Compounds > 8-chloroadenosine
Page last updated: 2024-09-04

8-chloroadenosine and adenosine

8-chloroadenosine has been researched along with adenosine in 5 studies

Compound Research Comparison

Studies
(8-chloroadenosine)		Trials
(8-chloroadenosine)		Recent Studies (post-2010)
(8-chloroadenosine)		Studies
(adenosine)		Trials
(adenosine)		Recent Studies (post-2010) (adenosine)
6001532,5361,0758,930

Protein Interaction Comparison

ProteinTaxonomy8-chloroadenosine (IC50)adenosine (IC50)
high affinity choline transporter 1 isoform aHomo sapiens (human)0.3851
Sodium/nucleoside cotransporter 1Homo sapiens (human)5.5
Sodium/nucleoside cotransporter 2Homo sapiens (human)5.5
Adenosine receptor A3Homo sapiens (human)0.0011
Adenosine receptor A1Homo sapiens (human)0.0023
Equilibrative nucleoside transporter 1Homo sapiens (human)63
Solute carrier family 28 member 3Homo sapiens (human)3.3

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's2 (40.00)2.80

Authors

AuthorsStudies
Harris, AL; Houlbrook, S; Priddle, JD; Robbins, SK1
Ayres, ML; Chen, LS; Gandhi, V; Krett, NL; Nowak, BJ; Rosen, ST; Zhang, S1
Feng, G; Gandhi, V; Krett, NL; McBrayer, SK; Qian, J; Rosen, ST; Shanmugam, M; Yarrington, M1
Cottrell, KA; Dizon, MG; Torres, LS; Weber, JD1
Lertsuwan, J; Satayavivad, J; Svasti, J1

Other Studies

5 other study(ies) available for 8-chloroadenosine and adenosine

ArticleYear
8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs.
    Cancer chemotherapy and pharmacology, 2001, Volume: 48, Issue:6

    Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Antineoplastic Agents; Cell Division; Chlorine Compounds; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Temperature

2001
Inhibition of ATP synthase by chlorinated adenosine analogue.
    Biochemical pharmacology, 2009, Sep-15, Volume: 78, Issue:6

    Topics: 2-Chloroadenosine; Adenosine; Antineoplastic Agents; ATP Synthetase Complexes; Glycolysis; Halogenation; Hydrolysis; Models, Molecular; Oxygen Consumption; Protein Binding; Protein Conformation

2009
Integrative gene expression profiling reveals G6PD-mediated resistance to RNA-directed nucleoside analogues in B-cell neoplasms.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: 2-Chloroadenosine; Adenosine; Cell Line, Tumor; Clinical Trials, Phase I as Topic; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucosephosphate Dehydrogenase; Hematologic Neoplasms; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Multiple Myeloma; Neoplasm Proteins; Pentose Phosphate Pathway; RNA, Neoplasm

2012
8-azaadenosine and 8-chloroadenosine are not selective inhibitors of ADAR.
    Cancer research communications, 2021, Volume: 1, Issue:2

    Topics: 2-Chloroadenosine; Adenosine; Interferon Type I

2021
8-Chloroadenosine Induces ER Stress and Apoptotic Cell Death in Cholangiocarcinoma Cells.
    Anticancer research, 2023, Volume: 43, Issue:12

    Topics: Adenosine; Animals; Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Proliferation; Cholangiocarcinoma; Endoplasmic Reticulum Stress; Hydroxychloroquine; Mice; RNA

2023