8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with clozapine in 65 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.08) | 18.7374 |
| 1990's | 20 (30.77) | 18.2507 |
| 2000's | 29 (44.62) | 29.6817 |
| 2010's | 12 (18.46) | 24.3611 |
| 2020's | 2 (3.08) | 2.80 |
| Authors | Studies |
|---|---|
| Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP | 1 |
| Bull, D; den Daas, I; Foord, S; Goodson, S; Kilpatrick, G; Lee, M; Rees, S | 1 |
| Hamblin, MW; Jose, PA; Metcalf, MA; Monsma, FJ; Shen, Y; Sibley, DR | 1 |
| Amlaiky, N; Hen, R; Plassat, JL | 1 |
| Arrang, JM; Diaz, J; Leurs, R; Ruat, M; Schwartz, JC; Tardivel-Lacombe, J; Traiffort, E | 1 |
| Brown, AM; Collin, LL; Ellis, CE; Forbes, IT; Gittins, SA; Gloger, I; Hagan, J; Middlemiss, DN; Riley, G; Thomas, DR | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Grabtree, GW; Grailhe, R; Hen, R | 1 |
| Bach, T; Krobert, KA; Kvingedal, AM; Levy, FO; Syversveen, T | 1 |
| Berardi, F; Colabufo, NA; De Giorgio, P; Lacivita, E; Leopoldo, M; Perrone, R; Tortorella, V | 1 |
| Glennon, RA | 1 |
| Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D | 1 |
| Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO | 1 |
| Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
| Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S | 1 |
| Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L | 1 |
| Bienkowski, P; Bucki, A; Jaśkowska, J; Kazek, G; Kowalski, P; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Mitka, K; Pawłowski, M; Siwek, A; Wasik, A; Wesołowska, A | 1 |
| Bojarski, AJ; Bucki, A; Chłoń-Rzepa, G; Jastrzębska-Więsek, M; Kołaczkowski, M; Partyka, A; Satała, G; Wasik, A; Wesołowska, A | 1 |
| Bienkowski, P; Bucki, A; Jastrzębska-Więsek, M; Kazek, G; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Siwek, A; Śniecikowska, J; Wasik, A; Wesołowska, A | 1 |
| Harding, WW; Madapa, S | 1 |
| Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E | 1 |
| Andres-Mach, M; Bączek, T; Belka, M; Czuczwar, SJ; Gomółka, AE; Herold, F; Jastrzębska-Więsek, M; Nowak, G; Partyka, A; Siwek, A; Stefanowicz, J; Słowiński, T; Turło, J; Ulenberg, S; Wesołowska, A; Wróbel, MZ; Zagaja, M; Żołnierek, M; Łuszczki, JJ | 1 |
| Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E | 1 |
| Bączek, T; Belka, M; Bojarski, A; Herold, F; Kleps, J; Kozioł, AE; Król, M; Nowak, G; Siwek, A; Ślifirski, G; Stachowicz, K; Szewczyk, B; Turło, J; Ulenberg, S | 1 |
| Alberts, I; Harding, WW; Juarez, R; Karki, A; Namballa, HK | 1 |
| Alberts, I; Harding, WW; Karki, A; Namballa, HK | 1 |
| Mason, SL; Reynolds, GP | 1 |
| Barnes, NM; Costall, B; Domeney, AM; Gerrard, PA; Kelly, ME; Krähling, H; Naylor, RJ; Tomkins, DM; Williams, TJ | 1 |
| Gudelsky, GA; Meltzer, HY; Nash, JF | 1 |
| Czyrak, A; Frankiewicz, T; Maj, J; Rogóz, Z; Skuza, G | 1 |
| Conway, PC; Corbett, R; Dunn, RW; Hartman, H; Helsley, GC; Kerman, LL; Strupczewski, JT; Woods, AT | 1 |
| Arbaoui, J; Chagraoui, A; Mocaër, E; Protais, P | 1 |
| Cools, AR; Ellenbroek, BA; Prinssen, EP | 1 |
| Taubes, G | 1 |
| Chaput, C; Millan, MJ; Newman-Tancredi, A; Verriele, L | 1 |
| Burnet, PW; Chen, CP; Franklin, M; Harrison, PJ; McGowan, S | 1 |
| Bartoszyk, GD; Roos, C; Ziegler, H | 1 |
| Nakajima, S; Patterson, RL | 1 |
| Gervais, J; Rouillard, C; Tremblay, PO | 1 |
| Barnes, NM; Stowe, RL | 1 |
| Kulkarni, SK; Ninan, I | 1 |
| Ichikawa, J; Meltzer, HY | 1 |
