Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin

8-hydroxy-2-(di-n-propylamino)tetralin and colforsin

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with colforsin in 70 studies

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-19909 (12.86)18.7374
1990's40 (57.14)18.2507
2000's20 (28.57)29.6817
2010's1 (1.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Heller, PH; Levine, JD; Taiwo, YO1
Iben, L; Meller, E; Yocca, FD1
Bohmaker, K; Chalfin, M; Meller, E1
Newman-Tancredi, A; Strange, PG; Wootton, R1
Liau, LM; Peroutka, SJ; Pitha, J; Sleight, AJ1
Ben-Zeev, A; Lerer, B; Newman, ME1
Osborne, NN1
Bosch, AI; de Kloet, ER; Molewijk, HE; Schipper, J; Sijbesma, H1
Arvidsson, LE; Cornfield, LJ; Hacksell, U; Lambert, G; Mellin, C; Nelson, DL; Vallgårda, J1
Clarke, WP; Maayani, S1
Harrington, MA; Peroutka, SJ; Slaughter, JL1
Nomura, Y; Okada, F; Tokumitsu, Y1
Aono, H; Baba, A; Iwata, H; Kanda, T; Matsuda, T; Saito, K; Seong, YH; Tobe, A1
Cornfield, LJ; Martin, AR; Nelson, DL; Taylor, EW1
Bockaert, J; Dumuis, A; Sebben, M1
Devivo, M; Maayani, S1
De Vivo, M; Maayani, S1
Oksenberg, D; Peroutka, SJ1
Bockaert, J; Bouhelal, R; Smounya, L1
Harrington, MA; Oksenberg, D; Peroutka, SJ1
Billecocq, A; Bolaños-Jiménez, F; Fillion, G; Hedlund, PB1
Baba, A; Kawai, N; Moroji, T; Yamamoto, H; Yamamoto, T1
Katsuki, H; Kawahara, F; Saito, H1
Ciaranello, RD; Harrington, MA; Shaw, K; Zhong, P1
Adrien, J; Fattaccini, CM; Gozlan, H; Haj-Dahmane, S; Jolas, T; Kidd, EJ; Lanfumey, L; Langlois, X; Laporte, AM; Vantalon, V1
Cadogan, AK; Kendall, DA; Marsden, CA1
Bockaert, J; Harris, B; Jouin, P; Le Nguyen, D; McClue, S; Varrault, A1
Bansse, MT; Stam, NJ; van Huizen, F1
Allgeier, A; Czernilofsky, A; Dumont, JE; Maenhaut, C; Massart, C; Van Sande, J; Vassart, G1
Leysen, JE; Pauwels, PJ; Van Gompel, P1
Rabin, RA; Winter, JC1
Ikeda, M; Mikuni, M; Saitoh, K; Takahashi, K; Tomita, U; Yamazaki, C1
Endo, K; Hori, Y; Takahashi, T1
Colpaert, FC; Pauwels, PJ1
Gutierrez, M; Lübbert, H; Schoeffter, P; Ullmer, C; Weitz-Schmidt, G1
Dietrich, C; Kilbinger, H1
Cowen, DS; Manning, DR; Sowers, RS1
Lima, L; Schmeer, C; Urbina, M1
Hall, DA; Strange, PG1
