8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with bmy 7378 in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.78) | 18.7374 |
| 1990's | 27 (75.00) | 18.2507 |
| 2000's | 4 (11.11) | 29.6817 |
| 2010's | 4 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carrupt, PA; Gaillard, P; Schambel, P; Testa, B | 1 |
| Bolognesi, ML; Budriesi, R; Cavalli, A; Chiarini, A; Gotti, R; Leonardi, A; Melchiorre, C; Minarini, A; Poggesi, E; Recanatini, M; Rosini, M; Tumiatti, V | 1 |
| Barlocco, D; Cignarella, G; De Benedetti, PG; Fanelli, F; Leonardi, A; Montesano, F; Motta, G; Poggesi, E; Seeber, M; Testa, R | 1 |
| Amantini, C; Carrieri, A; Del Bello, F; Farande, Y; Giannella, M; Leonardi, A; Lucciarini, R; Piergentili, A; Pigini, M; Poggesi, E; Quaglia, W; Rafaiani, G; Santoni, G | 1 |
| Angeli, P; Baraldi, A; Brasili, L; Buccioni, M; Cilia, A; Fossa, P; Franchini, S; Poggesi, E; Prandi, A; Sorbi, C; Tait, A | 1 |
| Baraldi, A; Brasili, L; Buccioni, M; Cichero, E; Cilia, A; Fossa, P; Franchini, S; Marucci, G; Pirona, L; Prandi, A; Sorbi, C; Tait, A | 1 |
| Brasili, L; Buccioni, M; Cichero, E; Cilia, A; Fossa, P; Franchini, S; Manasieva, LI; Marucci, G; Pirona, L; Prandi, A | 1 |
| Amantini, C; Bonifazi, A; Del Bello, F; Farande, Y; Farfariello, V; Giannella, M; Leonardi, A; Menegon, S; Nabissi, M; Piergentili, A; Pigini, M; Poggesi, E; Quaglia, W; Santoni, G | 1 |
| Brightwell, CI; Cliffe, IA; Fletcher, A; Forster, EA; Mansell, HL; Reilly, Y; Routledge, C; White, AC | 1 |
| Bohmaker, K; Chalfin, M; Meller, E | 1 |
| Buisson-Defferier, S; Van den Buuse, M | 1 |
| Allen, T; Grahame-Smith, DG; Grasby, PM; Sharp, T | 1 |
| Barrett, JE; Gleeson, S | 1 |
| Ahlers, ST; Barrett, JE; Weissman, BA | 1 |
| Glaser, T; Greuel, JM | 1 |
| Elliott, PJ; Higgins, GA | 1 |
| Moser, PC | 1 |
| Connor, HE; Feniuk, W; Stubbs, CM | 1 |
| Hjorth, S | 1 |
| Laubie, M; Mennecier, P; Verbeuren, TJ | 1 |
| Canton, H; Laubie, M; Lavielle, G; Lejeune, F; Millan, MJ; Rivet, JM | 1 |
| Bohmaker, K; Goldstein, M; Meller, E | 1 |
| Backus, LI; Bramwell, SR; Grahame-Smith, DG; Hjorth, S; Sharp, T | 1 |
| Lucot, JB | 1 |
| Chaput, Y; de Montigny, C | 1 |
| Iben, LG; Mahle, CD; Yocca, FD | 1 |
| Fornal, CA; Jacobs, BL; Marrosu, F; Metzler, CW; Tada, K | 1 |
| Fozard, JR; Hoyer, D; McQuade, R; Sharp, T | 1 |
| Dourish, CT; Gurling, J; Routledge, C; Wright, IK | 1 |
| Cox, RF; Meller, E; Waszczak, BL | 1 |
| Francisco, T; Mendelson, SD; Quartermain, D; Shemer, A | 1 |
| Canton, H; Gobert, A; Le Marouille-Girardon, S; Millan, MJ; Rivet, JM | 1 |
| Fornal, CA; Jacobs, BL; Marrosu, F; Metzler, CW | 1 |
| Christ, G; Kaynan, A; Maayani, S; Melman, A; Rehman, J; Valcic, M | 1 |
| Gannon, RL | 1 |
| Gannon, RL; Lungwitz, E | 1 |
36 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and bmy 7378
| Article | Year |
|---|---|
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; CHO Cells; Cloning, Molecular; Cricetinae; Dioxanes; HeLa Cells; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spleen; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1999 |
Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Binding Sites; CHO Cells; Cricetinae; Guinea Pigs; HeLa Cells; Humans; Imides; In Vitro Techniques; Ligands; Male; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Protein Structure, Tertiary; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-1; Sequence Alignment; Serotonin 5-HT1 Receptor Antagonists; Spiro Compounds; Structure-Activity Relationship | 2004 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel alpha1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents.