| Hillefors, M; von Euler, G | 1 |
| Koch, T; Korf, J; Kuipers, SD; Sebens, JB; Ter Horst, GJ | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| Gainetdinov, RR; Grekhova, TV; Rayevsky, KS; Sotnikova, TD | 1 |
| Colpaert, FC; Pauwels, PJ; Tardif, S; Wurch, T | 1 |
| Honda, M; Ono, H | 1 |
| Dai, J; Ichikawa, J; Meltzer, HY | 1 |
| Bijak, M; Tokarski, K; Zahorodna, A | 1 |
| Inoue, T; Itoh, S; Morimoto, T; Ogawa, S; Saito, M; Wakisaka, S | 1 |
| Saifullah, AS; Tomioka, K | 1 |
| Baker, LE; Meltzer, HY; Prus, AJ | 1 |
| Hou, Y; Huang, M; Wu, CF; Yang, JY | 1 |
| Asgari, K; Body, S; Bradshaw, CM; Rickard, JF; Szabadi, E; Zhang, Z | 1 |
| De Bernardi, F; Groppelli, S; Pennati, R; Sotgia, C; Zega, G | 1 |
| Bruins Slot, LA; Kleven, MS; Newman-Tancredi, A | 1 |
| Hochman, S; Machacek, DW; Sawchuk, M; Shay, BL | 1 |
| Centurión, D; Gupta, S; MaassenVanDenBrink, A; Mehotra, S; Sánchez-López, A; Villalón, CM | 1 |
| Assié, MB; Carilla-Durand, E; Cosi, C; Leduc, N; Maraval, M; Newman-Tancredi, A; Ormiere, AM | 1 |
| Bogeski, M; Gogos, A; van den Buuse, M | 1 |
| Auclair, AL; Barret-Grévoz, C; Barreto, M; Depoortère, R; Kleven, MS; Newman-Tancredi, A | 1 |
| Bruins Slot, LA; Cussac, D; Grevoz-Barret, C; Lestienne, F; Newman-Tancredi, A | 1 |
| Chen, YW; Lai, WS | 1 |
| Baroni, S; Betti, L; Castagna, M; Catena-Dell'Osso, M; Dell'Osso, L; Giannaccini, G; Luccachini, A; Marazziti, D; Naccarato, AG; Palego, L | 1 |
1 review(s) available for 8-hydroxy-2-(di-n-propylamino)tetralin and clozapine
| Article | Year |
|---|---|
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
64 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and clozapine
| Article | Year |
|---|---|
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 1989 |
Cloning and characterisation of the human 5-HT5A serotonin receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; Genome, Human; GTP-Binding Proteins; Humans; Mice; Molecular Sequence Data; Radioligand Assay; Receptors, Serotonin; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Serotonin; Tissue Distribution; Transfection | 1994 |
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Cell Line; Cell Membrane; Cloning, Molecular; Cyclic AMP; Gene Expression; Kidney Tubules, Proximal; Lysergic Acid Diethylamide; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Radioligand Assay; Rats; Receptors, Serotonin; Recombinant Proteins; Serotonin; Transfection | 1993 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; CHO Cells; Cricetinae; Cyclic AMP; DNA; Genomic Library; Kinetics; Lysergic Acid Diethylamide; Mianserin; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Organ Specificity; Rats; Receptors, Serotonin; Restriction Mapping; Serotonin; Serotonin Receptor Agonists; Transfection | 1993 |
Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719.
Topics: Adenylyl Cyclases; Cell Line; Cloning, Molecular; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Piperidines; Protein Binding; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Sulfonamides | 1998 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Cell Line; COS Cells; DNA; Evolution, Molecular; Gene Expression; Genes; Humans; Membranes; Mice; Molecular Sequence Data; Phylogeny; Radioligand Assay; Receptors, Serotonin; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 2001 |
The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution.