Ardenghi, P; Bevilaqua, L; Bianchin, M; Bromberg, E; Izquierdo, I; Medina, JH; Quevedo, J; Schaeffer, E; Schmitz, PK; Schröder, N; Walz, R2
Anmela, MC; Gardier, AM; Jacquot, C; Langlois, M; Malagié, I; Mathé-Allainmat, M; Trillat, AC1
Kimura, T; Kontani, T; Mase, T; Naito, R; Nomura, T; Tsukamoto, S; Wanibuchi, F; Yamaguchi, T; Yamashita, H; Yasunaga, T1
Assié, MB; Carilla-Durand, E; Colpaert, FC; Cosi, C; Dupont-Passelaigue, E; John, G; Kleven, MS; Koek, W; Palmier, C; Patoiseau, JF; Pauwels, PJ; Tarayre, JP; Valentin, JP1
Arias, A; Camacho, A; Carmena, MJ; Garcia-López, E; Montalvo, L; Prieto, JC; Solano, RM1
Assié, MB; Bonnaud, B; Cosi, C; Funes, P; Jubault, N; Koek, W; Vacher, B1
Borsini, F; Cassano, GB; Giannaccini, G; Giromella, A; Lucacchini, A; Marazziti, D; Mazzoni, MR; Naccarato, AG; Palego, L1
Azmitia, EC; Nishi, M1
Assié, MB; Cosi, C; Koek, W1
Bigazzi, F; Borsini, F; Cassano, GB; Giannaccini, G; Giromella, A; Lucacchini, A; Marazziti, D; Mazzoni, MR; Naccarato, AG; Palego, L1
Jackson, A; Maswood, S; Uphouse, L1
Dremencov, E; Gur, E; Lerer, B; Newman, ME1
Lambert, HW; Lauder, JM; Weiss, ER1
Holden-Dye, L; Lockyer, M; Trim, JE; Walker, RJ; Willson, J1
Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J1
Beneytez, ME; Benhamu, B; Caicoya, AG; Delgado, M; Fuentes, JA; López-Rodríguez, ML; Manzanares, J; Morcillo, MJ; Pozo, MA; Rubia, FJ1
Assié, MB; Colpaert, FC; Cosi, C; Koek, W; Patoiseau, JF; Pauwels, PJ; Vacher, B1
Gean, PW; Huang, YC; Lin, CH; Tsai, JJ1
Subhash, MN; Vinod, KY1
Borsini, F; Cassano, GB; Giromella, A; Lucacchini, A; Marazziti, D; Mayer, N; Mazzoni, MR; Naccarato, AG; Palego, L1
Saifullah, AS; Tomioka, K1
Morales, M; Oz, M; Rotondo, A; Sun, H; Zhang, L1
Lisinicchia, JG; Watts, VJ1
Carreira, I; Lima, L; Mizrahi, C; Stojanovic, A; Urbina, M1
Benhamú, B; Caicoya, AG; Delgado, M; Fernández-Alfonso, MS; Fuentes, JA; Greciano, V; López-Rodríguez, ML; Manzanares, J; Pozo, MA1
Majumdar, D; Peterson-Ford, A; Uphouse, L1
Dilks, DW; Dunlop, J; Khawaja, XZ; Nawoschik, SP; Olsen, M; Schechter, LE; Smith, DL; Zhang, J1
Lee, HM; Prosser, RA; Wehner, A1
Chen, L; Li, X; Salinas, GD1
Gong, WG; Ren, QG; Wang, YJ; Xu, L; Zhang, ZJ; Zhou, QD1