Topics: Adrenergic alpha-1 Receptor Antagonists; Benzene; Cell Line, Tumor; Cell Survival; Dioxanes; Ethylamines; Humans; Models, Molecular; Molecular Structure; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-1; Serotonin Receptor Agonists; Structure-Activity Relationship | 2008 |
Discovery of a new series of 5-HT1A receptor agonists.
Topics: Drug Discovery; Serotonin 5-HT1 Receptor Agonists | 2010 |
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Dioxolanes; Humans; Imides; Lactams; Ligands; Male; Models, Molecular; Protein Binding; Protein Conformation; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-1; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2010 |
Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors.
Topics: Animals; Aorta, Thoracic; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclopentanes; Drug Partial Agonism; Furans; HeLa Cells; Humans; In Vitro Techniques; Ligands; Male; Models, Molecular; Piperazines; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-1; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Spleen; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 2012 |
Structure-activity relationships in 1,4-benzodioxan-related compounds. 11. (1) reversed enantioselectivity of 1,4-dioxane derivatives in α1-adrenergic and 5-HT1A receptor binding sites recognition.
Topics: Binding Sites; Cell Line; Dioxanes; Humans; Magnetic Resonance Spectroscopy; Receptor, Serotonin, 5-HT1A; Receptors, Adrenergic, alpha-1; Receptors, Serotonin, 5-HT1; Stereoisomerism; Structure-Activity Relationship | 2013 |
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.
Topics: Animals; Binding Sites; Piperazines; Rats; Receptors, Serotonin; Serotonin Antagonists; Stereoisomerism; Synapses | 1993 |
Serotonin 5-HT1A receptor-mediated hypothermia in mice: absence of spare receptors and rapid induction of tolerance.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Body Temperature; Colforsin; Drug Tolerance; Fenclonine; Hypothermia; Male; Mice; Pindolol; Piperazines; Quinolines; Receptors, Serotonin; Serotonin | 1992 |
Cardiovascular effects of the 5-HT1A receptor ligand, MDL 73005EF, in conscious spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Buspirone; Dioxins; Heart Rate; Hypertension; Male; Pindolol; Piperazines; Rats; Rats, Inbred SHR; Receptors, Serotonin; Serotonin Receptor Agonists; Spiro Compounds; Vasodilator Agents | 1992 |
The putative 5-HT1A antagonist BMY 7378 blocks 8-OH-DPAT-induced changes in local cerebral glucose utilization in the conscious rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Blood Pressure; Body Temperature; Brain; Glucose; Male; Organ Specificity; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Reference Values; Serotonin Antagonists; Stereotyped Behavior | 1992 |
Discriminative stimulus effects of 8-OH-DPAT in pigeons: antagonism studies with the putative 5-HT1A receptor antagonists BMY 7378 and NAN-190.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Indoles; Pindolol; Piperazines; Prazosin; Serotonin Antagonists | 1992 |
Antagonism studies with BMY-7378 and NAN-190: effects on 8-hydroxy-2-(di-n-propylamino)tetralin-induced increases in punished responding of pigeons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Columbidae; Dose-Response Relationship, Drug; Drug Antagonism; Midazolam; Piperazines; Radioligand Assay; Serotonin Antagonists; Tetrahydronaphthalenes | 1992 |
The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electrophysiology; In Vitro Techniques; Male; Piperazines; Propranolol; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin Antagonists; Tetrahydronaphthalenes | 1992 |
Differential behavioural activation following intra-raphe infusion of 5-HT1A receptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Behavior, Animal; Dose-Response Relationship, Drug; Male; Motor Activity; Piperazines; Posture; Pyrimidines; Raphe Nuclei; Rats; Receptors, Serotonin; Tetrahydronaphthalenes | 1991 |
The effect of putative 5-HT1A receptor antagonists on 8-OH-DPAT-induced hypothermia in rats and mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Dioxanes; Dose-Response Relationship, Drug; Hypothermia, Induced; Male; Mice; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1991 |
BMY 7378 is an agonist at 5-HT1A receptors mediating hypotension and renal sympatho-inhibition in anaesthetised cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Cats; Female; Heart Rate; Kidney; Male; Piperazines; Receptors, Serotonin; Spiperone; Sympathetic Nervous System; Sympatholytics; Tetrahydronaphthalenes | 1991 |
Single-dose 8-OH-DPAT pretreatment does not induce tachyphylaxis to the 5-HT release-reducing effect of 5-HT1A autoreceptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding Sites; Feedback; Hippocampus; Male; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tachyphylaxis; Tetrahydronaphthalenes | 1991 |
