Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin

8-hydroxy-2-(di-n-propylamino)tetralin and 5-hydroxy-2-n,n-dipropylaminotetralin

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with 5-hydroxy-2-n,n-dipropylaminotetralin in 29 studies

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (20.69)	18.7374
1990's	12 (41.38)	18.2507
2000's	7 (24.14)	29.6817
2010's	4 (13.79)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andersson, B; Carlsson, A; Elebring, T; Hallnemo, G; Rollema, H; Svensson, K; Wikström, H	1
Arvidsson, LE; Carlsson, A; Hacksell, U; Hjorth, S; Lindberg, P; Nilsson, JL; Sanchez, D; Wikstrom, H	1
Arvidsson, LE; Carlsson, A; Hacksell, U; Hjorth, S; Johansson, A; Lindberg, P; Nilsson, JL; Sanchez, D; Wikström, H	1
Boije, M; Carlsson, A; Duncan, JN; Ekman, A; King, LJ; Martin, IJ; Romero, AG; Sonesson, C; Svensson, K; Wikström, H	1
Freeman, HS; McDermed, JD; McKenzie, GM	1
Hjorth, S; Tao, R	1
Andén, NE; Björk, L; Hacksell, U; Karlsson, A; Pettersson, C	1
Arvidsson, LE; Hacksell, U; Johansson, AM; Karlén, A; Kenne, L	1
Dyck, LE	1
Corbin, AE; Glase, SA; Heffner, TG; Pugsley, TA; Wise, LD	1
Hacksell, U; Johansson, AM; Malmberg, A; Mohell, N; Nordvall, G	1
Burnet, PW; Eastwood, SL; Harrison, PJ	1
Lima, L; Schmeer, C; Urbina, M	1
Barros, DM; de Souza, MM; Izquierdo, I; Izquierdo, LA; Medina, JH; Mello e Souza, T	1
Hećimović, H; Kelly, JS	1
Audinot, V; Cussac, D; Dubuffet, T; Lavielle, G; Loutz, A; Millan, MJ; Newman-Tancredi, A	1
Chattopadhyay, A; Harikumar, KG	1
Christian, BT; Mukherjee, J; Narayanan, TK; Shi, B; Yang, ZY	2
Dijkstra, D; Rodenhuis, N; Timmerman, W; Wikström, HV	1
Christian, BT; Dunigan, KA; Mantil, J; Mukherjee, J; Narayanan, TK; Shi, B	1
Bouwstra, JA; Danhof, M; Dijkstra, D; Li, L; Nugroho, AK; Wikström, H	1
Bouwstra, JA; Danhof, M; de Vries, JB; Della-Pasqua, O; Dijkstra, D; Nugroho, AK; Romeijn, SG; Wikström, H; Zwier, R	1
Naumenko, VS; Plyusnina, IZ; Popova, NK	1
Calderón-Rosete, G; Flores, G; Rodríguez-Sosa, L	1
Ackaert, OW; Bouwstra, JA; Danhof, M; De Graan, J; Dijkstra, D; Van Smeden, J	1
Ackaert, OW; Bouwstra, JA; Capancioni, R; Danhof, M; De Graan, J; Della Pasqua, OE; Dijkstra, D; Westerink, BH	1
Ackaert, OW; Bouwstra, JA; Danhof, M; De Graan, J; Dijkstra, D; Pasqua, OE; Shi, S; Vreeken, R; Westerink, BH	1
Burke, RE; Cebrián, C; Cheng, HC; Gershon, M; Hernandez, D; Kholodilov, N; Mosharov, EV; Setlik, W; Sulzer, D; Tang, G; Torres, CA; Yarygina, O	1

Other Studies

29 other study(ies) available for 8-hydroxy-2-(di-n-propylamino)tetralin and 5-hydroxy-2-n,n-dipropylaminotetralin