Other Studies

70 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and colforsin

ArticleYear
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
    Neuroscience, 1992, Volume: 48, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes

1992
Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes.
    Molecular pharmacology, 1992, Volume: 41, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Animals; Colforsin; Hippocampus; Male; Membranes; Quinolines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Stimulation, Chemical; Substrate Specificity; Synapses; Tetrahydronaphthalenes; Tryptamines

1992
Serotonin 5-HT1A receptor-mediated hypothermia in mice: absence of spare receptors and rapid induction of tolerance.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Body Temperature; Colforsin; Drug Tolerance; Fenclonine; Hypothermia; Male; Mice; Pindolol; Piperazines; Quinolines; Receptors, Serotonin; Serotonin

1992
High-level stable expression of recombinant 5-HT1A 5-hydroxytryptamine receptors in Chinese hamster ovary cells.
    The Biochemical journal, 1992, Aug-01, Volume: 285 ( Pt 3)

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Binding, Competitive; Blotting, Northern; Cattle; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Gene Expression; Guanosine Triphosphate; Hippocampus; Humans; Receptors, Serotonin; Recombinant Proteins; Tetrahydronaphthalenes; Transfection

1992
Characterization of a novel and potent 5-hydroxytryptamine1A receptor antagonist.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Behavior, Animal; Colforsin; Drug Interactions; Male; Molecular Structure; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Serotonin Antagonists; Tetrahydronaphthalenes

1991
Chloroamphetamine did not prevent the effects of chronic antidepressants on 5-hydroxytryptamine inhibition of forskolin-stimulated adenylate cyclase in rat hippocampus.
    European journal of pharmacology, 1991, Jul-12, Volume: 207, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Antidepressive Agents; Binding Sites; Cerebral Cortex; Chlorides; Colforsin; Hippocampus; Imipramine; Lithium; Lithium Chloride; Male; p-Chloroamphetamine; Paroxetine; Piperidines; Rats; Serotonin; Synapses; Tetrahydronaphthalenes

1991
Effects of GTP, forskolin, sodium fluoride, serotonin, dopamine, and carbachol on adenylate cyclase in Teleost retina.
    Neurochemical research, 1990, Volume: 15, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Atropine; Carbachol; Colforsin; Cyclic AMP; Dopamine; Drug Synergism; Fishes; GTP-Binding Proteins; Guanosine Triphosphate; Pertussis Toxin; Retina; Serotonin; Sodium Fluoride; Tetrahydronaphthalenes; Virulence Factors, Bordetella

1990
8-hydroxy-2-(di-N-propylamino)tetralin increases the activity of adenylate cyclase in the hippocampus of freely-moving rats.
    Neuropharmacology, 1991, Volume: 30, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Behavior, Animal; Colforsin; Cyclic AMP; Dialysis; Hippocampus; Male; Norepinephrine; Radioimmunoassay; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes

1991
Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase.
    Molecular pharmacology, 1991, Volume: 39, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Colforsin; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes

1991
Estrogen effects on 5-HT1A receptors in hippocampal membranes from ovariectomized rats: functional and binding studies.
    Brain research, 1990, Jun-04, Volume: 518, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Drug Implants; Estradiol; Female; Guanylyl Imidodiphosphate; Hippocampus; Kinetics; Ovariectomy; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes

1990
6-substituted tricyclic partial ergoline compounds are selective and potent 5-hydroxytryptamine1A receptor agents.
    Life sciences, 1990, Volume: 47, Issue:15

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Binding, Competitive; Cattle; Cerebral Cortex; Colforsin; Ergolines; Rats; Receptors, Neurotransmitter; Receptors, Serotonin; Swine; Tetrahydronaphthalenes

1990
Pertussis toxin attenuates 5-hydroxytryptamine1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes.
    Journal of neurochemistry, 1989, Volume: 52, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Buspirone; Cell Membrane; Colforsin; GTP-Binding Proteins; Hippocampus; Male; Membrane Proteins; Molecular Weight; Pertussis Toxin; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes; Virulence Factors, Bordetella

1989
Agonist activity of a novel compound, 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (BP-554), at central 5-HT1A receptors.
    European journal of pharmacology, 1989, Oct-24, Volume: 170, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Amines; Animals; Body Temperature; Brain Chemistry; Chromatography, High Pressure Liquid; Colforsin; Corticosterone; Kinetics; Male; Mice; Mice, Inbred Strains; Piperazines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes

1989
MDL 73005EF: partial agonist at the 5-HT1A receptor negatively linked to adenylate cyclase.
    European journal of pharmacology, 1989, Dec-07, Volume: 173, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Animals; Buspirone; Colforsin; Cyclic AMP; Dioxins; Hippocampus; In Vitro Techniques; Male; Membranes; Pindolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiro Compounds; Tetrahydronaphthalenes; Tryptamines

1989
Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture.
    Molecular pharmacology, 1988, Volume: 33, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Ergolines; Hippocampus; Mice; Neurons; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes; Tryptamines; Vasoactive Intestinal Peptide

1988
Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists.
    European journal of pharmacology, 1985, Dec-17, Volume: 119, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes

1985
Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Buspirone; Colforsin; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Indoles; Lisuride; Mathematics; Pyrimidines; Rats; Receptors, Serotonin; Tetrahydronaphthalenes