Topics: Adenylyl Cyclases; Alternative Splicing; Binding, Competitive; Brain; Cell Line; Cloning, Organism; Genetic Variation; Humans; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tissue Distribution | 2001 |
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.
Topics: Animals; Benzamides; Benzofurans; Cell Line; Cerebral Cortex; Hippocampus; Humans; In Vitro Techniques; Ligands; Piperazines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship | 2002 |
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2004 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles | 2005 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides | 2014 |
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Mice; Purines; Receptor, Serotonin, 5-HT1A; Structure-Activity Relationship | 2015 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming | 2015 |
Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.
Topics: Aporphines; Ligands; Molecular Structure; Receptors, Serotonin; Structure-Activity Relationship | 2015 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
Synthesis and biological investigation of new equatorial (β) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile.
Topics: Animals; Antipsychotic Agents; Benzene Derivatives; Dopamine D2 Receptor Antagonists; Male; Mice; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Serotonin 5-HT2 Receptor Antagonists; Stereoisomerism; Structure-Activity Relationship; Tropanes | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT
Topics: Animals; Chemistry Techniques, Synthetic; Drug Design; Ligands; Mice; Pyrimidines; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Tryptamines | 2019 |
Identification of C10 nitrogen-containing aporphines with dopamine D
Topics: Aporphines; Dopamine Agonists; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Receptors, Dopamine D1; Receptors, Dopamine D5; Structure-Activity Relationship | 2020 |
Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT
Topics: Aporphines; Cell Line; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship | 2020 |
Clozapine has sub-micromolar affinity for 5-HT1A receptors in human brain tissue.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Brain; Clozapine; Humans; In Vitro Techniques; Receptors, Serotonin | 1992 |
The effects of umespirone as a potential anxiolytic and antipsychotic agent.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Buspirone; Callithrix; Clozapine; Diazepam; Dopamine; Female; Interpersonal Relations; Limbic System; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Drug; Substance Withdrawal Syndrome; Tetrahydronaphthalenes | 1991 |
Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Body Temperature; Butyrophenones; Chlorpromazine; Clozapine; Corticosterone; Haloperidol; Male; Neurosecretory Systems; Pyrazines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1988 |
Pharmacological action of zotepine and other antipsychotics on central 5-hydroxytryptamine receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Body Temperature; Clozapine; Dibenzothiepins; Exploratory Behavior; Haloperidol; Isoxazoles; Male; Mice; Motor Activity; Piperazines; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Risperidone; Serotonin Antagonists; Serotonin Receptor Agonists | 1994 |
Effects of atypical antipsychotic agents on social behavior in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Catalepsy; Chlorpromazine; Clozapine; Diazepam; Haloperidol; Isoxazoles; Male; Mice; Mice, Inbred Strains; Piperidines; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Social Behavior | 1993 |
Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Benzamides; Benzazepines; Catalepsy; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Grooming; Male; Mice; Piperazines; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Stereotyped Behavior | 1994 |
The role of serotonin receptor subtypes in the behavioural effects of neuroleptic drugs. A paw test study in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Behavior, Animal; Clozapine; Haloperidol; Ketanserin; Male; Rats; Rats, Wistar; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists | 1994 |
Will new dopamine receptors offer a key to schizophrenia?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Brain; Clozapine; Dopamine Antagonists; Humans; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Schizophrenia | 1994 |
Clozapine is a partial agonist at cloned, human serotonin 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; CHO Cells; Clozapine; Cricetinae; Dose-Response Relationship, Drug; Haloperidol; Humans; Kinetics; Receptors, Serotonin | 1996 |
The effects of clozapine and haloperidol on serotonin-1A, -2A and -2C receptor gene expression and serotonin metabolism in the rat forebrain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Cerebral Cortex; Clozapine; Corpus Striatum; Haloperidol; Hippocampus; Hydroxyindoleacetic Acid; In Situ Hybridization; Ketanserin; Male; Organ Specificity; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reference Values; RNA, Messenger; Serotonin; Transcription, Genetic; Tritium | 1996 |
