz-Martínez, AM; Escartín-Pérez, RE; Florán-Garduño, B; López-Alonso, VE; Mancilla-Díaz, JM; Tejas-Juárez, JG1
Cedillo Zavaleta, LN; Jiménez, JC; Miranda, F; Ruíz-García, I; Sandoval-Sánchez, AR1

Reviews

2 review(s) available for 8-hydroxy-2-(di-n-propylamino)tetralin and gamma-aminobutyric acid

ArticleYear
Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system.
    Appetite, 1986, Volume: 7 Suppl

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Appetite; Appetite Depressants; Brain; Brain Chemistry; Dopamine; Endorphins; Feeding Behavior; Fenfluramine; gamma-Aminobutyric Acid; Hydroxyindoleacetic Acid; Neural Pathways; Norepinephrine; Piperazines; Pyridines; Quipazine; Rats; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes

1986
Neurobiology of REM sleep.
    Handbook of clinical neurology, 2011, Volume: 98

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Eye Movements; gamma-Aminobutyric Acid; Humans; Intracellular Signaling Peptides and Proteins; Models, Biological; Neural Pathways; Neurobiology; Neurons; Neuropeptides; Orexins; Serotonin; Serotonin Receptor Agonists; Sleep, REM

2011

Other Studies

43 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and gamma-aminobutyric acid

ArticleYear
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship

2008
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship

2008
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
    European journal of medicinal chemistry, 2013, Volume: 63

    Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship

2013
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
    Bioorganic & medicinal chemistry, 2013, May-15, Volume: 21, Issue:10

    Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship

2013
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine

2016
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
    Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

    Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship

2017
Interaction of GABA and serotonin in the anxiolytic action of diazepam and serotonergic anxiolytics.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Diazepam; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

1992
Effect of repeated electroconvulsive shocks on serotonergic neurons.
    European journal of pharmacology, 1992, Feb-18, Volume: 211, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Brain Stem; Dendrites; Electroconvulsive Therapy; gamma-Aminobutyric Acid; Guinea Pigs; Hypothalamus; Hypothermia; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes; Tritium

1992
Serotonin and GABA-induced depolarizations of frog primary afferent fibers.
    Brain research, 1990, Nov-05, Volume: 532, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Afferent Pathways; Animals; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Pyrimidines; Rana pipiens; Receptors, GABA-A; Serotonin; Serotonin Antagonists; Spinal Cord; Tetrahydronaphthalenes; Tetrodotoxin

1990
Agonist-induced stimulation of inositol phosphates in primary rabbit retinal cultures.
    Journal of neurochemistry, 1988, Volume: 50, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Carbachol; Cells, Cultured; Clonidine; Dopamine; gamma-Aminobutyric Acid; Inositol Phosphates; Isoproterenol; Neurotransmitter Agents; Nicotine; Norepinephrine; Rabbits; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Serotonin; Retina; Serotonin; Sugar Phosphates; Tetrahydronaphthalenes

1988
Serotonin reduces inhibition via 5-HT1A receptors in area CA1 of rat hippocampal slices in vitro.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:11

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electric Conductivity; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Interneurons; Neural Inhibition; Neurons; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synapses; Synaptic Transmission

1995
Effect of pertussis toxin on the response of rat medial prefrontal cortex cells to the iontophoresis of serotonin receptor agonists.
    Journal of neural transmission. General section, 1994, Volume: 95, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Amphetamines; Animals; Frontal Lobe; gamma-Aminobutyric Acid; GTP-Binding Proteins; Iontophoresis; Neurons; Pertussis Toxin; Rats; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Signal Transduction; Virulence Factors, Bordetella

1994
Inhibition by 5-HT7 receptor stimulation of GABAA receptor-activated current in cultured rat suprachiasmatic neurones.
    The Journal of physiology, 1994, Jul-01, Volume: 478 ( Pt 1)

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Membrane Potentials; Neurons; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Serotonin; Ritanserin; Serotonin; Suprachiasmatic Nucleus

1994
Localisation of muscarinic (m1) and other neurotransmitter receptors on corticofugal-projecting pyramidal neurones.
    Brain research, 1993, Dec-31, Volume: 632, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Cerebral Cortex; Functional Laterality; gamma-Aminobutyric Acid; Glycoproteins; Kainic Acid; Male; N-Glycosyl Hydrolases; Neurons; Neurotoxins; Pirenzepine; Plant Lectins; Plant Proteins; Prazosin; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, Muscarinic; Receptors, Neurotransmitter; Receptors, Serotonin; Ribosome Inactivating Proteins, Type 2; Ricin; Tritium

1993
Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cholera Toxin; gamma-Aminobutyric Acid; GTP-Binding Proteins; Hippocampus; Male; Neurons; Pertussis Toxin; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Synapses; Virulence Factors, Bordetella