1986
Antagonism of 5-hydroxytryptamine1A (5-HT1A) receptor-mediated modulation of adenylate cyclase activity by pindolol and propranolol isomers.
    Biochemical pharmacology, 1988, Sep-15, Volume: 37, Issue:18

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Colforsin; GTP-Binding Proteins; Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Pindolol; Propranolol; Rats; Receptors, Serotonin; Serotonin Antagonists; Stereoisomerism; Tetrahydronaphthalenes

1988
5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra.
    European journal of pharmacology, 1988, Jul-07, Volume: 151, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Substantia Nigra; Tetrahydronaphthalenes; Tissue Distribution

1988
5-Hydroxytryptamine1A receptors are linked to a Gi-adenylate cyclase complex in rat hippocampus.
    European journal of pharmacology, 1988, Sep-01, Volume: 154, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Colforsin; GTP-Binding Proteins; Hippocampus; In Vitro Techniques; Pertussis Toxin; Potassium Channels; Rats; Receptors, Serotonin; Tetrahydronaphthalenes; Virulence Factors, Bordetella

1988
Characterization of galanin and 5-HT1A receptor coupling to adenylyl cyclase in discrete regions of the rat brain.
    European journal of pharmacology, 1994, Oct-14, Volume: 269, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain; Brain Chemistry; Colforsin; Entorhinal Cortex; Galanin; Hippocampus; Hypothalamus; In Vitro Techniques; Male; Neuropeptides; Peptide Fragments; Peptides; Rats; Rats, Wistar; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Receptors, Serotonin; Second Messenger Systems; Serotonin

1994
Inhibitory effect of idazoxan on forskolin-stimulated adenylate cyclase activity through 5-hydroxytryptamine1A receptors.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Animals; Colforsin; Dioxanes; Hippocampus; Idazoxan; In Vitro Techniques; Male; Membranes; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Serotonin

1994
Inhibition by 5-HT7 receptor stimulation of GABAA receptor-activated current in cultured rat suprachiasmatic neurones.
    The Journal of physiology, 1994, Jul-01, Volume: 478 ( Pt 1)

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Membrane Potentials; Neurons; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Serotonin; Ritanserin; Serotonin; Suprachiasmatic Nucleus

1994
Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Arachidonic Acid; Binding Sites; Calcium; Colforsin; Enzyme Activation; HeLa Cells; Humans; Ligands; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Quinacrine; Receptors, Serotonin; Serotonin; Tetradecanoylphorbol Acetate

1994
Central pre- and postsynaptic 5-HT1A receptors in rats treated chronically with a novel antidepressant, cericlamine.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Antidepressive Agents; Binding Sites; Catecholamines; Colforsin; Dopamine; Electrophysiology; Enzyme Activation; Hippocampus; Male; Neurons; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Synapses

1994
Serotonin 5-HT1A receptor activation increases cyclic AMP formation in the rat hippocampus in vivo.
    Journal of neurochemistry, 1994, Volume: 62, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Colforsin; Cyclic AMP; Hippocampus; Kinetics; Male; Microdialysis; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Time Factors

1994
5-Hydroxytryptamine1A receptor synthetic peptides. Mechanisms of adenylyl cyclase inhibition.
    The Journal of biological chemistry, 1994, Jun-17, Volume: 269, Issue:24

    Topics: 3T3 Cells; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Clone Cells; Colforsin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hippocampus; Humans; Kinetics; Male; Mice; Molecular Sequence Data; Moths; Peptide Fragments; Pertussis Toxin; Protein Structure, Secondary; Rats; Rats, Wistar; Receptors, Serotonin; Virulence Factors, Bordetella

1994
Agonist-induced down-regulation of human 5-HT1A and 5-HT2 receptors in Swiss 3T3 cells.
    Neuroreport, 1993, Sep-30, Volume: 4, Issue:12

