8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with diazepam in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.00) | 18.7374 |
| 1990's | 20 (40.00) | 18.2507 |
| 2000's | 17 (34.00) | 29.6817 |
| 2010's | 10 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP | 1 |
| Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO | 1 |
| Bojarski, AJ; Chłoń-Rzepa, G; Duszyńska, B; Nikiforuk, A; Pawłowski, M; Tatarczyńska, E; Zajdel, P; Zmudzki, P | 1 |
| Bugno, R; Chojnacka-Wójcik, E; Duszyńska, B; Lenda, T; Nikiforuk, A; Paluchowska, MH; Tatarczyńska, E | 1 |
| Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X | 1 |
| Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
| Chojnacka-Wójcik, E; Dybała, M; Jurczyk, S; Nikiforuk, A; Nowak, G; Pawłowski, M; Tatarczyńska, E; Zagórska, A | 1 |
| Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S | 1 |
| Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L | 1 |
| Bojarski, AJ; Bucki, A; Chłoń-Rzepa, G; Jastrzębska-Więsek, M; Kołaczkowski, M; Partyka, A; Satała, G; Wasik, A; Wesołowska, A | 1 |
| Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E | 1 |
| Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E | 1 |
| Glennon, RA | 1 |
| Hirose, A; Kumasaka, Y; Nakamura, M; Shimizu, H; Tanaka, H | 1 |
| Fernández-Guasti, A; López-Rubalcava, C; Saldívar, A | 1 |
| Barnes, NM; Cheng, CH; Costall, B; Ge, J; Naylor, RJ | 1 |
| Hirose, A; Kumasaka, Y; Nakamura, M; Shimizu, H; Tanaka, H; Tatsuno, T | 1 |
| Barnes, NM; Costall, B; Domeney, AM; Gerrard, PA; Kelly, ME; Krähling, H; Naylor, RJ; Tomkins, DM; Williams, TJ | 1 |
| Fozard, JR; Hibert, MF; Middlemiss, DN; Mir, AK; Moser, PC; Tricklebank, MD | 1 |
| Borsini, F; D'Aranno, V; Lecci, A; Mancinelli, A; Meli, A; Stasi, MA; Volterra, G | 1 |
| Rodgers, RJ; Shepherd, JK | 1 |
| Carli, M; Prontera, C; Samanin, R | 1 |
| Peroutka, SJ | 1 |
| Cheng, CH; Costall, B; Ge, J; Naylor, RJ | 1 |
| Conway, PC; Corbett, R; Dunn, RW; Hartman, H; Helsley, GC; Kerman, LL; Strupczewski, JT; Woods, AT | 1 |
| Arishima, K; Naito, H; Tonoue, T | 1 |
| Imaizumi, M; Miyazaki, S | 1 |
| Imaizumi, M; Machida, H; Miyazaki, S | 1 |
| Bill, DJ; Dourish, CT; Fletcher, A; Grewal, SS; Shepherd, JK | 2 |
| Sánchez, C | 1 |
| Gozlan, H; Haj-Dahmane, S; Hamon, M; Lanfumey, L; Laporte, AM; Martin, P | 1 |
| Andersson, G; Enerbäck, C; Engel, JA; Söderpalm, B | 1 |
| Fernández-Guasti, A; López-Rubalcava, C | 1 |
| Cremer, H; Delling, M; Hoyer, D; Schachner, M; Stork, O; Welzl, H; Wotjak, CT | 1 |
| Kaneko, T; Kikusui, T; Tonohiro, T | 1 |
| Fernández-Guasti, A; Ferreira, A; Pereira, M; Picazo, O; Uriarte, N | 1 |
| Adhumeau, A; Brocco, M; Dekeyne, A; Gobert, A; Millan, MJ | 1 |
| Blier, P; Debs, PC; Gobbi, G; Heath, MJ; Hen, R; Santarelli, L; Sibille, ET | 1 |
| Kurasawa, M; Nakamura, K | 1 |
| Aida, R; Akiyama, M; Moriya, T; Shibata, S; Shimomura, H; Takahashi, S; Yoshinobu, Y | 1 |
| Mogil, JS; Nemmani, KV | 1 |
| Cannizzaro, C; Cannizzaro, E; Gagliano, M; Martire, M; Mineo, A; Monastero, R; Provenzano, G | 1 |
| Chojnacka-Wójcik, E; Gołembiowska, K; Paluchowska, MH; Wesołowska, A | 1 |
| Estrada-Camarena, E; Hernandez-Aragon, A; Picazo, O | 1 |
| Hirose, N; Kamei, J; Nozaki, C; Oka, T; Saitoh, A; Yamada, M | 1 |
| Jakovcevski, M; Morellini, F; Schachner, M | 1 |
| Dickinson, A; Fernando, AB; Mar, AC; Robbins, TW; Urcelay, GP | 1 |
| Andreatini, R; Baretta, IP; Chioca, LR; Ferreira, J; Ferro, MM; Losso, EM; Oliveira, SM; Silva, CR | 1 |
| Chapman, GW; Hasselmo, ME; Monaghan, CK | 1 |
50 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and diazepam
| Article | Year |
|---|---|
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 1989 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles | 2005 |
7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Ligands; Male; Mice; Molecular Structure; Motor Activity; Purines; Rats; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Swimming | 2007 |
The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.