1993
Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drug Antagonism; gamma-Aminobutyric Acid; Hippocampus; Male; Methiothepin; Neurons; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Synapses

1993
The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin.
    Brain research, 1996, Jun-10, Volume: 724, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Bicuculline; Convulsants; Fenclonine; Fluoxetine; gamma-Aminobutyric Acid; Male; Microinjections; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Seizures; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists; Substantia Nigra

1996
Independent depressive mechanisms of GABA and (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide on young rat spinal axons.
    Neuroscience, 1996, Volume: 75, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Axons; gamma-Aminobutyric Acid; Rats; Reaction Time; Spinal Cord

1996
Regulation of GABA release via NMDA and 5-HT1A receptors in guinea pig dentate gyrus.
    Brain research, 1997, Jun-27, Volume: 761, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Calcium; Chromatography, High Pressure Liquid; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Magnesium; Male; N-Methylaspartate; Neurons; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin

1997
In vivo administration of the 5-HT1A receptor agonist 8-OH-DPAT interferes with brain GABA(A)/benzodiazepine receptor complexes.
    Neuropharmacology, 1997, Volume: 36, Issue:8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Chlorides; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Synaptosomes

1997
Effect of acute, short- and long-term milnacipran administration on rat locus coeruleus noradrenergic and dorsal raphe serotonergic neurons.
    Neuropharmacology, 1998, Volume: 37, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Biological Transport; Brimonidine Tartrate; Clonidine; Cyclopropanes; Desipramine; Drug Administration Schedule; gamma-Aminobutyric Acid; Hippocampus; Hypothalamus; Injections, Subcutaneous; Kinetics; Locus Coeruleus; Lysergic Acid Diethylamide; Male; Mesencephalon; Milnacipran; Neurons; Norepinephrine; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Spiperone; Time Factors

1998
Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats.
    The Journal of physiology, 1999, Jan-15, Volume: 514 ( Pt 2)

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Anesthesia, General; Animals; Cats; Cell Membrane; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Hypoxia; Medulla Oblongata; Microdialysis; Microinjections; Phrenic Nerve; Piperazines; Potassium Channels; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Respiratory Mechanics; Serotonin; Serotonin Antagonists

1999
The serotonin 5-HT2 receptor-phospholipase C system inhibits the induction of long-term potentiation in the rat visual cortex.
    The European journal of neuroscience, 2000, Volume: 12, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Bicuculline; Electrophysiology; Estrenes; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Long-Term Potentiation; Male; Phosphodiesterase Inhibitors; Piperazines; Pyrrolidinones; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists; Tropanes; Type C Phospholipases; Visual Cortex

2000
Role of cholinergic and GABAergic systems in the feedback inhibition of dorsal raphe 5-HT neurons.
    Neuroreport, 2000, Oct-20, Volume: 11, Issue:15

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cholinergic Fibers; Electrophysiology; Feedback; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscarinic Antagonists; Neural Inhibition; Neurons; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists

2000
Presynaptic modulation of synaptic gamma-aminobutyric acid transmission by tandospirone in rat basolateral amygdala.
    European journal of pharmacology, 2000, Nov-03, Volume: 407, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Amygdala; Animals; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Isoindoles; Neurons; Piperazines; Presynaptic Terminals; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptic Transmission

2000
Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.
    Journal of neurochemistry, 2001, Volume: 79, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Indoles; Male; Oxadiazoles; Pindolol; Piperazines; Potassium; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Ventral Tegmental Area

2001
Serotonin (1A) receptor ligands act on norepinephrine neuron firing through excitatory amino acid and GABA(A) receptors: a microiontophoretic study in the rat locus coeruleus.
    Synapse (New York, N.Y.), 2001, Dec-15, Volume: 42, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electrophysiology; Excitatory Amino Acids; gamma-Aminobutyric Acid; Iontophoresis; Ligands; Locus Coeruleus; Male; Neurons; Norepinephrine; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists

2001
Modulation of tianeptine on ion currents induced by inhibitory neurotransmitters in acutely dissociated dorsal raphe neurons of Sprague-Dawley rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2002, Volume: 12, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Brain; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ethylmaleimide; Excitatory Amino Acids; Female; gamma-Aminobutyric Acid; Glutamine; Glycine; In Vitro Techniques; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium Channels; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Thiazepines

2002
Effects of methylprednisolone on axonal depression induced by hypoxia, gamma-aminobutyric acid, and (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide.
    Neurosurgery, 2002, Volume: 51, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Axons; gamma-Aminobutyric Acid; Hypoxia; In Vitro Techniques; Methylprednisolone; Neuroprotective Agents; Rats; Rats, Long-Evans; Spinal Cord

2002
Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia.
    Neuropharmacology, 2003, Volume: 44, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Fenclonine; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Morphine; Pain Threshold; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Serotonin Agents; Serotonin Antagonists