Article	Year
Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. Journal of medicinal chemistry, 1988, Volume: 31, Issue:6 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Catechol O-Methyltransferase; Hydroxylation; Male; Methylation; Naphthalenes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Tetrahydronaphthalenes	1988
8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. Journal of medicinal chemistry, 1981, Volume: 24, Issue:8 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Molecular Conformation; Naphthalenes; Rats; Receptors, Serotonin; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes	1981
Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. Journal of medicinal chemistry, 1982, Volume: 25, Issue:8 Topics: 5-Hydroxytryptophan; Animals; Brain Chemistry; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; In Vitro Techniques; Motor Activity; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin	1982
Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Behavior, Animal; Biological Availability; Biotransformation; Chemical Phenomena; Chemistry, Physical; Hydrocarbons, Fluorinated; Injections, Intravenous; Ligands; Liver; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes	1993
Synthesis and dopaminergic activity of (+/-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene. Journal of medicinal chemistry, 1976, Volume: 19, Issue:4 Topics: 2-Naphthylamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dogs; Dopamine; Humans; Naphthols; Rats; Stereoisomerism; Stereotyped Behavior; Structure-Activity Relationship; Vomiting	1976
Differences in the in vitro and in vivo 5-hydroxytryptamine extraction performance among three common microdialysis membranes. Journal of neurochemistry, 1992, Volume: 59, Issue:5 Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cellulose; Dialysis; Hippocampus; Hydroxyindoleacetic Acid; Male; Membranes, Artificial; Osmolar Concentration; Polymers; Potassium; Rats; Rats, Sprague-Dawley; Serotonin	1992
(R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): assessment of optical purities and dopaminergic activities. Chirality, 1990, Volume: 2, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dihydroxyphenylalanine; Dopamine Agents; In Vitro Techniques; Male; Naphthalenes; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Tetrahydronaphthalenes; Tyrosine 3-Monooxygenase	1990
Conformational analysis of the dopamine-receptor agonist 5-hydroxy-2-(dipropylamino)tetralin and its C(2)-methyl-substituted derivative. Journal of medicinal chemistry, 1986, Volume: 29, Issue:6 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Magnetic Resonance Spectroscopy; Molecular Conformation; Naphthalenes; Receptors, Dopamine; Structure-Activity Relationship; Tetrahydronaphthalenes	1986
Release of radiolabeled dopamine, p-tyramine, and m-tyramine from rat striatal slices by some aminotetralins. Neurochemical research, 1981, Volume: 6, Issue:4 Topics: 2-Naphthylamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Caudate Nucleus; Dopamine; In Vitro Techniques; Isomerism; Male; Naphthalenes; Rats; Tetrahydronaphthalenes; Tyramine	1981
Synthesis and dopaminergic activity of pyridine analogs of 5-hydroxy-2-(di-n-propylamino)tetralin. Journal of medicinal chemistry, 1995, Aug-04, Volume: 38, Issue:16 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; CHO Cells; Cricetinae; Dopamine Agents; Male; Mice; Motor Activity; Protein Binding; Pyridines; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Structure-Activity Relationship	1995
Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors. Molecular pharmacology, 1994, Volume: 46, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Computer Graphics; Humans; Methylation; Mice; Models, Molecular; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Tetrahydronaphthalenes	1994
5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1996, Volume: 15, Issue:5 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Animals; Antipsychotic Agents; Autoradiography; Binding Sites; Brain; Female; Haloperidol; Humans; Ketanserin; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Schizophrenia	1996
5HT1A receptor agonist differentially increases cyclic AMP concentration in intact and lesioned goldfish retina. In vitro inhibition of outgrowth by forskolin. Neurochemistry international, 1996, Volume: 29, Issue:5 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dopamine Antagonists; Goldfish; Nerve Crush; Nerve Regeneration; Optic Nerve; Piperazines; Retina; Serotonin Antagonists; Serotonin Receptor Agonists	1996
Short- and long-term memory are differentially regulated by monoaminergic systems in the rat brain. Neurobiology of learning and memory, 1998, Volume: 69, Issue:3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Avoidance Learning; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Entorhinal Cortex; Hippocampus; Male; Memory; Memory, Short-Term; Models, Neurological; Norepinephrine; Parietal Lobe; Piperazines; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Biogenic Amine; Receptors, Dopamine D1; Receptors, Serotonin; Serotonin Antagonists; Statistics, Nonparametric; Timolol	1998
Okadaic acid antagonizes the inhibitory action of internal GTP-gamma-S on the calcium current of dorsal raphe neurons but not that of 5-HT1A receptor activation. Annals of the New York Academy of Sciences, 1999, Apr-30, Volume: 868 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Barium; Calcium Channels; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Neurons; Okadaic Acid; Phosphorylation; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1	1999
Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonist. Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Iodine Radioisotopes; Pyrroles; Pyrrolidines; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Sulpiride; Tetrahydronaphthalenes; Transfection	1999