    Topics: 3T3 Cells; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Colforsin; Cyclic AMP; Down-Regulation; Humans; Hydrolysis; Ketanserin; Kinetics; Mice; Mice, Inbred Strains; Pertussis Toxin; Phosphatidylinositols; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Virulence Factors, Bordetella

1993
The human and dog 5-HT1D receptors can both activate and inhibit adenylate cyclase in transfected cells.
    European journal of pharmacology, 1993, Oct-15, Volume: 247, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenal Glands; Animals; Base Sequence; Cells, Cultured; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Dogs; Enzyme Activation; Humans; Molecular Sequence Data; Pertussis Toxin; Proteins; Receptors, Serotonin; Serotonin; Sumatriptan; Transfection; Virulence Factors, Bordetella

1993
Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells.
    Biochemical pharmacology, 1993, Jan-26, Volume: 45, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Colforsin; Cyclic AMP; HeLa Cells; Humans; Indoles; Lysergic Acid Diethylamide; Models, Biological; Pindolol; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Transfection

1993
Studies of the biochemical basis for the discriminative properties of 8-hydroxy-2-(di-n-propylamino)tetralin.
    European journal of pharmacology, 1993, Apr-28, Volume: 235, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Colforsin; Hippocampus; In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

1993
Serotonin-induced 5-HT1A receptor desensitization in C6BU-1 glioma cells transfected with 5-HT1A receptor gene.
    Neuroscience letters, 1995, Oct-27, Volume: 199, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Neoplasms; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Glioma; Rats; Receptors, Serotonin; Serotonin; Time Factors

1995
Long-lasting synaptic facilitation induced by serotonin in superficial dorsal horn neurones of the rat spinal cord.
    The Journal of physiology, 1996, May-01, Volume: 492 ( Pt 3)

    Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Colforsin; Electrophysiology; Naphthalenes; Neurons; Patch-Clamp Techniques; Phorbol Esters; Protein Kinase C; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Spinal Cord; Synapses; Tetrodotoxin

1996
Stereoselectivity of 8-OH-DPAT enantiomers at cloned human 5-HT1D receptor sites.
    European journal of pharmacology, 1996, Apr-04, Volume: 300, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Line; Colforsin; Cyclic AMP; Humans; Neuroglia; Rats; Receptors, Serotonin; Stereoisomerism; Sumatriptan; Transfection

1996
Functional serotonin 5-HT1D receptors and 5-HT1D beta receptor mRNA expression in human umbilical vein endothelial cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Humans; Polymerase Chain Reaction; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Umbilical Veins

1995
5-HT1A receptor-mediated inhibition of acetylcholine release from guinea pig myenteric plexus: potential mechanisms.
    Neuropharmacology, 1996, Volume: 35, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Adenylate Cyclase Toxin; Animals; Colforsin; Cyclic AMP; Enzyme Activation; Female; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Naphthyridines; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphodiesterase Inhibitors; Protein Kinase C; Receptors, Serotonin; Serotonin Receptor Agonists; Signal Transduction; Virulence Factors, Bordetella

1996
Activation of a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of phosphatidylinositol 3-kinase, but to an inhibitor of phosphatidylcholine hydrolysis.
    The Journal of biological chemistry, 1996, Sep-13, Volume: 271, Issue:37

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Androstadienes; Animals; Bridged-Ring Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrolysis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Norbornanes; Pertussis Toxin; Phosphatidylcholines; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiocarbamates; Thiones; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin

1996
5HT1A receptor agonist differentially increases cyclic AMP concentration in intact and lesioned goldfish retina. In vitro inhibition of outgrowth by forskolin.
    Neurochemistry international, 1996, Volume: 29, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dopamine Antagonists; Goldfish; Nerve Crush; Nerve Regeneration; Optic Nerve; Piperazines; Retina; Serotonin Antagonists; Serotonin Receptor Agonists

1996
Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors.
    British journal of pharmacology, 1997, Volume: 121, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Butaclamol; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine Agonists; Receptors, Dopamine D2

1997
Agents that affect cAMP levels or protein kinase A activity modulate memory consolidation when injected into rat hippocampus but not amygdala.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1997, Volume: 30, Issue:8