2003
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2003, Volume: 13, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Female; gamma-Aminobutyric Acid; Handling, Psychological; Male; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists

2003
5-HT1A receptor expression in pyramidal neurons of cortical and limbic brain regions.
    Cell and tissue research, 2005, Volume: 321, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basal Ganglia; Binding, Competitive; Calcium-Binding Proteins; Cerebral Cortex; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; Hippocampus; Interneurons; Limbic System; Male; Pyramidal Cells; Radioligand Assay; Receptor, Serotonin, 5-HT1A; RNA, Messenger; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Tupaia

2005
Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.
    Journal of neurophysiology, 2006, Volume: 96, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Chiroptera; Dose-Response Relationship, Drug; Electrodes; Electrophysiology; Evoked Potentials, Auditory; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Inferior Colliculi; Iontophoresis; Male; Pyrazines; Pyridines; Pyrroles; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Receptor Agonists

2006
5-HT1A/7 receptor agonist excites cardiac vagal neurons via inhibition of both GABAergic and glycinergic inputs.
    Acta pharmacologica Sinica, 2008, Volume: 29, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobutyric Acid; Glycine; Heart; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Synaptic Transmission; Vagus Nerve

2008
Serotonin inhibits GABA synaptic transmission in presympathetic paraventricular nucleus neurons.
    Neuroscience letters, 2008, Jul-11, Volume: 439, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amino Acids; Animals; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Neural Inhibition; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Piperazines; Piperidones; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Spiro Compounds; Synaptic Transmission

2008
Neural mechanisms mediating circadian phase resetting by activation of 5-HT(7) receptors in the dorsal raphe: roles of GABAergic and glutamatergic neurotransmission.
    Brain research, 2010, Dec-17, Volume: 1366

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Circadian Rhythm; Cricetinae; Dizocilpine Maleate; Drug Administration Schedule; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mesocricetus; Microinjections; Muscimol; N-Methylaspartate; Raphe Nuclei; Receptors, Serotonin; Serotonin Receptor Agonists; Synaptic Transmission

2010
5-HT1A receptor agonists enhance pyramidal cell firing in prefrontal cortex through a preferential action on GABA interneurons.
    Cerebral cortex (New York, N.Y. : 1991), 2012, Volume: 22, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; gamma-Aminobutyric Acid; Interneurons; Male; Neural Pathways; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Wistar; Serotonin 5-HT1 Receptor Agonists

2012
Further evidence for involvement of the dorsal hippocampus serotonergic and γ-aminobutyric acid (GABA)ergic pathways in the expression of contextual fear conditioning in rats.
    Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:12

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Conditioning, Psychological; Fear; Freezing Reaction, Cataleptic; gamma-Aminobutyric Acid; Hippocampus; Male; Muscimol; Prefrontal Cortex; Rats; Rats, Wistar; Reflex, Startle; Serotonin; Serotonin Receptor Agonists; Time Factors

2013
Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents.
    Neuropharmacology, 2014, Volume: 79

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Analgesics; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Dipeptides; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Organoplatinum Compounds; Oxaliplatin; Piperazines; Piperidines; Quinazolines; Rats; Rats, Sprague-Dawley; Spinal Cord; Touch; TRPA1 Cation Channel; TRPC Cation Channels; Tryptamines

2014
Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function.
    Journal of neurophysiology, 2014, Jun-15, Volume: 111, Issue:12

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Phrenic Nerve; Piperazines; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Respiration; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Solitary Nucleus; Synaptic Transmission; Tissue Culture Techniques

2014
Medial prefrontal cortex serotonergic and GABAergic mechanisms modulate the expression of contextual fear: intratelencephalic pathways and differential involvement of cortical subregions.
    Neuroscience, 2015, Jan-22, Volume: 284

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biotin; Conditioning, Psychological; Dextrans; Fear; Freezing Reaction, Cataleptic; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Limbic Lobe; Male; Muscimol; Neural Pathways; Neuroanatomical Tract-Tracing Techniques; Neuronal Tract-Tracers; Prefrontal Cortex; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Reflex, Startle; Serotonin; Serotonin 5-HT1 Receptor Agonists

2015
CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2018, Volume: 28, Issue:11

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Arachidonic Acids; Cyproheptadine; Drug Interactions; Eating; gamma-Aminobutyric Acid; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Piperazines; Piperidines; Piperidones; Pyrazoles; Pyridines; Pyrroles; Rats; Receptor, Cannabinoid, CB1; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Tritium

2018
Administration of low doses of the 5-HT
    Pharmacology, biochemistry, and behavior, 2020, Volume: 193

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamine; Animals; Aversive Agents; Central Nervous System Stimulants; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Male; Microdialysis; Nucleus Accumbens; Raphe Nuclei; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Presynaptic; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Signal Transduction; Taste; Ventral Tegmental Area

2020