Topics: Animals; Body Temperature; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Imides; Ligands; Lip; Maze Learning; Mice; Molecular Structure; Motor Activity; Piperazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin; Stereoisomerism; Structure-Activity Relationship; Swimming | 2007 |
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives.
Topics: Animals; Antidepressive Agents; Body Temperature; Cerebral Cortex; Imidazoles; Male; Mice; Molecular Structure; Motor Activity; Piperazines; Protein Binding; Purines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Theophylline | 2009 |
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Mice; Purines; Receptor, Serotonin, 5-HT1A; Structure-Activity Relationship | 2015 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
Topics: Animals; Central Nervous System Stimulants; Chemistry, Pharmaceutical; Dopamine; Drug Discovery; Hallucinogens; Humans; Illicit Drugs; Norepinephrine; Phenethylamines; Psychotropic Drugs; Receptors, Serotonin; Serotonin | 2017 |
Anticonflict action of tandospirone in a modified Geller-Seifter conflict test in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Operant; Conflict, Psychological; Diazepam; Electroshock; Flumazenil; Isoindoles; Male; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes | 1992 |
Interaction of GABA and serotonin in the anxiolytic action of diazepam and serotonergic anxiolytics.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Diazepam; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1992 |
Differential modulation of extracellular levels of 5-hydroxytryptamine in the rat frontal cortex by (R)- and (S)-zacopride.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Buspirone; Diazepam; Dose-Response Relationship, Drug; Frontal Lobe; Hydroxyindoleacetic Acid; Male; Ondansetron; Rats; Serotonin; Serotonin Antagonists; Stereoisomerism | 1992 |
Autoradiographic localization and pharmacological characterization of [3H]tandospirone binding sites in the rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Autoradiography; Benzodiazepines; Binding Sites; Brain; Diazepam; In Vitro Techniques; Isoindoles; Male; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Serotonin; Tetrahydronaphthalenes | 1991 |
The effects of umespirone as a potential anxiolytic and antipsychotic agent.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Buspirone; Callithrix; Clozapine; Diazepam; Dopamine; Female; Interpersonal Relations; Limbic System; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Drug; Substance Withdrawal Syndrome; Tetrahydronaphthalenes | 1991 |
Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Conditioning, Operant; Diazepam; Dioxins; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Reaction Time; Serotonin Antagonists; Spiro Compounds; Tetrahydronaphthalenes | 1990 |
Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Body Temperature Regulation; Buspirone; Diazepam; Ergolines; Fenclonine; Fever; Flumazenil; Imidazoles; Male; Mice; Ondansetron; Piperazines; Piperidines; Ritanserin; Serotonin; Serotonin Antagonists; Stress, Psychological; Tetrahydronaphthalenes | 1990 |
8-OH-DPAT specifically enhances feeding behaviour in mice: evidence from behavioural competition.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Avoidance Learning; Competitive Behavior; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Feeding Behavior; Imidazoles; Male; Mice; Mice, Inbred DBA; Naphthalenes; Ondansetron; Social Behavior; Tetrahydronaphthalenes | 1990 |
Effect of 5-HT1A agonists on stress-induced deficit in open field locomotor activity of rats: evidence that this model identifies anxiolytic-like activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Desipramine; Diazepam; Male; Models, Biological; Motor Activity; Pyrazoles; Rats; Receptors, Serotonin; Stress, Psychological; Tetrahydronaphthalenes | 1989 |
Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Buspirone; Cattle; Depression, Chemical; Diazepam; Flunitrazepam; In Vitro Techniques; Lorazepam; Pyrimidines; Receptors, Serotonin; Tetrahydronaphthalenes | 1985 |
The profiles of interaction of yohimbine with anxiolytic and putative anxiolytic agents to modify 5-HT release in the frontal cortex of freely-moving rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Clonidine; Dialysis; Diazepam; Drug Interactions; Extracellular Space; Frontal Lobe; Hydroxyindoleacetic Acid; Male; Ondansetron; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Yohimbine | 1993 |