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Benzazepines; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Hippocampus; Male; Memory; Norepinephrine; Rats; Rats, Wistar; Signal Transduction

1997
Effects of WAY 100635 and (-)-5-Me-8-OH-DPAT, a novel 5-HT1A receptor antagonist, on 8-OH-DPAT responses.
    European journal of pharmacology, 1998, Apr-17, Volume: 347, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Body Temperature; Colforsin; Cyclic AMP; Drug Interactions; Female; Hippocampus; Male; Mice; Microdialysis; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stereoisomerism; Stimulation, Chemical

1998
Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists.
    Journal of medicinal chemistry, 1998, Jul-16, Volume: 41, Issue:15

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Behavior, Animal; CHO Cells; Chromones; Colforsin; Cricetinae; Dioxoles; Drug Evaluation, Preclinical; Electrophysiology; Humans; In Vitro Techniques; Male; Neurons; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship

1998
F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-1 Receptor Antagonists; Animals; Anti-Anxiety Agents; Antidepressive Agents; Colforsin; Columbidae; Conflict, Psychological; Corticosterone; Cyclic AMP; Dopamine Antagonists; HeLa Cells; Humans; Male; Microdialysis; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Triazines

1998
5-hydroxytryptamine1A receptor-mediated effects on adenylate cyclase and nitric oxide synthase activities in rat ventral prostate.
    Cellular signalling, 1998, Volume: 10, Issue:8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Colforsin; In Vitro Techniques; Male; Nitric Oxide Synthase; Prostate; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Signal Transduction; Vasoactive Intestinal Peptide

1998
Drugs acting upon the cyclic adenosine monophosphate/protein kinase A signalling pathway modulate memory consolidation when given late after training into rat hippocampus but not amygdala.
    Behavioural pharmacology, 1997, Volume: 8, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Amygdala; Animals; Avoidance Learning; Benzazepines; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine Agonists; Dopamine Antagonists; Hippocampus; Indoles; Male; Memory; Norepinephrine; Piperazines; Pyrroles; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Dopamine D1; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction; Time Factors; Timolol

1997
Design and synthesis of a series of 6-substituted-2-pyridinylmethylamine derivatives as novel, high-affinity, selective agonists at 5-HT1A receptors.
    Journal of medicinal chemistry, 1998, Dec-03, Volume: 41, Issue:25

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Azetidines; Cell Line; Colforsin; Cyclic AMP; Drug Design; HeLa Cells; Humans; Methylamines; Mice; Oxazoles; Pyridines; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Structure-Activity Relationship

1998
Effects of postmortem delay on serotonin and (+)8-OH-DPAT-mediated inhibition of adenylyl cyclase activity in rat and human brain tissues.
    Brain research, 1999, Jan-16, Volume: 816, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Age Factors; Aged; Animals; Brain; Cerebral Cortex; Colforsin; Female; Frontal Lobe; Hippocampus; Humans; Male; Middle Aged; Postmortem Changes; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reproducibility of Results; Serotonin; Serotonin Receptor Agonists; Time Factors

1999
Agonist- and antagonist-induced plasticity of rat 5-HT1A receptor in hippocampal cell culture.
    Synapse (New York, N.Y.), 1999, Mar-01, Volume: 31, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cells, Cultured; Colforsin; Cyclic AMP Response Element-Binding Protein; Hippocampus; In Situ Hybridization; Nerve Tissue Proteins; Neuronal Plasticity; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; RNA, Messenger; Serotonin Antagonists; Serotonin Receptor Agonists

1999
Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity.
    European journal of pharmacology, 1999, Dec-10, Volume: 386, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Colforsin; GTP-Binding Protein alpha Subunits, Gi-Go; Guanylyl Imidodiphosphate; HeLa Cells; Hippocampus; Humans; In Vitro Techniques; Male; Membranes; Pertussis Toxin; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Virulence Factors, Bordetella