5-HT1A receptors are not involved in clozapine's lack of cataleptogenic potential.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Catalepsy; Clozapine; Haloperidol; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Ultrasonics; Vocalization, Animal | 1996 |
The involvement of dopamine D2 receptors, but not D3 or D4 receptors, in the rewarding effect of brain stimulation in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Reward; Salicylamides; Self Stimulation | 1997 |
Modification of haloperidol-induced pattern of c-fos expression by serotonin agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
Selective labelling of 5-HT7 receptor recognition sites in rat brain using [3H]5-carboxamidotryptamine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Brain; Clozapine; Indoles; Kinetics; Male; Pindolol; Piperazines; Pyridines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Recombinant Proteins; Serotonin; Sulfonamides; Tritium | 1998 |
Quinpirole, 8-OH-DPAT and ketanserin modulate catalepsy induced by high doses of atypical antipsychotics.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Benzodiazepines; Catalepsy; Clozapine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Imidazoles; Indoles; Ketanserin; Male; Mice; Mice, Inbred BALB C; Olanzapine; Pirenzepine; Quinpirole; Random Allocation; Rats; Rats, Wistar; Risperidone; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Species Specificity | 1999 |
The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dopamine; Fluorobenzenes; Haloperidol; Male; Microdialysis; Nucleus Accumbens; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Risperidone; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium | 2000 |
Pharmacology of [3H]R(+)-7-OH-DPAT binding in the rat caudate-putamen.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Binding, Competitive; Caudate Nucleus; Clozapine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Guanidines; Guanosine Triphosphate; Haloperidol; Heterotrimeric GTP-Binding Proteins; Indans; Kinetics; Magnesium; Male; Oxazines; Protein Binding; Putamen; Quinpirole; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Remoxipride; Sodium; Specific Pathogen-Free Organisms; Sulfones; Sulpiride; Tetrahydronaphthalenes | 2001 |
Limited participation of 5-HT(1A) and 5-HT(2A/2C) receptors in the clozapine-induced Fos-protein expression in rat forebrain regions.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Clozapine; Corticosterone; Immunohistochemistry; Male; Oncogene Proteins v-fos; Prosencephalon; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 2000 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Microdialysis; Rats; Rats, Wistar; Receptors, Dopamine D3; Spiperone; Tetrahydronaphthalenes | 2001 |
Real-time analysis of dopamine: antagonist interactions at recombinant human D2long receptor upon modulation of its activation state.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alternative Splicing; Animals; Binding, Competitive; Butaclamol; Calcium; CHO Cells; Clozapine; Cricetinae; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Genotype; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Lisuride; Mutation; Plasmids; Receptors, Dopamine; Receptors, Dopamine D2; Recombinant Proteins; Sulfur Radioisotopes; Time Factors | 2001 |
No involvement of 5-HT(7) or 5-HT(1D) receptors in the (R)-8-OH-DPAT-induced depression of the monosynaptic reflex in spinalized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Decerebrate State; Dose-Response Relationship, Drug; Ergolines; Indoles; Male; Methiothepin; Oxadiazoles; Phenols; Piperazines; Pyridines; Rats; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Reflex, Monosynaptic; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Time Factors | 2001 |
5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Clozapine; Corpus Striatum; Dopamine Antagonists; Fluorobenzenes; Haloperidol; Indophenol; Male; Microdialysis; Nucleus Accumbens; Piperazines; Piperidines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2002 |
Imipramine but not 5-HT(1A) receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT(1A) and 5-HT(4) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Antidepressive Agents; Antipsychotic Agents; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Clozapine; Haloperidol; Hippocampus; Imipramine; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Involvement of 5-HT7 receptors in serotonergic effects on spike afterpotentials in presumed jaw-closing motoneurons of rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Alkaloids; Animals; Benzophenanthridines; Brain Stem; Calcium; Clozapine; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Inhibitors; Isoquinolines; Jaw; Membrane Potentials; Motor Neurons; Phenanthridines; Pindolol; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides | 2002 |
5-HT(7)-like receptors mediate serotonergic modulation of photo-responsiveness of the medulla bilateral neurons in the cricket, Gryllus bimaculatus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Colforsin; Dose-Response Relationship, Drug; Electrophysiology; Gryllidae; Ketanserin; Light; Neurons; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Visual Pathways | 2003 |
Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Butyrophenones; Clozapine; Discrimination, Psychological; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Fluorobenzenes; Generalization, Stimulus; Haloperidol; Male; Muscarinic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Trihexyphenidyl | 2004 |
Effects of clozapine, olanzapine and haloperidol on ethanol-induced ascorbic acid release in mouse striatum.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Ascorbic Acid; Benzodiazepines; Brain Chemistry; Central Nervous System Depressants; Clozapine; Dialysis; Ethanol; Haloperidol; Male; Mice; Neostriatum; Olanzapine; Serotonin Receptor Agonists | 2005 |
Comparison of the effects of clozapine and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on progressive ratio schedule performance: evidence against the involvement of 5-HT1A receptors in the behavioural effects of clozapine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Clozapine; Conditioning, Operant; Female; Psychopharmacology; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT1; Reinforcement Schedule; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2005 |
Dopamine and serotonin modulate the onset of metamorphosis in the ascidian Phallusia mammillata.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Clozapine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Fluorescent Antibody Technique; Histological Techniques; Immunohistochemistry; Larva; Lisuride; Metamorphosis, Biological; Methyltyrosines; Piperazines; Pyridines; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction; Urochordata | 2005 |
Effects of novel antipsychotics with mixed D(2) antagonist/5-HT(1A) agonist properties on PCP-induced social interaction deficits in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Dioxanes; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Interpersonal Relations; Male; Phencyclidine; Piperazines; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Remoxipride; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Tropanes | 2005 |
Serotonin 5-HT2 receptors induce a long-lasting facilitation of spinal reflexes independent of ionotropic receptor activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Animals, Newborn; Clozapine; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Female; Ganglia, Spinal; Immunohistochemistry; In Vitro Techniques; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT2; Reflex; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Time Factors | 2005 |
Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Buspirone; Clozapine; Decerebrate State; Dose-Response Relationship, Drug; Drug Interactions; Ergotamine; Heart Rate; Ketanserin; Lisuride; Male; Metergoline; Methiothepin; Methysergide; Phenylephrine; Piperazines; Pizotyline; Prazosin; Pyridines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Serotonin Receptor Agonists; Yohimbine | 2006 |
Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antipsychotic Agents; Aripiprazole; Benzoxazoles; Binding, Competitive; Cell Line; Clozapine; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Male; Piperazines; Prolactin; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Spodoptera; Sulfur Radioisotopes; Tropanes | 2006 |
Role of serotonin-1A receptors in the action of antipsychotic drugs: comparison of prepulse inhibition studies in mice and rats and relevance for human pharmacology.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Haloperidol; Inhibition, Psychological; Male; Mice; Mice, Inbred Strains; Olanzapine; Piperazines; Quinolones; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Reflex, Startle; Risperidone; Serotonin Receptor Agonists; Species Specificity | 2008 |
Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Benzamides; Benzodiazepines; Benzoxazoles; Catalepsy; Clozapine; Dibenzothiazepines; Dioxanes; Dopamine Antagonists; Female; Haloperidol; Macaca fascicularis; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Remoxipride; Risperidone; Serotonin Receptor Agonists; Thiazoles; Tropanes; Video Recording | 2009 |
F15063, a potential antipsychotic with dopamine D(2)/D(3) receptor antagonist and 5-HT(1A) receptor agonist properties: influence on immediate-early gene expression in rat prefrontal cortex and striatum.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Benzofurans; Benzylamines; Clozapine; Cyclopentanes; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Gene Expression Regulation; Genes, Immediate-Early; Haloperidol; Male; Mitogen-Activated Protein Kinase 3; Neostriatum; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine; Receptors, Dopamine D3; RNA, Messenger; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Time Factors | 2009 |
Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Antipsychotic Agents; Auditory Cortex; Clozapine; Dendrites; Fear; Female; Glycogen Synthase Kinase 3; Indoles; Male; Maleimides; Maze Learning; Mice; Mice, Knockout; Motor Activity; Phenotype; Proto-Oncogene Proteins c-akt; Pyramidal Cells; Raclopride; Reflex, Startle; Sex Factors | 2011 |
Clozapine effects on adenylyl cyclase activity and serotonin type 1A receptors in human brain post-mortem.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aged; Antipsychotic Agents; Brain; Clozapine; Cyclic AMP; Female; Humans; Male; Receptor, Serotonin, 5-HT1A | 2014 |