Effects of atypical antipsychotic agents on social behavior in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Catalepsy; Chlorpromazine; Clozapine; Diazepam; Haloperidol; Isoxazoles; Male; Mice; Mice, Inbred Strains; Piperidines; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Social Behavior | 1993 |
Neonatal damage to neocortex abolishes the anxiolytic action of diazepam in adult rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Anxiety; Cerebral Cortex; Diazepam; Female; Male; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Serotonin; Ultrasonics; Vocalization, Animal | 1995 |
[Assessment of anxiolytics (2)--An elevated plus-maze test].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Diazepam; Drug Evaluation, Preclinical; Male; Maze Learning; Mice; Mice, Inbred ICR; Rats; Serotonin | 1995 |
Discriminative stimulus properties of diazepam and the novel anxiolytic agent 1-amino-5-bromouracil in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Bromouracil; Clonidine; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Generalization, Stimulus; Imipramine; Male; Rats; Rats, Wistar | 1994 |
Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Ondansetron; Piperazines; Posture; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists | 1994 |
Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two-compartment black and white text box.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anxiety Disorders; Buspirone; Chlordiazepoxide; Darkness; Diazepam; Disease Models, Animal; Exploratory Behavior; Fenfluramine; Light; Male; Mice; Penbutolol; Propanolamines; Pyrimidines; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists | 1995 |
Effects of chronic diazepam treatment on pre- and postsynaptic 5-HT1A receptors in the rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Anti-Anxiety Agents; Autoradiography; Brain; Buspirone; Diazepam; Hippocampus; Male; Neurons; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1997 |
In vivo administration of the 5-HT1A receptor agonist 8-OH-DPAT interferes with brain GABA(A)/benzodiazepine receptor complexes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Chlorides; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Synaptosomes | 1997 |
Behavioural and pharmacological characterisation of the canopy stretched attend posture test as a model of anxiety in mice and rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Diazepam; Drug Evaluation, Preclinical; Male; Mice; Posture; Rats; Rats, Sprague-Dawley | 1997 |
Modification of the anxiolytic action of 5-HT1A compounds by GABA-benzodiazepine agents in rats.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Bicuculline; Buspirone; Diazepam; Drug Interactions; Flumazenil; GABA Agonists; Male; Psychomotor Performance; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1 | 1998 |
Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Autoradiography; Binding, Competitive; Brain Chemistry; Buspirone; Diazepam; Exploratory Behavior; Genotype; Hydroxyindoleacetic Acid; Male; Maze Learning; Mice; Mice, Knockout; Mice, Mutant Strains; Mice, Transgenic; Neural Cell Adhesion Molecules; Potassium Channels; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Spatial Behavior | 1999 |
The allocentric place discrimination task is selectively and highly dependent on the central muscarinic system in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Diazepam; Discrimination Learning; Dizocilpine Maleate; Flumazenil; Male; Mecamylamine; Ondansetron; Rats; Rats, Inbred F344; Receptors, Muscarinic; Scopolamine; Swimming | 2000 |
Inhibitory effect of buspirone and diazepam, but not of 8-OH-DPAT, on maternal behavior and aggression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Anti-Anxiety Agents; Body Temperature; Buspirone; Diazepam; Dose-Response Relationship, Drug; Female; Lactation; Male; Maternal Behavior; Motor Activity; Rats; Rats, Wistar; Serotonin Receptor Agonists | 2000 |
The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolyt
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Ataxia; Conflict, Psychological; Dialysis; Diazepam; Dose-Response Relationship, Drug; Hippocampus; Interpersonal Relations; Male; Motor Activity; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2000 |
Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Corticosterone; Diazepam; Indoles; Isoindoles; Male; Mice; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Receptors, Neurokinin-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Stress, Physiological | 2001 |
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bromocriptine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Fear; Fluvoxamine; Haloperidol; Indophenol; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred ICR; Moclobemide; Motor Activity; Nicotine; Nicotinic Antagonists; Nortriptyline; Physostigmine; Picolinic Acids; Pyrrolidinones; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Stress, Psychological | 2001 |
Extended action of MKC-242, a selective 5-HT(1A) receptor agonist, on light-induced Per gene expression in the suprachiasmatic nucleus in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Cell Cycle Proteins; Circadian Rhythm; Diazepam; Dioxanes; Dioxoles; GABA Modulators; Gene Expression Regulation; In Situ Hybridization; Light; Male; Mice; Motor Activity; Nuclear Proteins; Paroxetine; Period Circadian Proteins; Piperazines; Pyridines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Suprachiasmatic Nucleus; Transcription Factors | 2002 |
Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Fenclonine; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Morphine; Pain Threshold; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Serotonin Agents; Serotonin Antagonists | 2003 |
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Female; gamma-Aminobutyric Acid; Handling, Psychological; Male; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 2003 |
Pharmacological characterization of MP349, a novel 5-HT1A-receptor antagonist with anxiolytic-like activity, in mice and rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Behavior, Animal; Body Temperature; Body Temperature Regulation; Diazepam; Male; Mice; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors | 2003 |
Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Motor Activity; Ovariectomy; Rats; Rats, Wistar; Reaction Time; Serotonin Receptor Agonists; Time Factors | 2006 |
Changes in emotional behavior of mice in the hole-board test after olfactory bulbectomy.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Diazepam; Dose-Response Relationship, Drug; Emotions; Exploratory Behavior; Head Movements; Male; Mice; Mice, Inbred ICR; Motor Activity; Olfaction Disorders; Olfactory Bulb; Piperazines; Reaction Time; Social Isolation; Zinc Sulfate | 2006 |
Susceptibility to the long-term anxiogenic effects of an acute stressor is mediated by the activation of the glucocorticoid receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anti-Anxiety Agents; Cocaine; Conditioning, Operant; Corticotropin-Releasing Hormone; Diazepam; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Hormone Antagonists; Hypothalamus; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mifepristone; Proto-Oncogene Proteins c-fos; Radioimmunoassay; Rats; Receptors, Glucocorticoid; RNA, Messenger; Serotonin Receptor Agonists; Stress, Psychological; Time Factors; Tyrosine 3-Monooxygenase | 2011 |
Comparison of the conditioned reinforcing properties of a safety signal and appetitive stimulus: effects of d-amphetamine and anxiolytics.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Conditioning, Classical; Conditioning, Operant; Dextroamphetamine; Diazepam; Food; Food Deprivation; Male; Rats; Reinforcement Schedule; Reward; Serotonin Receptor Agonists; Sucrose | 2013 |
Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA/benzodiazepine neurotransmission.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Inhalation; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Diazepam; Flunitrazepam; GABA-A Receptor Antagonists; Lavandula; Male; Mice; Motor Activity; Oils, Volatile; Picrotoxin; Piperazines; Plant Oils; Pyridines; Rats; Receptors, GABA-A; Serotonin Antagonists; Serotonin Receptor Agonists; Serotonin Syndrome; Synaptic Transmission | 2013 |
Systemic administration of two different anxiolytic drugs decreases local field potential theta frequency in the medial entorhinal cortex without affecting grid cell firing fields.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Cortical Excitability; Diazepam; Entorhinal Cortex; Grid Cells; Rats; Rats, Long-Evans; Serotonin Receptor Agonists; Theta Rhythm | 2017 |