1999
Lack of stereoselectivity of 8-hydroxy-2(di-N-propylamino)tetralin-mediated inhibition of forskolin-stimulated adenylyl cyclase activity in human pre- and post-synaptic brain regions.
    Neurochemistry international, 2000, Volume: 36, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adult; Aged; Aged, 80 and over; Brain; Colforsin; Enzyme Inhibitors; Female; Hippocampus; Humans; Male; Middle Aged; Prefrontal Cortex; Presynaptic Terminals; Serotonin Receptor Agonists; Stereoisomerism; Synapses

2000
Factors elevating cAMP attenuate the effects of 8-OH-DPAT on lordosis behavior.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bucladesine; Colforsin; Cyclic AMP; Estradiol; Female; Ovariectomy; Posture; Proestrus; Progesterone; Rats; Rats, Inbred F344; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Sexual Behavior, Animal; Ventromedial Hypothalamic Nucleus

2000
Functional effects of corticosterone on 5-HT(1A) and 5-HT(1B) receptor activity in rat brain: in vivo microdialysis studies.
    European journal of pharmacology, 2001, Jan-05, Volume: 411, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Inflammatory Agents; Brain; Colforsin; Corticosterone; Cyclic AMP; Hippocampus; Hypothalamus; Male; Microdialysis; Oxadiazoles; Piperazines; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

2001
Activation of 5-HT receptors that stimulate the adenylyl cyclase pathway positively regulates IGF-I in cultured craniofacial mesenchymal cells.
    Developmental neuroscience, 2001, Volume: 23, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Insulin-Like Growth Factor I; Mandible; Mesoderm; Mice; Phosphodiesterase Inhibitors; Phosphorylation; Promoter Regions, Genetic; Receptors, Serotonin; Serotonin Receptor Agonists; Thionucleotides

2001
Characterization of 5-HT receptors in the parasitic nematode, Ascaris suum.
    Parasitology, 2001, Volume: 122, Issue:Pt 2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Ascaris; Cerebral Cortex; Colforsin; Cyclic AMP; Female; Inositol Phosphates; Male; Muscles; Pharynx; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

2001
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
    Journal of neurochemistry, 2001, Volume: 77, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine

2001
Biochemical, electrophysiological and neurohormonal studies with B-20991, a selective 5-HT1A receptor agonist.
    Pharmacology, 2001, Volume: 62, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Body Temperature; Buspirone; Colforsin; Corticosterone; Cyclic AMP; Dendrites; Dose-Response Relationship, Drug; Electrophysiology; HeLa Cells; Humans; Imidazoles; Male; Mice; Neurons; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

2001
5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential.
    European journal of pharmacology, 2001, May-25, Volume: 420, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Antidepressive Agents; Binding, Competitive; Buspirone; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Male; Motor Activity; Piperazines; Piperidines; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming

2001
Modulation of voltage-dependent calcium currents by serotonin in acutely isolated rat amygdala neurons.
    Synapse (New York, N.Y.), 2001, Sep-15, Volume: 41, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylate Cyclase Toxin; Adenylyl Cyclases; Amygdala; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Colforsin; Cyclic AMP; Enzyme Inhibitors; Ethylmaleimide; GTP-Binding Proteins; In Vitro Techniques; Isoproterenol; Male; Membrane Potentials; Neurons; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Pertussis Toxin; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sympathomimetics; Thionucleotides; Virulence Factors, Bordetella

2001
Lamotrigine induced selective changes in 5-HT(1A) receptor mediated response in rat brain.
    Neurochemistry international, 2002, Volume: 40, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Colforsin; Cyclic AMP; Down-Regulation; Frontal Lobe; Hippocampus; Lamotrigine; Male; Nerve Tissue Proteins; Organ Specificity; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Second Messenger Systems; Serotonin Receptor Agonists; Triazines

2002
Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain.
    The international journal of neuropsychopharmacology, 2002, Volume: 5, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aged; Aged, 80 and over; Benzimidazoles; Binding, Competitive; Brain; Buspirone; Colforsin; Dose-Response Relationship, Drug; Female; Hippocampus; Humans; Male; Middle Aged; Piperazines; Prefrontal Cortex; Raphe Nuclei; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists

2002
5-HT(7)-like receptors mediate serotonergic modulation of photo-responsiveness of the medulla bilateral neurons in the cricket, Gryllus bimaculatus.
    Zoological science, 2003, Volume: 20, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Colforsin; Dose-Response Relationship, Drug; Electrophysiology; Gryllidae; Ketanserin; Light; Neurons; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Visual Pathways

2003
Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors.
    Synapse (New York, N.Y.), 2003, Dec-15, Volume: 50, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Chelating Agents; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine Diphosphate; Haloperidol; Humans; Indazoles; Inhibitory Concentration 50; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pertussis Toxin; Piperazine; Piperazines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT2; Receptors, Serotonin, 5-HT3; Recombinant Proteins; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Thionucleotides; Tropanes; Xenopus laevis

2003
Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors.
    Cellular signalling, 2003, Volume: 15, Issue:12

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Arachidonic Acid; Buspirone; Calcimycin; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Flavonoids; Humans; Indoles; Indomethacin; Maleimides; Pertussis Toxin; Phorbol Esters; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Time Factors; Tryptamines

2003
Differential cAMP levels and serotonin effects in blood peripheral mononuclear cells and lymphocytes from major depression patients.
    International immunopharmacology, 2004, Volume: 4, Issue:8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Colforsin; Cyclic AMP; Depressive Disorder, Major; Female; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lymphocytes; Male; Middle Aged; Norepinephrine; Piperazines; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists

2004
Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.
    European journal of pharmacology, 2005, Mar-21, Volume: 511, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Anti-Anxiety Agents; Behavior, Animal; Binding, Competitive; Body Temperature Regulation; Bradycardia; Colforsin; Dopamine; Dose-Response Relationship, Drug; Guinea Pigs; HeLa Cells; Humans; Hydroxyindoleacetic Acid; Hypothalamus; Ileum; In Vitro Techniques; Male; Membrane Potentials; Mice; Motor Activity; Muscle Contraction; Neurons; Piperazines; Pyrazines; Radioligand Assay; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Receptor Agonists; Social Behavior; Transfection

2005
8-OH-DPAT attenuates isoproterenol- but not forskolin-stimulated accumulation of cAMP in mediobasal hypothalamus.
    Brain research, 2006, Feb-23, Volume: 1075, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Colforsin; Cyclic AMP; Female; Hypothalamus; In Vitro Techniques; Isoproterenol; Rats; Rats, Inbred F344

2006
WAY-100635 antagonist-induced plasticity of 5-HT receptors: regulatory differences between a stable cell line and an in vivo native system.
    Journal of neurochemistry, 2006, Volume: 98, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Brain Mapping; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Humans; Male; Neuronal Plasticity; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium

2006
Serotonergic pre-treatments block in vitro serotonergic phase shifts of the mouse suprachiasmatic nucleus circadian clock.
    Neuroscience, 2006, Oct-13, Volume: 142, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Circadian Rhythm; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; In Vitro Techniques; Male; Mice; Neurons; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Suprachiasmatic Nucleus; Time Factors; Tryptophan

2006
Regulation of serotonin 1B receptor by glycogen synthase kinase-3.
    Molecular pharmacology, 2009, Volume: 76, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Benzazepines; Cell Line; CHO Cells; Cholera Toxin; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Glycogen Synthase Kinase 3; Humans; Indoles; Male; Maleimides; Mice; Mice, Inbred BALB C; Oxadiazoles; Oximes; Piperidines; Piperidones; Protein Kinase Inhibitors; Purines; Pyridines; Receptor, Serotonin, 5-HT1B; Roscovitine; Serotonin; Spiro Compounds

2009
Escitalopram Ameliorates Forskolin-Induced Tau Hyperphosphorylation in HEK239/tau441 Cells.
    Journal of molecular neuroscience : MN, 2015, Volume: 56, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Citalopram; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Humans; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Selective Serotonin Reuptake Inhibitors; tau Proteins

2015