Differential discrimination of G-protein coupling of serotonin(1A) receptors from bovine hippocampus by an agonist and an antagonist. FEBS letters, 1999, Sep-03, Volume: 457, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Cattle; Cell Membrane; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Piperazines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction	1999
Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1'-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors. Nuclear medicine and biology, 1999, Volume: 26, Issue:7 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Brain; Carbon Radioisotopes; Dopamine Agonists; Dopamine Antagonists; Isotope Labeling; Male; Phenethylamines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Tetrahydronaphthalenes	1999
Thiophene analogs of naphthoxazines and 2-aminotetralins: bioisosteres with improved relative oral bioavailability, as compared to 5-OH-DPAT. European journal of pharmacology, 2000, Apr-14, Volume: 394, Issue:2-3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Binding, Competitive; Biological Availability; Injections, Subcutaneous; Male; Microdialysis; Motor Activity; Naphthalenes; Neostriatum; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Reserpine; Sympatholytics; Tetrahydronaphthalenes; Thiophenes	2000
In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate. Synapse (New York, N.Y.), 2000, Volume: 37, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Brain; Brain Chemistry; Carbon Radioisotopes; Dopamine Agonists; In Vitro Techniques; Macaca mulatta; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Tomography, Emission-Computed	2000
Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, 11C-PPHT and 11C-ZYY-339 in rodents and imaging in non-human primates by PET. Synapse (New York, N.Y.), 2004, Volume: 54, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Brain Chemistry; Brain Mapping; Carbamates; Carbon Isotopes; Corpus Striatum; Guanylyl Imidodiphosphate; In Vitro Techniques; Inhibitory Concentration 50; Macaca mulatta; Male; Phenethylamines; Positron-Emission Tomography; Pyrimidines; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Dopamine D3; Time Factors; Tissue Distribution	2004
Transdermal iontophoresis of the dopamine agonist 5-OH-DPAT in human skin in vitro. Journal of controlled release : official journal of the Controlled Release Society, 2005, Mar-21, Volume: 103, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Dopamine Agonists; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Iontophoresis; Skin; Skin Absorption	2005
Pharmacokinetics and pharmacodynamics analysis of transdermal iontophoresis of 5-OH-DPAT in rats: in vitro-in vivo correlation. Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:7 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Cutaneous; Animals; Dopamine; Dopamine Agonists; Iontophoresis; Male; Microdialysis; Models, Biological; Rats; Rats, Wistar; Reproducibility of Results; Skin	2006
Involvement of brain serotonin 5-HT1A receptors in genetic predisposition to aggressive behavior. Neuroscience and behavioral physiology, 2007, Volume: 37, Issue:6 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Analysis of Variance; Animals; Behavior, Animal; Brain; Gene Expression Regulation; Genetic Predisposition to Disease; Mice; Mice, Inbred C3H; Mice, Knockout; Monoamine Oxidase; Rats; Receptor, Serotonin, 5-HT1A; RNA, Messenger; Serotonin Receptor Agonists	2007
Circadian and ultradian rhythms in the crayfish caudal photoreceptor. Synapse (New York, N.Y.), 2008, Volume: 62, Issue:9 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Activity Cycles; Animals; Astacoidea; Biological Clocks; Circadian Rhythm; Ganglia, Invertebrate; Lighting; Neurons; Photoreceptor Cells, Invertebrate; Receptor, Serotonin, 5-HT1A; Serotonin; Temperature; Tritium	2008
Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro. Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetaminophen; Administration, Cutaneous; Antiparkinson Agents; Electroosmosis; Humans; In Vitro Techniques; Iontophoresis; Skin; Skin Absorption; Solubility	2010
The in vitro and in vivo evaluation of new synthesized prodrugs of 5-OH-DPAT for iontophoretic delivery. Journal of controlled release : official journal of the Controlled Release Society, 2010, Jun-15, Volume: 144, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Stability; Humans; Hydrolysis; In Vitro Techniques; Iontophoresis; Male; Microdialysis; Models, Biological; Molecular Structure; Prodrugs; Rats; Skin; Skin Absorption; Solubility; Structure-Activity Relationship; Tissue Distribution	2010
The pharmacokinetics and pharmacological effect of (S)-5-OH-DPAT following controlled delivery with transdermal iontophoresis. Journal of pharmaceutical sciences, 2011, Volume: 100, Issue:7 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Cutaneous; Anesthetics, Inhalation; Animals; Antiparkinson Agents; Basal Ganglia; Delayed-Action Preparations; Diffusion; Dopamine; Dopamine Agonists; Infusions, Intravenous; Iontophoresis; Isoflurane; Male; Microdialysis; Models, Biological; Nonlinear Dynamics; Rats; Rats, Wistar	2011
Regulation of presynaptic neurotransmission by macroautophagy. Neuron, 2012, Apr-26, Volume: 74, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Autophagy; Autophagy-Related Protein 7; Behavior, Animal; Brain; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Electrochemistry; Gene Expression Regulation; Genotype; Immunosuppressive Agents; In Vitro Techniques; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Presynaptic Terminals; RNA, Messenger; Sirolimus; TOR Serine-Threonine Kinases; Tyrosine 3-Monooxygenase	2012