5-Hydroxytryptamine-induced vasodilatation in the isolated perfused rat kidney: are endothelial 5-HT1A receptors involved?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Angiotensin II; Animals; Atrial Natriuretic Factor; Endothelium, Vascular; Kidney; Male; Nitroglycerin; Papaverine; Piperazines; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes; Thiophenes; Vasodilation | 1991 |
S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alprenolol; Animals; Behavior, Animal; Binding, Competitive; Dose-Response Relationship, Drug; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes; Thiophenes | 1991 |
Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Cerebral Cortex; Hippocampus; Male; Piperazines; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1990 |
Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Apomorphine; Brain Chemistry; Dialysis; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Male; Motor Activity; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Stereotyped Behavior; Tetrahydronaphthalenes | 1990 |
Effects of serotonin antagonists on motion sickness and its suppression by 8-OH-DPAT in cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cats; Dose-Response Relationship, Drug; Ergolines; Female; Metergoline; Motion Sickness; Piperazines; Propranolol; Serotonin Antagonists; Stereoisomerism; Tetrahydronaphthalenes | 1990 |
Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electric Stimulation; Electrophysiology; Indoles; Male; Methiothepin; Norepinephrine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Synaptic Transmission; Tetrahydronaphthalenes | 1988 |
Differential sensitivity of 3H-agonist binding to pre- and postsynaptic 5-HT1A receptors in bovine brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Cattle; Guanylyl Imidodiphosphate; Hippocampus; In Vitro Techniques; Kinetics; Piperazines; Radioligand Assay; Raphe Nuclei; Rats; Receptors, Presynaptic; Receptors, Serotonin; Serotonin Receptor Agonists | 1994 |
Effects of the putative 5-hydroxytryptamine1A antagonists BMY 7378, NAN 190 and (-)-propranolol on serotonergic dorsal raphe unit activity in behaving cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cats; Female; Male; Neurons; Piperazines; Propranolol; Raphe Nuclei; Serotonin; Serotonin Antagonists | 1994 |
The novel 5-HT1A receptor antagonist, SDZ 216-525, decreases 5-HT release in rat hippocampus in vivo.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Dialysis; Electrophysiology; GTP-Binding Proteins; Hippocampus; Indoles; Male; Neurons; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Thiazoles | 1993 |
Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: an in vivo microdialysis study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dopamine; Hippocampus; Injections, Subcutaneous; Male; Microdialysis; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Stereoisomerism | 1993 |
Electrophysiological evidence for a large receptor reserve for inhibition of dorsal raphe neuronal firing by 5-HT1A agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electrophysiology; Extracellular Space; Male; Microelectrodes; Neurons; Piperazines; Pyrimidines; Quinolines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
5-HT1A receptor agonists induce anterograde amnesia in mice through a postsynaptic mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amnesia; Amphetamine; Animals; Avoidance Learning; Drug Administration Schedule; Injections, Subcutaneous; Isoindoles; Male; Mice; Piperazines; Pyrimidines; Receptors, Serotonin; Serotonin Receptor Agonists | 1993 |
Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature Regulation; Corticosterone; Hypothermia; Male; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
5-HT1A agonists induce hippocampal theta activity in freely moving cats: role of presynaptic 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Analysis of Variance; Animals; Cats; Electroencephalography; Hippocampus; Male; Movement; Neurons; Piperazines; Pyrimidines; Receptors, Serotonin; Serotonin Receptor Agonists; Sleep, REM; Theta Rhythm | 1996 |
Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Buspirone; Copulation; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Penile Erection; Penis; Piperazines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex; Serotonin; Serotonin Receptor Agonists; Spiperone | 1999 |
Serotonergic serotonin (1A) mixed agonists/antagonists elicit large-magnitude phase shifts in hamster circadian wheel-running rhythms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Circadian Rhythm; Cricetinae; Dioxins; Dose-Response Relationship, Drug; Drug Combinations; Male; Motor Activity; Photoperiod; Piperazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Suprachiasmatic Nucleus | 2003 |
Serotonin1A-mediated amplification of light-induced phase advances of circadian rhythms in the Syrian hamster: post-light effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Circadian Rhythm; Cricetinae; Light; Mesocricetus; Motor Activity; Piperazines; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists | 2009 |